CN1088596C - Chinese medicine with immunosuppression fuction for treating immunosterility (immunoacyesis) - Google Patents
Chinese medicine with immunosuppression fuction for treating immunosterility (immunoacyesis) Download PDFInfo
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Abstract
The present invention discloses new traditional Chinese medicine for treating immunity sterility, which is proportionally prepared from peach seed, glossy privet fruit, angelica, common cnidium fruit, epimedium herb, sharpleaf galangal fruit, desertliving cistanche, barbary wolfberry fruit, Chinese magnolivine fruit and radix glycyrrhiza. Traditional Chinese medicine having immunosuppressive action and traditional Chinese medicine having the effects of activating blood circulation to dissipate blood stasis are compounded by the traditional Chinese medicine of the present invention which has the advantages of low cost and no poison and side effect. The new traditional Chinese medicine for treating immunity sterility has obvious curative effects on sterility symptoms caused by immunization reasons, such as anti-sperm antibodies, anti-endometrium antibodies, etc. At the same time, the traditional Chinese medicine of the present invention has better curative effects on autoimmune diseases, such as lupus erythematosus, etc.
Description
The present invention relates to a kind of Chinese medicine, specifically treat the Chinese medicine of immune infertility (pregnant) with immunosuppressive action.
The reason of sterile (pregnant) is very complicated, the participation of immune factor and some morbidity have confidential relation, the antisperm antibody (ASAb) that all may occur the masculinity and femininity patient, sperm is had braking and cytotoxicity, and the anti-endometrial antibodies (EMAb) that occurs in the women can stop the implantation of germ cell.The medicine of treatment immune infertility (pregnant) mainly is a large dose oral administration adrenocortical hormone etc. at present, because erious adverse reaction, uncertain therapeutic efficacy is cut, and the patient is difficult to accept.
Purpose of the present invention is exactly in order to address the above problem, propose a kind of evident in efficacy, the Chinese medicine of the treatment immune infertility (pregnant) that contains immunosuppressive action that has no side effect.
Technical solution of the present invention:
A kind of Chinese medicine that contains the treatment immune infertility (pregnant) of immunosuppressive action, it is made by following component: (consumption is weight percentage)
Semen Persicae 15-30%
Fructus Alpiniae Oxyphyllae 15-30%
Herba Epimedii 10-20%
Radix Angelicae Sinensis 10-20%
Radix Glycyrrhizae 10-15%.
Chinese medicine of the present invention, preferably add Herba Cistanches, Fructus Ligustri Lucidi, Fructus Cnidii, Fructus Lycii, Fructus Schisandrae Chinensis Chinese medicine of the five flavours again, they can add (only needing suitable adjustment of percentage by weight got final product) separately, preferably by monarch, minister, help, make effect to add simultaneously, wherein Fructus Ligustri Lucidi and Semen Persicae are principal agent also, Fructus Cnidii is a ministerial drug with working as merger, and Herba Cistanches, Fructus Lycii, Fructus Schisandrae Chinensis and Herba Epimedii, Fructus Alpiniae Oxyphyllae are adjuvant drug also, and messenger drug still is a Radix Glycyrrhizae.In this ten flavors Chinese medicine, owing to increased Chinese medicine of the five flavours, its percentage by weight should suitably be adjusted, and the percentage by weight of its new group of Chinese medicine is:
Semen Persicae 12-15%
Fructus Ligustri Lucidi 8-10%
Radix Angelicae Sinensis 10-13%
Fructus Cnidii 8-10%
Herba Epimedii 8-10%
Fructus Alpiniae Oxyphyllae 10-15%
Herba Cistanches 8-10%
Fructus Lycii 8-10%
Fructus Schisandrae Chinensis 8-10%
Radix Glycyrrhizae 10-15%.
Chinese medicine of the present invention can be made decoction, also can be made into tablet, also can be made into powder, or said any dosage form on the pharmaceutics.
Chinese medicine of the present invention will have Chinese medicine immunosuppressive action and blood circulation promoting and blood stasis dispelling and carry out compatibility.Immune infertility thinks to belong to cold blood stasis, kidney yang losss etc., the rule of treatment is that nourishing kidney is invigorated blood circulation in the traditional Chinese medical science more.Herba Epimedii warming and recuperating the kidney-YANG among the we, Fructus Lycii nourishing YIN liver and kidney tonifying, and Spermatogenic action is arranged; Semen Persicaes etc. match and are blood circulation promoting and blood stasis dispelling, and microcirculation improvement has certain inhibitory action to immune system; Radix Angelicae Sinensis has the two-ways regulation function to immunologic function, helps the homeostasis of body's immunity, and Herba Epimedii has the men and women of adjusting gonadal hormone, and sexual function improving is regulated effects such as basal body temperature, and Radix Glycyrrhizae has similar hormone immunity inhibitory action.Chinese medicine cost of the present invention is low, has no side effect, and is owing to immunogen sterile (pregnant) disease because of causing, evident in efficacy to antisperm antibody, anti-endometrial antibodies etc.Chinese medicine of the present invention also has curative effect preferably to autoimmune diseases such as lupus erythematosus simultaneously.
Embodiment 1 (taking potion with the patient is example):
Get commercially available single medicinal material raw material Semen Persicae 25 grams that have, Fructus Alpiniae Oxyphyllae 25 grams, Herba Epimedii 20 grams, Radix Angelicae Sinensis 20 grams, Radix Glycyrrhizae 10 restrains, and they is mixed to decoct promptly can take by its decoction.
Embodiment 2:
Get Semen Persicae 20 grams, Fructus Alpiniae Oxyphyllae 30 grams, Herba Epimedii 15 grams, Radix Angelicae Sinensis 20 grams, Radix Glycyrrhizae 15 grams.Mix to decoct and promptly can take by its decoction.
Embodiment 3:
Get Semen Persicae 30 grams, Fructus Alpiniae Oxyphyllae 20 grams, Herba Epimedii 20 grams, Radix Angelicae Sinensis 15 grams, Radix Glycyrrhizae 15 grams mix to decoct and promptly can take by its decoction.
Embodiment 4 (is example with potion water preparation medicine):
Get commercially available single medicinal material raw material Semen Persicae 15 grams, Fructus Ligustri Lucidi 10 grams, Radix Angelicae Sinensis 10 grams, Fructus Cnidii 8 grams, Herba Epimedii 8 restrains, Fructus Alpiniae Oxyphyllae 13 grams, Herba Cistanches 8 grams, Fructus Lycii 8 grams, Fructus Schisandrae Chinensis 10 grams, Radix Glycyrrhizae 10 restrains, and they is mixed decocting and can take.
Embodiment 5:
Get Semen Persicae 12 grams, Fructus Ligustri Lucidi 8 grams, Radix Angelicae Sinensis 12 grams, Fructus Cnidii 9 grams, Herba Epimedii 9 grams, Fructus Alpiniae Oxyphyllae 10 grams, Herba Cistanches 9 grams, Fructus Lycii 9 grams, Fructus Schisandrae Chinensis 8 grams, Radix Glycyrrhizae 14 grams.Mix to decoct and promptly can take by its decoction.
Embodiment 6, are example with 1000 of production Chinese medicinal tablets of the present invention (every 0.25 gram):
Get Semen Persicae 182 grams, Fructus Ligustri Lucidi 121 grams, Herba Epimedii 121 grams, Herba Cistanches 121 grams, Radix Angelicae Sinensis 121 grams, Fructus Cnidii 121 grams, Fructus Alpiniae Oxyphyllae 147 grams, Radix Glycyrrhizae 121 grams, Fructus Lycii 121 grams, Fructus Schisandrae Chinensis 121 grams are after their decocting in water, alcohol extraction, with adjuvant mixing reconcentration, drying, after tablet machine is made the tablet of Chinese medicine of the present invention.
Medicinal Semen Persicae among the present invention, when being classified as the parasite killing of invigorating blood circulation, Fructus Ligustri Lucidi, the Herba Epimedii negative and positive are mended mutually, real is the main characteristic of this prescription.In the medicine component, Semen Persicae early is stated from " Sheng Nong's herbal classic " in the present invention, and acrid in the mouth is bitter sweet and gas flat, hot can dissipating blood stasis is capable stagnating, bitter can lead to fall lead down, sweet energy and smooth QI and blood are so there is logical dirt to lead the stasis of blood, the effect of regulating menstruation by adjusting the flow of blood is the commonly used special medicine that blood stasis blood closes, and all blood stasis are stagnant, women's amenorrhea, traumatic injury and the pain caused by ecchymoma that causes, no matter new and old inside and outside, often can receive merit, " medication heart method " said right, " Semen Persicae, bitter to let out stagnant blood; sweet with tissue regeneration promoting blood, thus blood coagulation palpus usefulness, the heat in dehematizing again." book on Chinese herbal medicine cloud again: " Semen Persicae can ' kill small worm, kill three worms ' ".So the immune infertility due to being suitable for infecting, damage, blocking, can blood circulation promoting and blood stasis dispelling, again can parasite killing disappear stagnantly, be the monarch drug in the side.
Fructus Ligustri Lucidi bitter but sweet flavor flat " book on Chinese herbal medicine dredge through " cloud: " the Fructus Ligustri Lucidi abnormal smells from the patient is all cloudy, just going into kidney remove vulcanize essence will product, kidney must be mended then the five internal organs and all pacifies, and is spiritual self-sustaining, and disease is gone and fatten oneself strong." " book on Chinese herbal medicine just " also cloud " Fructus Ligustri Lucidi is apt to cloudy gas, and the Pingyin fire is separated the dysphoria with smothery sensation hectic fever due to YIN-deficiency, ends sweating due to debility, and it is puckery to disappear, and stranguria with turbid discharge, metrorrhagia, have blood in stool, hematuria, the erosion of vulva, anal fistula convulsion pain." " book on Chinese herbal medicine is stated " more spell out: Fructus Ligustri Lucidi " in the promptly wide side of heiring also use " more.The Fructus Ligustri Lucidi invigorating the liver and kidney, the Pingyin fire is mended one with Semen Persicae one and is rushed down, and is monarch drug altogether.
The hot temperature of Radix Angelicae Sinensis sweet in the mouth, it is gentle to enrich blood, and menstruction regulating and pain relieving is moisturized laxation." Japan hanako materia medica " cloud: " Radix Angelicae Sinensis is controlled a wind cutting, and all blood are mended all labor, and broken stagnant blood is supported fresh blood, and the primary symptom addiction, " Li Gao is cloud also: " the Radix Angelicae Sinensis tip, the primary symptom addiction, broken stagnant blood, and puerperal the stagnant blood upper punch, go that all skin infection are swollen controls the incised wound stagnant blood, warming middle-JIAO is moisturized pain relieving." the bitter temperature of Fructus Cnidii acrid in the mouth, warming the kidney to activate YANG, dispeiling pathogenic wind and removing dampness parasite killing." not Lu " cloud: " the Fructus Cnidii warming the middle warmer and descending qi makes the dirty heat of married woman's, man's postcoital protrusion, and woman's color has been made us son." " herbal classic " also cloud: " and swell and ache in housewife people's the moon, the impotence in male pruritus due to damp pathogen ... dislike wound." so Radix Angelicae Sinensis, Fructus Cnidii are ministerial drug altogether.
The traditional Chinese medical science is paid attention to the leading position of healthy energy among morbidity especially.Think " healthy energy deposit in, heresy can not be done " that " institute of heresy gathers, and its gas must be empty." " the most empty part is the ground that holds heresy." so our except big agent blood circulation promoting and blood stasis dispelling, dredging the meridian, outside the dispeling disease and evil, the lay special stress on reinforcing body resistance mainly is the importance of liver and kidney tonifying here.Append Herba Epimedii acrid-sweet flavor temperature in the side, kidney invigorating and YANG supporting, expelling wind and removing dampness; The acid of Herba Cistanches sweet in the mouth becomes warm in nature, and the kidney invigorating and essence nourishing is moisturized laxation; The Fructus Lycii sweet in the mouth is hot flat, the nourishing kidney lung moistening, and tonifying liver makes eye bright, and the Fructus Schisandrae Chinensis sour in the mouth is warm in nature, and the nourishing kidney of astringing the lung is promoted the production of body fluid and is received the antiperspirant arresting seminal emission; The Fructus Alpiniae Oxyphyllae acrid in the mouth is warm in nature, warming the spleen warming the kidney, solid and gas arresting seminal emission.So set upright promptly eliminating evilly, just winning then heresy meaning but also.So Herba Epimedii, Herba Cistanches, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Alpiniae Oxyphyllae are adjuvant drug.
Radix Glycyrrhizae and middle detoxifcation, coordinating the actions of various ingredients in a prescription draws all medicines and returns 12 warps for making.
Above-listed ten flavor Chinese medicines, prescription is careful, and compatibility is rigorous, plays blood circulation promoting and blood stasis dispelling altogether, the merit of liver and kidney tonifying, sincere strengthening vital QI to eliminate pathogenic factors, the wonderful recipe of resolving and invigoration therapies being applied simultaneously is also.
In suffering from the patient of sterile (pregnant) disease, the sterile reason that the 20%-30% infertile couples is arranged approximately is folk prescription or both sides' serum and a genital secretion, as existing in sperm, refining, the cervical mucus due to the antisperm antibody.In order to confirm Chinese medicine of the present invention, carry out efficacy experiment research after setting up the positive model of antisperm antibody (ASAb) with new zealand rabbit to the mechanism of immunogen because of barrenness caused patient treatment effect.
Experimental group: 60 of new zealand rabbits, male and female half and half, body weight 1.5kg.Be used to prepare the positive model of ASAb.
Matched group 1: 40 of new zealand rabbits of breeding, male and female half and half, doe has farrowed more than 3 tires, and male rabbit is the kind rabbit of copulation more than 10 times.Matched group 2: 40 of new zealand rabbits, male and female half and half, body weight 1.0-1.5kg.
The preparation of new zealand rabbit sperm suspension: get 10 male rabbit seminal fluid of planting and select motility of sperm good, count more than 0.3 hundred million/ml pus cell +++following seminal fluid, mix after washing 3 times with PBS, school sperm concentration 1,200,000/ml, it is standby to add gentamycin 1000u/ml.
Chinese medicine of the present invention also is developed into concentrate aqueous liquid respectively according to the above ratio by above-mentioned ten flavor Chinese medicines and Chinese medicine of the five flavours respectively.
The anti-rabbit sperm antibody of rabbit detection method, with rabbit sperm smear (methanol is fixed) → (37 ℃ of water tanks were placed 30 minutes to add rabbit anteserum, PBS washes 3 times) → (37 ℃ of water tanks were placed 30 minutes to add goat-anti rabbit HRP, PBS washes 3 times) → add substrate solution (37 ℃ of water tanks are placed and washed 3 times in 15 minutes) to wait to do oily sem observation.
Positive: the rabbit sperm is brown.Negative: the rabbit sperm is not painted.
The foundation of the positive model of new zealand rabbit: get 1,200,000 ml new zealand rabbit sperm suspensions, immune new zealand rabbit is 60 respectively, first through the ear vein injection, per injection 1ml only, 10 days Intradermal, subcutaneous multiple spot supplementary immunization are 1 time at interval, totally 3 times.Back 10 days of last immunity, ear vein blood sampling separation of serum detects the anti-rabbit sperm antibody of rabbit, gathers the breeding rabbit simultaneously, locates rabbit in contrast.
Experimental group and matched group rabbit ASAb testing result see Table 1: the table 1 group example number ASAb positive
(n) routine number (n) positive rate (%) experimental group 60 (male 30) 60 (male 30) 100% (30/30)
(female 30) (female 30) 100% (30/30) matched group 1 40 (male 20) 1 (male 1) 2.5% (1/40)
(female 20) (female 0) 0 (0) matched group 2 40 (male 20) 00 (0)
(female 20) 00 (0)
Chinese medicine of the present invention is irritated stomach with the concentrate aqueous liquid of the present invention's ten flavor Chinese medicines and Chinese medicine of the five flavours respectively to the positive new zealand rabbit of the therapeutic outcome of the positive new zealand rabbit of ASAb: ASAb, every day 1 time, each 4ml, 40 positive rabbit of ASAb of irritating stomaches promptly have 22 (22/40) and 20 (20/40) respectively after 21 days, account for 55% and 50% rabbit ASAb respectively and turn out cloudy.Prolong with treatment time, negative conversion rate constantly raises, and reaches 90% and 85% respectively to 32 days negative conversion rates, and it is extremely low not irritate the positive new zealand rabbit nature of 20 ASAb negative conversion rates of stomach.See Table 2 (ten flavor Chinese medicine) and tables 3 (Chinese medicine of the five flavours).
Table 2
Several 21 days 32 days 45 days treatment groups 40 (male 20) of example 22 (55.0%) male 8 (40.0%) 38 (95.0%) male 12 (90.0%) 39 (97.5) heros 19 (95.0%)
(female 20) female 14 (70.0%) female 20 (100%) female 20 (100%) matched groups 20 (male 10) 1 (5%) male 101 (5.0%) male 101 (5%) male 10
(female 10) female 0 female 00 female 00
Table 3
Several 21 days 32 days 45 days treatment groups 40 (male 20) of example 20 (50.0%) male 7 (35.0%) 34 (85.0%) male 17 (85.0%) 38 (95.0%) heros 19 (95.0%)
(female 20) female 13 (65.0%) female 17 (85.0%) female 19 (95.0%) matched groups 20 (male 10) 1 (5.0%) male 101 (5.0%) male 101 (5.0%) male 10
(female 10) female 00 female 00 female 00
Experimental results show that sperm is a kind of sequestered antigen,, can make 100% rabbit generation ASAb with sperm antigen immunity new zealand rabbit of the same race.Chinese medicine of the present invention can make the positive rabbit of ASAb turn out cloudy rapidly, and especially doe is more remarkable, feeds Chinese medicine and has 70% positive doe to turn out cloudy in the time of 21 days irritating.The male rabbit of doe negative conversion rate is high by 30%, experiment shows that the male natural negative conversion rate of ASAb is very low, in view of there are substantial connection in immunological infertility (pregnant) disease and ASAb, Chinese medicine of the present invention makes the ASAb effect of turning out cloudy rapidly, may be that it is to one of some infertility patient treatment effective mechanism.
In order to confirm this point, Chinese medicine of the present invention has also carried out some clinical trials.Immune infertility (pregnant) disease due to application the present invention ten flavor herbal mixtures treatment antisperm antibodys (ASAb), anti-endometrial antibodies (EMAb) positive is swallowed 6 at every turn, 3 times/day, takes 1-3 the course of treatment.The result: male's serum, refining ASAb positive person treat 1 course of treatment (1.5 months) negative conversion rate and are respectively 56.5% and 36.8%; Be respectively 88.7% and 76.3% after treating 2 courses of treatment; Treat 3 the course of treatment negative conversion rate can reach 92% and 89.3% respectively; Women's serum, cervical mucus ASAb positive person treat 1 the course of treatment negative conversion rate can reach 92.2% and 90.4% respectively; Be respectively 98% and 96.8% after treating 2 courses of treatment; Serum, cervical mucus EMAb positive person treat negative conversion rate, and be respectively 94.7% and 85.7% 1 course of treatment; Be respectively 99% and 95.2% after 2 courses of treatment; Negative conversion rate can reach 99% and 97.6% respectively after treating 3 courses of treatment.Through incomplete feedback, ASAb, the EMAb positive sterile (pregnant) Mr. and Mrs are after treatment, and pregnancy rate reaches 52%-65%, conclusion: Chinese medicine of the present invention has significant curative effect to immune infertility (pregnant) due to ASAb, the EMAb.See Table 4:
Table 4
Curative effect treatment two curative effects treatments, three curative effects treatments total negative conversion rate sex antibody type of turning out cloudy of turning out cloudy of turning out cloudy
N (%) n (%) n (%) is male blood AsAb 35 35/62 (56.5) 55 55/62 (88.7) 57 57/62 (92) 57/62 (92) (%)
Refining AsAb 14 14/38 (36.8) 29 29/38 (76.3) 34 34/38 (89.5) 34/38 (89.5) women blood AsAb 153 153/166 (92.2) 163 163/166 (98.2) 163/166 (98.2)
Cervical mucus AsAb 28 28/31 (90.3) 30 30/31 (96.8) 30/31 (96.8)
Blood EMAb 90 90/95 (94.7) 94 94/95 (99.0) 94/95 (99.0)
Cervical mucus EMAb 36 36/42 (85.7) 40 40/42 (95.2) 41 41/42 (97.6) 41/42 (97.6)
Claims (4)
1, a kind of have the treatment immune infertility of immunosuppressive action and infertile Chinese medicine, it is characterized in that it is the medicament of being made by following weight percentages:
Semen Persicae 15-30%
Fructus Alpiniae Oxyphyllae 15-30%
Herba Epimedii 10-20%
Radix Angelicae Sinensis 10-20%
Radix Glycyrrhizae 10-15%.
2, a kind of have the treatment immune infertility of immunosuppressive action and infertile Chinese medicine, it is characterized in that: be the medicament made from following weight percentages:
Semen Persicae 12-15%
Fructus Ligustri Lucidi 8-10%
Radix Angelicae Sinensis 10-13%
Fructus Cnidii 8-10%
Herba Epimedii 8-10%
Fructus Alpiniae Oxyphyllae 10-15%
Herba Cistanches 8-10%
Fructus Lycii 8-10%
Fructus Schisandrae Chinensis 8-10%
Radix Glycyrrhizae 10-15%.
3, according to claim 1 and 2 have the treatment immune infertility of immunosuppressive action and infertile Chinese medicine, it is characterized in that said Chinese drugs agentia is a said dosage form on any pharmaceutics.
4, according to claim 3 have the treatment immune infertility of immunosuppressive action and infertile Chinese medicine, it is characterized in that said Chinese drugs agentia is decoction or tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN99120678A CN1088596C (en) | 1999-12-30 | 1999-12-30 | Chinese medicine with immunosuppression fuction for treating immunosterility (immunoacyesis) |
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| Application Number | Priority Date | Filing Date | Title |
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| CN99120678A CN1088596C (en) | 1999-12-30 | 1999-12-30 | Chinese medicine with immunosuppression fuction for treating immunosterility (immunoacyesis) |
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| CN1263769A CN1263769A (en) | 2000-08-23 |
| CN1088596C true CN1088596C (en) | 2002-08-07 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104587341A (en) * | 2015-01-28 | 2015-05-06 | 山东省计划生育科学技术研究所 | Traditional Chinese medicine for treating male infertility oligosermia |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943688B (en) * | 2016-06-29 | 2018-05-29 | 黑龙江中医药大学 | A kind of Chinese medicine preparation promotes the application in the drug of immune function when preparing immunosuppressive therapy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1154858A (en) * | 1996-11-05 | 1997-07-23 | 李德时 | Traditional Chinese medicinal preparation for treating barrenness |
| CN1188659A (en) * | 1997-01-20 | 1998-07-29 | 许其旺 | Traditional Chinese medicine preparation for treating female barrenness |
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1999
- 1999-12-30 CN CN99120678A patent/CN1088596C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1154858A (en) * | 1996-11-05 | 1997-07-23 | 李德时 | Traditional Chinese medicinal preparation for treating barrenness |
| CN1188659A (en) * | 1997-01-20 | 1998-07-29 | 许其旺 | Traditional Chinese medicine preparation for treating female barrenness |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104587341A (en) * | 2015-01-28 | 2015-05-06 | 山东省计划生育科学技术研究所 | Traditional Chinese medicine for treating male infertility oligosermia |
| CN104587341B (en) * | 2015-01-28 | 2017-10-27 | 山东省计划生育科学技术研究所 | A kind of Chinese medicine for treating male's azoospermia |
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| CN1263769A (en) | 2000-08-23 |
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