CN111632124A - A Chinese medicinal composition for treating hepatocarcinoma, and its preparation method - Google Patents
A Chinese medicinal composition for treating hepatocarcinoma, and its preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a traditional Chinese medicine composition for treating liver cancer and a preparation method thereof. The traditional Chinese medicine composition for treating liver cancer comprises astragalus membranaceus, scutellaria barbata and turmeric, wherein the weight ratio of the astragalus membranaceus to the scutellaria barbata to the turmeric is as follows: barbed skullcap herb: the turmeric is 1-4: 0.5-3: 0.5-2. The preparation method is simple and is obtained by decocting twice to obtain decoction. The traditional Chinese medicine composition is prepared by compatibility and combination based on a spleen strengthening and detoxifying method, and is in a fixed dose proportion with the dosage summarized by years of clinical experience, so that the traditional Chinese medicine composition can achieve the efficacies of tonifying qi, strengthening body resistance, tonifying deficiency, clearing away heat and toxic materials, eliminating stagnation, regulating qi, promoting blood circulation, relieving pain and the like, and has a good treatment effect on liver cancer and the like.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating liver cancer and a preparation method thereof.
Background
Liver cancer is one of the most difficult-to-cure sexual malignant tumors worldwide, and has the characteristics of high morbidity and high mortality. Drug therapy is the main treatment method for middle and late stage liver cancer patients who cannot be treated by operation or intervention. However, most of the chemotherapy drugs for treating liver cancer at present have limited curative effect and have toxic and side effects of different degrees. The traditional Chinese medicine is a means with characteristics and rich curative effects in the treatment scheme of liver cancer patients in China; plays an active role in preventing and treating the occurrence and development of liver cancer, reducing recurrence and metastasis, improving the life quality of patients and the like, and has low medicine price and no toxic or side effect.
The traditional Chinese medicine for treating liver cancer at present has the problems of non-uniform syndrome differentiation and classification, uncertain medicine compatibility and dosage and the like, and causes uneven treatment effect of the traditional Chinese medicine for treating liver cancer.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine composition for treating alcoholic fatty liver and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for treating liver cancer is prepared from astragalus membranaceus, scutellaria barbata and turmeric in a weight ratio of astragalus membranaceus: barbed skullcap herb: the turmeric is 1-4: 0.5-3: 0.5-2.
The astragalus has the effects of tonifying qi, strengthening body resistance and tonifying deficiency, and is added with the barbed skullcap herb which has the functions of clearing away heat and toxic materials, promoting blood circulation and removing blood stasis and the turmeric which has the functions of promoting the circulation of qi and relieving pain, dredging collaterals and eliminating stagnation, so that the astragalus has good treatment effects on liver cancer and the like.
Preferably, the weight ratio of the astragalus to the scutellaria is that: barbed skullcap herb: 1-3: 0.5 to 1.
More preferably, the weight ratio of the astragalus to the scutellaria is that: barbed skullcap herb: turmeric is 2:2: 1.
The proportion of the traditional Chinese medicine composition is obtained by combining years of clinical experience with a spleen strengthening and detoxifying method, and the traditional Chinese medicine composition has a good treatment effect on liver cancer.
The preparation method of the traditional Chinese medicine composition is characterized by comprising the following steps:
(1) adding 400-500 mL of water to the medicinal materials, and soaking for 15-20 minutes;
(2) adding 100-200 mL of water into the traditional Chinese medicine raw materials in the step (1), decocting with strong fire until boiling, decocting with slow fire for 15-20 minutes after boiling, and taking traditional Chinese medicine decoction;
(3) adding 80-120 mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the materials are boiled, decocting with slow fire for 15-20 minutes after the materials are boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
The method can fully obtain the effective components in the traditional Chinese medicinal materials, so that the traditional Chinese medicine composition can better exert the effect.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition is prepared by compatibility based on a spleen strengthening and detoxifying method, is in fixed proportion with a dosage which is summarized by years of clinical experience, can achieve the efficacies of tonifying qi, strengthening body resistance, tonifying deficiency, clearing away heat and toxic materials, eliminating stagnation, regulating qi, dredging collaterals, relieving pain and the like, and has a better treatment effect on liver cancer and the like.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific embodiments.
The materials used in the examples of the present invention are commercially available unless otherwise specified.
The basic conditions of the main raw materials are described in the following according to the Chinese pharmacopoeia, the Chinese dictionary, the Chinese herbal medicine, and the like.
Astragalus root: sweet in flavor and warm in nature. Has the effects of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, removing toxic substance, expelling pus, healing sore, and promoting granulation. Can be used for treating deficiency of qi, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration, qi deficiency, edema, internal heat, diabetes, blood deficiency, hemiplegia, arthralgia, numbness, carbuncle, cellulitis, and ulcer.
Barbed skullcap herb: it is neither pungent nor bitter, and cold in nature. Has the effects of clearing away heat and toxic materials, removing blood stasis, and promoting urination. Can be used for treating furuncle, swelling and pain of throat, traumatic injury, edema, jaundice, snake and insect bite.
Turmeric: bitter taste and warm nature. Has effects of removing blood stasis, activating qi-flowing, dredging channels and relieving pain. Can be used for treating thoracic and hypochondriac pain, chest beat, cardialgia, dysmenorrhea, amenorrhea, abdominal mass, rheumatism, shoulder and arm pain, and traumatic injury with swelling and pain.
Example 1:
a traditional Chinese medicine composition for treating liver cancer comprises the following raw materials: 10g of astragalus, 10g of barbed skullcap herb and 5g of turmeric.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) adding 450mL of water to submerge the medicinal materials, and soaking for 17 minutes;
(2) adding 150mL of water into the traditional Chinese medicine raw materials, decocting with strong fire until boiling, decocting with slow fire for 17 minutes after boiling, and taking traditional Chinese medicine decoction;
(3) adding 120mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the water is boiled, decocting with slow fire for 18 minutes after the water is boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
Example 2:
a traditional Chinese medicine composition for treating liver cancer comprises the following raw materials: 20g of astragalus, 20g of barbed skullcap herb and 10g of turmeric.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) adding 450mL of water to submerge the medicinal materials, and soaking for 17 minutes;
(2) adding 150mL of water into the traditional Chinese medicine raw materials, decocting with strong fire until boiling, decocting with slow fire for 17 minutes after boiling, and taking traditional Chinese medicine decoction;
(3) adding 120mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the water is boiled, decocting with slow fire for 18 minutes after the water is boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
Example 3:
a traditional Chinese medicine composition for treating liver cancer comprises the following raw materials: 30g of astragalus, 30g of barbed skullcap herb and 15g of turmeric.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) adding 450mL of water to submerge the medicinal materials, and soaking for 17 minutes;
(2) adding 150mL of water into the traditional Chinese medicine raw materials, decocting with strong fire until boiling, decocting with slow fire for 17 minutes after boiling, and taking traditional Chinese medicine decoction;
(3) adding 120mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the water is boiled, decocting with slow fire for 18 minutes after the water is boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
Example 4:
a traditional Chinese medicine composition for treating liver cancer comprises the following raw materials: 20g of astragalus, 15g of barbed skullcap herb and 10g of turmeric.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) adding 500mL of water to submerge the medicinal materials, and soaking for 20 minutes;
(2) adding 200mL of water into the traditional Chinese medicine raw materials, decocting with strong fire until boiling, decocting with slow fire for 20 minutes after boiling, and taking traditional Chinese medicine decoction;
(3) adding 80mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the water is boiled, decocting with slow fire for 20 minutes after the water is boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
Example 5:
a traditional Chinese medicine composition for treating liver cancer comprises the following raw materials: 30 parts of astragalus, 30 parts of barbed skullcap herb and 10 parts of turmeric.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) adding 400mL of water to submerge the medicinal materials, and soaking for 15 minutes;
(2) adding 100mL of water into the traditional Chinese medicine raw materials, decocting with strong fire until boiling, decocting with slow fire for 15 minutes after boiling, and taking the traditional Chinese medicine decoction;
(3) adding 120mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the water is boiled, decocting with slow fire for 15 minutes after the water is boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
Comparative example 1
A traditional Chinese medicine composition for treating liver cancer comprises the following raw materials: 20g of astragalus, 30g of barbed skullcap herb and 15g of turmeric.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) adding 450mL of water to submerge the medicinal materials, and soaking for 17 minutes;
(2) adding 150mL of water into the traditional Chinese medicine raw materials, decocting with strong fire until boiling, decocting with slow fire for 17 minutes after boiling, and taking traditional Chinese medicine decoction;
(3) adding 120mL of water into the traditional Chinese medicine raw materials again, heating and decocting with strong fire until the water is boiled, decocting with slow fire for 18 minutes after the water is boiled, and taking traditional Chinese medicine decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
Effect example 1: animal experiments
(1) Experimental animals: SPF SD male rats with weight of 200g +/-20 g and 50 rats; purchased from the medical animal experiment center of Guangdong province (license number: SCXK (Guangdong) 2018-.
(2) The experimental method comprises the following steps: the experiment was started one week after acclimation feeding. The rat adopts Walker-256 tumor strain (the concentration is about 100 ten thousand cells/ml) to extract 0.5ml by using a sterile syringe, inoculates the extract on the neck and back subcutaneous parts of a BALB/c nude mouse, cuts off the tumor when the subcutaneous tumor of the nude mouse grows to the diameter of about 1.0-1.5 cm, removes the necrotic tissue in the center of the tumor in a solution containing Hank's, and divides the tumor into 1mm tumor3And (5) small blocks. After the rats are anesthetized by propofol inhalation, the rats are locally and regularly disinfected to move the lower abdominal midline longitudinal 1c of the xiphoid processm, cutting, exposing liver, collecting 1 piece of tumor tissue, implanting into deep parenchyma of liver lobe of rat with a thick needle within 30min in vitro, observing for a moment, and compressing to stop bleeding to close abdomen. After molding, the samples were randomly divided into 10 groups of 10 samples each, including a model group, a control group and 3 experimental groups. The experimental groups 1, 2 and 3 were drenched with the compound Chinese medicinal preparations of examples 1, 2 and 3, respectively. The control group was given the compound Chinese medicinal preparation of comparative example 1. The model group was administered with the same volume of saline. 1 time per day for 6 weeks.
(3) Observation indexes are as follows: and observing the mass change and the survival time of the rat body.
(4) Data processing: the data were presented as mean ± standard deviation using SPSS 16.0 statistical software. And measuring normal data to perform variance analysis, measuring abnormal data to perform rank sum test, and considering that the statistical difference exists when P is less than 0.05.
(5) Results of the experiment
Table 1 comparison of body constitution of each group
Note that compared with the experimental group 3,*P＜0.05。
TABLE 2 comparison of survival time for each group
Note that compared with the experimental group 3,**P＜0.01。
as can be seen from tables 1 and 2, astragalus: barbed skullcap herb: the turmeric has better curative effect when the dosage ratio is 2:2:1, and can obviously improve the body quality of a liver cancer model and prolong the survival time.
Effect example 2:
in the week XX, men and 75, the liver occupies more than 3 years, the liver cancer is diagnosed as liver cancer, the radio frequency ablation is carried out for 2 times, the traditional Chinese medicine composition is taken every day after the operation, the traditional Chinese medicine composition is continuously taken till now, the regular examination shows that the focus in the liver is not obviously increased at present, and the liver function is normal.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. A Chinese medicinal composition for treating hepatocarcinoma is characterized by comprising radix astragali, herba Scutellariae Barbatae and Curcuma rhizome; the weight ratio of the astragalus to the scutellaria is that: barbed skullcap herb: the turmeric is 1-4: 0.5-3: 0.5-2.
2. The traditional Chinese medicine composition of claim 1, wherein the weight ratio of the astragalus membranaceus, the scutellaria barbata and the turmeric is astragalus: barbed skullcap herb: the turmeric is 1-3: 0.5-1.
3. The traditional Chinese medicine composition of claim 1, wherein the weight ratio of the astragalus membranaceus, the scutellaria barbata and the turmeric is astragalus: barbed skullcap herb: turmeric is 2:2: 1.
4. The preparation method of the traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following steps:
(1) soaking the Chinese medicinal materials in water;
(2) adding water, heating and decocting the traditional Chinese medicine raw materials in the step (1) to obtain traditional Chinese medicine juice;
(3) adding water into the Chinese medicinal materials, decocting under heating, and collecting decoction;
(4) and (3) mixing the Chinese medicine juice obtained in the step (2) and the Chinese medicine juice obtained in the step (3) to obtain the Chinese medicine composition.
5. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the amount of water added in the step (1) is 400-500 mL.
6. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the soaking time in the step (1) is 15-20 min.
7. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the amount of water added in the step (2) is 100-200 mL.
8. The method for preparing the Chinese medicinal composition according to claim 4, wherein the decocting method comprises the following steps: heating and boiling, and then continuously heating for 15-20 min.
9. The preparation method of the traditional Chinese medicine composition according to claim 4, wherein the amount of water added in the step (3) is 80-120 mL.
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| Title |
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| 骆殊等: "黄芪甲苷与姜黄素配伍对人肝癌裸鼠原位移植瘤", 《中华肿瘤防治杂志》 * |
| 龙爱华等: "抑癌复方对大鼠肝癌前病变的抑制作用", 《中国癌症杂志》 * |
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Application publication date: 20200908 |