CN111658719A

CN111658719A - Hair-blacking and hair-growing medicine and preparation method thereof

Info

Publication number: CN111658719A
Application number: CN202010650871.3A
Authority: CN
Inventors: 张巾英; 徐振岩
Original assignee: Individual
Current assignee: Zhang Jinying
Priority date: 2020-07-08
Filing date: 2020-07-08
Publication date: 2020-09-15

Abstract

The invention discloses a hair-blacking and hair-growing medicine, and the pharmacodynamic raw material medicine comprises ganoderma lucidum. Also comprises a preparation method of the medicine for blacking and growing hair, which comprises the following steps: weighing raw materials according to weight ratio, grinding, adding the powder into a fermentation tank for fermentation, fermenting until hyphae grow out, taking out all the mixtures in the fermentation tank, grinding, baking, and making into powder, granule, capsule, pill or tablet. According to the invention, the ganoderma lucidum is innovatively used for blackening and growing hair, the compatibility of each component is scientific and reasonable, the components have synergistic effect, the efficacy of each medicine is improved by 4-40 times after fermentation, the functions of liver and kidney can be improved, the metabolism of liver and kidney is enhanced, the functions of internal organs of a human body are coordinated, the circulation of cardiovascular and cerebrovascular blood vessels is accelerated, the metabolism function of the body is accelerated, the nutrition is improved, the immunity is improved, the human body is full of spirit, the sleep is sufficient, the renal water is smooth, liver wood is proofed, and the head and brain are clear, so that the white hair and alopecia are radically cured, the effect is fast after use, and the medicine is nontoxic, has no side.

Description

Hair-blacking and hair-growing medicine and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and relates to a hair-blacking and hair-growing medicine and a preparation method thereof, which are mainly used for treating white hair and alopecia.

Background

White hair is a normal physiological change, and generally a person starts to grow white hair after age 40. However, in modern life, due to factors such as fast pace of life, strong social competition, high mental stress, environmental influence and the like, more and more people generate poliosis prematurely, and some people generate a great amount of poliosis in a younger age. This premature occurrence of a large number of premature gray hairs is called a gray hair disease, as compared with the average person. White hair can be classified into congenital and acquired. Congenital white hair often has family history, and local white hair is more common. The acquired white hair includes senile white hair and juvenile white hair. The causes of acquired white hair are mainly: lack of nutrition, long-term mental stress, insufficient sunlight, etc. The traditional Chinese medicine considers that white hair is caused by kidney yin deficiency, and the metabolic function of a body is slowed down due to renal failure, so that the treatment of the white hair needs to supplement the kidney yin first, and the regulation and treatment are fundamentally realized. The condition of the white hair caused by congenital heredity can be improved by treating the white hair generated by acquired reasons. Many people are very interested in the negative influence of the hair on their own image, so the hair is dyed regularly, but most of the hair dyes contain chemical substances, and the frequent dyeing has great threat to the health of human bodies.

Alopecia is also a problem that afflicts modern people, and normally shed hair is hair in the catagen and telogen phases, and the normal amount of hair can be maintained because the hair entering the catagen phase and the hair newly entering the anagen phase are constantly in dynamic balance. Pathological hair loss refers to abnormal or excessive loss of hair for a number of reasons. In the traditional Chinese medicine, the cause of alopecia is mainly kidney, if the deficiency of both liver and kidney qi and blood is insufficient, the blood circulation of the whole body is weak, nutrient substances cannot be conveyed to the top of the head at the highest position of the human body, hair follicles on the head cannot be nourished and gradually atrophy, alopecia can be caused, kidney stores essence, and controls reproduction, the hair is bloomed in the hair, the hair is the surplus of blood, the kidney is considered as the congenital foundation, the hair is a product of the blood, the kidney stores essence, the liver stores blood, and the essence and the blood are homologously transformed, and the deficiency of the kidney and the blood is not possible.

At present, different traditional Chinese medicines for treating leukotrichia and alopecia exist in the market, but certain defects exist, such as long treatment course, slow effect, slight curative effect after long-time administration and the like, and few medicines with good effects for treating alopecia and leukotrichia simultaneously exist.

Disclosure of Invention

Aiming at the problems, the invention aims to provide a hair-blacking and hair-growing medicine which has good curative effect, high effective rate and no toxic or side effect on human bodies and a preparation method thereof.

The technical scheme adopted by the invention is as follows:

the invention provides a hair-blacking and hair-growing medicine, and pharmacodynamic raw material medicines of the medicine comprise ganoderma lucidum.

Preferably, in the hair-blacking and hair-growing medicine, the ganoderma lucidum accounts for 19-60% of the total weight of the medicine raw materials.

A preferable medicine for blackening and promoting hair growth comprises Ganoderma, rhizoma Dioscoreae, and Ganoderma; preferably, the yam is dioscorea opposita.

Preferably, in the hair-blacking and hair-growing medicine, the pharmacodynamic raw material medicines are in parts by weight: 15-40 parts of ganoderma lucidum, 15-25 parts of Chinese yam and 15-40 parts of ganoderma lucidum.

Preferably, the pharmacodynamic raw material medicine is one of the following in parts by weight:

15 parts of ganoderma lucidum, 15 parts of Chinese yam and 15 parts of ganoderma lucidum;

40 parts of ganoderma lucidum, 25 parts of Chinese yam and 40 parts of ganoderma lucidum;

30 parts of ganoderma lucidum, 20 parts of Chinese yam and 30 parts of ganoderma lucidum;

35 parts of ganoderma lucidum, 18 parts of Chinese yam and 28 parts of ganoderma lucidum.

The medicament for blackening and growing hair of the invention is in the dosage form of powder, granules, capsules, pills or tablets.

In another aspect of the present invention, there is provided a method for preparing any one of the above hair-blackening and hair-growing medicines, comprising the steps of: weighing raw materials according to weight ratio, grinding, adding the powder into a fermentation tank for fermentation, fermenting until hyphae grow out, taking out all the mixtures in the fermentation tank, grinding, baking, and making into powder, granule, capsule, pill or tablet.

Preferably, after the powder is filled into a fermentation tank, the temperature in the fermentation tank is rapidly increased to 80 ℃, and then the temperature is reduced to 45-55 ℃ for fermentation, wherein the fermentation time is 40-45 days.

Preferably, the baking temperature after fermentation and grinding is 30-60 ℃.

In another aspect of the invention, the application of ganoderma lucidum in preparing a hair-blacking medicament or a hair-growing medicament is provided.

The raw materials adopted by the medicine for blacking and growing hair of the invention have the pharmacological and medicinal properties as follows:

meat ganoderma lucidum: the folk custom called "Taisui" is a slime mold complex. The record of Shen nong Ben Cao Jing: meat ganoderma lucidum is nontoxic, can tonify middle-jiao, benefit vital essence and qi, increase wisdom, treat middle-jiao in chest, and lighten and not old after long-term use. The title of Shanhai Jing is "meat for watching", "meat for gathering", "Taisui", "seal", which is a good food for health preservation of ancient emperor. The ganoderma lucidum is sweet in nature, mild and nontoxic, and has the effects of tonifying the kidney, benefiting the liver, tonifying the spleen and moistening the lung. Modern pharmacology indicates that: it has antibacterial, antituberculosis, antifatigue, antiaging, blood sugar and blood pressure lowering, immunity improving, and nutritional components rich in protein, eighteen amino acids, nucleic acid, trace elements, vitamins, SOD, polysaccharide, and PQQ. The report that the compound is used as a main effective component of a hair-blacking and hair-growing medicament is not seen yet.

Chinese yam: is a tuber of dioscorea opposita of the family dioscoreaceae, has sweet and mild properties and mainly functions as follows: to invigorate the spleen, tonify the lung, strengthen the kidney and replenish vital essence. It is indicated for diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition. Tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat.

Ganoderma lucidum: the scientific name Gaoderma Lucidum Karst is also called Ruicao, Shenzhi, Xiancao, Yao grass, Huanyang grass, Lingzhiling, Junzhi, Wannian mushroom, Ling grass, Chizhi, Danzhi, Qiongzhen and the like, and is a fruiting body of Ganoderma Lucidum which is a fungus of Polyporaceae. The main functions and effects are: 1. improving immunity, and enhancing immunity. 2. Anticancer, and enhance anticancer ability of body. 3. Reducing blood sugar, promoting sugar metabolism, and effectively reducing blood sugar. 4. Preventing and treating cardiovascular diseases, and can be widely used for treating and preventing coronary heart disease, angina pectoris, etc. 5. Relieving cough and eliminating phlegm. 6. Delaying aging, and repairing skin.

The invention has the beneficial effects that:

the ganoderma lucidum is innovatively used for blackening and growing hair, the ganoderma lucidum is selected as a monarch drug, and the effects are doubled by integrating all people according to the theory of mutual generation and restriction of internal five elements and the external factors of generation and restriction of external five elements in the traditional Chinese medicine, so that the effect of building the body is achieved. The yam is selected as a ministerial drug, and the yam is mainly used for tonifying spleen and nourishing stomach, nourishing kidney and benefiting lung, delaying senility, improving sleep and the like, is combined with the ganoderma lucidum to increase the excretion function of kidney, and nourish liver and kidney. The ganoderma lucidum has the effects of reducing blood triglyceride, expanding coronary artery, improving coronary blood flow, promoting the smooth circulation of heart and brain blood, achieving sufficient qi and blood with the ganoderma lucidum, ensuring the smooth and sufficient blood circulation of the whole body, and being beneficial to the effects of soothing the nerves and refreshing the brain during sleeping.

The components of the invention have scientific and reasonable compatibility, the components have synergistic effect, the efficacy of each medicine is improved by 4-40 times after fermentation, the liver and kidney functions can be improved after eating, the metabolism of the liver and kidney functions is enhanced, the functions of internal organs of a human are coordinated, the cardiovascular and cerebrovascular circulation is accelerated, the body metabolism function is accelerated, the nutrition is improved, the immunity is improved, the human is full of spirit and sufficient in sleep, the kidney water is accessible, liver wood is proofed, the head and the brain are clear, thereby the white hair and the alopecia are radically cured, and the effect is quick after use.

The invention has no toxic or side effect, can be taken for a long time, and can ensure that the nutrition of the vertex of the head is sufficient, the hair is blackened and the alopecia is stopped after being taken for about 2 months generally. Compared with other traditional Chinese medicine hair blackening products, the traditional Chinese medicine hair blackening product has quick response and small dosage. The medicine disclosed by the invention is matched with black sesame and black soybean to eat, so that the effects of blackening and growing hair are more remarkable.

Detailed Description

The invention is further illustrated by the following examples, which are not intended to be limiting.

The experimental procedures in the following examples are conventional unless otherwise specified. Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.

The formulations of examples 1-6 and comparative examples are shown in Table 1:

TABLE 1 raw material ratios in the examples

Comparative example 1 was prepared by directly grinding yam and ganoderma lucidum, without ganoderma lucidum.

The formulation of comparative example 2 was the same as that of example 1, but was not fermented and was directly obtained by mixing and pulverizing the raw materials.

The preparation methods of the different formulations are as follows: cleaning and airing raw materials of ganoderma lucidum (dry medicinal materials), Chinese yam and ganoderma lucidum, weighing according to the weight part ratio, mixing and grinding the raw materials into powder, grinding the powder into 100 meshes, then filling the obtained powder into a fermentation tank, quickly raising the temperature in the fermentation tank to 80 ℃ (sterilizing), then cooling to 50 ℃ (or 45-55 ℃) for fermentation, growing hypha in the fermentation tank after fermenting for 40-45 days, taking out all the mixture in the fermentation tank, grinding into 100 meshes, baking at 30-60 ℃ to prepare powder, or filling capsule shells made of corn into capsules, or tabletting and forming by a machine, or uniformly mixing with honey and making into pills by a machine.

Powder preparation: each bag is 1.3 g, 2-3 bags are taken each time, three times a day, and two months are taken as a treatment course.

And (3) capsule preparation: each capsule is 0.25 g, 3-5 capsules are taken each time, three times a day, and the capsules are taken with warm water, and a treatment course is two months.

And (3) tablet preparation: each tablet is 0.25 g, 3-5 tablets each time, three times a day, and two months are taken as a treatment course.

And (3) pill preparation: each pill is 0.65 g, 2 pills each time, three times a day, and two months are a treatment course.

The clinical experiment aiming at the white hair treatment comprises the following steps:

(1) general data:

a total of 170 patients, 74 females, 96 males, 16 years of least age, 57 years of maximum age. 130 patients took the product of example 1 in table 1, 20 patients took the product of comparative example 1, and 20 patients took the product of comparative example 2. (2) Diagnostic criteria: white hair due to natural aging of the elderly is excluded.

(3) The treatment method comprises the following steps: the powder of the embodiment 1 or the comparative example is orally taken with boiled water, 3 times a day, 2.6 g each time, and 2 months are taken as a treatment course.

(4) Evaluation criteria:

and (3) curing: the white hair turns from white to gray and from gray to black, the rate of turning white hair to black is more than 95 percent, and the hair is not relapsed;

the effect is shown: the number of white hairs is obviously reduced, more than four fifths of white hairs are changed into black hairs, and new hairs are grown into black hairs;

the method has the following advantages: the number of white hairs is obviously reduced, more than one third of white hairs are changed into black hairs, and the new black hairs are generated;

and (4) invalidation: the white hair before and after treatment is not obviously improved.

(5) The experimental results are as follows: the therapeutic effect of the product of example 1 after 1 course of treatment is shown in Table 2; depending on the patient condition, some patients continued to be treated for one treatment course, and the treatment effect after 2 treatment courses was as shown in table 2.

TABLE 2 curative effect on leukotrichia

It can be seen that the product of example 1 uses ganoderma lucidum as a monarch drug, and compared with comparative example 1 without ganoderma lucidum and comparative example 2 without fermentation, the product has the advantages of better and faster obvious effect, obviously improved hair blackening rate and shortened treatment period.

(6) Typical cases

Plum, 47 years old, male, had almost white hair, and after three months of taking the product of example 1, white hair turned black by more than four fifths.

Muzhi, age 26, female, young white head, and the white hair turned completely black after two months of taking the product of example 1.

Second, clinical trials for alopecia treatment:

(1) general data:

30 seborrheic alopecia patients, wherein 14 women and 16 men are aged at least 26 years old and 60 years old at most, and the average age is 35 years old. 50 patients with dystrophic alopecia were treated, 21 women and 29 men, with the ages of 21 years minimum and 63 years maximum, and the average age was 39 years.

(2) Diagnostic criteria: alopecia is more than three months, and alopecia can be diagnosed for more than 50 alopecia per day.

(3) The treatment method comprises the following steps: the powder of the embodiment 1 is taken orally with boiled water, 3 times a day, 2.6 g each time, one treatment course of two months, and 1 treatment course.

(4) Evaluation criteria:

and (3) curing: after treatment, the hair becomes thick and thin, no hair loss occurs, and the hair growth rate at the original hair loss position is more than 90%.

The effect is shown: after treatment, basically no alopecia exists, and the hair growth rate of the original alopecia part is more than 60%.

The method has the following advantages: the number of the alopecia is obviously reduced, and the hair growth rate of the original alopecia part is more than 40 percent.

And (4) invalidation: the symptoms of alopecia are not obviously improved.

(5) The experimental results are as follows: the therapeutic effect of 80 patients taking the product of example 1 after 1 course of treatment is shown in Table 3.

TABLE 3 therapeutic effect on alopecia

Type of alopecia	Cases of disease	Is effective	Show effect	Cure of disease	Invalidation	High efficiency	Cure rate
								Seborrheic alopecia	30	30	30	26	0	100％	86.7％
Malnutritional alopecia	50	50	48	45	0	100％	90％

Wherein, 30 patients suffering from seborrheic alopecia are treated by the powder in the embodiment 1, after 1 course of treatment, 26 patients are cured (86.7%), 30 patients are effective (100%), 0 patients are ineffective (0%), and the total effective rate of treatment is 100%. 4 patients who are not cured after taking 1 course continue to take 1 course, and are cured after taking 2 courses without alopecia.

(6) Typical cases

Zhangzhi, 50 years old, female, hair sparse, and continuous alopecia, the daily alopecia amount is about 70, after taking the product for one treatment course, the alopecia symptoms are obviously improved, basically no alopecia phenomenon exists, the hair growth rate of the original alopecia part reaches more than 90%, and the number of newly increased black hairs is increased gradually.

Third, clinical experiment aiming at treatment of alopecia and poliosis

(1) General data:

a total of 94 patients, 41 women, 53 men, the minimum age of 20 years, the maximum age of 63 years, 30 patients between 20 and 35 years, and 64 patients between 35 and 63 years.

(2) Diagnostic criteria: the white hair and the alopecia are more than three months, and the number of the alopecia per day is more than 50, so that the diagnosis can be carried out.

(3) The treatment method comprises the following steps: the powder of the embodiment 1 is taken orally with boiled water, 3 times a day, 2.6 g each time, 2 months as one treatment course, and two treatment courses are treated.

(4) Evaluation criteria:

and (3) curing: the alopecia of the alopecia patient is stopped, the hair growth rate of the original alopecia part is more than 90 percent, and the white hair turns black to be more than 95 percent.

The effect is shown: after treatment, basically no hair loss occurs, the hair growth rate of the original hair loss part is more than 60 percent, and more than four fifths of white hair is converted into black hair. The method has the following advantages: the hair loss amount is obviously reduced, the hair growth rate of the original hair loss position is more than 40 percent, and more than one third of white hair is converted into black hair. And (4) invalidation: the symptoms are not obviously improved.

(5) The experimental results are as follows: as shown in table 4.

TABLE 4 therapeutic effect on alopecia and leukotrichia

Age group of alopecia and poliosis	Cases of disease	Is effective	Show effect	Cure of disease	Invalidation	High efficiency	Cure rate
								20-35 years old	30	30	30	28	0	100％	93％
35-63 years old	64	64	62	57	0	100％	89％

(6) Typical cases

Wangzhi, 33 years old, male, white hair with more than 70 hair loss amount per day, after taking the product for two months, white hair begins to turn black greatly, and hair loss stops. After the oral liquid is taken for two months, the new hair growth rate of the original alopecia part is more than 90 percent, and more than 90 percent of white hair is converted into black hair.

The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.

Claims

1. The hair-blacking and hair-growing medicine is characterized in that pharmacodynamic raw material medicines comprise ganoderma lucidum.

2. The hair-blacking and hair-growing medicine according to claim 1, wherein the ganoderma lucidum accounts for 19-60% of the total weight of the raw materials of the medicine.

3. The hair-blacking and hair-growing medicine according to claim 1, which is characterized in that the pharmacodynamic raw material medicines comprise ganoderma lucidum, yam and ganoderma lucidum;

preferably, the yam is dioscorea opposita.

4. The hair blackening and growing medicine of claim 3, which is characterized in that the pharmacodynamic raw material medicines are in parts by weight: 15-40 parts of ganoderma lucidum, 15-25 parts of Chinese yam and 15-40 parts of ganoderma lucidum.

5. The hair blackening and growing medicine of claim 4, wherein the pharmacodynamic raw material medicines are one of the following materials in parts by weight:

6. The hair-blacking and hair-growing medicine according to any one of claims 1 to 5, wherein the dosage form of the hair-blacking and hair-growing medicine is powder, granules, capsules, pills or tablets.

7. The method for preparing the hair-blacking and hair-growing medicine of any one of claims 1 to 6, which is characterized by comprising the following steps: weighing raw materials according to weight ratio, grinding, adding the powder into a fermentation tank for fermentation, fermenting until hyphae grow out, taking out all the mixtures in the fermentation tank, grinding, baking, and making into powder, granule, capsule, pill or tablet.

8. The preparation method of the medicine for blackening and growing hair according to claim 7, wherein the powder is put into a fermentation tank, the temperature in the fermentation tank is rapidly raised to 80 ℃, and then the temperature is lowered to 45-55 ℃, preferably 50 ℃ for fermentation, and the fermentation time is 40-45 days.

9. The method for preparing a hair blackening and growing medicine according to claim 7 or 8, wherein the baking temperature after fermenting and grinding is 30 ℃ to 60 ℃.

10. Application of Ganoderma in preparing hair blackening or hair growth promoting medicine is provided.