CN111617000A - Lightyellow sophora root nano-silver washing-free disinfectant and preparation method thereof - Google Patents
Lightyellow sophora root nano-silver washing-free disinfectant and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/614—By macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/651—The particulate/core comprising inorganic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention discloses a lightyellow sophora root nano-silver washing-free disinfectant and a preparation method thereof, belonging to the technical field of cosmetics and comprising a component A and a component B; wherein the component A comprises the following substances in percentage by weight: 2.0 to 4.0 percent of compound lightyellow sophora root extract, 0.5 to 2.0 percent of nano-silver, 0.1 to 0.5 percent of thickening agent, 1.0 to 2.0 percent of humectant and 64.0 to 71.0 percent of ethanol; the component B comprises the following substances in percentage by weight: 0.1 to 1.0 percent of aloe extract, 0.2 to 1.0 percent of panthenol, 0.1 to 0.5 percent of triethanolamine and 0.1 to 1.0 percent of tea extract; the balance of deionized water; adding the substances with the corresponding weight percentage of the component A and deionized water into an emulsifying pot, stirring and homogenizing until the substances are completely dissolved, defoaming for standby, adding the substances with the corresponding weight percentage of the component B into the emulsifying pot, stirring uniformly until the substances are clear, transparent and sticky, sampling, controlling, discharging and subpackaging to obtain a finished product. The no-clean disinfectant disclosed by the invention has the advantages of mild components, obvious antibacterial and bacteriostatic effects, excellent volatility, quick air drying effect, convenience in use and comfort.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly belongs to a no-clean disinfectant and a preparation method thereof.
Background
Along with the improvement of standard requirements of people on life quality, the requirements of people on sanitary standards are higher and higher, and sometimes people go out to travel and constantly take part in activities in public places and contact various unknown environments, particularly hands, so that the people need to contact various propagation sources, contact own mouths and noses and foods, or be in the field or other public places without washing hands with water, and the people are very inconvenient. Therefore, how to conveniently, quickly and effectively clean and disinfect hands is an important problem, and the washing-free disinfectant is produced at the same time.
However, the quality of the no-clean disinfectant in the current market is uneven, and some of the no-clean disinfectants are doped with a large amount of components in order to pursue high-efficiency antibiosis, so that the irritation of the disinfectant is large, and the disinfectant can damage hands after long-term use; and the other components are mild, but the disinfection degree is not high enough, and the effect is not ideal.
In addition, although the no-clean disinfectant on the market at present does not need clear water to wash, the no-clean disinfectant remains on the hands all the time, causes the hands to be wet all the time, is uncomfortable, needs a long time to air dry, and this is with the intention of the no-clean disinfectant: the cleaning device is used for cleaning hands quickly and conveniently.
Disclosure of Invention
Aiming at the defects and shortcomings in the background technology, the invention provides the sophora flavescens nano-silver no-clean disinfectant which can be sprayed on hands to efficiently carry out antibiosis and bacteriostasis, and has the advantages of high volatilization speed, mild and safe components.
The second purpose of the invention is to provide a preparation method of the sophora flavescens nano-silver washing-free disinfectant, which can keep the activity of each substance, improve the overall efficacy and action, reduce the irritation of the components and achieve the mild and efficient effects.
In order to realize the purpose, the invention adopts the following technical scheme to realize the purpose:
a radix Sophorae Flavescentis nano-silver washing-free disinfectant comprises component A and component B;
wherein the component A comprises the following substances in percentage by weight: 2.0 to 4.0 percent of compound lightyellow sophora root extract, 0.5 to 2.0 percent of nano-silver, 0.1 to 0.5 percent of thickening agent, 1.0 to 2.0 percent of humectant and 64.0 to 71.0 percent of ethanol;
the component B comprises the following substances in percentage by weight: 0.1 to 1.0 percent of aloe extract, 0.2 to 1.0 percent of panthenol, 0.1 to 0.5 percent of triethanolamine and 0.1 to 1.0 percent of tea extract;
the balance of deionized water;
the compound radix sophorae flavescentis extract comprises matrine (matrine), oxymatrine (oxymatrine), oxymatrine (sodium-anol), N-methylcantharine (N-methylcytisine), anagerine (anagyrine), bap-ifinoline (bap-iifoline), dehydromatrine (Sophorcarpine), d-isomatrine (d-isomatrine), kuraridine (kurarid-in), norkurarinone (norkurarinone), kurarinol (kurarinol), neokurarinol (neo-kurarinol), norkurarinol (norkurarinol), isokurarinone, and formononetin (formononetin).
Further measures taken are: the component A comprises the following substances in percentage by weight: 2.5 to 4.0 percent of compound lightyellow sophora root extract, 1.4 to 2.0 percent of nano-silver, 0.2 to 0.5 percent of thickening agent, 1.0 to 2.0 percent of humectant and 65.50 to 70.5 percent of ethanol;
the component B comprises the following substances in percentage by weight: 0.3 to 0.8 percent of aloe extract, 0.4 to 1.0 percent of panthenol, 0.2 to 0.5 percent of triethanolamine and 0.4 to 1.0 percent of tea extract;
the balance being deionized water.
Further measures taken are: the component A comprises the following substances in percentage by weight: 4.0% of compound sophora flavescens extract, 2.0% of nano-silver, 0.5% of thickening agent, 2.0% of humectant and 67.5% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.5%, panthenol 1.0%, triethanolamine 0.5%, and tea extract 1.0%;
the balance being deionized water.
Further measures taken are: the nano silver is nano-level simple substance silver, the size is 2-5nm, and the optical density OD is 4.
Further measures taken are: the thickening agent is one or a mixture of more of carbomer 940, carbomer 941, carbomer U20 and carbomer U21;
further measures taken are: the humectant is one or a mixture of more of glycerol, propylene glycol and butanediol.
A preparation method of a sophora flavescens nano-silver washing-free disinfectant comprises the following steps:
s1: adding the composite lightyellow sophora root extract, the nano-silver, the thickening agent, the humectant, the ethanol and the deionized water which are in the corresponding weight percentage of the component A into an emulsifying pot, stirring and homogenizing until the components are completely dissolved, and defoaming for later use;
s2: sequentially adding the aloe extract, the panthenol, the triethanolamine and the tea extract which are in the corresponding weight percentage of the component B into the component A to be used after the step S1, and uniformly stirring until the mixture is clear, transparent and sticky;
and S3, sampling, controlling, discharging and subpackaging to obtain the finished product.
Further measures taken are: the formononetin in the compound sophora flavescens extract is obtained by extracting and purifying the formononetin from the axanthus axletus and the astragalus membranaceus, and the main process comprises the following steps: firstly, carrying out superfine grinding on herba axici and radix astragali by using a traditional Chinese medicine superfine grinder to obtain herba axici and radix astragali superfine powder, mixing uniformly according to a solid-liquid ratio of 1 (13-15), adding an extraction solvent ethanol and formic acid, then accelerating the diffusion and permeation of the extraction solvent into cells by using ultrasonic waves, rapidly dissolving formononetin in the herba axici and the radix astragali in the extraction solvent, stopping the ultrasonic waves, carrying out water bath heating to 38-40 ℃, keeping the temperature for 1h, then carrying out supercritical fluid extraction under the condition of 20-21Mpa by using nitric oxide under the condition of keeping the temperature for 4.5-5h, finally purifying and concentrating by using a polymer permeable membrane, and carrying out vacuum drying to obtain the formononetin.
Further measures taken are: the traditional Chinese medicine ultrafine grinder comprises a grinding cavity, a grinding cavity shell, a grinding funnel and a grinding cavity, wherein the grinding cavity is installed in the grinding cavity shell through a rotating shaft, the grinding funnel is located below the grinding cavity and is installed in the grinding cavity shell through a rotating groove, the bottom of the grinding funnel is connected with the grinding cavity through a blanking channel, and the blanking channel and the blanking funnel are integrally formed; the blanking channel is provided with a gear rotary drive in a matching way, and the blanking channel and the crushing hopper are driven to rotate through the gear rotary drive;
the feeding device is characterized in that a feeding brush is arranged in the crushing hopper, the feeding brush is tightly attached to the inner wall of the crushing hopper and arranged along the contraction direction of the crushing hopper, and the top end of the feeding brush is fixedly connected with the shell of the crushing cavity.
Further measures taken are: the rotary drive comprises a driving gear, a driven gear and a driving motor, the blanking channel penetrates through the driven gear and is fixed in the driven gear, the driven gear is meshed with the driving gear, and the driving gear is in power connection with the output end of the driving motor; the rotary groove is circular, the outer side of the rotary groove is fixedly connected with the inner wall of the crushing cavity shell, a groove matched with the top edge of the crushing funnel is formed in the inner side of the rotary groove, and the crushing funnel is rotatably clamped and connected with the groove.
Further measures taken are: the unloading brush includes brush board and brush hair, the one end of brush board is equipped with the bolt, the inboard of broken chamber shell be equipped with bolt assorted screw hole, the brush board passes through bolt and screw hole spiro union are fixed in the inboard of broken chamber shell, the brush board is isosceles triangle, the top of brush board corresponds triangular's apex angle, the bottom rigid coupling brush hair of brush board.
The nano-silver has the mechanical adsorption and fixation effects on viruses, a layer of polymer with the thickness of 5-10nm is covered on the surface of the nano-ultrafine particles, a large amount of protein and enzyme, especially polysaccharides can be identified, and a plurality of polysaccharides can possibly prevent the adsorption of the viruses and host cells, so that the nano-silver has stronger antiviral activity; meanwhile, due to the colloidal stability and strong adsorbability of the nano material particles, the virus loses survival conditions and dies.
The nano silver can prevent viruses from entering host cells and inhibit the combination of the viruses and cell receptors, thereby preventing the infection of the viruses on the host cells. Some nano small molecules can be combined with a conserved space structure of virus surface protein to inhibit the interaction between the virus and a receptor, and the nano material can prevent the virus from entering the cell and directly inactivate the virus. For example, the nano silver particles bind to-SH of the virion surface protein to form-SAg complexes, inactivate enzyme proteins, interfere with human cells of the virus, or kill the virus, etc., resulting in inactivation of the virus. The nano silver can be combined with virus nucleic acid, so that the structure of virus DNA or RNA is changed, the replication of DNA or RNA is influenced, and the virus is inactivated. Ag + released by the nano silver directly has a destructive effect on viruses.
Flavescent sophora root: bitter taste and cold nature. It enters heart, liver, stomach, large intestine and bladder meridians. Clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis. Treatise on herb Property: for heat-toxin wind, skin and muscle fantod and sores, scabby eyebrow, it is mainly used to remove hot and somnolence, cold and pain in abdomen, nausea and abdominal pain, and to remove body stuffiness and accumulation of heart and abdomen. "
The radix sophorae flavescentis contains rich alkalies and flavonoids, and through research and experiments, compounds which are matched with each other and have excellent antibacterial and bacteriostatic effects are selected, formononetin which is extracted from herba hyperici and radix astragali through a special process is particularly added, irritation is removed, and the activity of isoflavone components is activated, so that the effect of the composite radix sophorae flavescentis extract is greatly improved, and the composite radix sophorae flavescentis extract has excellent antifungal and skin barrier improving effects.
The composite lightyellow sophora root extract is matched with the nano silver and the ethanol, the ratio of the components is strictly controlled, the remarkable synergistic effect is achieved, the antibacterial and bacteriostatic effects are more remarkable than the addition effect of the effect of singly using one of the components, the virus inactivation effect is more excellent, the composite lightyellow sophora root extract can be quickly volatilized, no residue is left, the use is more comfortable, and the discomfort of hands is avoided.
Through the technical scheme, compared with the prior art, the invention has the following beneficial effects:
1. the sophora flavescens nano-silver disinfectant disclosed by the invention utilizes a special matching mode, and meanwhile, the formononetin after special treatment is added, so that substances exert different effects, the overall synergistic effect is greatly improved, the effects of quickly and efficiently performing antibiosis and bacteriostasis are achieved, the volatilization speed is high, the air drying time is short, the components are mild, and the skin cannot be damaged after long-term use.
2. The preparation method is simple and effective, and can be used for extracting and treating partial effective components more finely by using special equipment, so that the special activity of the effective components is exerted, the whole effect is greatly improved, and the irritation of the components is inhibited, so that the aims of obviously sterilizing and inhibiting bacteria, and being mild and non-irritating are fulfilled.
Drawings
Fig. 1 is an internal structure view of a superfine Chinese medicine pulverizer according to an embodiment of the present invention;
FIG. 2 is a front view and a left side view of a brush for a super micro pulverizer for traditional Chinese medicines according to an embodiment of the present invention;
FIG. 3 is a histogram showing the results of the indoor and outdoor air drying effect tests of examples 1 to 5 and the control groups 1 to 2 according to the present invention.
Wherein: 1. a crushing chamber housing; 2. a crushing chamber; 3. crushing a funnel; 4. a driven gear; 5. a driving gear; 6. a drive motor; 7. a grinding chamber; 8. a blanking brush; 801. brushing; 9. the groove is rotated.
Detailed Description
In order to clearly understand the technical solutions adopted by the present invention, the following description is made on the preferred embodiments of the present invention, and it should be understood that the embodiments described herein are only used for illustrating and explaining the present invention, and are not used to limit the present invention.
Example 1: a radix Sophorae Flavescentis nano-silver washing-free disinfectant comprises component A and component B;
wherein the component A comprises the following substances in percentage by weight: 2.0% of compound sophora flavescens extract, 0.5% of nano-silver, 0.1% of thickening agent, 1.0% of glycerol and 64.0% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.1%, panthenol 0.2%, triethanolamine 0.1%, and tea extract 0.1%;
the balance being deionized water.
Example 2: a radix Sophorae Flavescentis nano-silver washing-free disinfectant comprises component A and component B;
wherein the component A comprises the following substances in percentage by weight: 3.0% of compound sophora flavescens extract, 1.2% of nano-silver, 0.3% of thickening agent, 1.5% of propylene glycol and 71.0% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.1%, panthenol 0.6%, triethanolamine 0.3%, and tea extract 0.5%;
the balance being deionized water.
Example 3: a radix Sophorae Flavescentis nano-silver washing-free disinfectant comprises component A and component B;
wherein the component A comprises the following substances in percentage by weight: 4.0% of compound radix sophorae flavescentis extract, 2.0% of nano-silver, 0.5% of thickening agent, 1.0% of butanediol, 1.0% of glycerol and 67.5% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.5%, panthenol 1.0%, triethanolamine 0.5%, and tea extract 1.0%;
the balance being deionized water.
Example 4: a radix Sophorae Flavescentis nano-silver washing-free disinfectant comprises component A and component B;
wherein the component A comprises the following substances in percentage by weight: 2.5% of compound sophora flavescens extract, 1.0% of nano-silver, 0.2% of thickening agent, 1.8% of glycerol and 65.5% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.3%, panthenol 0.4%, triethanolamine 0.2%, and tea extract 0.4%;
the balance being deionized water.
Example 5: a radix Sophorae Flavescentis nano-silver washing-free disinfectant comprises component A and component B;
wherein the component A comprises the following substances in percentage by weight: 3.5% of compound sophora flavescens extract, 1.6% of nano-silver, 0.4% of thickening agent, 1.4% of butanediol and 70.5% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.8%, panthenol 0.8%, triethanolamine 0.4%, and tea extract 0.8%;
the balance being deionized water.
The above examples 1-5 were all prepared by the following preparation method, comprising the steps of:
s1: adding the composite lightyellow sophora root extract, the nano-silver, the thickening agent, the humectant, the ethanol and the deionized water which are in the corresponding weight percentage of the component A into an emulsifying pot, stirring and homogenizing until the components are completely dissolved, and defoaming for later use;
s2: sequentially adding the aloe extract, the panthenol, the triethanolamine and the tea extract which are in the corresponding weight percentage of the component B into the component A to be used after the step S1, and uniformly stirring until the mixture is clear, transparent and sticky;
and S3, sampling, controlling, discharging and subpackaging to obtain the finished product.
Wherein: the nanosilver in examples 1-5 was nano-scale elemental silver, 2-5nm in size, and had an optical density OD of 4.
The formononetin in the composite lightyellow sophora root extract in the embodiments 1-5 is obtained by extracting and purifying the common clover and the astragalus, and the main technical process comprises the following steps: firstly, carrying out superfine grinding on herba axici and radix astragali by using a traditional Chinese medicine superfine grinder to obtain herba axici and radix astragali superfine powder, mixing the obtained herba axici and radix astragali superfine powder uniformly according to a solid-liquid ratio of 1 (13-15), adding an extraction solvent ethanol and formic acid, then accelerating the diffusion and permeation of the extraction solvent into cells by using ultrasonic waves, rapidly dissolving formononetin in the herba axici and the radix astragali in the extraction solvent, stopping the ultrasonic waves, carrying out water bath heating to 38-40 ℃, keeping the temperature for 1h, then carrying out supercritical fluid extraction under the condition of 20-21Mpa by using nitric oxide under the condition of keeping the temperature for 4.5-5h, finally purifying and concentrating by using a polymer permeable membrane, and drying in vacuum to obtain the herba axici and radix astragali superfine powder.
Carry out superfine kibbling super little rubbing crusher of traditional chinese medicine to axletree grass and astragalus includes broken chamber 2, broken chamber shell 1, broken funnel 3 and crushing chamber 7, broken chamber 2 is installed in broken chamber shell 1 through the pivot, broken funnel 3 is located broken chamber 2 below to install in broken chamber shell 1 through rotatory recess 9, rotatory recess 9 is circular, the outside of rotatory recess 9 and the inner wall rigid coupling of broken chamber shell 1, the inboard of rotatory recess 9 seted up with 3 topside assorted recesses of broken funnel, broken funnel 3 with but the rotatable block of recess is connected.
The bottom of the crushing funnel 3 is connected with the crushing cavity 7 through a discharging channel, and the discharging channel and the discharging funnel 3 are integrally formed; the blanking channel is provided with a gear rotary drive in a matching way, and the blanking channel and the crushing hopper 3 are driven to rotate through the gear rotary drive; the rotary driving device comprises a driving gear 5, a driven gear 4 and a driving motor 6, a discharging channel penetrates through the driven gear 4 and is fixed in the driven gear 4, the driven gear 4 is meshed with the driving gear 5, and the driving gear 5 is in power connection with the output end of the driving motor 6.
Be equipped with unloading brush 8 in broken funnel 3, the unloading brush hugs closely 3 inner walls of broken funnel and sets up along 3 shrink directions of broken funnel, and the top of unloading brush 8 and broken chamber shell 1 rigid coupling. Unloading brush 8 is equipped with the bolt including brush board and brush hair 801, the one end of brush board, the inboard of broken chamber shell 1 be equipped with bolt assorted screw hole, the brush board passes through bolt and screw hole spiro union are fixed in the inboard of broken chamber shell 1, and the brush board is isosceles triangle, and the top of brush board corresponds triangular apex angle, the bottom rigid coupling brush hair 801 of brush board.
The crushing funnel 3 collects the Chinese herbal medicine raw materials crushed by the crushing cavity 2, and drives the driving gear 5 to rotate through the driving motor 6 to drive the driven gear 4 and the blanking channel to rotate, so that the blanking funnel 3 rotates along with the rotation of the driving gear, and the blanking is accelerated; meanwhile, the residual Chinese herbal medicines on the inner wall of the crushing funnel 3 are brushed away by the blanking brush 8, so that the crushing of other types of Chinese herbal medicines is facilitated, the residual Chinese herbal medicines are prevented from being mixed with the next Chinese herbal medicine to be crushed, and the pure crushing of each crushed Chinese herbal medicine and the accuracy of the subsequent proportioning are guaranteed; finally, the crushed Chinese herbal medicines are guided into a crushing cavity 7 through a blanking channel for superfine crushing.
When carrying out the superfine grinding of traditional chinese medicine, can avoid the material on the unloading funnel to pile up through the unloading brush to the traditional chinese medicine after remaining breakage on the unloading funnel is brushed off, thereby when avoiding carrying out next traditional chinese medicine and smashing, remaining traditional chinese medicine mixes with next traditional chinese medicine, produces the deviation when leading to the later stage to batching and draw, influences the drug effect. The materials on the discharging funnel are cleaned in order through the discharging brush, the driving motor drives the discharging funnel to rotate for discharging, so that the materials uniformly and orderly enter the superfine crushing cavity, the superfine crushing cavity is protected to operate smoothly, material gathering cannot occur during idling, the superfine crushing effect and quality are guaranteed, the obtained superfine powder particles are uniform and fine, and the follow-up extraction degree and extraction effect of active ingredients are guaranteed.
Note that: the whole preparation process must be executed strictly according to each step, temperature and heat preservation time, otherwise the effect of the finished product is influenced.
Control group 1: the preparation was carried out according to example 1 in patent application No. 201710096973.3 entitled "leave-on nano silver antibacterial hand sanitizer" and the preparation steps thereof to obtain a finished product of control group 1.
Control group 2: the same type of conventional qualified products of the no-clean disinfection solution purchased on the market are used as finished products of the control group 2.
The disposable disinfection of the embodiments 1-5 was also tested according to the evaluation method of WS/T650-2019 antibacterial and bacteriostatic effects, and the results are as follows:
the antibacterial requirement is as follows: not less than 90 percent is qualified, and the antibacterial rate of the lightyellow sophora root nano-silver washing-free disinfectant in the embodiments 1-5 is not less than 99.99 percent
The bacteriostatic requirement is as follows: not less than 50 percent is qualified, and the bacteriostatic rates of the lightyellow sophora root nano-silver washing-free disinfectant in the embodiments 1-5 are not less than 99.9 percent
The bacteriostatic rate is more than or equal to 90 percent (with stronger bacteriostatic action), and the lightyellow sophora root nano-silver washing-free disinfectant of the examples 1-5 has the bacteriostatic rate more than 90 percent and stronger bacteriostatic action.
Secondly, the leave-on disinfectant of the invention in the embodiment 1-5 and the products of the control group 1-2 are subjected to a plurality of skin irritation tests for a long time, and the test process and the results are as follows:
selecting the same batch of adult white rabbits, 35 male rabbits and 35 female rabbits, wherein the female rabbits are infertile and infertile, randomly grouping all the rabbits into 10 groups, and 7 groups respectively corresponding to the finished products of the examples 1-5 and the finished products of the control groups 1-2 of the invention to carry out skin irritation tests, in the whole test process, carrying out single-cage feeding on all the tested rabbits, keeping the feeding environment as the same as possible, feeding the same feed and water, and before carrying out the test, placing the tested animals in a laboratory animal room for feeding for 5 days.
Approximately 24 hours before the test, all hairs on both sides of the spine of the tested rabbit are cut off, the epidermis cannot be damaged, and the hair removing range on the left side and the right side is approximately 3cm multiplied by 3 cm. Directly coating 0.5mL of disinfectant of corresponding embodiment or control group on the dehaired skin on one side of spinal column, covering with two layers of gauze 2.5cm × 2.5cm and a layer of cellophane or the like, and fixing with non-irritating adhesive plaster and bandage; the skin on the other side was coated with deionized water and then covered with two layers of gauze 2.5cm by 2.5cm, a layer of cellophane or the like and secured with a non-irritating adhesive tape and bandage as a blank control. The test sample is applied for 1 time every day, the application is continuously carried out for 14 days, shearing is carried out before each application from the next day, the skin of the test part is cleaned by clear water, the reaction phenomena of the skin at two sides of the spine of the test rabbit are observed before the test sample is applied and one hour after the test sample is applied every day, the formation conditions of erythema and edema are recorded, the scoring is carried out according to the skin reaction phenomenon scoring rule shown in the following table 1, finally, the data are summarized, the average score of the erythema and the edema of each group is calculated (namely the sum of the average daily obtained erythema or edema scores of the test rabbits in the group is divided by the total number of animals in the group), and the result is shown in the following table 2.
Table 1: skin reaction phenomenon scoring rules
Table 2: skin multiple irritation test scoring results
| Group of | Erythema formation score | Edema formation score | Aggregate scores |
| Example 1 | 0.00 | 0.00 | 0.00 |
| Example 2 | 0.10 | 0.00 | 0.10 |
| Example 3 | 0.00 | 0.00 | 0.00 |
| Example 4 | 0.00 | 0.00 | 0.00 |
| Example 5 | 0.00 | 0.00 | 0.00 |
| Control group 1 | 0.50 | 0.10 | 0.60 |
| |
0.60 | 0.30 | 0.90 |
Table 3 below is a table of stimulation intensity levels corresponding to skin stimulation scores.
Table 3: skin irritation score versus irritation intensity
| Score of | Stimulation intensity rating |
| 0.0-0.5 | Has no irritation |
| 0.5-2.0 | Mild irritation |
| 2.0-6.0 | Moderate irritation |
| 6.0-8.0 | Strong irritation |
The results show that: no edema condition appears in the rabbits coated with the no-clean disinfectant of the embodiments 1-5 of the invention after 14 days, only individual mice of a group of rabbits have slight erythema symptom, and the average of the final erythema forming score is 0.1, and is in the score range of 0.0-0.5, which is nonirritating, so the no-clean disinfectant of the invention is safe and nonirritating, and the skin can not be damaged even if the no-clean disinfectant is used for a long time. The final stimulation total scores of the control group 1 and the control group 2 were 0.6 and 0.9, respectively, and were both in the range of 0.5-2.0, which were mild irritations, and the skin was likely to be slightly damaged by long-term use.
(III) test of air drying Effect
Effect test: the results of the tests were compared with those of the above examples 1 to 5 and the control groups 1 to 2.
The experimental control conditions and procedures were as follows:
140 volunteers aged 25-30 years, 70 males and 70 females, were selected at the same time in the same area and randomly divided into 7 groups of 20 individuals. In a closed windless environment at the same time in the same indoor place, each volunteer can quickly and uniformly smear 5ml of the no-clean disinfectant of the corresponding group on the hand, naturally flatten the palm, test the time for air drying, and record the time. Then, in the same outdoor place and at the same time, in an unobstructed open flat land without direct sunlight or strong wind, all groups of volunteers face the wind direction, each volunteer is quickly and uniformly smeared on the hand by using 5ml of the no-clean disinfectant of the corresponding group, then the palm is naturally flattened, the time for air drying is tested, and the record is carried out; test data and information conditions are summarized, and the average air drying time of different fields in each group is calculated, and the result is shown in the attached figure 3.
It is obvious from the data and the comparison result of the column-shaped conditions in the attached figure 3 that, compared with the non-washing disinfectant prepared by the comparison group 1 according to the published patent formula and the preparation method and the conventional product disinfectant purchased in the comparison group 2 on the market, the non-washing disinfectant obtained in the embodiments 1-5 of the present invention has extremely high volatilization speed, the average air drying speed used indoors reaches 14.64-16.10 seconds, the average air drying speed used outdoors can reach 8.91-10.06 seconds, and the effect of quickly reaching the air drying state is provided, so that the uncomfortable feeling of wet hand or sticky hand can not be caused, and the use feeling is better. The average indoor air drying speed of the no-clean disinfectant of the comparison group 1-2 after use is over 27.31 seconds, the average outdoor air drying speed is over 19.25 seconds, and the air drying speed both outdoors and indoors is obviously slower than that of the embodiment 1-5, so that the no-clean disinfectant consumes longer time, is not beneficial to touching other objects by hands of users, causes much inconvenience and has poor use feeling.
By integrating the antibacterial and bacteriostatic effect detection, multiple irritation tests and the use air drying effect test, the no-clean disinfectant obtained in the embodiments 1-5 of the invention has obvious antibacterial and bacteriostatic effects, is mild in components, does not cause damage to skin even if used for a long time, is excellent in volatility, has a quick air drying effect, is more convenient and comfortable to use, and is suitable for popularization and application.
The above description is only for the purpose of illustrating the embodiments of the present invention and not for the purpose of limiting the same, and equivalent modifications and variations of the embodiments of the present invention will be apparent to those skilled in the art without departing from the overall spirit of the invention.
Claims (10)
1. A lightyellow sophora root nano-silver washing-free disinfectant is characterized in that: comprises a component A and a component B; wherein the component A comprises the following substances in percentage by weight: 2.0 to 4.0 percent of compound lightyellow sophora root extract, 0.5 to 2.0 percent of nano-silver, 0.1 to 0.5 percent of thickening agent, 1.0 to 2.0 percent of humectant and 64.0 to 71.0 percent of ethanol;
the component B comprises the following substances in percentage by weight: 0.1 to 1.0 percent of aloe extract, 0.2 to 1.0 percent of panthenol, 0.1 to 0.5 percent of triethanolamine and 0.1 to 1.0 percent of tea extract;
the balance of deionized water;
the compound radix sophorae flavescentis extract comprises matrine (matrine), oxymatrine (oxymatrine), oxymatrine (sodium-anol), N-methylcantharine (N-methylcytisine), anagerine (anagyrine), bap-ifinoline (bap-iifoline), dehydromatrine (Sophorcarpine), d-isomatrine (d-isomatrine), kuraridine (kurarid-in), norkurarinone (norkurarinone), kurarinol (kurarinol), neokurarinol (neo-kurarinol), norkurarinol (norkurarinol), isokurarinone, and formononetin (formononetin).
2. The lightyellow sophora root nano-silver no-clean disinfectant as claimed in claim 1, which is characterized in that: the component A comprises the following substances in percentage by weight: 2.5 to 4.0 percent of compound lightyellow sophora root extract, 1.4 to 2.0 percent of nano-silver, 0.2 to 0.5 percent of thickening agent, 1.0 to 2.0 percent of humectant and 65.50 to 70.5 percent of ethanol;
the component B comprises the following substances in percentage by weight: 0.3 to 0.8 percent of aloe extract, 0.4 to 1.0 percent of panthenol, 0.2 to 0.5 percent of triethanolamine and 0.4 to 1.0 percent of tea extract;
the balance being deionized water.
3. The lightyellow sophora root nano-silver no-clean disinfectant as claimed in claim 2, which is characterized in that: the component A comprises the following substances in percentage by weight: 4.0% of compound sophora flavescens extract, 2.0% of nano-silver, 0.5% of thickening agent, 2.0% of humectant and 67.5% of ethanol;
the component B comprises the following substances in percentage by weight: aloe extract 0.5%, panthenol 1.0%, triethanolamine 0.5%, and tea extract 1.0%;
the balance being deionized water.
4. The lightyellow sophora root nano-silver no-clean disinfectant as claimed in claim 1, which is characterized in that: the nano silver is nano-level simple substance silver, the size is 2-5nm, and the optical density OD is 4.
5. The lightyellow sophora root nano-silver no-clean disinfectant as claimed in claim 1, which is characterized in that: the thickening agent is one or a mixture of more of carbomer 940, carbomer 941, carbomer U20 and carbomer U21;
the humectant is one or a mixture of more of glycerol, propylene glycol and butanediol.
6. The preparation method of the lightyellow sophora root nano-silver washing-free disinfectant as claimed in any one of claims 1 to 5, which is characterized in that: the method comprises the following steps:
s1: adding the composite lightyellow sophora root extract, the nano-silver, the thickening agent, the humectant, the ethanol and the deionized water which are in the corresponding weight percentage of the component A into an emulsifying pot, stirring and homogenizing until the components are completely dissolved, and defoaming for later use;
s2: sequentially adding the aloe extract, the panthenol, the triethanolamine and the tea extract which are in the corresponding weight percentage of the component B into the component A to be used after the step S1, and uniformly stirring until the mixture is clear, transparent and sticky;
and S3, sampling, controlling, discharging and subpackaging to obtain the finished product.
7. The preparation method of the lightyellow sophora root nano-silver washing-free disinfectant as claimed in claim 6, which is characterized in that: the formononetin in the composite lightyellow sophora root extract is obtained by extracting and purifying the axanthus axyridis and the astragalus membranaceus, and the main process comprises the following steps: firstly, carrying out superfine grinding on herba axici and radix astragali by using a traditional Chinese medicine superfine grinder to obtain herba axici and radix astragali superfine powder, mixing uniformly according to a solid-liquid ratio of 1 (13-15), adding an extraction solvent ethanol and formic acid, then accelerating the diffusion and permeation of the extraction solvent into cells by using ultrasonic waves, rapidly dissolving formononetin in the herba axici and the radix astragali in the extraction solvent, stopping the ultrasonic waves, carrying out water bath heating to 38-40 ℃, keeping the temperature for 1h, then carrying out supercritical fluid extraction under the condition of 20-21Mpa by using nitric oxide under the condition of keeping the temperature for 4.5-5h, finally purifying and concentrating by using a polymer permeable membrane, and carrying out vacuum drying to obtain the formononetin.
8. The preparation method of the lightyellow sophora root nano-silver washing-free disinfectant as claimed in claim 7, which is characterized in that: the traditional Chinese medicine ultrafine grinder comprises a grinding cavity, a grinding cavity shell, a grinding funnel and a grinding cavity, wherein the grinding cavity is installed in the grinding cavity shell through a rotating shaft, the grinding funnel is located below the grinding cavity and is installed in the grinding cavity shell through a rotating groove, the bottom of the grinding funnel is connected with the grinding cavity through a blanking channel, and the blanking channel and the blanking funnel are integrally formed; the blanking channel is provided with a gear rotary drive in a matching way, and the blanking channel and the crushing hopper are driven to rotate by the gear rotary drive;
the feeding device is characterized in that a feeding brush is arranged in the crushing hopper, the feeding brush is tightly attached to the inner wall of the crushing hopper and arranged along the contraction direction of the crushing hopper, and the top end of the feeding brush is fixedly connected with the shell of the crushing cavity.
9. The preparation method of the lightyellow sophora root nano-silver washing-free disinfectant as claimed in claim 8, which is characterized in that: the rotary drive comprises a driving gear, a driven gear and a driving motor, the blanking channel penetrates through the driven gear and is fixed in the driven gear, the driven gear is meshed with the driving gear, and the driving gear is in power connection with the output end of the driving motor; the rotary groove is circular, the outer side of the rotary groove is fixedly connected with the inner wall of the crushing cavity shell, a groove matched with the top edge of the crushing funnel is formed in the inner side of the rotary groove, and the crushing funnel is rotatably clamped and connected with the groove.
10. The preparation method of the lightyellow sophora root nano-silver washing-free disinfectant as claimed in claim 8, which is characterized in that: the unloading brush includes brush board and brush hair, the one end of brush board is equipped with the bolt, the inboard of broken chamber shell be equipped with bolt assorted screw hole, the brush board passes through bolt and screw hole spiro union are fixed in the inboard of broken chamber shell, the brush board is isosceles triangle, the top of brush board corresponds triangular's apex angle, the bottom rigid coupling brush hair of brush board.
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