CN111714386A - High-power sunscreen composition and preparation method thereof - Google Patents
High-power sunscreen composition and preparation method thereof Download PDFInfo
- Publication number
- CN111714386A CN111714386A CN202010706979.XA CN202010706979A CN111714386A CN 111714386 A CN111714386 A CN 111714386A CN 202010706979 A CN202010706979 A CN 202010706979A CN 111714386 A CN111714386 A CN 111714386A
- Authority
- CN
- China
- Prior art keywords
- percent
- phase
- parts
- components
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 32
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000002537 cosmetic Substances 0.000 claims abstract description 17
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940081733 cetearyl alcohol Drugs 0.000 claims abstract description 12
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940031569 diisopropyl sebacate Drugs 0.000 claims abstract description 11
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 claims abstract description 11
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960000601 octocrylene Drugs 0.000 claims abstract description 11
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 claims abstract description 10
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims abstract description 10
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960005193 avobenzone Drugs 0.000 claims abstract description 10
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940068171 ethyl hexyl salicylate Drugs 0.000 claims abstract description 10
- 239000013543 active substance Substances 0.000 claims abstract description 8
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims abstract description 8
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 24
- 239000000047 product Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 230000001804 emulsifying effect Effects 0.000 claims description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 229920001577 copolymer Polymers 0.000 claims description 12
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- -1 polyethylene Polymers 0.000 claims description 11
- 229920006037 cross link polymer Polymers 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 9
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 7
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 claims description 7
- 239000000377 silicon dioxide Substances 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 6
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 6
- 229940100460 peg-100 stearate Drugs 0.000 claims description 6
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 229940008099 dimethicone Drugs 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 229940075529 glyceryl stearate Drugs 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 238000000855 fermentation Methods 0.000 claims description 4
- 230000004151 fermentation Effects 0.000 claims description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 4
- 235000013599 spices Nutrition 0.000 claims description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 3
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 3
- 241000168517 Haematococcus lacustris Species 0.000 claims description 3
- 244000179886 Moringa oleifera Species 0.000 claims description 3
- 235000011347 Moringa oleifera Nutrition 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 3
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims description 2
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- 108010024636 Glutathione Proteins 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 2
- 229940022405 astaxanthin Drugs 0.000 claims description 2
- 235000013793 astaxanthin Nutrition 0.000 claims description 2
- 239000001168 astaxanthin Substances 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 229960003180 glutathione Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 229940101267 panthenol Drugs 0.000 claims description 2
- 235000020957 pantothenol Nutrition 0.000 claims description 2
- 239000011619 pantothenol Substances 0.000 claims description 2
- 229940048845 polyglyceryl-3 diisostearate Drugs 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 229940094944 saccharide isomerate Drugs 0.000 claims description 2
- LWBVAHQZGAKXPU-BOXHHOBZSA-M sodium;(4s)-4-amino-5-octadecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O LWBVAHQZGAKXPU-BOXHHOBZSA-M 0.000 claims description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 239000012071 phase Substances 0.000 claims 16
- 239000008346 aqueous phase Substances 0.000 claims 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 229940035437 1,3-propanediol Drugs 0.000 claims 1
- 241000219357 Cactaceae Species 0.000 claims 1
- 244000042664 Matricaria chamomilla Species 0.000 claims 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 229940082906 centella asiatica leaf extract Drugs 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 33
- 238000012216 screening Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 5
- 239000002085 irritant Substances 0.000 abstract description 3
- 231100000021 irritant Toxicity 0.000 abstract description 3
- 238000013329 compounding Methods 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 22
- 238000003756 stirring Methods 0.000 description 15
- 241000282414 Homo sapiens Species 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 7
- 238000005086 pumping Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 230000037072 sun protection Effects 0.000 description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000000498 cooling water Substances 0.000 description 3
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 231100000430 skin reaction Toxicity 0.000 description 3
- 229940104261 taurate Drugs 0.000 description 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 3
- 244000146462 Centella asiatica Species 0.000 description 2
- 235000004032 Centella asiatica Nutrition 0.000 description 2
- 240000003538 Chamaemelum nobile Species 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 210000000270 basal cell Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 244000174681 Michelia champaca Species 0.000 description 1
- 241001646133 Myrothamnus flabellifolia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 241001536489 Pterosperma Species 0.000 description 1
- 241000223252 Rhodotorula Species 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 229940111047 opUNTia streptacantha stem extract Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/496—Triazoles or their condensed derivatives, e.g. benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a high-power sunscreen composition and a preparation method thereof, and relates to the technical field of cosmetics. The composition comprises, by weight, 0.1-5 parts of butyl methoxy dibenzoyl methane, 0.1-8 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5-10 parts of octocrylene, 1-5 parts of ethylhexyl salicylate, 0.2-5 parts of ethylhexyl triazone, 0.1-6 parts of diethylamino hydroxybenzoyl hexyl benzoate and 0.05-8 parts of methylene bis-benzotriazolyl tetramethyl butylphenol. The composition contains a plurality of sun-screening components, and through experimental tests, the sun-screening index can reach SPF50+ PA + + + + +, and the composition has a high-power broad-spectrum sun-screening effect; further compounding with components such as polyhydric alcohol, cetearyl alcohol, diisopropyl sebacate, skin feel regulator, efficacy active substance and the like, and the finally obtained product has good experience, and is mild and non-irritant in use. The preparation process of the composition is simple and easy to operate, has low economic cost, is green and safe, and has good industrial application prospect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a high-power sunscreen composition and a preparation method thereof.
Background
The ultraviolet rays in sunlight are subdivided into three sections according to different wavelengths, and the classification and characteristics are detailed in table 1. The ultraviolet rays reaching the earth's surface are mainly long-wave ultraviolet rays UVA, accounting for about 95%, medium-wave ultraviolet rays UVB accounting for about 5%, and short-wave ultraviolet rays UVC, which are substantially blocked outside the earth's atmosphere.
TABLE 1 classification & characteristics of UV
Table 1Ultraviolet classification and its characteristics
| Name (R) | Wavelength lambda/nm | Characteristics of |
| Short wave ultraviolet UVC | 200～280 | High in energy but substantially blocked by the atmosphere |
| Medium wave ultraviolet UVB | 280～320 | Can penetrate through stratum corneum to cause acute injury such as skin erythema |
| Long wave ultraviolet UVA | 320～400 | Has strong penetrating power, and can penetrate into dermis to cause skin to be suntanned " |
With the rapid development of the industrialization process, the influence of the environment on human beings to some extent, such as the destruction of the ozone layer, is changing, resulting in the gradual increase of the ultraviolet rays reaching the earth surface. It is known that excessive ultraviolet radiation is not good for human health, and light people can cause skin sunburn after long-term exposure to ultraviolet radiation, and skin cell damage, photoaging, erythema and even light-related skin diseases such as sunburn and skin cancer can be caused for a long time. The united states cancer foundation states: more than 90% of skin cancers are associated with sunlight. Basal cells are located in the lowest layer of the epidermis, and long-term exposure to sunlight is the main cause of basal cell carcinogenesis. Therefore, people pay more and more attention to sun protection to a certain extent.
At present, one of the most effective means of uv protection is the use of sunscreen cosmetics. Especially, people who are exposed to sunlight for a long time need to be protected from sunlight, especially people who play on the beach, swim, climb up, hike, and the like, and need to use high-power sunscreen cosmetics to protect the skin from being sunburned. However, the high-power sunscreen cosmetics (SPF50+, PA + + +) on the market are not abundant, and there are mainly technical barriers. The skin feeling experience is good, the skin feeling is fresh and cool without being sticky, and meanwhile, products reaching SPF50+ PA + + + + are rare.
Therefore, the development of a high-power sunscreen (SPF50+ PA + + +) cosmetic is one of the technical problems to be solved in the technical field.
Disclosure of Invention
The invention aims to solve the technical problems that the existing high-power sun-screening composition has poor skin feel, especially the sun-screening index SPF50+ PA + + + + product, and provides a high-power sun-screening composition which has good skin feel experience and is fresh and non-sticky.
In order to solve the above problems, the present invention proposes the following technical solutions:
in a first aspect, the invention provides a high power sunscreen composition, which comprises the following components in parts by weight:
0.1-5 parts of butyl methoxy dibenzoyl methane, 0.1-8 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5-10 parts of octocrylene, 1-5 parts of ethylhexyl salicylate, 0.2-5 parts of ethylhexyl triazone, 0.1-6 parts of diethylamino hydroxybenzoyl hexyl benzoate and 0.05-8 parts of methylene bis-benzotriazolyl tetramethyl butyl phenol.
The further technical scheme is that the high-power sunscreen composition comprises the following components in percentage by weight:
0.1 to 5 percent of butyl methoxy dibenzoyl methane, 0.1 to 8 percent of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5 to 10 percent of octocrylene, 1 to 5 percent of ethylhexyl salicylate, 0.2 to 5 percent of ethylhexyl triazone, 0.1 to 6 percent of diethylamino hydroxybenzoyl hexyl benzoate, and 0.05 to 8 percent of methylene bis-benzotriazolyl tetramethyl butyl phenol;
0.5-8.0% of polyol, 1-3.5% of cetearyl alcohol and 1.5-10% of diisopropyl sebacate;
0.5 to 3.5 percent of emulsifier and 0.1 to 1.8 percent of thickener;
0.5-5% of skin feel regulator, 0-1% of preservative and 0-5% of efficacy active substance;
0.05 to 0.3 percent of essence and spice and the balance of deionized water.
Preferably, the weight percentage of the preservative is 0.1-0.6%, the weight percentage of the cetearyl alcohol is 1.8% -3%, and the weight percentage of the diisopropyl sebacate is 3-7%.
The further technical scheme is that the polyalcohol is at least one selected from 1, 3-propylene glycol, glycerol, propylene glycol, butanediol, 1, 2-pentanediol, polyethylene glycol-8 and 1, 2-hexanediol.
Further, the polyhydric alcohol is preferably one or more of butanediol, glycerol, 1, 2-hexanediol, polyethylene glycol-8 and 1, 2-pentanediol.
Further technical scheme is that the functional active substance is selected from at least one of tetrahydro-methyl pyrimidine carboxylic acid, Moringa pterosperma (MORINGA PTERYGOSPERMA) seed extract, centella asiatica (CENTELLA ASIATICA) leaf extract, Anthemis NOBILIS (Anthemis NOBILIS) flower extract, Opuntia STREPTACANTHA stem extract, Michelia crenata (Myrothamnus FLABELLIFOLIA) leaf/stem extract, glutathione, nicotinamide, yeast/rice fermentation product filtrate, saccharide isomerate, panthenol, astaxanthin, Haematococcus PLUVIALIS (Haematococcus PLUVIALIS) extract, and Rhodotorula bifida fermentation product lysate.
The further technical scheme is that the emulsifier comprises a water phase emulsifier and an oil phase emulsifier, wherein the weight ratio of the water phase emulsifier to the oil phase emulsifier is 0.5-2: 0.5-1.5.
Preferably, in the high power sunscreen composition, the proportion of the emulsifier in the water phase is 0.5-2%, and the proportion of the emulsifier in the oil phase is 0.5-1.5%.
The further technical scheme is that the water phase emulsifier is at least one selected from potassium cetyl phosphate, sodium stearyl glutamate and hydrogenated lecithin.
Further, the water phase emulsifier is preferably at least one of potassium cetyl phosphate and hydrogenated lecithin;
the further technical proposal is that the oil phase emulsifier is at least one selected from glycerol stearate/PEG-100 stearate, cetearyl alcohol/cetearyl glucoside and polyglycerol-3 diisostearate.
Further, the oil phase emulsifier is preferably one or more of cetearyl alcohol/cetearyl glucoside, glyceryl stearate/PEG-100 stearate, and polyglyceryl-3 diisostearate.
The further technical proposal is that the thickening agent is selected from xanthan gum, hydroxyethyl cellulose, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, carbomer, acryloyl dimethyl ammonium taurate/VP copolymer, VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer,
EG，
at least one of the NS.
Further, the thickener is preferably at least one of ammonium acryloyldimethyltaurate/VP copolymer, acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer, VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer, and xanthan gum.
The further technical proposal is that the skin feel regulator is at least one selected from silica, polymethylsilsesquioxane, polydimethylsiloxane/vinyl polydimethylsiloxane cross-linked polymer and C30-45 alkyl cetearyl polydimethylsiloxane cross-linked polymer.
Further, the skin feeling regulator is preferably one or more of silica, C30-45 alkyl cetearyl polydimethylsiloxane cross-linked polymer and polymethylsilsesquioxane.
In a second aspect, the present invention provides a method for preparing a high power sunscreen cosmetic composition, comprising the steps of:
1) taking A, B, C phase components, wherein the phase A comprises 30-70% of deionized water, 0.5-2% of water phase emulsifier, 0.5-8.0% of polyalcohol and 0.1-1.8% of thickener by weight percentage; the phase B comprises 0.5 to 1.5 percent of oil phase emulsifier, 1.8 to 3 percent of cetostearyl alcohol, 1.5 to 10 percent of diisopropyl sebacate, 0.1 to 5 percent of butyl methoxy dibenzoyl methane, 0.1 to 8 percent of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5 to 10 percent of octocrylene, 1 to 5 percent of ethylhexyl salicylate, 0.2 to 5 percent of ethylhexyl triazone, 0.1 to 6 percent of diethylamino hydroxybenzoyl hexyl benzoate and 0.05 to 8 percent of methylene bis-benzotriazolyl tetramethyl butyl phenol; the phase C comprises 0.5-5% of skin feel regulator, 0.1-0.6% of preservative, 0-5% of efficacy active substance and 0.05-0.3% of essence and spice;
2) adding the components of the phase A into a water phase pot, heating to 75-85 ℃, and completely dissolving and uniformly mixing;
3) adding the components of the phase B into an oil phase pot, heating to 75-85 ℃, and completely dissolving and uniformly mixing;
4) mixing the phase A and the phase B obtained in the step 2) and the step 3) at 75-85 ℃, homogenizing and emulsifying after fully mixing uniformly, and keeping the temperature;
5) and cooling the product of the step 4) to 40-50 ℃, adding the components of the phase C, uniformly mixing, filtering and discharging after the inspection is qualified.
Compared with the prior art, the invention can achieve the following technical effects:
the high-power sun-screening composition provided by the invention contains a plurality of sun-screening components, and the sun-screening index of the composition can reach SPF50+ PA + + + + +, and the high-power broad-spectrum sun-screening effect is achieved; can be further compounded with components such as polyhydric alcohol, cetearyl alcohol, diisopropyl sebacate, skin feel regulator, efficacy active substance and the like, and the finally obtained product has good experience, and is mild and non-irritant in use.
The high-power sunscreen composition provided by the invention has the advantages of simple preparation process, easiness in operation, low economic cost, greenness, safety and good industrial application prospect.
Drawings
FIG. 1 is a graph showing the relationship between the transmittance and the wavelength of a high power sunscreen composition provided in example 3 of the present invention.
Detailed Description
The technical solutions in the examples will be clearly and completely described below. It is apparent that the embodiments to be described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The raw materials used in the examples of the present invention were all commercially available.
Example 1
This example provides a high power sunscreen composition comprising a phase a component, a phase B component, and a phase C component.
Wherein: the phase A comprises the following components in percentage by weight (the sum of the components is 100 percent): deionized water 46%, glycerol 3%, 1, 2-pentanediol 1.5%, 1, 2-hexanediol 0.5%, potassium cetyl phosphate 1%, hydrogenated lecithin 0.5%, ammonium acryloyldimethyl taurate/VP copolymer 0.3%, and VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer 0.8%;
phase B component comprises 1% glyceryl stearate/PEG-100 stearate, 2.5% cetearyl alcohol, 5% diisopropyl sebacate, 3% butyl methoxydibenzoylmethane, 1.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 8.5% octocrylene, 3% ethylhexyl salicylate, 1% ethylhexyl triazone, 2% hexyl diethylaminobenzoyl benzoate, 6% methylenebis-benzotriazolyl tetramethylbutylphenol;
phase C component comprises silica 2%, antiseptic 0.5%, essence 0.15%, effective active 1%, and deionized cooling water in balance.
The preparation method of the above embodiment comprises the following steps:
1) adding the components of the phase A into a water phase pot, heating to 80 ℃, and stirring to dissolve completely;
2) adding the components of the phase B into an oil phase pot, heating to 80 ℃, and stirring to dissolve completely;
3) pumping the components of the phase A into an emulsifying pot, pumping the components of the phase B into the emulsifying pot, stirring the components and the emulsifying pot uniformly, starting homogenizing and emulsifying, and keeping the temperature;
4) and stirring and cooling the product of the step 3) to 45 ℃, adding the components of the phase C into an emulsifying pot, uniformly stirring, homogenizing when necessary, and filtering and discharging after the inspection is qualified.
Example 2
This example provides a high power sunscreen composition comprising a phase a component, a phase B component, and a phase C component.
Wherein: the phase A comprises the following components in percentage by weight (the sum of the components is 100 percent): 45% of deionized water, 2.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.3% of 1, 2-hexanediol, 0.8% of potassium cetyl phosphate, 0.6% of hydrogenated lecithin, 0.28% of acryloyldimethyl ammonium taurate/VP copolymer and 1.3% of VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer;
phase B component comprises glyceryl stearate/PEG-100 stearate 1.5%, cetearyl alcohol 2%, diisopropyl sebacate 6%, butyl methoxydibenzoylmethane 2.8%, bis-ethylhexyloxyphenol methoxyphenyl triazine 1.5%, octocrylene 8%, ethylhexyl salicylate 4%, ethylhexyl triazone 1.5%, diethylamino hydroxybenzoyl hexyl benzoate 1.8%, methylene bis-benzotriazolyl tetramethylbutylphenol 6%;
phase C component comprises silica 1.8%, C30-45 alkyl cetearyl dimethicone crosspolymer 3%, antiseptic 0.5%, essence 0.15%, efficacy active 1%, and deionized cooling water balance.
The preparation method of the above embodiment comprises the following steps:
1) adding the components of the phase A into a water phase pot, heating to 80 ℃, and stirring to dissolve completely;
2) adding the components of the phase B into an oil phase pot, heating to 80 ℃, and stirring to dissolve completely;
3) pumping the components of the phase A into an emulsifying pot, pumping the components of the phase B into the emulsifying pot, stirring the components and the emulsifying pot uniformly, starting homogenizing and emulsifying, and keeping the temperature;
4) and stirring and cooling the product of the step 3) to 45 ℃, adding the components of the phase C into an emulsifying pot, uniformly stirring, homogenizing when necessary, and filtering and discharging after the inspection is qualified.
Example 3
This example provides a high power sunscreen composition comprising a phase a component, a phase B component, and a phase C component.
Wherein: the phase A comprises the following components in percentage by weight (the sum of the components is 100 percent): 41% of deionized water, 2.5% of butanediol, 1.5% of 1, 2-pentanediol, 0.3% of 1, 2-hexanediol, 1% of potassium cetyl phosphate, 0.6% of hydrogenated lecithin, 0.25% of acryloyldimethyl ammonium taurate/VP copolymer and 1% of VP/acrylic acid (ester)/lauryl alcohol methacrylate copolymer;
phase B component comprises 1% glyceryl stearate/PEG-100 stearate, 2.3% cetearyl alcohol, 5% diisopropyl sebacate, 3% butyl methoxydibenzoylmethane, 1.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 8% octocrylene, 3% ethylhexyl salicylate, 1.5% ethylhexyl triazone, 2% hexyl diethylaminobenzoyl benzoate, 6% methylenebis-benzotriazolyl tetramethylbutylphenol;
phase C component comprises silica 1.8%, C30-45 alkyl cetearyl dimethicone crosspolymer 3%, antiseptic 0.5%, essence 0.15%, efficacy active 1%, and deionized cooling water balance.
The preparation method of the above embodiment comprises the following steps:
1) adding the components of the phase A into a water phase pot, heating to 80 ℃, and stirring to dissolve completely;
2) adding the components of the phase B into an oil phase pot, heating to 80 ℃, and stirring to dissolve completely;
3) pumping the components of the phase A into an emulsifying pot, pumping the components of the phase B into the emulsifying pot, stirring the components and the emulsifying pot uniformly, starting homogenizing and emulsifying, and keeping the temperature;
4) and stirring and cooling the product of the step 3) to 45 ℃, adding the components of the phase C into an emulsifying pot, uniformly stirring, homogenizing when necessary, and filtering and discharging after the inspection is qualified.
(I) Mild testing
The human skin closed patch test was performed according to the human skin patch test specified in the technical standards for cosmetic safety (2015 edition).
1. The test purpose is as follows: and detecting the potential possibility of the test object causing the adverse reaction of the human skin.
2. And (3) test design: the patch tester with the test substance is applied to the skin of the back of the subject for 24 hours. When the test substance is a cosmetic product, the control well is a blank control (containing no substance), and when the test substance is a diluted cosmetic, the diluent of the cosmetic is used in the control well. And respectively grading the skin according to the skin reaction grading standard of the skin closed patch test 30min (after the indentation disappears), 24h and 48h after the test object patch tester is removed.
3. Test samples: the product of example 3 was used as a test sample.
4. Test instruments/materials: an analytical balance, a 1mm plaque tester, a medical adhesive tape, a sterilized cotton swab and a 1ml syringe;
5. the test method comprises the following steps:
the volunteer requires: selecting a volunteer with the age of 18-60 and meeting the test requirements as a subject, 30 persons;
the testing steps are as follows: the selected area is not more than 50mm2And qualified spot test equipment with the depth of about 1 mm. The test substance is put into a small chamber of a spot tester, and the dosage is about 0.020g to 0.025 g. Control wells are blank. The spot test device with the tested object is applied to the back of the tested object by using a low-sensitivity adhesive tape, and is lightly pressed by hands to be uniformly applied to the skin for 24 hours.
The skin reactions were observed according to the standard of table 2 30min (after disappearance of the indentation), 24h and 48h after removal of the test article plaque test device, respectively, and the observation results were recorded.
TABLE 2 skin response grading Standard for skin Enclosed Patch test
6. And (3) analyzing an experimental result:
TABLE 3 test results of human skin occlusion patch
7. And (4) conclusion: the result of the human skin closed patch test shows that 0 of 30 people has positive reaction.
As can be seen from the above test of skin-enclosed patches on human body, the high-power sunscreen composition provided by the invention is very mild and non-irritating to human body.
(II) Sun protection index test
The product of example 3 was used as a test sample.
The test method comprises the following steps: SPF was measured using UV-2000s (Labsphere UV Transmission Analyzer), and UVAPF was measured using UV-2000s and Atlas (SUNTEST CPS +), the latter being a solar simulator, for measuring the photostability of the samples.
In the standard of sunscreen products, SPF > 50, i.e. designated SPF50 +; PA > 16, denoted PA + + +; critical wavelength/nm is more than 370nm, which shows that the product has broad-spectrum sunscreen effect.
The results of the transmittance vs. wavelength test for example 3 are shown in FIG. 1:
the sun protection index test results are as follows:
SPF＝72.6±2.0；PA＝31.2±0.5；Critical wavelength/nm＝380.75nm。
therefore, the high-power sun-screening composition provided by the invention has the sun-screening index reaching SPF50+ and PA + + + + +, and has a broad-spectrum sun-screening effect.
Comparison of the properties of example 3 with comparative examples 1 to 4:
the sunscreen product of the comparative example prepared without a certain ingredient was selected and tested for performance using example 3 as a reference, and the ratio of example 3 to comparative example and the results of the performance test are shown in table 1.
The test results show that the comparative example 1 has an SPF of less than 50 and a smaller sun protection performance than example 3 in the sun protection test due to the absence of octocrylene; comparative example 2 lacks methylenebis-benzotriazolyl tetramethylbutylphenol, which has a lower sunscreen index against UVA than example 3; comparative example 3 lacks potassium cetyl phosphate, the prepared product has poor stability and cannot meet the production requirement; comparative example 4 lacks silica and the resulting product is highly tacky and has poor in-use experience.
In conclusion, the high-power sun-screening composition provided by the invention contains a plurality of sun-screening components, and is compounded through experimental tests, so that the sun-screening index of the composition can reach SPF50+ PA + + + +, and the high-power broad-spectrum sun-screening effect is achieved; can be further compounded with components such as polyhydric alcohol, cetearyl alcohol, diisopropyl sebacate, skin feel regulator, efficacy active substance and the like, and the finally obtained product has good experience, and is mild and non-irritant in use.
TABLE 1 formulation of example 3 and comparative examples and results of performance tests (in weight percent)
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
While the invention has been described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. The high-power sunscreen composition is characterized by comprising the following components in parts by weight:
0.1-5 parts of butyl methoxy dibenzoyl methane, 0.1-8 parts of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5-10 parts of octocrylene, 1-5 parts of ethylhexyl salicylate, 0.2-5 parts of ethylhexyl triazone, 0.1-6 parts of diethylamino hydroxybenzoyl hexyl benzoate and 0.05-8 parts of methylene bis-benzotriazolyl tetramethyl butyl phenol.
2. The high power sunscreen composition according to claim 1 comprising, in weight percent:
0.1 to 5 percent of butyl methoxy dibenzoyl methane, 0.1 to 8 percent of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5 to 10 percent of octocrylene, 1 to 5 percent of ethylhexyl salicylate, 0.2 to 5 percent of ethylhexyl triazone, 0.1 to 6 percent of diethylamino hydroxybenzoyl hexyl benzoate, and 0.05 to 8 percent of methylene bis-benzotriazolyl tetramethyl butyl phenol;
0.5-8.0% of polyol, 1-3.5% of cetearyl alcohol and 1.5-10% of diisopropyl sebacate;
0.5 to 3.5 percent of emulsifier and 0.1 to 1.8 percent of thickener;
0.5-5% of skin feel regulator, 0-1% of preservative and 0-5% of efficacy active substance;
0.05 to 0.3 percent of essence and spice and the balance of deionized water.
3. A high power sunscreen composition according to claim 2 wherein said polyhydric alcohol is selected from at least one of 1, 3-propanediol, glycerin, propylene glycol, butylene glycol, 1, 2-pentanediol, polyethylene glycol-8, 1, 2-hexanediol.
4. The high power sunscreen cosmetic composition of claim 2 wherein said efficacy active is selected from at least one of the group consisting of tetrahydro-methyl pyrimidine carboxylic acid, moringa pterocarpa seed extract, centella asiatica leaf extract, chamomile flower extract, cactus stem extract, mulukhiya leaf/stem extract, glutathione, niacinamide, yeast/rice fermentation product filtrate, saccharide isomerate, panthenol, astaxanthin, haematococcus pluvialis extract, schizosaccharomyces cerevisiae fermentation product lysate.
5. The high power sunscreen cosmetic composition of claim 2 wherein said emulsifier comprises an aqueous phase emulsifier and an oil phase emulsifier, wherein the weight ratio of the aqueous phase emulsifier to the oil phase emulsifier is from 0.5 to 2: 0.5-1.5.
6. The high power sunscreen cosmetic composition of claim 5 wherein said aqueous phase emulsifier is selected from at least one of potassium cetyl phosphate, sodium stearyl glutamate, hydrogenated lecithin.
7. A high power sunscreen cosmetic composition according to claim 5 wherein the oil phase emulsifier is selected from at least one of glyceryl stearate/PEG-100 stearate, cetearyl alcohol/cetearyl glucoside, polyglyceryl-3 diisostearate.
8. The high power sunscreen cosmetic composition of claim 2 wherein said thickener is selected from the group consisting of xanthan gum, hydroxyethyl cellulose, acrylic acid/C10-30 alkanol acrylate crosspolymer, carbomer, ammonium acryloyldimethyl taurate/VP copolymer, VP/acrylic acid/lauryl alcohol methacrylate copolymer,
EG，
at least one of the NS.
9. The high power sunscreen composition of claim 2 wherein said skin feel modifier is selected from at least one of silica, polymethylsilsesquioxane, dimethicone/vinyl dimethicone crosspolymer, C30-45 alkyl cetearyl dimethicone crosspolymer.
10. A preparation method of a high-power sunscreen cosmetic composition is characterized by comprising the following steps:
1) taking A, B, C phase components, wherein the phase A comprises 30-70% of deionized water, 0.5-2% of water phase emulsifier, 0.5-8.0% of polyalcohol and 0.1-1.8% of thickener by weight percentage; the phase B comprises 0.5 to 1.5 percent of oil phase emulsifier, 1.8 to 3 percent of cetostearyl alcohol, 1.5 to 10 percent of diisopropyl sebacate, 0.1 to 5 percent of butyl methoxy dibenzoyl methane, 0.1 to 8 percent of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5 to 10 percent of octocrylene, 1 to 5 percent of ethylhexyl salicylate, 0.2 to 5 percent of ethylhexyl triazone, 0.1 to 6 percent of diethylamino hydroxybenzoyl hexyl benzoate and 0.05 to 8 percent of methylene bis-benzotriazolyl tetramethyl butyl phenol; the phase C comprises 0.5-5% of skin feel regulator, 0.1-0.6% of preservative, 0-5% of efficacy active substance and 0.05-0.3% of essence and spice;
2) adding the components of the phase A into a water phase pot, heating to 75-85 ℃, and completely dissolving and uniformly mixing;
3) adding the components of the phase B into an oil phase pot, heating to 75-85 ℃, and completely dissolving and uniformly mixing;
4) mixing the phase A and the phase B obtained in the step 2) and the step 3) at 75-85 ℃, homogenizing and emulsifying after fully mixing uniformly, and keeping the temperature;
5) and cooling the product of the step 4) to 40-50 ℃, adding the components of the phase C, uniformly mixing, filtering and discharging after the inspection is qualified.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010706979.XA CN111714386A (en) | 2020-07-21 | 2020-07-21 | High-power sunscreen composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010706979.XA CN111714386A (en) | 2020-07-21 | 2020-07-21 | High-power sunscreen composition and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111714386A true CN111714386A (en) | 2020-09-29 |
Family
ID=72573032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010706979.XA Pending CN111714386A (en) | 2020-07-21 | 2020-07-21 | High-power sunscreen composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111714386A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112315820A (en) * | 2020-12-02 | 2021-02-05 | 广东嘉丹婷日用品有限公司 | Oil-in-water sunscreen emulsion and preparation method thereof |
| CN112386516A (en) * | 2020-11-25 | 2021-02-23 | 上海新高姿化妆品有限公司 | Low-permeability mild sunscreen composition and preparation method and application thereof |
| CN112451395A (en) * | 2020-12-02 | 2021-03-09 | 广东嘉丹婷日用品有限公司 | Water-in-oil sunscreen emulsion and preparation method thereof |
| CN115137657A (en) * | 2022-07-29 | 2022-10-04 | 上海百雀羚生物科技有限公司 | Composition for stabilizing color of cosmetic gardenia pigment and application thereof |
| CN115252470A (en) * | 2022-08-01 | 2022-11-01 | 晟薇药业(上海)有限公司 | Sunscreen repair composition |
| CN115350137A (en) * | 2022-07-14 | 2022-11-18 | 中山市天图精细化工有限公司 | Binary bag packaged non-combustible sun-proof spray aerosol composition and preparation method thereof |
| CN115894410A (en) * | 2022-11-22 | 2023-04-04 | 无锡凯高贸易有限公司 | Sunscreen compound, sunscreen cosmetic and preparation method thereof |
| CN116211745A (en) * | 2022-12-28 | 2023-06-06 | 妙梵医药科技(广州)有限公司 | Mild and non-irritating composition with sun-screening effect and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478471A (en) * | 2018-04-29 | 2018-09-04 | 佛山云裳化妆品有限公司 | A kind of suncream and preparation method thereof of the high protective capacities of non-greasy |
| CN108852943A (en) * | 2018-09-06 | 2018-11-23 | 广州艾蓓生物科技有限公司 | A kind of foundation compositions and preparation method thereof without titanium dioxide |
-
2020
- 2020-07-21 CN CN202010706979.XA patent/CN111714386A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478471A (en) * | 2018-04-29 | 2018-09-04 | 佛山云裳化妆品有限公司 | A kind of suncream and preparation method thereof of the high protective capacities of non-greasy |
| CN108852943A (en) * | 2018-09-06 | 2018-11-23 | 广州艾蓓生物科技有限公司 | A kind of foundation compositions and preparation method thereof without titanium dioxide |
Non-Patent Citations (3)
| Title |
|---|
| FAMAR: "Forteplus Face & Body Cream SPF 50+", 《DATABASE GNPD（WWW.MINTEL.COM）》 * |
| 匿名: "Angstrom HYDRAXOL 50+ CREMA SOLARE ULTRA IDRATANTE", 《COSDNA（WWW.COSDNA.COM）》 * |
| 裘丙毅等: "《现代化妆品科学与技术：全3册》", 31 March 2016, 中国轻工业出版社 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112386516A (en) * | 2020-11-25 | 2021-02-23 | 上海新高姿化妆品有限公司 | Low-permeability mild sunscreen composition and preparation method and application thereof |
| CN112315820A (en) * | 2020-12-02 | 2021-02-05 | 广东嘉丹婷日用品有限公司 | Oil-in-water sunscreen emulsion and preparation method thereof |
| CN112451395A (en) * | 2020-12-02 | 2021-03-09 | 广东嘉丹婷日用品有限公司 | Water-in-oil sunscreen emulsion and preparation method thereof |
| CN115350137A (en) * | 2022-07-14 | 2022-11-18 | 中山市天图精细化工有限公司 | Binary bag packaged non-combustible sun-proof spray aerosol composition and preparation method thereof |
| CN115350137B (en) * | 2022-07-14 | 2023-10-27 | 中山市天图精细化工有限公司 | Binary bag packaged incombustible sun-proof spray aerosol composition and preparation method thereof |
| CN115137657A (en) * | 2022-07-29 | 2022-10-04 | 上海百雀羚生物科技有限公司 | Composition for stabilizing color of cosmetic gardenia pigment and application thereof |
| CN115137657B (en) * | 2022-07-29 | 2024-02-23 | 上海百雀羚生物科技有限公司 | Composition for stabilizing color of cosmetic gardenia pigment and application thereof |
| CN115252470A (en) * | 2022-08-01 | 2022-11-01 | 晟薇药业(上海)有限公司 | Sunscreen repair composition |
| CN115894410A (en) * | 2022-11-22 | 2023-04-04 | 无锡凯高贸易有限公司 | Sunscreen compound, sunscreen cosmetic and preparation method thereof |
| CN115894410B (en) * | 2022-11-22 | 2024-05-14 | 百特威(上海)化妆品有限公司 | Sun-screening compound, sun-screening cosmetic and preparation method of sun-screening cosmetic |
| CN116211745A (en) * | 2022-12-28 | 2023-06-06 | 妙梵医药科技(广州)有限公司 | Mild and non-irritating composition with sun-screening effect and preparation method thereof |
| CN116211745B (en) * | 2022-12-28 | 2023-12-01 | 妙梵医药科技(广州)有限公司 | Mild and non-irritating composition with sun-screening effect and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111714386A (en) | High-power sunscreen composition and preparation method thereof | |
| CN103006519B (en) | Natural plant sun-screening agent as well as preparation method and application of natural plant sun-screening agent | |
| CN108635274B (en) | Light protection composition and preparation method and application thereof | |
| GB2206282A (en) | Topical composition for protecting against solar radiation | |
| CN111265459B (en) | Sunscreen lotion for children and preparation method thereof | |
| US11510857B2 (en) | Cosmetic compositions having antioxidant properties | |
| CN112294667A (en) | Composition with broad-spectrum light protection effect and application thereof | |
| CN113181095A (en) | Anti-inflammatory repairing cosmetic composition and application thereof | |
| CN107929152A (en) | Cosmetic composition of sun-proof reparation and preparation method thereof | |
| EP3103433A1 (en) | Cosmetic composition for uv and high-energy visible light | |
| WO2024066643A1 (en) | Sun-screening composition and use thereof | |
| CN112516022B (en) | Sun-screening lotion and preparation method thereof | |
| CN114404330A (en) | Sunscreen composition and preparation method thereof | |
| CN113425649A (en) | Sunscreen synergistic composition, cosmetic composition and preparation method thereof | |
| CN108014060B (en) | Sunscreen synergistic composition and application thereof | |
| CN112263493B (en) | Sunscreen composition, sunscreen gel containing sunscreen composition and preparation method of sunscreen gel | |
| CN116139064B (en) | Sun-proof synergistic composition, application thereof and cosmetics | |
| CN112220693A (en) | Solid spray containing Norwegian spruce leaf extract for after-sun repair and preparation method thereof | |
| CN106074226A (en) | A kind of sunscreen composition and prepared cosmetics thereof | |
| CN104586706B (en) | A kind of Phellinus suncream and preparation method thereof | |
| KR20150041938A (en) | Mixture for protecting skin and Cosmetic composition comprising thereof for protecting skin from ultraviolet rays | |
| CN113730269B (en) | Mild gel with sun-screening effect and preparation method thereof | |
| CN108354858A (en) | A kind of suncream and preparation method thereof containing marine organisms sun-screening agent | |
| KR101934793B1 (en) | Composition for preventing or improving skin photoaging comprising extract of Diospyros lotus leaf as effective component | |
| CN115969749A (en) | Sunscreen composition and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200929 |