CN111670196A - 人源化和去免疫化抗体 - Google Patents
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Hospice & Palliative Care (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
Description
Claims (17)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP18154427.1 | 2018-01-31 | ||
EP18154427.1A EP3521308B1 (en) | 2018-01-31 | 2018-01-31 | Humanized and de-immunized antibodies |
PCT/EP2019/052100 WO2019149689A1 (en) | 2018-01-31 | 2019-01-29 | Humanized and de-immunized antibodies |
Publications (1)
Publication Number | Publication Date |
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CN111670196A true CN111670196A (zh) | 2020-09-15 |
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EP (1) | EP3521308B1 (zh) |
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KR (1) | KR20200116095A (zh) |
CN (1) | CN111670196A (zh) |
AU (1) | AU2019214280A1 (zh) |
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Cited By (1)
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CN113957095A (zh) * | 2021-10-22 | 2022-01-21 | 江苏集萃药康生物科技股份有限公司 | 一种用于构建阿尔兹海默症动物模型的构建方法及其核酸组合物和应用 |
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WO2024107683A1 (en) * | 2022-11-17 | 2024-05-23 | Eli Lilly And Company | ANTI-N3pGlu AMYLOID BETA ANTIBODIES, DOSES, AND USES THEREOF |
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EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
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- 2018-01-31 EP EP18154427.1A patent/EP3521308B1/en active Active
-
2019
- 2019-01-29 US US16/964,892 patent/US20210032315A1/en active Pending
- 2019-01-29 MX MX2020007986A patent/MX2020007986A/es unknown
- 2019-01-29 CA CA3088606A patent/CA3088606A1/en active Pending
- 2019-01-29 SG SG11202006378PA patent/SG11202006378PA/en unknown
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- 2019-01-29 EA EA202091629A patent/EA202091629A1/ru unknown
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CN113957095A (zh) * | 2021-10-22 | 2022-01-21 | 江苏集萃药康生物科技股份有限公司 | 一种用于构建阿尔兹海默症动物模型的构建方法及其核酸组合物和应用 |
Also Published As
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JP7337077B2 (ja) | 2023-09-01 |
EP3521308C0 (en) | 2024-03-13 |
BR112020015194A2 (pt) | 2020-12-29 |
AU2019214280A1 (en) | 2020-07-23 |
WO2019149689A1 (en) | 2019-08-08 |
IL276101A (en) | 2020-08-31 |
JP2021512100A (ja) | 2021-05-13 |
EA202091629A1 (ru) | 2020-09-23 |
EP3521308A1 (en) | 2019-08-07 |
ZA202004784B (en) | 2021-09-29 |
EP3521308B1 (en) | 2024-03-13 |
CA3088606A1 (en) | 2019-08-08 |
SG11202006378PA (en) | 2020-08-28 |
US20210032315A1 (en) | 2021-02-04 |
MX2020007986A (es) | 2020-09-09 |
KR20200116095A (ko) | 2020-10-08 |
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