CN111603498A - Preparation method of pain-relieving plaster - Google Patents
Preparation method of pain-relieving plaster Download PDFInfo
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- CN111603498A CN111603498A CN202010569442.3A CN202010569442A CN111603498A CN 111603498 A CN111603498 A CN 111603498A CN 202010569442 A CN202010569442 A CN 202010569442A CN 111603498 A CN111603498 A CN 111603498A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a puncture analgesic plaster, and particularly discloses a preparation method of an analgesic plaster, which comprises the following steps: cleaning and drying pseudo-ginseng, mixing the pseudo-ginseng, frankincense, menthol and asarum according to the weight ratio of 1:1:1:1, putting the pseudo-ginseng, the frankincense, the menthol and the asarum into a traditional Chinese medicine grinding machine, grinding the mixture into fine powder, then mixing the fine powder and purified water according to the weight ratio of 1:3, uniformly stirring the mixture into paste, and placing the paste into an aluminum hose for sealed storage or placing the paste on a sealing plastic for sealed storage; the patch or paste ensures the safety of the product, is convenient to carry, is applied to a patient before conventional treatment puncture, achieves the effect of local pain relief after being absorbed by skin, and can eliminate inflammation and reduce thrombosis.
Description
Technical Field
The invention relates to an analgesic plaster, in particular to a preparation method of a plaster which is suitable for maintaining puncture treatment to relieve pain, achieves local analgesic effect after skin absorption, and can eliminate inflammation and reduce thrombosis.
Background
With the aging of population, the incidence and prevalence of uremia, end-stage renal disease (ESRD), have increased significantly in the last decade, and uremia patients requiring hemodialysis, which is a main means of kidney replacement therapy for modern chronic renal failure patients, have become a comprehensive treatment technology across disciplines. The vascular access is the life line of a long-term hemodialysis patient, and the establishment and maintenance of a well-functioning vascular access are the keys for ensuring the dialysis adequacy, the quality of life and even the long-term survival of the dialysis patient. The ideal vascular access needs sufficient blood flow, lasts for a long time, has few complications, is easy to perform the operation, is convenient, safe and reliable to use, has the autologous arteriovenous internal fistula (AVF) closest to the standard, and has the puncture of each dialysis patient reaching about 300-400 needles every year. AVF has been the most desirable permanent pathway for long-term use in patients with end-stage renal failure since its application to hemodialysis. In order to ensure the sufficiency of dialysis and improve the quality of life and the blood flow of extracorporeal circulation per minute, the rope ladder type puncture pointed out by experts in vascular access in 2019 is the most effective scheme at present.
The internal fistula puncture needle widely used in the world at present is a common steel sharp needle, the puncture needle specification is 14-18G, the smaller the number of characters is, the thicker the puncture needle diameter is, and the higher the blood flow rate per minute is. 15-17G is commonly used in Asian region, 16G is dominant in arteriovenous internal fistula puncture needles of various domestic hospitals, and most dialysis patients are unwilling to accept new puncture points to cause repeated regional puncture to further affect arteriovenous internal fistula blood vessel injury except the blood vessel condition of the patients when AVF of the patients is used for a long time, thereby causing complications such as hematoma of the puncture points and surrounding tissues, hemangioma, thrombosis, internal fistula stenosis and the like. How to make the patient receive the rope ladder puncture and improve the blood flow, adopt 14-15 pjncture needles, reduce the painful of bringing when the patient punctures, improve the speed of dialysis blood flow, protect and prolong the life of AVF, improve the quality of life of the patient who dialyses is the problem that hemodialysis special branch of academic or vocational study lasts continuously.
There are very few reports and literature on reducing internal fistula puncture pain worldwide. Local anesthetics such as lidocaine have indications and limitations of medication in the field of western medicine. At present, the domestic and foreign nursing of the arteriovenous internal fistula is only limited to simple guidance and home nursing after puncture and needle withdrawal, the most widely used external medicine is a happiness ointment, and local thermotherapy is added to reduce the formation of scars at puncture points so as to achieve the purpose of softening blood vessels, but no help and curative effect are provided for reducing puncture pain; there are also reports in the literature that the buttonhole puncturing method can reduce the pain of the internal fistula puncture of the patient and improve the compliance of the rope ladder type puncture of the internal fistula of the patient, but because the probability of infection is high, the buttonhole puncturing method is not implemented nationwide.
The Chinese medicine has a history of thousands of years, is a very rich empirical summary of the Chinese people struggling with diseases for a long time, and makes a great contribution to the prosperity and prosperity of the Chinese nation. The earliest pharmacopoeia in the world carries 844 medicaments, which not only has great influence on the development of the pharmacology of China, but also makes important contribution to the development of the medicine in the world.
Disclosure of Invention
The invention aims to provide a preparation method of an analgesic plaster, so that the prepared plaster or plaster is convenient to carry, a patient can apply the plaster before conventional treatment puncture, and the product can achieve the effect of local analgesia after being absorbed by skin, and can eliminate inflammation and reduce thrombus.
The technical scheme adopted by the invention for solving the technical problems is as follows: a preparation method of an analgesic plaster comprises the following steps:
cleaning and drying pseudo-ginseng, mixing the pseudo-ginseng, frankincense, menthol and asarum according to the weight ratio of 1:1:1:1, putting the mixture into a traditional Chinese medicine grinding machine, grinding the mixture into fine powder, then mixing the fine powder and purified water according to the weight ratio of 1:3, uniformly stirring the mixture into paste, and placing the paste into an aluminum hose for sealed storage or preparing the paste for storage.
Preferably, the fine powder has a discharge particle size of 0.1 to 0.001 mm.
The Chinese medicinal components in the pain-relieving plaster have the following characteristics:
notoginseng radix, named as Chinese medicine, is the dried root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae. Has effects of removing blood stasis, stopping bleeding, promoting blood circulation, and relieving pain. Can be used for treating traumatic injury, and swelling and pain due to blood stasis. Nothing in Ben Cao gang mu states that san Qi stops bleeding and relieves pain, falls over a sore on stick, is chewed and smeared or is not mixed.
Frankincense, name of traditional Chinese medicine. Is resin exuded from bark of Boswellia carterii Birdw of Burseraceae and Boswellia bhauradaijiana Birdw of the same genus. Has special fragrance and slightly bitter taste. Has the effects of promoting blood circulation, activating qi-flowing, relieving pain, eliminating swelling and promoting granulation. The book Ben Cao Hui Yan (treatise on materia Medica): olibanum, a Chinese medicine for promoting blood circulation, dispelling wind, relaxing muscles and tendons and alleviating pain. The book of materia medica claiming is as follows: the frankincense enters the heart through the fragrance, namely blood is released and tendons stretch, and the frankincense enters the kidney to warm and invigorate the kidney, so that qi and blood are mutually communicated and activated. Modern medicine and clinical research find that the frankincense extract has the effects of resisting oxidation, easing pain, resisting inflammation, resisting tumor and the like.
Menthol, consisting of a saturated cyclic alcohol obtained from peppermint oil. Has effects in dispelling pathogenic wind, clearing away heat, relieving pain, removing toxic substances, and relieving inflammation. Is mainly used for treating symptoms such as sore throat, tooth swelling, skin pruritus and the like.
Herba asari has effects in expelling pathogenic wind, expelling cold, relieving pain, tranquilizing mind, resisting histamine, inducing resuscitation, relieving pain, warming lung, and eliminating phlegm. Herbs with pungent and warm natured exterior-releasing herbs belong to the category of exterior-releasing herbs. Has local anesthetic effect, has certain inhibition effect on arthritis, also has certain antibacterial and anti-inflammatory effects, and has functions of enhancing lipid metabolism and regulating organism smooth muscle. The volatile oil can lower blood pressure of anesthetized animals, and has anticonvulsive effect.
The Chinese medicinal ointment for treating the internal arteriovenous fistula puncture pain disclosed by the invention fills the blank in the field of blood purification of the internal arteriovenous fistula at home and abroad, ensures the safety of the medicament under the condition of the proportion of purified water, is convenient to carry, can be absorbed by skin to achieve the effect of local pain relief after a patient applies the ointment before conventional treatment puncture, and can also eliminate inflammation, reduce thrombus formation and improve the puncture compliance of the patient.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects solved by the present invention more apparent, the present invention is further described below with reference to the following embodiments.
The invention relates to a preparation method of an analgesic plaster, which comprises the following steps:
cleaning and drying pseudo-ginseng, mixing the pseudo-ginseng, frankincense, menthol and asarum according to the weight ratio of 1:1:1:1, putting the mixture into a traditional Chinese medicine grinding machine, grinding the mixture into fine powder, then mixing the fine powder and purified water according to the weight ratio of 1:3, stirring the mixture evenly into paste, and placing the paste into an aluminum hose for sealed storage or preparing the paste for sealed storage by using a PVC bag.
Adopts a traditional Chinese medicine grinding machine and a superfine grinding machine with the grinding degree, the discharge granularity is 0.1-0.001mm, the feed granularity is less than 10 mm, and the model KS-200 KUNSEN micro-nano technology company is produced.
The pure water used in the proportioning needs to be regularly used for detecting bacteria and endotoxin, so that the bacterial colony count and the endotoxin are not overproof, the use safety of a patient is ensured, and the infection is avoided.
Firstly, a clinical implementation process:
(1) using the object: aiming at puncture pain, traumatic injury and pain of the whole body;
(2) signing a notice, and making propaganda and education communication, action principle, possible anaphylactic reaction and other unknown uncomfortable reactions;
(3) the blood vessel puncture part is uniformly smeared 3-5 minutes before operation until absorption, and cleaning is not needed.
(4) Can be directly applied or pasted for treating traumatic injury and pain of whole body.
Second, example 50.
Thirdly, detailed rules:
(1) before puncture treatment, patients with the daily maintenance puncture are externally coated with an arteriovenous pain relieving paste or pasted on the arteriovenous puncture blood vessel, and are massaged until absorption without cleaning;
(2) conventional skin disinfection and puncture.
Fourthly, implementation results: no infection and allergy cases occurred.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention should fall within the protection scope of the present invention.
Claims (2)
1. The preparation method of the pain-relieving plaster is characterized by comprising the following steps:
cleaning and drying pseudo-ginseng, mixing the pseudo-ginseng, frankincense, menthol and asarum according to the weight ratio of 1:1:1:1, putting the mixture into a traditional Chinese medicine grinding machine, grinding the mixture into fine powder, then mixing the fine powder and purified water according to the weight ratio of 1:3, uniformly stirring the mixture into paste, and placing the paste into an aluminum hose for sealed storage or preparing the paste for storage.
2. The method for preparing an analgesic patch as claimed in claim 1, wherein: the discharge granularity of the fine powder is 0.1-0.001 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010569442.3A CN111603498A (en) | 2020-06-20 | 2020-06-20 | Preparation method of pain-relieving plaster |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010569442.3A CN111603498A (en) | 2020-06-20 | 2020-06-20 | Preparation method of pain-relieving plaster |
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| Publication Number | Publication Date |
|---|---|
| CN111603498A true CN111603498A (en) | 2020-09-01 |
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| CN202010569442.3A Pending CN111603498A (en) | 2020-06-20 | 2020-06-20 | Preparation method of pain-relieving plaster |
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| CN (1) | CN111603498A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367416A (en) * | 2014-11-07 | 2015-02-25 | 薛景 | Fast pain relieving method for children blood vessel puncture and pain relieving paste |
| CN106074849A (en) * | 2016-06-30 | 2016-11-09 | 柳州市妇幼保健院 | A kind of artery and vein puncture expansion blood vessel analgesic antiphlogistic patch |
| CN111888444A (en) * | 2020-08-17 | 2020-11-06 | 钦州市第一人民医院 | Composition for promoting blood circulation and removing obstruction in channels for repairing internal fistula after puncture, preparation method and preparation |
-
2020
- 2020-06-20 CN CN202010569442.3A patent/CN111603498A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367416A (en) * | 2014-11-07 | 2015-02-25 | 薛景 | Fast pain relieving method for children blood vessel puncture and pain relieving paste |
| CN106074849A (en) * | 2016-06-30 | 2016-11-09 | 柳州市妇幼保健院 | A kind of artery and vein puncture expansion blood vessel analgesic antiphlogistic patch |
| CN111888444A (en) * | 2020-08-17 | 2020-11-06 | 钦州市第一人民医院 | Composition for promoting blood circulation and removing obstruction in channels for repairing internal fistula after puncture, preparation method and preparation |
Non-Patent Citations (2)
| Title |
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| 杨筱敏;黄蔷薇;叶白如;谷禾;葛红;金领微;郑育;: "自制复方丹参喜疗妥软膏预防血液透析患者动静脉内瘘并发症的效果观察", 护理学报, vol. 15, no. 05, pages 69 - 70 * |
| 陈民;李正;钟思敏;: "复方利多卡因乳膏对内瘘血管穿刺的镇痛作用观察", 实用医院临床杂志, vol. 8, no. 02, pages 111 - 113 * |
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