CN111603988B - Serum melts equipment - Google Patents

Serum melts equipment Download PDF

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Publication number
CN111603988B
CN111603988B CN202010467972.7A CN202010467972A CN111603988B CN 111603988 B CN111603988 B CN 111603988B CN 202010467972 A CN202010467972 A CN 202010467972A CN 111603988 B CN111603988 B CN 111603988B
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China
Prior art keywords
serum
box body
tray
controller
crankshaft
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CN202010467972.7A
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Chinese (zh)
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CN111603988A (en
Inventor
刘韬光
刘派利
王宝鑫
刘伟
张大鹏
李旭
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Liaoning Chengda Biotechnology Co ltd
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Liaoning Chengda Biotechnology Co ltd
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Priority to CN202010467972.7A priority Critical patent/CN111603988B/en
Publication of CN111603988A publication Critical patent/CN111603988A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor

Abstract

A serum melting device belongs to the technical field of biological pharmacy, and particularly relates to a serum melting device. The invention provides serum thawing equipment. The serum box comprises a box body and is characterized in that a serum placing frame is arranged in the box body and is arranged on an oscillating device; also comprises an air flow driving component in the box body.

Description

Serum melts equipment
Technical Field
The invention belongs to the technical field of biological pharmacy, and particularly relates to serum melting equipment.
Background
In the biopharmaceutical industry, vaccines are produced by a reactor culture technique, and cells are cultured in a large scale by a spinner flask and a bioreactor. Among these, the amount of serum used is considerable. During the use of serum, the process of thawing the serum has a considerable influence on subsequent production and experiments.
Disclosure of Invention
The invention aims at the problems and provides serum thawing equipment.
In order to achieve the purpose, the invention adopts the following technical scheme that the serum box comprises a box body and is characterized in that a serum placing frame is arranged in the box body, and the serum placing frame is arranged on an oscillating device;
also comprises an air flow driving component in the box body.
As a preferable scheme, the airflow driving part of the invention adopts a fan.
As another preferred scheme, the fan is arranged at the upper end of the serum placing rack and is vertically ventilated.
As another preferred scheme, the number of the fans is two, and the fans are arranged on two sides of the upper end of the serum placing rack.
As another preferred scheme, the two fans are connected in parallel and then are connected with a power supply through a fan protection circuit breaker.
As another preferred scheme, 316L stainless steel is adopted by the box body.
As another preferred scheme, a sliding door is arranged on the box body.
As another preferred scheme, a plurality of through holes are uniformly distributed on the surface of the box body.
As another preferred scheme, the lower end of the box body is provided with a foot margin and universal wheels.
As another preferred scheme, the lower part of the box body is provided with a water outlet.
As another preferable scheme, a temperature sensor is arranged in the box body, and a detection signal output port of the temperature sensor is connected with a detection signal input port of the controller.
As another preferred scheme, the temperature sensor of the invention adopts TH 10S-B.
As another preferable scheme, a touch screen is arranged on the box body, and a signal transmission port of the touch screen is connected with a signal transmission port of the controller.
As another preferred solution, the controller of the present invention employs a TPC7072GI touch screen.
As another preferred scheme, the serum rack provided by the invention adopts a multi-layer structure from top to bottom.
As another preferred scheme, the fan works intermittently.
As another preferable mode, the oscillation device of the present invention is intermittently operated.
As another preferable mode, the oscillation mode of the oscillation device of the present invention is a convolution mode.
As another preferred scheme, the oscillating device comprises a vertical crankshaft and a crankshaft rotation driving part, wherein the lower end of the crankshaft is connected with the lower end of the box body through a lower bearing seat, and the upper end of the crankshaft is connected with the lower end of the serum placing frame through an upper bearing seat.
In another preferred embodiment, the number of the crankshafts is multiple, and one of the crankshafts is provided with a crankshaft rotation driving part.
As another preferred scheme, the number of the crankshafts is three, and the crankshafts are arranged in a triangular mode.
As another preferred scheme, the balance weight block is sleeved on the outer side of the middle of the crankshaft.
As another preferred scheme, the crankshaft rotation driving part comprises a motor, a driving belt pulley, a driven belt pulley and a belt, wherein the motor shaft is connected with the driving belt pulley, the driving belt pulley is connected with the driven belt pulley through the belt, and the driven belt pulley is connected with the lower end of the crankshaft.
As another preferred scheme, the upper bearing seat is arranged on a connecting plate, and the connecting plate is connected with the lower end of the serum placing frame through a fastener.
As another preferable scheme, a signal transmission port of the motor is connected with a signal transmission port of the controller.
As another preferable scheme, the motor of the present invention employs a servo motor.
As another preferred scheme, the servo motor adopts an ASD-B2-1521-B servo driver, and a 27-pin buzzer of the ASD-B2-1521-B servo driver.
As another preferred scheme, a water receiving tray is arranged at the lower end of the serum placing rack.
As another preferred scheme, the water pan is an inclined water pan, and the bottom end of the water pan is connected with a water outlet at the lower part of the box body.
As another preferred scheme, the water pan is an inclined water pan, and the bottom end of the water pan is connected with a water outlet at the lower part of the box body through a hose.
As another preferred scheme, a drain valve is arranged at the water outlet.
As another preferred scheme, a serum tray is arranged on the serum placing frame, and a condensed water outflow hole is formed in the serum tray.
As another preferable scheme, each serum tray is provided with a transverse partition plate and a longitudinal partition plate, and the serum tray is divided into a plurality of areas.
And secondly, a tray in-out sliding rail is arranged on the serum placing frame at the lower end of the serum tray.
In addition, the serum tray is provided with a handle.
The invention has the beneficial effects.
When the serum thawing device is used, the serum bottle is placed on the serum placing frame, and efficient and reliable thawing work can be performed on serum by matching the oscillating device with the airflow driving part in the box body.
Drawings
The invention is further described with reference to the following figures and detailed description. The scope of the invention is not limited to the following expressions.
FIGS. 1 to 3 are schematic views of the structure of the present invention.
Fig. 4 and 5 are schematic structural diagrams of the oscillation device of the present invention.
Fig. 6 is an external view of the present invention.
FIGS. 7-11 are schematic diagrams of the circuit of the present invention.
In the figure, 1 is a water outlet, 2 is a water pan, 3 is a serum placing frame, 4 is a fan, 5 is a tray, 6 is a sliding rail, 7 is a motor, 8 is a universal wheel, 9 is a ground foot, 10 is a box body, 11 is an electric box, 12 is a lower bearing seat, 13 is a balancing weight, 14 is a crankshaft, 15 is a bottom plate frame, 16 is a bottom plate, 17 is a connecting plate, 18 is a driven belt pulley, 19 is a belt, 20 is a driving belt pulley, 21 is a motor, 22 is an upper bearing seat, 23 is a bottom surface sealing plate, 24 is a drain valve, and 25 is a through hole.
Detailed Description
As shown in the figure, the serum box comprises a box body, wherein a serum placing frame is arranged in the box body and is arranged on an oscillating device; the oscillation device generates an oscillation effect on the serum placing rack;
also comprises an airflow driving component in the box body.
The airflow driving part adopts a fan.
The fan sets up in serum rack upper end, vertical ventilation.
The two fans are arranged on two sides of the upper end of the serum rack; the air current evenly distributed in the assurance box, frozen bovine serum melts with higher speed, and the density of bovine serum obtains guaranteeing simultaneously.
And the two fans are connected in parallel and then are connected with a power supply through a fan protection circuit breaker.
The box body is made of 316L stainless steel.
The box body is provided with a sliding door.
A plurality of through holes are uniformly distributed on the surface of the box body; the ventilation is convenient.
The lower end of the box body is provided with feet and universal wheels.
A water outlet is formed in the lower part of the box body; and discharging the melted condensed water out of the equipment.
A temperature sensor is arranged in the box body, and a detection signal output port of the temperature sensor is connected with a detection signal input port of the controller. The controller can control the alarm when the overtemperature phenomenon occurs according to the signal input by the temperature sensor.
The temperature sensor detects the ambient temperature inside the device and displays it via the display 27 of the controller.
The temperature sensor adopts TH 10S-B.
The box body is provided with a touch screen, and a signal transmission port of the touch screen is connected with a signal transmission port of the controller.
The controller employs a TPC7072GI touch screen.
The serum rack adopts a multilayer placement structure from top to bottom.
The fan is operated intermittently. The time can be set manually, and the intermittent synchronous work of the fan and the oscillating device can be set.
The oscillating device works intermittently, and the oscillating device can be controlled by the controller to obtain the oscillating intermittent time.
The oscillating device comprises a vertical crankshaft and a crankshaft rotation driving part, the lower end of the crankshaft is connected with the lower end of the box body through a lower bearing seat, and the upper end of the crankshaft is connected with the lower end of the serum containing frame through an upper bearing seat.
The bent axle is a plurality of, and one of them bent axle is equipped with the bent axle and rotates drive unit.
The number of the crankshafts is three, and the crankshafts are arranged in a triangular mode.
A balancing weight is sleeved on the outer side of the middle part of the crankshaft; the moment is convenient to balance, and the abrasion of the shaft is reduced.
The crankshaft rotation driving part comprises a motor, a driving belt pulley, a driven belt pulley and a belt, a motor shaft is connected with the driving belt pulley, the driving belt pulley is connected with the driven belt pulley through the belt, and the driven belt pulley is connected with the lower end of the crankshaft.
The upper bearing seat is arranged on a connecting plate, and the connecting plate is connected with the lower end of the serum placing frame through a fastener. Under the drive of the crankshaft, the connecting plate generates rotary motion, so that the serum placing frame is driven to generate rotary motion.
And the signal transmission port of the motor is connected with the signal transmission port of the controller.
The motor adopts a servo motor.
The servo motor adopts an ASD-B2-1521-B servo driver, and a 27-pin buzzer of the ASD-B2-1521-B servo driver. The oscillation speed is controllable, and the rotary oscillation can be timed.
The oscillation mode of the oscillation device is a rotary mode.
The lower end of the serum placing frame is provided with a water receiving tray.
The water pan is an inclined water pan, and the bottom end of the water pan is connected with a water outlet at the lower part of the box body through a hose.
And a drain valve is arranged at the water outlet.
The serum placing frame is provided with a serum tray, and the serum tray is provided with a condensed water outflow hole. The serum is filled in the bottle, taken out from the refrigeration equipment, put at the hole of the tray, naturally melt in the device, and the condensed water flows to the water receiving tray along the bottle and then flows out; the inside of the equipment is convenient to clean and disinfect.
Each serum tray is provided with horizontal and vertical partition plate, divides the serum tray into a plurality of regions. The position of setting up the baffle and injecing the serum bottle guarantees the stability of oscillation process.
And a tray in-and-out sliding rail is arranged on the serum placing frame at the lower end of the serum tray. The tray can be drawn in and out along the sliding rail.
A handle is arranged on the serum tray.
The controller state part and the power supply part of the controller except the control button and the screen are arranged in an electric box on one side of the upper part of the box body, and the electric box is connected with the fan and the motor through a multi-core cable.
The serum tray can be a polytetrafluoroethylene tray or a stainless steel tray; rust prevention, easy cleaning and stable chemical characteristics.
The tray can be placed with four layers.
The connecting plate 17 comprises a rectangular plate, one side of the rectangular plate is connected with the long bottom edge of the isosceles trapezoid plate, two ends of one side of the rectangular plate are respectively provided with a mounting hole of the upper bearing seat 22, and the middle of the short bottom edge side of the isosceles trapezoid plate is provided with a mounting hole of the upper bearing seat 22.
A plurality of through holes 25 are uniformly distributed along the periphery of the rectangular plate, a plurality of through holes 25 are uniformly distributed along the central line of the rectangular plate, and the mounting holes of the upper bearing blocks 22 on the rectangular plate are symmetrically arranged on two sides of the central line.
The floor frame 15 and the bottom closure plate 23 are rectangular and have a plurality of through holes 25 uniformly distributed along the periphery of the rectangle.
A plurality of U-shaped openings 26 are uniformly distributed along the periphery of the bottom surface closing plate 23, and the U-shaped openings 26 and the through holes 25 are arranged at intervals; the inner end of the through hole 25 is positioned outside the inner end of the U-shaped opening 26, and the distance between the through hole 25 and the adjacent U-shaped openings 26 on the two sides is the same.
The provision of the through-hole 25 and the U-shaped opening 26 facilitates ventilation and drainage of condensed water.
The controller of the present invention may be connected to the UBS interface 28 to facilitate input and output of relevant information. During operation, every 1 minute can be set, and the controller generates and stores a data record (the content can include time, operator, vibration speed and box temperature).
The shaking and blowing time can be set by the controller (for example, 1L of serum is filled for 5-6 hours, and 500ml of serum is filled for 4-5 hours), and after the serum is melted, the serum is taken out. The invention has the advantages of standardized melting of serum, convenient operation, high working efficiency and guarantee of the optimal state of the serum, thereby guaranteeing the yield and the quality of products.
The serum rack is divided into four layers, the serum placing mode is that the serum is placed layer by layer from bottom to top, and the melting time is increased by 1 hour when 1 layer is added.
Serum placing mode Thawing time
1 layer (less than or equal to 32 bottles serum) 5 hours
2 layers (less than or equal to 64 bottles serum) 6 hours
3 layers (less than or equal to 96 bottles serum) 7 hours
4 layers (less than or equal to 128 bottles serum) 8 hours
The invention is suitable for bovine serum thawing, and can also be applied to serum thawing in the biopharmaceutical industry and the fields related to cell culture.
It should be understood that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, not limitation, and it will be understood by those skilled in the art that various changes and modifications may be made therein without departing from the spirit and scope of the invention; and are within the scope of the present invention as long as the requirements of use are met.

Claims (1)

1. A serum melting device comprises a box body, and is characterized in that a serum placing frame is arranged in the box body and arranged on an oscillating device;
a plurality of through holes are uniformly distributed on the surface of the box body; the lower end of the box body is provided with a foot margin and a universal wheel;
the serum placing rack adopts a multi-layer placing structure from top to bottom;
the oscillation mode of the oscillation device is a rotary mode;
the oscillating device comprises a vertical crankshaft and a crankshaft rotation driving part, the lower end of the crankshaft is connected with the lower end of the box body through a lower bearing seat, and the upper end of the crankshaft is connected with the lower end of the serum containing frame through an upper bearing seat;
the number of the crankshafts is multiple, and one crankshaft is provided with a crankshaft rotation driving part; the crankshaft rotation driving part comprises a motor, a driving belt pulley, a driven belt pulley and a belt, wherein a motor shaft is connected with the driving belt pulley, the driving belt pulley is connected with the driven belt pulley through the belt, and the driven belt pulley is connected with the lower end of the crankshaft;
a water receiving tray is arranged at the lower end of the serum placing frame; the water receiving tray is an inclined water receiving tray, and the bottom end of the water receiving tray is connected with a water outlet at the lower part of the box body;
a serum tray is arranged on the serum placing frame, and a condensed water outflow hole is formed in the serum tray;
the airflow driving part adopts a fan; the fan is arranged at the upper end of the serum placing rack and is vertically ventilated; the two fans are arranged on two sides of the upper end of the serum placing rack; the two fans are connected in parallel and then are connected with a power supply through a fan protection circuit breaker; the fan works intermittently;
each serum tray is provided with a transverse partition plate and a longitudinal partition plate, and the serum trays are divided into a plurality of areas;
a temperature sensor is arranged in the box body, and a detection signal output port of the temperature sensor is connected with a detection signal input port of the controller; the box body is provided with a touch screen, and a signal transmission port of the touch screen is connected with a signal transmission port of the controller; the number of the crankshafts is three, and the crankshafts are arranged in a triangular mode;
the box body is made of 316L stainless steel;
the box body is provided with a sliding door;
the temperature sensor adopts TH 10S-B;
the controller adopts a TPC7072GI touch screen;
the oscillating device works intermittently;
a balancing weight is sleeved on the outer side of the middle part of the crankshaft;
the upper bearing seat is arranged on a connecting plate, and the connecting plate is connected with the lower end of the serum rack through a fastener;
a signal transmission port of the motor is connected with a signal transmission port of the controller;
the motor adopts a servo motor;
the servo motor adopts an ASD-B2-1521-B servo driver, and a 27-pin buzzer of the ASDB2-1521-B servo driver;
a drain valve is arranged at the water outlet;
a tray in-out sliding rail is arranged on the serum placing frame at the lower end of the serum tray;
a handle is arranged on the serum tray;
when the serum thawing device is used, a serum bottle is placed on the serum placing frame, and efficient and reliable thawing work is performed on serum through the matching use of the oscillating device and the airflow driving part in the box body;
setting time manually, and setting the intermittent synchronous work of a fan and an oscillating device;
controlling an oscillation device to obtain oscillation intermittent time through a controller;
under the driving of the crankshaft, the connecting plate generates rotary motion, so that the serum placing rack is driven to generate rotary motion;
the serum is filled in the bottle, taken out from the refrigeration equipment, put at the hole of the tray, naturally melt in the device, and the condensed water flows to the water receiving tray along the bottle and then flows out; the interior of the equipment is convenient to clean and disinfect;
the controller state part and the power supply part of the controller except the control button and the screen are arranged in an electric box on one side of the upper part of the box body, and the electric box is connected with the fan and the motor through a multi-core cable;
the serum tray can be a polytetrafluoroethylene tray or a stainless steel tray; rust prevention, easy cleaning and stable chemical characteristics;
the tray can be placed in four layers;
the connecting plate comprises a rectangular plate, one side of the rectangular plate is connected with the long bottom edge of the isosceles trapezoid plate, two ends of one side of the rectangular plate are respectively provided with a mounting hole of the upper bearing block, and the middle part of the short bottom edge of the isosceles trapezoid plate is provided with a mounting hole of the upper bearing block;
a plurality of through holes are uniformly distributed along the periphery of the rectangular plate, a plurality of through holes are uniformly distributed along the central line of the rectangular plate, and mounting holes of the upper bearing block on the rectangular plate are symmetrically arranged at two sides of the central line;
the bottom plate frame and the bottom surface sealing plate are both rectangular, and a plurality of through holes are uniformly distributed along the periphery of the rectangle;
a plurality of U-shaped openings are uniformly distributed along the periphery of the bottom surface sealing plate, and the U-shaped openings and the through holes are arranged at intervals; the inner end of the through hole is positioned outside the inner end of the U-shaped opening, and the distance between the through hole and the adjacent U-shaped openings on the two sides of the through hole is the same;
the through hole and the U-shaped opening are arranged to facilitate ventilation and drainage of condensed water;
the controller can be connected with the UBS interface, so that the input and the output of related information are facilitated;
in the running process, setting a data record every 1 minute and storing the data record by the controller;
setting the oscillation and blowing time by a controller, and taking out the serum after the serum is melted;
the melting of the serum is standardized, the operation is convenient, the working efficiency is high, and the optimal state of the serum is ensured, so that the yield and the quality of the product are ensured;
the serum placing rack is divided into four layers, the serum placing mode is that the serum is placed layer by layer from bottom to top, and the melting time is increased by 1 hour when every 1 layer is added;
is suitable for bovine serum thawing and is applied to serum thawing in the biological pharmaceutical industry.
CN202010467972.7A 2020-05-28 2020-05-28 Serum melts equipment Active CN111603988B (en)

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Application Number Priority Date Filing Date Title
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113491797A (en) * 2021-07-29 2021-10-12 青岛海尔生物医疗科技有限公司 Vibration control method of dry type slurry melting machine
CN113909084B (en) * 2021-09-18 2022-07-19 北京擎科生物科技有限公司 Rotary oscillation mechanism

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CN107323877A (en) * 2017-06-23 2017-11-07 青岛市市立医院 A kind of efficient blood platelet concussion storage box

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CN1113686C (en) * 2001-06-04 2003-07-09 易荣大 3D motion type cyclone mixer
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Publication number Priority date Publication date Assignee Title
EP1352851A2 (en) * 2002-04-12 2003-10-15 Hynetics, LLC Feed bags and methods of use
CN204159276U (en) * 2014-11-07 2015-02-18 成都欧林生物科技股份有限公司 For the reciprocal shaker of polysaccharide and lockjaw adapter section
CN104353390A (en) * 2014-11-07 2015-02-18 成都欧林生物科技股份有限公司 Device for conveniently mixing mixed liquid in serum bottle evenly
CN105277477A (en) * 2015-01-28 2016-01-27 何向锋 Refrigeration light-tight vibrator special for flow-type pipe
CN107323877A (en) * 2017-06-23 2017-11-07 青岛市市立医院 A kind of efficient blood platelet concussion storage box

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