CN111632123A - Spleen-tonifying navel paste medicament - Google Patents

Spleen-tonifying navel paste medicament Download PDF

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CN111632123A
CN111632123A CN202010712480.XA CN202010712480A CN111632123A CN 111632123 A CN111632123 A CN 111632123A CN 202010712480 A CN202010712480 A CN 202010712480A CN 111632123 A CN111632123 A CN 111632123A
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spleen
navel
chinese medicine
traditional chinese
rhizoma
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陈海燕
程勇
陈鑫燕
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention discloses a spleen-tonifying navel paste medicament which comprises a breathable adhesive tape, a heating bag, an impermeable layer, an impermeable ring, traditional Chinese medicine components and a covering film, wherein the heating bag is fixed on the lower end face of the breathable adhesive tape, the impermeable layer is pasted on the heating bag, the impermeable ring is pasted on the impermeable layer, the traditional Chinese medicine components are filled in the middle of the impermeable ring, and the covering film is pasted on the traditional Chinese medicine components. Compared with the prior art, the spleen-invigorating navel patch has the advantages that modern transdermal technologies such as penetration enhancer and far infrared substances are applied to the spleen-invigorating navel patch, so that the transdermal absorption rate of the medicine can be enhanced; blending with vaseline to facilitate preservation of the navel paste; the modern technology is combined with the traditional technology, and a new formulation of the spleen-tonifying navel patch is developed, so that the utilization rate of the medicine can be improved, the curative effect is enhanced, the navel patch is convenient to store, and the clinic can be better served.

Description

Spleen-tonifying navel paste medicament
Technical Field
The invention relates to a medical drug, in particular to a spleen-tonifying navel patch medicament.
Background
In the pediatrics disease spectrum, the incidence rate of digestive system diseases is only lower than that of respiratory system diseases, and children have difficulty in taking medicines, so that the finding of a traditional Chinese medicine external treatment technology which is safe and effective and has high child acceptance is of great significance.
With the development of science and technology, skin administration has become the third most administration route, Chinese medicine can be said to have unique characteristics in this route, combine traditional Chinese medicine external treatment method with modern transdermal technology, form Chinese medicine transdermal therapeutic system will be a big development trend of internal disease external treatment method research. The existing pediatric spleen-tonifying navel patch has excellent formula and good curative effect, is widely used clinically, but has thicker particles and relatively low absorption rate due to the manufacturing process problem; on the other hand, the ginger juice is not easy to be prepared and stored, which brings great inconvenience to children patients. Therefore, the modern transdermal technology is combined with the spleen tonifying navel patch of the pediatric preparation in the hospital, a new dosage form of the spleen tonifying navel patch is researched, on one hand, the curative effect is enhanced, on the other hand, the problem of poor preservation is solved, and the spleen tonifying navel patch can better serve for clinic and parents.
Disclosure of Invention
The present invention aims at providing one kind of spleen invigorating navel plaster to solve the said problem.
The invention realizes the purpose through the following technical scheme:
the anti-seepage heating blanket comprises a breathable adhesive tape, a heating bag, an anti-seepage layer, an anti-seepage ring, traditional Chinese medicine components and a covering film, wherein the heating bag is fixed on the lower end face of the breathable adhesive tape, the anti-seepage layer is attached to the heating bag, the anti-seepage ring is attached to the anti-seepage layer, the traditional Chinese medicine components are filled in the middle of the anti-seepage ring, and the covering film is attached to the traditional Chinese medicine components.
Specifically, the heating bag comprises tourmaline, carbon dioxide and salt.
Specifically, the traditional Chinese medicine components comprise clove, endothelium corneum gigeriae galli, astragalus, fructus evodiae, semen cuscutae, fructus amomi, rhizoma atractylodis macrocephalae, rhizoma cyperi, rhizoma alismatis, pericarpium citri reticulatae, agastache rugosus, laurocapram, propylene glycol and vaseline.
Preferably, the temperature of the heating bag is controlled within 10 minutes, the temperature is continuously controlled between 45-55 ℃, and the required temperature is maintained for 6-8 hours.
Preferably, each part of the traditional Chinese medicine components comprises, by weight, 6% of clove, 5% of endothelium corneum gigeriae galli, 3% of astragalus membranaceus, 3% of fructus evodiae, 2% of semen cuscutae, 3% of fructus amomi, 5% of rhizoma atractylodis macrocephalae, 3% of rhizoma cyperi, 2% of rhizoma alismatis, 1% of pericarpium citri reticulatae, 2% of wrinkled gianthyssop herb, 10% of laurocapram, 5% of propylene glycol and 50% of vaseline.
Specifically, the preparation method of the traditional Chinese medicine components comprises the following steps: removing impurities from flos Caryophylli, endothelium corneum Gigeriae Galli, radix astragali, fructus evodiae, semen Cuscutae, fructus Amomi, Atractylodis rhizoma, rhizoma Cyperi, Alismatis rhizoma, pericarpium Citri Tangerinae, and herba Agastaches, mixing, pulverizing, sieving with 100 mesh sieve, melting vaseline with hot water bath method, adding into the medicinal powder mixture, adding laurocapram and propylene glycol, and stirring.
The invention has the beneficial effects that:
the invention is a spleen invigorating navel patch medicament, compared with the prior art, the invention applies modern transdermal technologies such as penetration enhancer and far infrared substance to the spleen invigorating navel patch, and can enhance the transdermal absorption rate of the medicament; blending with vaseline to facilitate preservation of the navel paste; the modern technology is combined with the traditional technology, and a new formulation of the spleen-tonifying navel patch is developed, so that the utilization rate of the medicine can be improved, the curative effect is enhanced, the navel patch is convenient to store, and the clinic can be better served.
Drawings
Fig. 1 is a schematic structural view of the present invention.
In the figure: 1-breathable adhesive plaster, 2-heating bag, 3-impermeable layer, 4-impermeable ring, 5-traditional Chinese medicine component and 6-covering film.
Detailed Description
The invention will be further described with reference to the accompanying drawings in which:
as shown in fig. 1: the anti-seepage heating blanket comprises a breathable adhesive tape 1, a heating bag 2, an anti-seepage layer 3, an anti-seepage ring 4, a traditional Chinese medicine component 5 and a covering film 6, wherein the heating bag is fixed on the lower end face of the breathable adhesive tape, the anti-seepage layer is attached to the heating bag, the anti-seepage ring is attached to the anti-seepage layer, the traditional Chinese medicine component is filled in the middle of the anti-seepage ring, and the covering film is attached to the traditional Chinese medicine component.
Specifically, the heating bag comprises tourmaline, carbon dioxide and salt.
Specifically, the traditional Chinese medicine components comprise clove, endothelium corneum gigeriae galli, astragalus, fructus evodiae, semen cuscutae, fructus amomi, rhizoma atractylodis macrocephalae, rhizoma cyperi, rhizoma alismatis, pericarpium citri reticulatae, agastache rugosus, laurocapram, propylene glycol and vaseline.
Preferably, the temperature of the heating bag is controlled within 10 minutes, the temperature is continuously controlled between 45-55 ℃, and the required temperature is maintained for 6-8 hours.
Preferably, each part of the traditional Chinese medicine components comprises, by weight, 6% of clove, 5% of endothelium corneum gigeriae galli, 3% of astragalus membranaceus, 3% of fructus evodiae, 2% of semen cuscutae, 3% of fructus amomi, 5% of rhizoma atractylodis macrocephalae, 3% of rhizoma cyperi, 2% of rhizoma alismatis, 1% of pericarpium citri reticulatae, 2% of wrinkled gianthyssop herb, 10% of laurocapram, 5% of propylene glycol and 50% of vaseline.
Specifically, the preparation method of the traditional Chinese medicine components comprises the following steps: removing impurities from flos Caryophylli, endothelium corneum Gigeriae Galli, radix astragali, fructus evodiae, semen Cuscutae, fructus Amomi, Atractylodis rhizoma, rhizoma Cyperi, Alismatis rhizoma, pericarpium Citri Tangerinae, and herba Agastaches, mixing, pulverizing, sieving with 100 mesh sieve, melting vaseline with hot water bath method, adding into the medicinal powder mixture, adding laurocapram and propylene glycol, and stirring.
The spleen-strengthening navel plaster has good clinical effect and depends on the following two aspects:
firstly, the medicine composition and the proportion are excellent, and the clove, the amomum villosum, the rhizoma cyperi and the evodia rutaecarpa in the prescription contain volatile oil, so that the functions of promoting infiltration and treating are good, and the key point of good curative effect is. In the formula, clove, pungent and warm in property, can warm the middle-jiao and descend the adverse qi, and is used for treating diseases such as emesis, hiccup, deficiency-cold of spleen and stomach, and the volatile oil of clove (eugenol, acetyl eugenol, caryophyllene, etc.) is a natural transdermal absorption enhancer. Pharmacological research proves that the clove can promote the secretion of gastric acid, pepsin and bile, relieve intestinal spasm, promote gastrointestinal functions, relieve flatulence, enhance digestion capacity, and relieve symptoms such as nausea, vomiting and abdominal distension. Wu Zhu Yu is pungent and warm in property, warming spleen and stomach and dispelling cold pathogen, so it is indicated for all syndromes because the middle-jiao is warm and qi is descending. Experimental study shows that fructus evodiae has effects of promoting synthesis and release of neurotransmitter calcitonin gene-related peptide and substance P, and relieving pain due to nerve desensitization. Fructus Amomi is pungent and warm, and has effects of resolving dampness, promoting appetite, warming spleen and relieving diarrhea, and fructus Amomi contains volatile oil, and has effects of promoting gastrointestinal motility, relieving pain, resisting inflammation and relieving diarrhea. Cyperus rotundus is pungent, slightly bitter, slightly sweet and neutral. It enters liver, spleen and triple energizer meridians. Has effects of dispersing stagnated liver qi, relieving qi stagnation, regulating qi-flowing, relieving epigastric distention, regulating menstruation and relieving pain. Pharmacological research shows that the rhizoma cyperi has the effects of promoting intestinal peristalsis and easing pain. The total formula can well play a role in warming the middle-jiao and strengthening the spleen, relieving pain and stopping diarrhea and vomiting.
Secondly, the acupoint selected by the spleen-invigorating navel patch is the Shenque acupoint, which is not only communicated with eight extra meridians but also connected with twelve meridians, thereby communicating muscles, limbs and sense organs. The umbilicus is the last closed part of the abdomen in human development, is the thinnest part of the skin of the abdomen, is almost not covered by fat tissues and has a plurality of blood vessels and lymphatic vessels. The effective molecular components of the traditional Chinese medicine can quickly diffuse into blood to reach the whole body after penetrating through the skin, thereby playing a role.
The application of Chinese medicine acupoint application, the composition of the medicine, the selection of transdermal enhancer, the acting position and the like are important factors influencing the absorption and utilization of the externally applied medicine. The spleen-tonifying navel patch disclosed by the invention is reasonable in selection of prescription composition and action part, but the development limitation of the navel patch is that the effective ingredients in the medicine cannot be completely and thoroughly absorbed, the ground traditional Chinese medicine ingredients are coarse particles, the molecular weight is large, the dissolution rate is low, and the effective ingredients are difficult to be sufficiently absorbed through skin; on the other hand, ginger juice is selected for blending, so that the storage is not good, and the clinical application of the navel paste is limited to a certain extent. Therefore, the improvement of the manufacturing process, the development of the transdermal permeation promoting technology, the improvement of the curative effect and the convenient preservation are the problems which need to be solved urgently in the development of the umbilical paste.
Firstly, the method comprises the following steps: the method for improving the transdermal rate of the medicine comprises the following steps:
1. using a penetration enhancer: such as laurocapram and propylene glycol, both of which can soften the stratum corneum of the skin, so that the medicament can pass through the skin barrier more easily, thereby improving the transdermal penetration of the medicament; both are nontoxic and safe and can be applied to clinic.
2. Matching with far infrared substances: the far infrared substance can increase the temperature of the navel patch after contacting with skin, promote the exudation of volatile oil of Chinese medicinal materials, increase the temperature, promote the absorption of medicinal materials by vasodilatation, and improve the utilization rate of medicinal materials.
Tourmaline is a natural ore with permanent electrodes, and can be used as the main component of far infrared ray material. The tourmaline can emit far infrared rays, promote drug permeation and stimulate meridian points, so that the tourmaline can be combined with the traditional manufacturing process of the spleen-invigorating navel patch to improve the difficulty of the traditional spleen-invigorating navel patch.
Tourmaline (Tourmaline), also called Tourmaline, has complex chemical components, and the mineral science name Tourmaline, and a large number of scientific researches prove that the Tourmaline has four special properties, namely emitting far infrared rays, releasing negative ions, bioelectricity phenomenon, mineral substances and trace elements. First characteristic, emitting far infrared rays: under the condition of a certain temperature, the tourmaline can emit far infrared rays with the wavelength of 4-14 um, and the wavelength is matched with the wavelength of far infrared absorption and radiation of a human body, so that the skin temperature of the human body is increased, the blood flow is accelerated, and the microcirculation is improved. Second, release of negative ions: tourmaline is called as a 'natural anion generator', and can automatically and permanently release anions, thereby achieving the effect of neutralizing free radicals, further activating cells and relieving fatigue. Third property, bioelectrical phenomenon: the bioelectricity generated by the tourmaline is 0.06mA, is similar to the bioelectricity of a human body, and when the bioelectricity acts on meridians and acupoints of the human body, the bioelectricity biological effect of the human body is caused, so that the human body is promoted to balance yin and yang, relax muscles and tendons, dredge collaterals, activate blood and remove blood stasis, beneficial effects are generated on promoting metabolism, regulating a nervous system and improving blood circulation, and the effect of preventing and treating diseases is achieved. The fourth characteristic, rich trace elements, promote human health.
Secondly, the method comprises the following steps: and (3) prolonging the preservation time: the medical white vaseline is used for replacing ginger juice to prepare the essential ingredients of the traditional Chinese medicine, is odorless ointment-shaped substance, is not hydrophilic and can not be absorbed, so that a protective film can be formed on the surface of the skin, the local part of the skin is in a closed state, the opportunity that external pathogenic bacteria are in contact with the skin is blocked, the moisture is not easy to evaporate and dissipate, the skin can be kept in a wet state for a long time, and the medicine is easier to absorb under the hydration action of the skin.
In conclusion, the traditional spleen-tonifying navel paste has the problems of low medicament utilization rate and difficult storage in the manufacturing process, the application of the penetration enhancer and the vaseline can promote the medicament penetration, the curative effect is improved, the storage is easy, and the preparation method combines the traditional manufacturing process of the spleen-tonifying navel paste with the penetration enhancer, the far infrared ray substance tourmaline and the like to develop a novel spleen-tonifying navel paste preparation form, so that the preparation method can be better used for clinic and has great significance.
The clinical verification of the spleen-tonifying navel patch of the invention is as follows:
100 pediatric outpatient cases are collected, the age is distributed between 6 months and 14 years, the pediatric diarrhea is diagnosed, and the infant is diagnosed as the infant with cold-dampness encumbering the spleen, the pediatric cases are divided into 50 cases respectively for an observation group and a control group according to a random digital table method, the two groups are subjected to conventional treatments such as antidiarrheal, fluid infusion and intestinal flora adjustment, the observation group is subjected to novel spleen tonifying navel patch treatment, and the control group is subjected to traditional spleen tonifying navel patch treatment. And observing the diarrhea symptom relief condition after the contrast medication, the adverse reaction and discomfort symptom generated during the use, the preservation condition of the navel patch and the like, and observing the preservation condition of the novel spleen-tonifying navel patch for 6 months.
Through clinical verification, the novel navel paste is improved in the aspects of medicine proportioning, heating indexes of a heating bag and the like so as to improve the curative effect and the use convenience rate.
The diarrhea recovery time results are given in the following table:
item 6 months old 1-2 years old 3-6 years old 6-10 years old 10-14 years old
Observation group 4-6 hours 5-7 hours 6 to 7 hours 7-9 hours 8-12 hours
Control group 10-12 hours 10-14 hours 12 to 16 hours 15-20 hours 16-24 hours
Diagnostic criteria: refer to the Chinese medicine industry Standard of the people's republic of China "Standard of curative Effect for diagnosis of TCM disease symptoms" (ZY/T001.4-94).
(1) The stool is thin or like a water sample, and the frequency is increased. It can be used for treating abdominal distention and pain.
(2) Acute diarrhea is sudden and short in course. It is accompanied by aversion to cold and fever.
(3) Chronic diarrhea has a slow onset, a long course of disease, repeated attacks, and mild and severe cases.
(4) Improper diet, cold or emotional changes can induce.
(5) A few red and white cells can be seen in routine excrement, and pathogenic bacteria in excrement culture are positive or negative.
(6) If necessary, X-ray barium enema or enteroscopy is performed.
Syndrome classification
Cold-dampness disturbing the spleen: clear and thin stool or watery stool, abdominal pain, borborygmus, aversion to cold and poor appetite. White and slippery coating and soft and slow pulse.
Inclusion criteria were: the age is 6 months to 14 years old, and the infant is diagnosed with infantile diarrhea and is identified as an infant with cold-dampness encumbering the spleen.
Rejection standard: 1) serious diseases such as severe pneumonia, severe central nervous system infection, etc. occur during follow-up; 2) infant patients with heat syndrome.
Shedding standard: no follow-up was given for various reasons after inclusion.
Intervention method
The two groups are treated by conventional treatments such as antidiarrheal, fluid infusion, and intestinal flora regulating, the observation group is applied with the novel spleen invigorating navel patch for 6-8 hours, and the control group is applied with the traditional spleen invigorating navel patch for 6-8 hours.
Observation index
1) Relief of diarrhea symptoms after administration;
2) allergy and scald during administration;
3) the deterioration and the drying of the two spleen-invigorating navel patches occur during the storage period, and the novel navel patch is placed and observed for 6 months.
Determination of therapeutic effect
Refer to the Chinese medicine industry Standard of the people's republic of China "Standard of curative Effect for diagnosis of TCM disease symptoms" (ZY/T001.4-94).
And (3) curing: normal stool, disappearance of other symptoms and normal clinical examination.
Improvement: the stool frequency is obviously reduced, and other symptoms are improved.
The disease is not cured: the symptoms are not improved.
Improvement of novel spleen-tonifying navel patch
Through clinical verification, the novel navel paste is improved in the aspects of medicine proportioning, heating indexes of a heating bag and the like so as to improve the curative effect and the use convenience rate.
The foregoing shows and describes the general principles and features of the present invention, together with the advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (6)

1. A spleen-tonifying navel paste medicament is characterized in that: the heating bag is fixed on the lower end face of the breathable adhesive tape, the impermeable layer is attached to the heating bag, the impermeable ring is attached to the impermeable layer, the traditional Chinese medicine components are filled in the middle of the impermeable ring, and the covering film is attached to the traditional Chinese medicine components.
2. The spleen-invigorating navel patch medicament according to claim 1, wherein: the heating bag consists of tourmaline, carbon dioxide and salt.
3. The spleen-invigorating navel patch medicament according to claim 1, wherein: the traditional Chinese medicine components comprise clove, endothelium corneum gigeriae galli, astragalus, fructus evodiae, semen cuscutae, fructus amomi, rhizoma atractylodis macrocephalae, rhizoma cyperi, rhizoma alismatis, pericarpium citri reticulatae, agastache rugosus, laurocapram, propylene glycol and vaseline.
4. The spleen-invigorating navel patch medicament according to claim 2, wherein: the temperature rise time of the heating package is controlled within 10 minutes, the temperature is continuously controlled between 45-55 degrees, and the required temperature is maintained for 6-8 hours.
5. The spleen-invigorating navel patch medicament according to claim 3, wherein: the traditional Chinese medicine composition comprises, by weight, 6% of clove, 5% of endothelium corneum gigeriae galli, 3% of astragalus membranaceus, 3% of fructus evodiae, 2% of semen cuscutae, 3% of fructus amomi, 5% of rhizoma atractylodis macrocephalae, 3% of rhizoma cyperi, 2% of rhizoma alismatis, 1% of pericarpium citri reticulatae, 2% of agastache rugosus, 10% of laurocapram, 5% of propylene glycol and 50% of vaseline.
6. The spleen-invigorating navel patch medicament according to claim 5, wherein: the preparation method of the traditional Chinese medicine components comprises the following steps: removing impurities from flos Caryophylli, endothelium corneum Gigeriae Galli, radix astragali, fructus evodiae, semen Cuscutae, fructus Amomi, Atractylodis rhizoma, rhizoma Cyperi, Alismatis rhizoma, pericarpium Citri Tangerinae, and herba Agastaches, mixing, pulverizing, sieving with 100 mesh sieve, melting vaseline with hot water bath method, adding into the medicinal powder mixture, adding laurocapram and propylene glycol, and stirring.
CN202010712480.XA 2020-07-22 2020-07-22 Spleen-tonifying navel paste medicament Pending CN111632123A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101596249A (en) * 2009-07-08 2009-12-09 成都晟铭医药科技有限公司 Treatment diarrheal Chinese medicine composition and Chinese medicine medicine and preparation method thereof
CN210991777U (en) * 2019-08-21 2020-07-14 蕲春千年艾科技有限公司 Health-preserving thermal moxibustion plaster

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101596249A (en) * 2009-07-08 2009-12-09 成都晟铭医药科技有限公司 Treatment diarrheal Chinese medicine composition and Chinese medicine medicine and preparation method thereof
CN210991777U (en) * 2019-08-21 2020-07-14 蕲春千年艾科技有限公司 Health-preserving thermal moxibustion plaster

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王志丹等: "《2017年中西医结合执业医师（含助理）实践技能考试应试指导》", 28 February 2017 *

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