CN111700934A - Plant-based gel for neurodermatitis and preparation process thereof - Google Patents

Plant-based gel for neurodermatitis and preparation process thereof Download PDF

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Publication number
CN111700934A
CN111700934A CN202010773864.2A CN202010773864A CN111700934A CN 111700934 A CN111700934 A CN 111700934A CN 202010773864 A CN202010773864 A CN 202010773864A CN 111700934 A CN111700934 A CN 111700934A
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neurodermatitis
plant
stirring
based gel
carbomer
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Inventor
刘春雨
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Suzhou Zhishi Biotechnology Co ltd
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Suzhou Zhishi Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to the field of medical drugs, in particular to a plant-based gel for neurodermatitis and a preparation process thereof. A plant-based gel for neurodermatitis is characterized by comprising the following substances in percentage by weight: 3-10% of cowherb seed, 1-5% of pittosporum tobira, 5-8% of lotus leaf, 2-3% of sophora flavescens, 2-3% of salvia miltiorrhiza, 2-8% of hovenia dulcis, 3-5% of centella asiatica, 3-5% of mulberry leaf, 2-5% of sophora flower, 1-2% of mint, 1-2% of thyme, 0.2-1% of carbomer, 0.2-1% of triethanolamine and the balance of deionized water. The invention has the repairing function to intractable neurodermatitis, and the main component of the invention is plant base, which has no stimulation to skin.

Description

Plant-based gel for neurodermatitis and preparation process thereof
Technical Field
The invention relates to the field of medical drugs, in particular to a plant-based gel for neurodermatitis and a preparation process thereof.
Background
Neurodermatitis is also called as chronic simple moss. Chronic skin diseases characterized by paroxysmal skin pruritus and lichenification are common skin diseases and are often seen in adults.
At the beginning, the skin has itching feeling without primary skin damage, and due to scratching and rubbing, the skin gradually appears flat papules from millet grains to mung bean, is round or polygonal, hard and glossy, and is reddish or normal in skin color and scattered in distribution. Due to paroxysmal severe itching, patients often scratch, papules gradually increase, and the papules are fused into pieces, become fat and moss-like after a long time, and are marked by deepened skin lines, raised skin ridges, dark brown skin damage, dryness and fine crumbling and desquamation. The patch-like lesions are well-defined and may have small flat papules on the margins, scattered and isolated. The number of the skin lesion and spot pieces is not constant, and the skin lesion and spot pieces can be singly or widely sent to the whole body, and have different sizes and shapes. It is good at the two sides of the neck, nape, elbow, popliteal fossa, sacrococcygeal region, wrist, ankle, and also at the lumbar and back, eyelids, four limbs, and vulva. The skin damage is limited to one or more parts, namely localized neurodermatitis; if the skin damage is widespread and even generalized in the whole body, it is called generalized neurodermatitis.
The main treatment means at present is H1 antihistamine preparation oral/injection/external or oral/injection/external glucocorticoid. The two measures can quickly relieve itching in a short time, but the itching is easy to recur after healing, and the medicine dependence and the dermatitis medicamentosa are easy to cause.
Disclosure of Invention
The invention aims to provide a plant-based gel for neurodermatitis and a preparation process thereof so as to solve the defects of the prior art.
The technical scheme adopted by the invention for solving the technical problem is as follows:
a plant-based gel for neurodermatitis comprises the following substances in percentage by weight:
Figure BDA0002617636150000021
a preparation process of a plant-based gel for neurodermatitis is characterized by comprising the following steps:
(1) weighing cowherb seed, pittosporum tobira, lotus leaf, sophora flavescens, salvia miltiorrhiza, hovenia dulcis thumb, centella, mulberry leaf, sophora flower and mint respectively, cleaning with clear water, draining, heating under vacuum for drying and dehydrating until the water content is less than 1%, micronizing to 550-650 meshes, putting into boiled deionized water, fully stirring and infiltrating for 2-4 hours, reheating to 95-100 ℃, infiltrating for 1-2 hours, and filtering to obtain filter residue and filtrate;
(2) membrane drying the filtrate obtained in the step (1) to obtain a concentrated extract for later use;
(3) weighing carbomer, putting into the rest deionized water, homogenizing at a high speed at 50-60 ℃ for 10-20 min, adding triethanolamine, stirring fully, and cooling at normal temperature to obtain carbomer gel;
(4) mixing the concentrated extract with carbomer gel under stirring, emulsifying, heating for 30-40min, and naturally cooling to obtain the final product.
Preferably, the stirring speed in the step (1) is 25-30 rpm.
Preferably, the homogenizing rotation speed in the step (3) is 2500-4000 rpm, and the emulsifying heating temperature is 50-60 ℃.
Preferably, the stirring speed in the step (4) is 250-450 rpm, and the emulsifying heating temperature is 50-60 ℃.
The invention has the advantages that:
(1) the invention can treat neurodermatitis, and the main components of the invention are all plant-based, thus having no stimulation to skin;
(2) the traditional Chinese medicine composition has a good effect of treating neurodermatitis, and the recurrence rate after healing is low.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1
(1) Weighing 8g of cowherb seed, 3g of pittosporum tobira, 5g of lotus leaf, 2g of sophora flavescens, 2g of salvia miltiorrhiza, 3.5g of hovenia dulcis thumb, 4g of centella asiatica, 3.5g of mulberry leaf, 3g of sophora flower and 1g of mint, cleaning with clear water, draining, heating under vacuum for drying and dehydrating until the water content is less than 1%, micronizing to 600 meshes, putting into boiled deionized water, fully stirring and soaking for 3 hours, reheating to 100 ℃, soaking for 1 hour, putting into a tubular centrifuge for filtration, and then putting into a mesh belt centrifuge for filtration to obtain filter residue and filtrate;
(2) membrane drying the filtrate obtained in the step (1) to obtain a concentrated extract for later use;
(3) weighing 1g of carbomer, putting the carbomer into the rest deionized water, homogenizing at a high speed for 10min at 60 ℃, adding 1g of triethanolamine, fully stirring, and cooling at normal temperature to obtain carbomer gel;
(4) and stirring and mixing the concentrated extract and carbomer gel, emulsifying and heating for 30min, and naturally cooling to obtain the finished product.
The stirring speed in the step (1) is 30 revolutions per minute.
The homogenizing rotation speed in the step (3) is 3000 r/min, and the emulsifying heating temperature is 50 ℃.
The stirring speed in the step (4) is 250 revolutions per minute, and the emulsifying heating temperature is 60 ℃.
103 patients with neurodermatitis are respectively treated at outpatient clinics of hospitals, and the age is distributed between 20 and 45 years. Among them, 101 cases of localized neurodermatitis and 2 cases of generalized neurodermatitis. Specific treatment results are shown in the following table:
first table patient treatment table
Figure BDA0002617636150000041
Figure BDA0002617636150000051
All patients were followed 1 year after cure, with 1 relapser.
The results show that the invention has good treatment effect and low recurrence rate after healing.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (4)

1. A plant-based gel for neurodermatitis is characterized by comprising the following substances in percentage by weight:
Figure FDA0002617636140000011
2. the process for preparing a plant-based gel for neurodermatitis according to claim 1, comprising the steps of:
(1) weighing cowherb seed, pittosporum tobira, lotus leaf, sophora flavescens, salvia miltiorrhiza, hovenia dulcis thumb, centella, mulberry leaf, sophora flower and mint respectively, cleaning with clear water, draining, heating under vacuum for drying and dehydrating until the water content is less than 1%, micronizing to 550-650 meshes, putting into boiled deionized water, fully stirring and infiltrating for 2-4 hours, reheating to 95-100 ℃, infiltrating for 1-2 hours, and filtering to obtain filter residue and filtrate;
(2) membrane drying the filtrate obtained in the step (1) to obtain a concentrated extract for later use;
(3) weighing carbomer, putting into the rest deionized water, homogenizing at a high speed at 50-60 ℃ for 10-20 min, adding triethanolamine, stirring fully, and cooling at normal temperature to obtain carbomer gel;
(4) mixing the concentrated extract with carbomer gel under stirring, emulsifying, heating for 30-40min, and naturally cooling to obtain the final product.
3. The method of claim 2, wherein: the stirring speed in the step (1) is 25-30 r/min.
4. The method of claim 2, wherein: the stirring speed in the step (4) is 2500-4000 rpm, and the emulsifying heating temperature is 50-60 ℃.
CN202010773864.2A 2020-08-04 2020-08-04 Plant-based gel for neurodermatitis and preparation process thereof Pending CN111700934A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110538275A (en) * 2019-10-09 2019-12-06 苏州知时生物科技有限公司 plant bacteriostatic liquid for field survival and preparation process thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110538275A (en) * 2019-10-09 2019-12-06 苏州知时生物科技有限公司 plant bacteriostatic liquid for field survival and preparation process thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
刘刚: "《常见皮肤病的中西医结合治疗学》", 31 March 2014, 东南大学出版社 *
朱坤福: "《中医外治特效疗法》", 31 May 2019, 中医古籍出版社 *
阮宏鹏等: "糠酸莫米松乳膏联合润燥止痒胶囊治疗神经性皮炎34例", 《现代中西医结合杂志》 *

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