CN111729015A - 一种辅助治疗膝骨关节炎的药物 - Google Patents
一种辅助治疗膝骨关节炎的药物 Download PDFInfo
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- CN111729015A CN111729015A CN202010816947.5A CN202010816947A CN111729015A CN 111729015 A CN111729015 A CN 111729015A CN 202010816947 A CN202010816947 A CN 202010816947A CN 111729015 A CN111729015 A CN 111729015A
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Abstract
本发明公开了一种辅助治疗膝骨关节炎的药物,制备所述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活、桑寄生、骨碎补、五加皮、桃仁、红花、川芎、怀牛膝、杜仲、当归、熟地黄、三七、生地、柴胡、甘草。本发明辅助治疗膝骨关节炎的药物可迅速缓解膝骨关节炎带来的疼痛和不舒适感,避免内服药物给肝肾功能带来的损害,配合针灸推拿、火针火罐等外部刺激手段,可有效促进关节液循环,加速局部代谢,修复关节损伤,进而防止疼痛的反复发作,迁延病程,并且药物的制备方法简单,使用方便快捷,不受环境限制,值得在临床推广应用。
Description
技术领域
本发明涉及中药技术领域,具体涉及一种辅助治疗膝骨关节炎的药物。
背景技术
膝骨关节炎(knee osteoarthritis,KOA)是一种慢性退行性骨关节疾病,属中医“痹症”范畴,临床上以膝关节疼痛、肿胀、僵硬及功能障碍为特点,多因寒湿之邪壅滞关节腔内或因外伤损伤筋骨所致,多见于中老年,女性多于男性。KOA最基本的的治疗目的是缓解疼痛,改善功能,延缓发病进程,其治疗的方法多种多样,包括功能锻炼、中药治疗、西药治疗(非甾体药物)、关节内注射药物、综合治疗(物理疗法等),以及手术治疗。其中中药治疗包括:内服中药、中草药的外用、针灸推拿、穴位注射等,但仅通过一般的药物(口服或外用)、局部理疗等缓解疼痛,改善局部血循环及代谢来改善关节的功能活动的疗效并不稳定。
中国专利CN108310181A公开了一种辅助火针治疗膝骨关节炎的中药搽剂,该中药擦剂的原料药组成为地龙、醋延胡索、透骨草、蝴蝶藤、南蛇藤、老虎刺、川芎、肉桂、龙血竭、蔓荆子。该中药搽剂与火针相结合来治疗膝骨关节炎,但是该专利制备的中药搽剂的效果不明显。
中国专利CN105412318A公开了一种治疗膝骨关节炎的中药熏洗袋泡剂及其制备方法,以重量比计主要有65~75份吸汁药材和25~35份的煎煮药材制备而成,煎煮药材包括红花、白芷、川穹、威灵仙、花椒,煎煮液药材包括海桐皮、续断、骨碎补、透骨草、伸筋草、槲寄生、艾绒、制川乌、制草乌。但是该专利用来治疗膝骨关节炎的疗效不佳。
发明内容
本发明针对上述问题,提供一种辅助治疗膝骨关节炎的药物。
本发明解决上述问题所采用的技术方案是:一种辅助治疗膝骨关节炎的药物,制备辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活40~60份、桑寄生40~60份、骨碎补35~50份、五加皮12~25份、桃仁20~45份、红花20~45份、川芎15~25份、怀牛膝20~30份、杜仲15~35份、当归10~30份、熟地黄10~20份、三七6~12份、生地15~35份、柴胡12~16份、甘草8~15份。
当风寒湿邪留于经络关节,气血运行不畅,就会发生痹症痛症,因此治疗膝骨关节炎原则在于扶正固本,祛湿寒之气,补血活血,消肿止痛,活络舒筋。独活微温,归肝,祛风胜湿,散寒之痛,用于风寒湿痹,腰膝疼痛,头痛齿痛;桑寄生味甘,平,入肝、肾经,补肝肾,强筋骨,除风湿,通经络,益血,安胎,独活和桑寄生对风寒湿痹患者的腰腿疼痛具有很好的效果,作为君药。骨碎补具有补肾强骨,续伤止痛的疗效;五加皮具有祛风湿,补益肝肾,强筋壮骨,利水消肿的作用,但有微毒,不可多加;川芎味辛性温,可行气开郁,祛除风噪湿,活血止痛,可治疗跌打损伤肿痛,风寒湿痹,肢体麻木等症状;怀牛膝味苦酸性平,活血散瘀,祛湿利尿,清热解毒,可治疗风湿关节炎,痈肿,跌打损伤等症状;杜仲可补肝肾,强筋骨,治疗腰脊酸疼,足膝萎弱等症状;桃仁、红花具有强劲的破血的作用,力主活血化瘀,将这七种药材作为臣药。三七具有止血、破血散瘀、消炎定痛和滋补之功效;生地味甘性寒,可治骨碎破,伤肢折臂,断筋损骨等症状,具有强筋骨的效果,再配合甘温的当归、熟地黄,增加补血之力,以祛瘀为核心,辅以养血、行气,具有活血化瘀,行气止痛的作用,这四种作为佐药。柴胡可透表泄热,疏肝解郁,升举阳气,可舒缓肝郁气滞,胸肋胀痛等症状,甘草味甘性平,补脾益气,缓急止痛,可调和药物烈性,将者作为使药。柴胡、枳壳、甘草和怀牛膝配合使用,可祛除肝胆之气不舒人的淤血;独活与当归、怀牛膝、桑寄生配合使用,可起到辛散苦燥,功善祛风湿,止痹痛,缓解腰膝疼痛、关节屈伸不利的症状,特别适合风寒湿痹患者。
进一步的,制备上述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活45~55份、桑寄生45~55份、骨碎补40~45份、五加皮15~20份、桃仁25~40份、红花25~40份、川芎17~22份、怀牛膝22~28份、杜仲20~30份、当归15~25份、熟地黄12~18份、三七8~10份、生地20~30份、柴胡13~15份、甘草10~13份。
进一步的,制备上述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活50份、桑寄生50份、骨碎补43份、五加皮18份、桃仁38份、红花38份、川芎20份、怀牛膝25份、杜仲25份、当归20份、熟地黄15份、三七9份、生地25份、柴胡14份、甘草12份。
进一步的,制备上述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活45份、桑寄生45份、骨碎补40份、五加皮15份、桃仁25份、红花25份、川芎17份、怀牛膝22份、杜仲20份、当归15份、熟地黄12份、三七8份、生地20份、柴胡13份、甘草10份。
进一步的,上述辅助治疗膝骨关节炎的药物的药剂形式选自酒浸剂、膏药剂和水煮剂中的一种。
更进一步的,上述治疗膝骨关节炎的药物的药剂形式为酒浸剂。
更进一步的,上述酒浸剂的制备方法包括以下步骤:
步骤S10,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤S20,将上述制备辅助治疗膝骨关节炎的药物的原料分别打成碎块状,混合,装入容器内,倒入米酒,浸泡30~45天,酒浸药材;
步骤S30,将步骤S20中的酒浸药材撞到布袋内,封口,并加入米酒,加热至50~70℃,得到酒浸剂。
使用时将熨烫药物趁热熏烫患者膝盖及周围,以局部温热潮红,稍有汗出为度,时间控制在25~40分钟,老年患者可将熨烫药物温度控制在50℃,中年患者以温度不高于70℃为度。
进一步的,上述辅助治疗膝骨关节炎的药物的药剂形式为膏药剂。
更进一步的,上述膏药剂的制备方法包括以下步骤:
步骤a,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤b,将上述重量份的独活、桑寄生、骨碎补、红花、杜仲、当归和三七分别研磨粉碎成细粉,并过60~100目筛网,得到细粉;
步骤c,将上述重量份的五加皮、桃仁、川芎、怀牛膝、熟地黄、生地、柴胡粉和甘草碎成粗粉,过10~40目筛网,得到粗粉;
步骤d,向粗粉中加入自身重量6~10倍的无水乙醇中,浸提5小时,得到第一滤液和第一药渣,向第一药渣中加入自身重量4~6倍的水中,浸提3~4小时,得到第二滤液和第二滤渣,将第一滤液和第二滤液合并后蒸发浓缩为相对密度为1.25~1.4的稠膏,
步骤e,将细粉加入到步骤d得到稠膏中,并加入纯芝麻油,小伙熬制2~3小时,得到半成品;
步骤f,将半成品进行成膏处理,加热熔化后加入鹿角,混合均匀后敷在膏药布上,得到膏药剂。
本发明的优点是:
(1)本发明辅助治疗膝骨关节炎的药物对因风寒湿邪之气痹阻经络、气血运兴不畅导致的膝关节疼痛,屈伸不利,活动受限的患者具有显著的疗效,长期使用可有效缓解疼痛,并能温经散寒,化瘀活血,从根本上延缓发病进程,主要用于辅助针灸推拿、火针火罐来治疗膝骨关节炎;
(2)本发明辅助治疗膝骨关节炎的药物可迅速缓解膝骨关节炎带来的疼痛和不舒适感,避免内服药物给肝肾功能带来的损害,配合针灸推拿、火针火罐等外部刺激手段,可有效促进关节液循环,加速局部代谢,修复关节损伤,进而防止疼痛的反复发作,迁延病程,并且药物的制备方法简单,使用方便快捷,不受环境限制,值得在临床推广应用。
除了上面所描述的目的、特征和优点之外,本发明还有其它的目的、特征和优点。下面将对本发明作进一步详细的说明。
具体实施方式
以下对本发明的实施例进行详细说明,但是本发明可以由权利要求限定和覆盖的多种不同方式实施。
实施例1
一种辅助治疗膝骨关节炎的药物
制备辅助治疗膝骨关节炎的药物的原料包括:独活45g、桑寄生45g、骨碎补40g、五加皮15g、桃仁25g、红花25g、川芎17g、怀牛膝22g、杜仲20g、当归15g、熟地黄12g、三七8g、生地20g、柴胡13g、甘草10g。
上述辅助治疗膝骨关节炎的药物的药剂形式为酒浸剂,通过以下方法制备:
步骤S10,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤S20,将上述制备辅助治疗膝骨关节炎的药物的原料分别打成碎块状,混合,装入容器内,倒入米酒,浸泡40天,酒浸药材;
步骤S30,将步骤S20中的酒浸药材撞到布袋内,封口,并加入米酒,加热至60℃,得到酒浸剂辅助治疗膝骨关节炎的药物。
酒浸剂辅助治疗膝骨关节炎的药物在使用时采用熨烫法,将药物趁热熏烫患者膝盖及周围,以局部温热潮红,稍有汗出为度,时间控制在35分钟。
实施例2
一种辅助治疗膝骨关节炎的药物
制备辅助治疗膝骨关节炎的药物的原料包括:独活55g、桑寄生55g、骨碎补45g、五加皮20g、桃仁40g、红花40g、川芎22g、怀牛膝28g、杜仲30g、当归25g、熟地黄18g、三七10g、生地30g、柴胡15g、甘草13g。
上述辅助治疗膝骨关节炎的药物的药剂形式为酒浸剂,通过以下方法制备:
步骤S10,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤S20,将上述制备辅助治疗膝骨关节炎的药物的原料分别打成碎块状,混合,装入容器内,倒入米酒,浸泡30天,酒浸药材;
步骤S30,将步骤S20中的酒浸药材撞到布袋内,封口,并加入米酒,加热至50℃,得到酒浸剂辅助治疗膝骨关节炎的药物。
酒浸剂辅助治疗膝骨关节炎的药物在使用时采用熨烫法,将药物物趁热熏烫患者膝盖及周围,以局部温热潮红,稍有汗出为度,时间控制在40分钟。
实施例3
一种辅助治疗膝骨关节炎的药物
制备辅助治疗膝骨关节炎的药物的原料包括:独活40g、桑寄生40g、骨碎补35g、五加皮12g、桃仁20g、红花20g、川芎15g、怀牛膝20g、杜仲15g、当归10g、熟地黄10g、三七6g、生地15g、柴胡12g、甘草8g。
上述辅助治疗膝骨关节炎的药物的药剂形式为酒浸剂,通过以下方法制备:
步骤S10,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤S20,将上述制备辅助治疗膝骨关节炎的药物的原料分别打成碎块状,混合,装入容器内,倒入米酒,浸泡35天,酒浸药材;
步骤S30,将步骤S20中的酒浸药材撞到布袋内,封口,并加入米酒,加热至65℃,得到酒浸剂辅助治疗膝骨关节炎的药物。
酒浸剂辅助治疗膝骨关节炎的药物在使用时采用熨烫法,将药物物趁热熏烫患者膝盖及周围,以局部温热潮红,稍有汗出为度,时间控制在30分钟。
实施例4
一种辅助治疗膝骨关节炎的药物
制备辅助治疗膝骨关节炎的药物的包括:独活50g、桑寄生50g、骨碎补43g、五加皮18g、桃仁38g、红花38g、川芎20g、怀牛膝25g、杜仲25g、当归20g、熟地黄15g、三七9g、生地25g、柴胡14g、甘草12g。
上述辅助治疗膝骨关节炎的药物的药剂形式为膏药剂,通过以下步骤制备:
步骤a,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤b,将上述重量份的独活、桑寄生、骨碎补、红花、杜仲、当归和三七分别研磨粉碎成细粉,并过60~100目筛网,得到细粉;
步骤c,将上述重量份的五加皮、桃仁、川芎、怀牛膝、熟地黄、生地、柴胡粉和甘草碎成粗粉,过10~40目筛网,得到粗粉;
步骤d,向粗粉中加入自身重量8倍的无水乙醇中,浸提5小时,得到第一滤液和第一药渣,向第一药渣中加入自身重量5倍的水中,浸提3.5小时,得到第二滤液和第二滤渣,将第一滤液和第二滤液合并后蒸发浓缩为相对密度为1.32的稠膏,
步骤e,将细粉加入到步骤d得到稠膏中,并加入纯芝麻油,小伙熬制2.5小时,得到半成品;
步骤f,将半成品进行成膏处理,加热熔化后加入鹿角,混合均匀后敷在膏药布上,得到膏药剂。
实施例5
一种辅助治疗膝骨关节炎的药物
制备辅助治疗膝骨关节炎的药物的包括:独活60g、桑寄生60g、骨碎补50g、五加皮25g、桃仁45g、红花45g、川芎25g、怀牛膝30g、杜仲35g、当归30g、熟地黄20g、三七12g、生地35g、柴胡16g、甘草15g。
上述辅助治疗膝骨关节炎的药物的药剂形式为膏药剂,通过以下步骤制备:
步骤a,按上述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤b,将上述重量份的独活、桑寄生、骨碎补、红花、杜仲、当归和三七分别研磨粉碎成细粉,并过60~100目筛网,得到细粉;
步骤c,将上述重量份的五加皮、桃仁、川芎、怀牛膝、熟地黄、生地、柴胡粉和甘草碎成粗粉,过10~40目筛网,得到粗粉;
步骤d,向粗粉中加入自身重量10倍的无水乙醇中,浸提5小时,得到第一滤液和第一药渣,向第一药渣中加入自身重量6倍的水中,浸提4小时,得到第二滤液和第二滤渣,将第一滤液和第二滤液合并后蒸发浓缩为相对密度为1.4的稠膏,
步骤e,将细粉加入到步骤d得到稠膏中,并加入纯芝麻油,小伙熬制3小时,得到半成品;
步骤f,将半成品进行成膏处理,加热熔化后加入鹿角,混合均匀后敷在膏药布上,得到膏药剂。
实验例
为了进一步说明本发明的技术进步性,现采用临床实验进一步说明。
临床实验
一、一般资料
观察病例204例,均为膝骨关节炎患者,男73例,女131例,年龄在40~82岁,病程在10天~30年,将患者随机分为三组,每组68人,一组使用本发明实施例1制备的酒浸剂,二组使用本发明制备实施例5制备的膏药剂,三组为对照组不使用辅助药物。
二、治疗方式
全部患者均采用针刺配合拔火罐方法治疗,治疗穴位包括:局部阿是穴、双膝眼、血海、鹤顶、梁丘、犊鼻、膝阳关、阳陵泉、足三里,湿重者家阴陵泉、三阴交,气滞血瘀者加膈俞,每次选4~6个穴位;针刺完成后在其上用消毒过的火罐闪罐法拔之,10min后取下,消毒针孔。针灸火罐之后使用本发明制备的辅助治疗膝骨关节炎的药物,对照组不使用该辅助药物。其中,膏药制剂在贴上24小时后取下,间隔3天针刺、火罐、酒浸剂/膏药剂一次。
三、疗效标准
参照国家中医药管理局颁发的《中医病诊断疗效标准》中膝骨关节炎的疗效标准:
(1)痊愈:膝关节肿痛、疼痛消失,屈伸活动范围恢复正常,行走自如;
(2)显效:膝关节肿痛基本消失或明显减退,疼痛明显减轻,屈伸活动范围基本正常;
(3)有效:膝关节肿痛、疼痛均有不同程度减轻及缓解,屈伸活性范围亦有改善;
(4)无效:膝关节肿痛、疼痛均无缓解。
四、治疗效果:该临床观察病例中,均为发生毒副作用,各组治疗效果如表1所示。
表1
项目 | 痊愈人数 | 显效人数 | 有效人数 | 无效人数 | 有效率(%) |
一组 | 2 | 53 | 10 | 3 | 95.6 |
二组 | 1 | 51 | 12 | 4 | 94.1 |
三组 | 0 | 42 | 18 | 8 | 88.2 |
实验结果表明,仅仅依靠针灸火罐来治疗膝关节炎的有效率仅为88%,而配合使用本发明制备的辅助治疗膝骨关节炎的药物后,有效率可达到94%以上,辅助使用时治疗效果明显。
以上仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (9)
1.一种辅助治疗膝骨关节炎的药物,其特征在于,制备所述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活40~60份、桑寄生40~60份、骨碎补35~50份、五加皮12~25份、桃仁20~45份、红花20~45份、川芎15~25份、怀牛膝20~30份、杜仲15~35份、当归10~30份、熟地黄10~20份、三七6~12份、生地15~35份、柴胡12~16份、甘草8~15份。
2.根据权利要求1所述的辅助治疗膝骨关节炎的药物,其特征在于,制备所述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活45~55份、桑寄生45~55份、骨碎补40~45份、五加皮15~20份、桃仁25~40份、红花25~40份、川芎17~22份、怀牛膝22~28份、杜仲20~30份、当归15~25份、熟地黄12~18份、三七8~10份、生地20~30份、柴胡13~15份、甘草10~13份。
3.根据权利要求1所述的辅助治疗膝骨关节炎的药物,其特征在于,制备所述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活50份、桑寄生50份、骨碎补43份、五加皮18份、桃仁38份、红花38份、川芎20份、怀牛膝25份、杜仲25份、当归20份、熟地黄15份、三七9份、生地25份、柴胡14份、甘草12份。
4.根据权利要求1所述的辅助治疗膝骨关节炎的药物,其特征在于,制备所述辅助治疗膝骨关节炎的药物的原料按其重量份包括:独活45份、桑寄生45份、骨碎补40份、五加皮15份、桃仁25份、红花25份、川芎17份、怀牛膝22份、杜仲20份、当归15份、熟地黄12份、三七8份、生地20份、柴胡13份、甘草10份。
5.根据权利要求1所述的辅助治疗膝骨关节炎的药物,其特征在于,所述辅助治疗膝骨关节炎的药物的药剂形式选自酒浸剂、膏药剂和水煮剂中的一种。
6.根据权利要求5所述的辅助治疗膝骨关节炎的药物,其特征在于,所述治疗膝骨关节炎的药物的药剂形式为酒浸剂。
7.根据权利要求6所述的辅助治疗膝骨关节炎的药物,其特征在于,所述酒浸剂的制备方法包括以下步骤:
步骤S10,按所述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤S20,将所述制备辅助治疗膝骨关节炎的药物的原料分别打成碎块状,混合,装入容器内,倒入米酒,浸泡30~45天,酒浸药材;
步骤S30,将步骤S20中的酒浸药材撞到布袋内,封口,并加入米酒,加热至50~70℃,得到酒浸剂。
8.根据权利要求5所述的辅助治疗膝骨关节炎的药物,其特征在于,所述辅助治疗膝骨关节炎的药物的药剂形式为膏药剂。
9.根据权利要求8所述的辅助治疗膝骨关节炎的药物的制备方法,其特征在于,所述膏药剂的制备方法包括以下步骤:
步骤a,按所述重量份称取制备辅助治疗膝骨关节炎的药物的原料;
步骤b,将所述重量份的独活、桑寄生、骨碎补、红花、杜仲、当归和三七分别研磨粉碎成细粉,并过60~100目筛网,得到细粉;
步骤c,将所述重量份的五加皮、桃仁、川芎、怀牛膝、熟地黄、生地、柴胡粉和甘草碎成粗粉,过10~40目筛网,得到粗粉;
步骤d,向粗粉中加入自身重量6~10倍的无水乙醇中,浸提5小时,得到第一滤液和第一药渣,向第一药渣中加入自身重量4~6倍的水中,浸提3~4小时,得到第二滤液和第二滤渣,将第一滤液和第二滤液合并后蒸发浓缩为相对密度为1.25~1.4的稠膏,
步骤e,将细粉加入到步骤d得到稠膏中,并加入纯芝麻油,小伙熬制2~3小时,得到半成品;
步骤f,将半成品进行成膏处理,加热熔化后加入鹿角,混合均匀后敷在膏药布上,得到膏药剂。
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