CN1116049C - Traditional Chinese medicine for curing non-gonococcal urethritis - Google Patents
Traditional Chinese medicine for curing non-gonococcal urethritis Download PDFInfo
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- CN1116049C CN1116049C CN 00108468 CN00108468A CN1116049C CN 1116049 C CN1116049 C CN 1116049C CN 00108468 CN00108468 CN 00108468 CN 00108468 A CN00108468 A CN 00108468A CN 1116049 C CN1116049 C CN 1116049C
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Abstract
The present invention relates to a traditional Chinese medicine which treats nongonococcal urethritis caused by mycoplasma infection or choamydiae infection by adopting the raw materials of pure Chinese medicines and scientific compounding. The present invention is mainly prepared from panacis quinquefolii radix, milkvetch root, glabrous greenbrier rhizome, lightyellow sophora root, hedyotis diffusa, atractylodes rhizome, coptis, calculus bovis, red peony root, rhizoma corydalis, honeysuckle flower, eucommia bark, red sage root, phellodendron bark, plantain seed and cape jasmine fruit; general oral administration medical dosage forms, such as pills (Dami pills, watered pills and concentrated pills), medicinal powder, tablets, capsules, oral medicinal liquid, etc., can be manufactured by the conventional processing and the extraction of the traditional Chinese medicines, and the ready-prepared medicine of the traditional Chinese medicines can be manufactured. The medicine has the efficiency of nourishing yin and clearing heat, supporting the healthy energy, removing dampness by diuresis, treating stranguria, killing bacteria, dispelling evils, resisting toxin, removing toxin, strengthening the spleen and enriching the kidney. The medicine has favorable treating action on the nongonococcal urethritis caused by the chlamydia infection or the mycoplasma infection, and the present invention belongs to a preferred domestic medicine variety for the pure Chinese medicine treatment of the nongonococcal urethritis.
Description
The present invention relates to a kind of Chinese medicine for the treatment of the nongonococcal urethritis that mycoplasma, chlamydiaceae pathogen infection cause.
Nongonococcal urethritis (Non-gonecoccul urethritic, NGU), be meant because property contact and infectious urethritis all can not be found gonococcal symptom through checking its secretions repeatedly, comprise that also gonorrhea cures the persistent gonorrhea posterior urethritis of posterior urethritis symptom.This disease is a classification of the urethritis of sexual transmission.Cause that this sick main pathogens is that chlamydia trachomatis accounts for 40-50%, secondly for mycoplasma accounts for 20-30%, other pathogen are trichomonas vaginitis, herpes simplex virus, Candida albicans, Hemophilus vaginalis(Hemophilus vaginalis) and foreskin bacillus etc.
In clinical, the nongonococcal urethritis that mycoplasma, chlamydiaceae pathogen infection cause, its classical symptom are that urethra is scratchy, with urgent micturition, dysurea, have slight or do not have dysuria, and urethral secretions is few or do not have, its urgent micturition, dysurea symptom than gonorrhea next gently.Morbidity slowly in a word, mild symptoms, longer duration be its Clinical symptoms.At present should disease have occupied first of sexually transmitted disease (STD).This disease can cause the multiple complications shape,, chronic prostatitis acute, epididymitis and seminal vesiculitis, urethral stricture, Reiter syndrome and female urethra inflammation, cervicitis, bartholinitis, urgent chronic pelvic inflammatory disease, proctitis as: non-gonococcal cowperitis, non-gonococcal, cause infertility even infection or hereditary offspring, not only, especially national quality is improved to constitute greatly and endanger for patient and family.Become global sexually transmitted disease (STD), the sickness rate height has become the common infectious disease of American-European countries since the seventies, exceeds more than the twice than the sickness rate of gonococcal urethritis.
And in Drug therapy, because chlamydia, mycoplasma substance volume are little, about 300-400 nanometer, it is the microorganism between antibacterial and pathogenic bacteria, general sterilization Western medicine medicine is strong or owing to local blood drug level is not enough, topical remedy action time is long, the reasons such as appearance of drug resistance diseased plant to its specific aim, it is not thorough to sterilize, so cause intractable recurrence and infection again, general relapse rate is up to 3%.There are 10% chlamydia trachomatis and 30% carbamide mycoplasma that antibiotics is failed to respond to any medical treatment simultaneously approximately.Even so also can't effect a radical cure significant relatively Tetracyclines of its effect and macrolide antibiotic, up-to-date Sparfloxacin medicine is also because side effect is big, to human internal organ such as Liver and kidney destroys damage and the crowd of being suitable for, applicable elements are affected.
The objective of the invention is to overcome the defective that exists in the prior art and provide a kind of based on motherland's traditional medical theory, contrast mycoplasma, the chlamydia infection symptom of nongonococcal urethritis with " pyretic stranguria " category of Chinese medicine and pharmacy, attached inspection means with the modern times, meticulous compatibility, capture that three warmers are hot and suffocating, gas wins in kidney, diseases caused by exogenous pathogenic factor bacterial strain, flows into bladder, and then damp invasion of lower energizer causes the Chinese medicine of nongonococcal urethritis, reaching sterilization sterilization, treating both the principal and secondary aspects of a disease, curative effect rapidly, short treating period, cure rate height, relapse rate be low, be suitable for the purpose that the crowd is wide, have no side effect.
Of the present invention theing contents are as follows:
The present invention is on the basis of treatment " pyretic stranguria ", not only consider to invade the mark reality that damp and hot heresy is accumulate long-pending bladder outward, more consider the deficiency in origin of deficiency of the kidney, adopt the method for strengthening vital QI to eliminate pathogenic factors, make to set upright and do not love heresy, not eliminating evil just the wound, the science of carrying out compatibility is checked the cooperation of means, repeated screening through clinical summary and definite efficacy analysis and doctor trained in Western medicine, the chemical examination authentication, development cost invention medicine.
The basic composition of medicine of the present invention is to be effective ingredient (calculating according to weight) with following pharmaceutical composition:
Radix Panacis Quinquefolii: 10-30 part Radix Astragali: 30-50 part Rhizoma Smilacis Glabrae: 30-50 part
Radix Sophorae Flavescentis: 20-40 part Herba Hedyotidis Diffusae: 20-40 part Rhizoma Atractylodis: 10-30 part
Rhizoma Coptidis: 7-19 part Calculus Bovis: 1-11 part Radix Paeoniae Rubra: 10-30 part
Rhizoma Corydalis: 10-30 part Flos Lonicerae: 22-42 part Cortex Eucommiae: 20-40 part
Radix Salviae Miltiorrhizae: 30-50 part Cortex Phellodendri: 10-30 part Semen Plantaginis: 20-40 part
Fructus Gardeniae: 1-20 part
The preferred weight proportioning of each constituent of aforementioned pharmaceutical compositions is:
Radix Panacis Quinquefolii: the 10g Radix Astragali: 20g Rhizoma Smilacis Glabrae: 20g
Radix Sophorae Flavescentis: 15g Herba Hedyotidis Diffusae: 15g Rhizoma Atractylodis: 10g
Rhizoma Coptidis: 6g Calculus Bovis: 3g Radix Paeoniae Rubra: 10g
Rhizoma Corydalis: 10g Flos Lonicerae: the 16g Cortex Eucommiae: 15g
Radix Salviae Miltiorrhizae: 20g Cortex Phellodendri: 10g Semen Plantaginis: 15g
Fructus Gardeniae: 5g
Aforementioned pharmaceutical compositions of the present invention, according to the process of Chinese medicine preparation of routine, can prepare becomes any endo-medicine dosage form commonly used, as: pill (big close ball, the watered pill, concentrated pill), powder, tablet, capsule, oral liquid etc.
The preparation method of medicine capsule of the present invention is: with above various medicines according to the rules proportioning choose medical material, cold water is cleaned, through dewatering → dry in the sun → oven dry, the pulverize separately powdered, mixing is crossed 120 mesh sieves, the branch capsule of packing into.The capsule specification is the 0.5g/ grain.
The effect of invention medicine, characteristics, superiority: medicine of the present invention has nourishing YIN and clearing away heat, strengthening the body resistance, dampness removing is treating stranguria, sterilization is eliminating evil, the effect of antitoxin detoxifcation, nourishing spleen and kidney, for the nongonococcal urethritis that causes by chlamydia, mycoplasma infection good therapeutical effect is arranged, clinical total effective rate reaches 99%, cure rate reaches 79%, clinical drug safety, the crowd of being suitable for is extensive, is subjected to the extensive patients favorable comment deeply.
Experimental example:
From year January in January, 1989 to 1999, treat nongonococcal urethritis patient 9698 examples altogether, male's 7564 examples, women's 2134 examples, the age is at 17-65 between year.Chlamydia infection 5876 examples wherein, mycoplasma infection 3720 examples, fungal infection 102 examples.Medical history is the longest 18 months, and is the shortest 1 month.All be through the invalid patient of western medicine.Through using capsule preparations of the present invention to carry out clinical treatment, obtain satisfied effect.Now be summarized as follows:
Clinical data:
1, case history choice criteria:
Patient is selected in diagnostic criteria according to Ministry of Public Health epidemic prevention department regulation.
(1), do not use medicine and other antibiotics of any treatment nongonococcal urethritis in 1 week;
(2), there is tangible urethritis symptom the urethra part, urethra is scratchy, scorching hot, causalgia, urine urgency-frequency, and purulence or mucus secretions are arranged;
(3), chlamydia, the mycoplasma positive are checked in the laboratory.
With year January in January, 1989 to 1999, treat nongonococcal urethritis patient 9698 examples altogether, male's 7564 examples, women's 2134 examples, the age is at 17-65 between year.Select chlamydia infection 5876 examples, mycoplasma infection 3720 examples.
2, Therapeutic Method and medication way
With capsule formulation of the present invention (mainly being made up of Radix Panacis Quinquefolii, the Radix Astragali, Poria, Radix Sophorae Flavescentis, Herba Hedyotidis Diffusae, Rhizoma Atractylodis, Rhizoma Coptidis, Calculus Bovis, Radix Paeoniae Rubra, Rhizoma Corydalis, Flos Lonicerae, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Semen Plantaginis, Fructus Gardeniae etc.) specification is 0.5; prepare into the scientific research medication by wide space andropathy in Zhengzhou City and infertility institute; each five; every day secondary; medication 20 days was a course of treatment, as required 2-3 course of treatment continuously.
In order to compare curative effect, the patient that will use western medicine the same period organizes in contrast.
3, criterion of therapeutical effect and efficacy analysis
Cure: the back clinical symptoms of taking medicine all disappears, and chemical examination chlamydia, mycoplasma are all turned out cloudy.
Produce effects: clinical symptoms disappears substantially after the medication, and the urethra sense of discomfort is arranged once in a while, but chemical examination detects chlamydia, mycoplasma is negative.
Invalid: clinical symptoms is obviously improved, but chemical examination detects chlamydia, mycoplasma is still positive.
4, therapeutic outcome
Clinical observation result shows, capsule treatment nongonococcal urethritis curative effect height of the present invention, and instant effect, non-evident effect, effective percentage are up to 99%, and its curative effect is apparently higher than antibiotic therapy group (seeing the following form in P＜0.05).Especially the mixed infection patient who delays for those obstinates, the state of an illness, and antibiotics drug resistance patient through after the treatment of 2-3 the course of treatment, also all obtains to cure.
The curative effect of capsule of the present invention and western medicine nongonococcal urethritis is relatively ... ... ... ... ... ... ... ... ... ... ... group example number healing produce effects is invalid
The example routine number of the routine number of number (%) (%) (%) ... ... ... ... ... ... ... ... ... ... ...
Wafer 9698 examples 7664 (79%) 1963 (20%) 71 (1%) are imitated in the present invention
Antibiotics 1352 examples 790 (58%) 268 (20%) 294 (22%)
Below in conjunction with embodiment medicine of the present invention is described further:
Be example with clinical use of capsule formulation:
Prescription:
Radix Panacis Quinquefolii 10g Radix Astragali 20g Rhizoma Smilacis Glabrae 20g
Radix Sophorae Flavescentis 15g Herba Hedyotidis Diffusae 15g Rhizoma Atractylodis 10g
Rhizoma Coptidis 6g Calculus Bovis 3g Radix Paeoniae Rubra 10g
Rhizoma Corydalis 10g Flos Lonicerae 16g Cortex Eucommiae 15g
Radix Salviae Miltiorrhizae 20g Cortex Phellodendri 10g Semen Plantaginis 15g
Fructus Gardeniae 5g
Embodiment with the preparation method of capsule medicine is: with above various medicines according to the rules proportioning choose medical material, cold water is cleaned, through dewatering → dry in the sun → oven dry, pulverize separately becomes powder, mixing is crossed 120 mesh sieves, the branch capsule of packing into.The capsule specification is the 0.5g/ grain.
Claims (1)
1; a kind of Chinese medicine for the treatment of nongonococcal urethritis; it is characterized in that: with Radix Panacis Quinquefolii 10-30 part; Radix Astragali 30-50 part; Rhizoma Smilacis Glabrae 30-50 part; Radix Sophorae Flavescentis 20-40 part; Herba Hedyotidis Diffusae 20-40 part; Rhizoma Atractylodis 10-30 part; Rhizoma Coptidis 7-19 part; Calculus Bovis 1-11 part; Radix Paeoniae Rubra 10-30 part; Rhizoma Corydalis 10-30 part; Flos Lonicerae 22-42 part; Cortex Eucommiae 20-40 part; Radix Salviae Miltiorrhizae 30-50 part; Cortex Phellodendri 10-30 part; Semen Plantaginis 20-40 part; Fructus Gardeniae 1-20 part is a prescription; above umber is parts by weight; above-mentioned every kind of composition is carried out Chinese medicine processing according to the predetermined weight umber, can make pill for oral administration commonly used; powder; tablet; capsule; the oral medicine liquid dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00108468 CN1116049C (en) | 2000-06-07 | 2000-06-07 | Traditional Chinese medicine for curing non-gonococcal urethritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00108468 CN1116049C (en) | 2000-06-07 | 2000-06-07 | Traditional Chinese medicine for curing non-gonococcal urethritis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1326750A CN1326750A (en) | 2001-12-19 |
| CN1116049C true CN1116049C (en) | 2003-07-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00108468 Expired - Lifetime CN1116049C (en) | 2000-06-07 | 2000-06-07 | Traditional Chinese medicine for curing non-gonococcal urethritis |
Country Status (1)
| Country | Link |
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| CN (1) | CN1116049C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018790B (en) * | 2009-09-11 | 2013-07-10 | 叶景华 | Composition for curing urinary tract infection |
| US9295705B2 (en) * | 2010-11-08 | 2016-03-29 | Development Center For Biotechnology | Treatment for nephritis |
| CN102935188A (en) * | 2012-11-03 | 2013-02-20 | 张敏 | Traditional Chinese medicine composition for treating candidiasis |
| CN103800756A (en) * | 2014-02-27 | 2014-05-21 | 徐晟伟 | Traditional Chinese medicine mixture for treating non-gonorrhea sexual genitourinary system infection caused by mycoplasma |
| CN106729321A (en) * | 2017-01-06 | 2017-05-31 | 朱以强 | A kind of prescription for treating NUG |
| CN107648516B (en) * | 2017-11-16 | 2020-08-25 | 河南中医药大学 | Traditional Chinese medicine for treating damp-heat downward flow type chronic non-gonococcal urethritis and preparation method thereof |
-
2000
- 2000-06-07 CN CN 00108468 patent/CN1116049C/en not_active Expired - Lifetime
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| Publication number | Publication date |
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| CN1326750A (en) | 2001-12-19 |
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