CN111684264A - 血液分析方法、血液分析系统及存储介质 - Google Patents

血液分析方法、血液分析系统及存储介质 Download PDF

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CN111684264A
CN111684264A CN201980008269.5A CN201980008269A CN111684264A CN 111684264 A CN111684264 A CN 111684264A CN 201980008269 A CN201980008269 A CN 201980008269A CN 111684264 A CN111684264 A CN 111684264A
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blood
volume
blood sample
red blood
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CN111684264B (zh
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叶波
郑文波
祁欢
李朝阳
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Abstract

一种血液分析方法、血液分析系统及存储介质,血液分析方法包括:提供血液样本(S200);将血液样本的第一部分与稀释液混合得到第一被测试样(S220);将血液样本的第二部分与溶解试剂混合得到第二被测试样(S225);检测第一被测试样的电阻抗信号(S230),得到第一体积分布数据(S250);检测第二被测试样的至少两种光学信号(S235),得到第二体积分布数据(S255);获取血液样本的红细胞检测数据(S257);基于第一体积分布数据、第二体积分布数据及红细胞检测数据,判断血液样本中是否可能含有裂红细胞(S270);当判断结果为是时,报警血液样本可能为含有裂红细胞的血液样本(S290)。

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PCT国内申请,说明书已公开。

Claims (31)

  1. PCT国内申请,权利要求书已公开。
CN201980008269.5A 2018-04-28 2019-04-26 血液分析方法、血液分析系统及存储介质 Active CN111684264B (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112557282A (zh) * 2020-11-17 2021-03-26 深圳市科曼医疗设备有限公司 一种血球分析仪的小孔堵孔识别方法和装置
CN114047109A (zh) * 2022-01-11 2022-02-15 深圳市帝迈生物技术有限公司 一种样本分析仪及其计数方法
CN116485273A (zh) * 2023-05-06 2023-07-25 中国人民解放军总医院 基于数据分析的诊断质量评估系统

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018148942A1 (zh) * 2017-02-17 2018-08-23 深圳迈瑞生物医疗电子股份有限公司 血液细胞分析方法及血液细胞分析仪
CN112557281B (zh) * 2020-11-23 2022-06-24 深圳市科曼医疗设备有限公司 血液细胞分析仪的plt粒子检测方法和装置

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116539A (en) * 1988-01-27 1992-05-26 Toa Medical Electronics Co., Ltd. Reagent and method for measuring leukocytes and hemoglobin in blood
US5532139A (en) * 1992-10-30 1996-07-02 Micro-Med, Inc. Micro lysis-analysis process to measure cell characteristics and diagnose diseases
CA2218728A1 (en) * 1995-04-21 1996-10-24 Abbott Laboratories Compositions and methods for the rapid analysis of reticulocytes
US6472215B1 (en) * 2001-07-27 2002-10-29 Coulter International Corp. Method of analyzing nucleated red blood cells in a blood sample
US20070054403A1 (en) * 2005-08-24 2007-03-08 Beckman Coulter, Inc. Method of preventing white blood cell interferences to red blood cell measurements of a blood sample
CN101464245A (zh) * 2007-12-19 2009-06-24 深圳迈瑞生物医疗电子股份有限公司 一种识别红细胞碎片的方法
WO2009150327A2 (fr) * 2008-05-20 2009-12-17 Biocode Hycel France Sa Procede de determination du taux d'hemoglobine, de numeration et de differenciation des globules blancs et milieu adapte
EP2182345A1 (en) * 2003-12-16 2010-05-05 Dynabyte Informationssysteme GmbH Method for analysing blood
CN102713914A (zh) * 2009-10-19 2012-10-03 提拉诺斯公司 集成的健康数据采集和分析系统
CN103472034A (zh) * 2013-08-23 2013-12-25 深圳中科强华科技有限公司 一种血细胞分析芯片、分析仪及分析方法
CN105074420A (zh) * 2013-03-15 2015-11-18 艾瑞思国际股份有限公司 血液学系统和方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3587651B2 (ja) * 1997-05-09 2004-11-10 シスメックス株式会社 粒子測定装置
JP4464534B2 (ja) * 2000-06-20 2010-05-19 シスメックス株式会社 破砕赤血球の測定方法
CN101470109B (zh) * 2007-12-25 2013-07-10 深圳迈瑞生物医疗电子股份有限公司 一种提高血液样本白细胞分类结果准确性的方法
US8906308B2 (en) * 2010-01-15 2014-12-09 Abbott Laboratories Method for determining volume and hemoglobin content of individual red blood cells
CN104297135B (zh) * 2013-07-16 2017-02-15 成都深迈瑞医疗电子技术研究院有限公司 血液样本中粒子的识别方法、系统及血液细胞分析仪
JP6661278B2 (ja) * 2015-03-27 2020-03-11 シスメックス株式会社 血液分析装置および血液分析方法
CN107817208A (zh) * 2016-09-12 2018-03-20 深圳市帝迈生物技术有限公司 一种血细胞计数装置及其白细胞计数修正方法

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116539A (en) * 1988-01-27 1992-05-26 Toa Medical Electronics Co., Ltd. Reagent and method for measuring leukocytes and hemoglobin in blood
US5532139A (en) * 1992-10-30 1996-07-02 Micro-Med, Inc. Micro lysis-analysis process to measure cell characteristics and diagnose diseases
CA2218728A1 (en) * 1995-04-21 1996-10-24 Abbott Laboratories Compositions and methods for the rapid analysis of reticulocytes
US6472215B1 (en) * 2001-07-27 2002-10-29 Coulter International Corp. Method of analyzing nucleated red blood cells in a blood sample
EP2182345A1 (en) * 2003-12-16 2010-05-05 Dynabyte Informationssysteme GmbH Method for analysing blood
US20070054403A1 (en) * 2005-08-24 2007-03-08 Beckman Coulter, Inc. Method of preventing white blood cell interferences to red blood cell measurements of a blood sample
CN101464245A (zh) * 2007-12-19 2009-06-24 深圳迈瑞生物医疗电子股份有限公司 一种识别红细胞碎片的方法
WO2009150327A2 (fr) * 2008-05-20 2009-12-17 Biocode Hycel France Sa Procede de determination du taux d'hemoglobine, de numeration et de differenciation des globules blancs et milieu adapte
CN102713914A (zh) * 2009-10-19 2012-10-03 提拉诺斯公司 集成的健康数据采集和分析系统
CN105074420A (zh) * 2013-03-15 2015-11-18 艾瑞思国际股份有限公司 血液学系统和方法
CN103472034A (zh) * 2013-08-23 2013-12-25 深圳中科强华科技有限公司 一种血细胞分析芯片、分析仪及分析方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
郝少丽等: "全自动血细胞分析仪XE-2100与XS-1000i的比较分析", 《现代预防医学》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112557282A (zh) * 2020-11-17 2021-03-26 深圳市科曼医疗设备有限公司 一种血球分析仪的小孔堵孔识别方法和装置
CN114047109A (zh) * 2022-01-11 2022-02-15 深圳市帝迈生物技术有限公司 一种样本分析仪及其计数方法
CN114047109B (zh) * 2022-01-11 2022-06-21 深圳市帝迈生物技术有限公司 一种样本分析仪及其计数方法
CN116485273A (zh) * 2023-05-06 2023-07-25 中国人民解放军总医院 基于数据分析的诊断质量评估系统
CN116485273B (zh) * 2023-05-06 2024-01-23 中国人民解放军总医院 基于数据分析的诊断质量评估系统

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CN116609243A (zh) 2023-08-18
WO2019206310A1 (zh) 2019-10-31
US11874212B2 (en) 2024-01-16
US20210041343A1 (en) 2021-02-11

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