CN111699983A - Multifunctional mouse hypoxia experimental device - Google Patents
Multifunctional mouse hypoxia experimental device Download PDFInfo
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- CN111699983A CN111699983A CN202010536231.XA CN202010536231A CN111699983A CN 111699983 A CN111699983 A CN 111699983A CN 202010536231 A CN202010536231 A CN 202010536231A CN 111699983 A CN111699983 A CN 111699983A
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- 206010021143 Hypoxia Diseases 0.000 title claims abstract description 28
- 230000007954 hypoxia Effects 0.000 title claims abstract description 25
- 238000007789 sealing Methods 0.000 claims abstract description 36
- 238000002474 experimental method Methods 0.000 claims abstract description 23
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 22
- 239000001301 oxygen Substances 0.000 claims abstract description 22
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000001681 protective effect Effects 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 9
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 claims description 9
- 238000013016 damping Methods 0.000 claims description 3
- 208000018875 hypoxemia Diseases 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 27
- 201000002859 sleep apnea Diseases 0.000 description 7
- 238000000034 method Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000001146 hypoxic effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 206010059410 Faecaluria Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 206010041235 Snoring Diseases 0.000 description 1
- 206010067775 Upper airway obstruction Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000020685 sleep-wake disease Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/032—Rabbit-hutches or cages
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/0047—Air-conditioning, e.g. ventilation, of animal housings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/01—Removal of dung or urine, e.g. from stables
- A01K1/0107—Cat trays; Dog urinals; Toilets for pets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/14—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by absorption
- B01D53/1456—Removing acid components
- B01D53/1475—Removing carbon dioxide
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2252/00—Absorbents, i.e. solvents and liquid materials for gas absorption
- B01D2252/10—Inorganic absorbents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2257/00—Components to be removed
- B01D2257/50—Carbon oxides
- B01D2257/504—Carbon dioxide
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- Engineering & Computer Science (AREA)
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- Biodiversity & Conservation Biology (AREA)
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Abstract
The invention discloses a multifunctional mouse hypoxia experiment device, which comprises a shell, a valve, an oxygen concentration sensor, a sealing door and a timer, wherein the shell is visible inside, an opening is formed in the side wall of the shell, the sealing door is hinged with the shell and used for opening and closing the opening, and the oxygen concentration sensor is arranged in the shell, so that the oxygen concentration in the shell can be monitored in real time, and the accuracy of experiment data is improved; simultaneously, set up the time-recorder at casing open end lateral wall, form the lug that corresponds with the time-recorder position on the sealing door, when the sealing door was closed the opening, the lug contacted automatic trigger timing with the time-recorder's chronograph switch, and it is more convenient to compare manual timing on the one hand, and on the other hand has improved the accuracy of timing.
Description
Technical Field
The invention relates to the technical field of medical experimental equipment, in particular to a multifunctional mouse hypoxia experimental device.
Background
Sleep Apnea Syndrome (SAS) is a sleep disorder in which breathing stops during sleep. The most common cause is upper airway obstruction, often ending with loud snoring, body twitching, or arm whipping. Sleep apnea is accompanied by sleep deficiency, daytime napping, fatigue, bradycardia or arrhythmia and electroencephalogram wakefulness, and causes certain harm to physical and mental health of people.
At present, the etiology and pathogenesis of various respiratory symptoms, particularly Sleep Apnea Syndrome (SAS) are still unclear, and the research on human bodies has certain limitations, so that the related animal research is particularly important. Because the mouse has spontaneous apnea phenomenon under the sleep state, and the brain electrical activity is similar to that of human beings, the mouse is used as a good animal model for researching sleep apnea syndrome, so that the mouse in the sealed space can breathe hypoxic gas for a long time until the hypoxic gas is anoxic by controlling the maintaining time of the gas concentration in the sealed space, and the mouse model simulating the SAS is established by the method. Based on the needs of mouse hypoxia experiment, it is necessary to provide a multifunctional mouse hypoxia experiment device for mouse hypoxia experiment.
Disclosure of Invention
In order to solve the technical problems, the invention provides a multifunctional mouse hypoxia experimental device, which comprises:
the shell is provided with an opening at the side surface, the interior of the shell is visible, and the shell is provided with at least one interface which extends out of the shell;
the valve is matched with the interface to control the opening or closing of the interface;
the oxygen concentration sensor is arranged in the shell; and
the timer is arranged on the side wall of the opening end of the shell;
the sealing door is hinged to the opening end of the shell and used for opening or closing the opening, a protruding block is arranged on the side wall of the sealing door and corresponds to the position of the timer, and when the sealing door rotates to the position where the opening is closed, the protruding block is in contact with a timing switch of the timer to trigger the timer to start timing.
Further, still include ventilative sensor protective housing, oxygen concentration sensor set up in inside the sensor protective housing.
Further, the sensor protective housing is a net-shaped protective housing, and a plurality of meshes are arranged on the net-shaped protective housing.
Further, be equipped with first magnetism sealing strip on the open end of casing, be equipped with on the sealing door with first sealed magnetic stripe cooperation realizes sealed second sealed magnetic stripe.
Further, the sealing door is hinged with the opening end of the shell through a damping hinge.
Further, still be equipped with the support in the casing, form limit baffle on the support, limit baffle is used for restricting the mouse on the support.
Further, still include the receiver, the receiver set up in the support bottom, be equipped with on the support with the through-hole of receiver intercommunication.
Further, a fan is arranged in the shell.
Further, the air-permeable shell further comprises an air-permeable container, the container is connected to the inner top wall of the shell, and soda lime is filled in the container.
Further, still including set up in PLC controller and display screen in the casing base, the PLC controller with the time-recorder oxygen concentration sensor connects respectively, the display screen is used for showing the time-recorder with oxygen concentration sensor's numerical value.
Compared with the prior art, the technical scheme of the invention has the following advantages:
(1) the multifunctional mouse hypoxia experiment device comprises a shell, a valve, an oxygen concentration sensor, a sealing door and a timer, wherein the shell is visible inside, an opening is formed in the side wall of the shell, the sealing door is hinged with the shell and used for opening and closing the opening, and the oxygen concentration sensor is arranged in the shell, so that the oxygen concentration in the shell can be monitored in real time, and the accuracy of experiment data is improved; simultaneously, set up the time-recorder at casing open end lateral wall, form the lug that corresponds with the time-recorder position on the sealing door, when the sealing door was closed the opening, the lug contacted automatic trigger timing with the time-recorder's chronograph switch, and it is more convenient to compare manual timing on the one hand, and on the other hand has improved the accuracy of timing.
(2) According to the multifunctional mouse hypoxia experiment device provided by the invention, the support is arranged in the shell, the limiting baffle is formed on the support, the mouse is limited on the support by the limiting baffle, the storage box is arranged at the bottom of the support, the through hole communicated with the storage box is formed between the support and the storage box, and the excrement of the mouse is collected by the storage box through the through hole, so that the pollution of the excrement of the mouse to the inner wall of the shell is prevented, and the cyclic use of the shell is facilitated.
(3) According to the multifunctional mouse hypoxia experimental device provided by the invention, the inner top wall of the shell is connected with the ventilating container, and soda lime is placed in the ventilating container and used for absorbing carbon dioxide in the shell, so that the experimental accuracy is improved; simultaneously, the soda lime is arranged in the ventilating container on the inner top wall of the shell, so that the mice are prevented from directly contacting the soda lime.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and it is obvious for those skilled in the art to derive other drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a multifunctional mouse hypoxia experiment device according to the present invention;
FIG. 2 is a schematic structural diagram of a multifunctional mouse hypoxia experiment device according to the present invention;
the reference numbers in the figures denote: 1-a shell; 2-opening; 3-a display screen; 4-a PLC controller; 5-a timer; 6-oxygen concentration sensor; 7-sensor protective housing; 8-a sealing door; 9-a bump; 10-a damped hinge; 11-an interface; 12-a valve; 13-a second sealing magnetic strip; 14-a first sealing magnetic strip; 15-a scaffold; 16-a storage box; 17-a fan; 18-a container; 19-base.
Detailed Description
The present invention now will be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. The embodiments in the present invention, other embodiments obtained by persons skilled in the art without any inventive work, belong to the protection scope of the present invention.
Example 1
As shown in fig. 1-2, the present embodiment discloses a multifunctional mouse hypoxia experiment device, which comprises a housing 1, a valve 12, an oxygen concentration sensor 6, a timer 5 and a sealing door 8. The shape of the housing 1 is not particularly limited, and in this embodiment, the housing 1 is a rectangular parallelepiped; the housing 1 is made of a light-transmitting material, so that the inside of the housing 1 is visible, the inside of the housing 1 can be observed from the outside of the housing 1, the housing 1 is provided with the ports 11, the ports 11 are used for adjusting the gas in the housing 1, and are used for connecting devices such as a gas storage device or a vacuum pump, and the number of the ports 11 is not particularly limited, in this embodiment, the number of the ports is three; the shape of the port 11 is not particularly limited, and may be a pipe formed by extending an opening formed in the housing 1 to the outside, or a pipe connected to an opening formed in the housing, and in this embodiment, the port 11 is a pipe connected to an opening formed in the housing. The valve 12 is partially installed on the pipe body, the valve 12 is matched with the interface 11 to open the interface 11 or close the interface 11, and when the valve 12 is opened, external low-oxygen gas or other experimental gas can be input into the shell 1 through the interface 11 to meet different experimental requirements. Oxygen concentration sensor 6 installs inside casing 1 for detect 1 inside oxygen concentration sensor 6 externally mounted has sensor protective housing 7 to prevent that the mouse from destroying it, does not do specific restriction to the structure of sensor protective housing, ventilative can, in this embodiment, sensor protective housing 7 is the netted of being equipped with a plurality of mesh, and sensor protective housing 7 is ventilative through the mesh.
An opening 2 is formed on the side surface of the shell 1, the shape of the opening 2 is not particularly limited, and the opening 2 can be square, circular and the like, and the opening 2 is one end surface of a cuboid in the embodiment; the sealing door 8 is connected to the opening 2, one end of the sealing door 8 is hinged to one end of the opening 2 through a hinge, the specific structure and number of the hinge are not limited, and the sealing door 8 is hinged to the opening 2 through two damping hinges 10 in the embodiment; the sealing door 8 rotates to a corresponding position through manual control to realize the function of opening or closing the opening 2; in order to make sealed effect better, set up first sealed magnetic stripe 14 on the opening 2 of casing 1, set up second sealed magnetic stripe 13 on sealing door 8, first sealed magnetic stripe 14 and second sealed magnetic stripe position are corresponding and mutually support and make and reach better sealed effect between sealing door 8 and the opening 2. The timer 5 is arranged on the side wall of the opening end of the shell 1, the side wall of the sealing door 8 is provided with a projection 9, the projection 9 corresponds to the timer 5, and when the sealing door 8 is operated to rotate to a position just closing the opening 2, the projection 9 is in contact with a timing switch of the timer 5 to trigger the timer to start timing.
Further, still be equipped with support 15 in the casing 1, form limit baffle on the support 15, during the experiment, place the mouse on support 15, limit baffle limits the home range of mouse on support 15, does not do not specifically limit to support 15 and limit baffle's shape, in this embodiment, the cross-sectional shape of support 15 is the H shape.
Further, still include receiver 16, receiver 16 sets up in support 15 bottom, is equipped with the through-hole with receiver 16 intercommunication on the support 15, and the fecaluria that the mouse formed on support 15 flows into receiver 16 through the through-hole in.
Further, the air purifier also comprises a fan 17, wherein the fan 17 is arranged on the inner wall of the shell 1, the position of the fan 17 in the shell 1 is not particularly limited, and when the fan 17 is opened, the air flow in the shell 1 is promoted so as to ensure that the concentration of the gas in the shell 1 is the same.
Further, the inner top wall of the shell 1 is also connected with a ventilating container 18, soda lime is filled in the container 18, the specific structure of the container 18 is not limited, and the container can contain soda lime and is ventilated.
Further, casing 1 below is equipped with base 19, and casing 1 and base 19 can be integrated into one piece also can be the components of a whole that can function independently installation, are equipped with PLC controller 3 and display screen 4 in the base, PLC controller 3 respectively with timer 15, oxygen concentration sensor 6 are connected, and the numerical value that timer 15 and oxygen concentration sensor 6 feed back shows on PLC controller 3's display screen 4.
The multifunctional mouse hypoxia experimental device provided by the invention is used in the following process:
the method comprises the steps of firstly placing a mouse inside a soda lime shell 1 or on a support 15 inside the shell 1, then closing a sealing door 8, then adjusting the concentration of gas inside the shell 1 as required, and then determining the end of an experiment according to the state of the mouse. The oxygen concentration parameter and/or the time parameter in the process can be displayed through the integrated display screen 3 or through a display screen carried by a timer and an oxygen concentration sensor.
In the multifunctional mouse hypoxia experiment device, the soda lime can be used at the bottom of the shell 1 or in the container 18, and can be flexibly selected according to requirements.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. The utility model provides a multi-functional mouse hypoxemia experimental apparatus which characterized in that includes:
the shell is provided with an opening at the side surface, the interior of the shell is visible, and the shell is provided with at least one interface which extends out of the shell;
the valve is matched with the interface to control the opening or closing of the interface;
the oxygen concentration sensor is arranged in the shell; and
the timer is arranged on the side wall of the opening end of the shell;
the sealing door is hinged to the opening end of the shell and used for opening or closing the opening, a protruding block is arranged on the side wall of the sealing door and corresponds to the position of the timer, and when the sealing door rotates to the position where the opening is closed, the protruding block is in contact with a timing switch of the timer to trigger the timer to start timing.
2. The multifunctional mouse hypoxia experiment device according to claim 1, further comprising an air-permeable protective sensor shell, wherein the oxygen concentration sensor is disposed inside the protective sensor shell.
3. The multifunctional mouse hypoxia experiment device according to claim 2, wherein the sensor protection shell is a net-shaped protection shell, and a plurality of meshes are arranged on the net-shaped protection shell.
4. The multifunctional mouse hypoxia experiment device according to claim 3, wherein a first magnetic sealing strip is arranged on the opening end of the shell, and a second sealing magnetic strip which is matched with the first sealing magnetic strip to realize sealing is arranged on the sealing door.
5. The multifunctional mouse hypoxia experiment device according to claim 4, wherein the sealing door is hinged with the open end of the shell through a damping hinge.
6. The multifunctional mouse hypoxia experiment device according to claim 5, wherein a support is further arranged in the housing, and a limit baffle is formed on the support and used for limiting a mouse on the support.
7. The multifunctional mouse hypoxia experiment device according to claim 6, further comprising a storage box, wherein the storage box is arranged at the bottom of the support, and the support is provided with a through hole communicated with the storage box.
8. The multifunctional mouse hypoxia experiment device according to claim 7, wherein a fan is further disposed in the housing.
9. The multifunctional mouse hypoxia experiment device according to claim 8, further comprising a gas permeable container attached to the inner top wall of the housing, wherein the container is filled with soda lime.
10. The multifunctional mouse hypoxia experiment device according to any one of claims 1 to 9, further comprising a PLC controller and a display screen, wherein the PLC controller and the timer are respectively connected to the oxygen concentration sensor, and the display screen is used for displaying the values of the timer and the oxygen concentration sensor.
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