CN111558405A - Driving and liquid adding device for micro-fluidic chip - Google Patents
Driving and liquid adding device for micro-fluidic chip Download PDFInfo
- Publication number
- CN111558405A CN111558405A CN202010467273.2A CN202010467273A CN111558405A CN 111558405 A CN111558405 A CN 111558405A CN 202010467273 A CN202010467273 A CN 202010467273A CN 111558405 A CN111558405 A CN 111558405A
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- push rod
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- microfluidic chip
- reagent
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- 239000007788 liquid Substances 0.000 title claims abstract description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 86
- 238000002347 injection Methods 0.000 claims abstract description 42
- 239000007924 injection Substances 0.000 claims abstract description 42
- 238000001514 detection method Methods 0.000 claims abstract description 40
- 230000007246 mechanism Effects 0.000 claims abstract description 40
- 238000001917 fluorescence detection Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 238000003908 quality control method Methods 0.000 description 6
- 238000003018 immunoassay Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000208818 Helianthus Species 0.000 description 2
- 235000003222 Helianthus annuus Nutrition 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a driving and liquid adding device for a microfluidic chip, which comprises: a chip tray for loading a microfluidic chip; the reagent injection mechanism is used for injecting a reagent pre-stored in the microfluidic chip into a detection area of the microfluidic chip; and a driving mechanism for moving the microfluidic chip on the chip tray relative to the reagent injection mechanism, the driving mechanism being connected to the chip tray; wherein the chip tray has a reagent injection position for inserting the reagent injection mechanism into the microfluidic chip to push the reagent. The invention can automatically add reagent and has convenient operation.
Description
Technical Field
The invention belongs to the field of medical instruments, and relates to a driving and liquid adding device for a microfluidic chip.
Background
Micro-fluidic chip systems are receiving more and more attention in the fields of chemical industry, energy, environment, medical treatment and the like. The micro-fluidic chip can realize functions of micro-analysis, mixing or separation and the like through controlling the fluid. For example, a phage chip, can be used to detect bacteria, such as Mycobacterium tuberculosis, etc., in a biological sample. When the detection is performed by the microfluidic chip, a series of processes such as adding various reagents (such as buffer solution, luminescence reaction solution, etc.) are often required. At present, most of the treatments are carried out manually, the operation is complex and inconvenient, the efficiency is low, and the automation degree is low.
Disclosure of Invention
In view of the above technical problems, an object of the present invention is to provide a driving and liquid adding device for a microfluidic chip, which can automatically add a reagent and is convenient to operate.
In order to achieve the purpose, the invention adopts the technical scheme that:
a drive and liquid feeding device for a microfluidic chip, comprising:
a chip tray for loading a microfluidic chip;
the reagent injection mechanism is used for injecting a reagent pre-stored in the microfluidic chip into a detection area of the microfluidic chip; and
a driving mechanism for moving the microfluidic chip on the chip tray relative to the reagent injection mechanism, the driving mechanism being connected to the chip tray;
wherein the chip tray has a reagent injection position for inserting the reagent injection mechanism into the microfluidic chip to push the reagent.
Furthermore, the chip tray is provided with a mounting groove for the micro-fluidic chip to be clamped in.
Further, the chip tray is slidably disposed on the guide rail.
Further, the reagent injection mechanism comprises one or more push rods capable of being inserted into the microfluidic chip.
In a specific embodiment, the reagent injection mechanism comprises a movable first push rod and a fixedly arranged second push rod.
Preferably, the reagent injection mechanism further comprises a mounting plate, the first push rod is movably arranged on the mounting plate, and the second push rod is fixedly arranged on the mounting plate.
More preferably, a push rod seat is fixedly arranged on the mounting plate, the first push rod can be movably arranged on the mounting plate in a penetrating manner along the length direction of the first push rod, one end part of the first push rod is movably inserted into the push rod seat, and an elastic piece is arranged between the one end part of the first push rod and the push rod seat.
Further preferably, the elastic member is a compression spring disposed between the one end of the first push rod and the push rod seat.
Further preferably, the length of the first push rod which can be inserted into the microfluidic chip is longer than the length of the second push rod which can be inserted into the microfluidic chip.
Further, the chip tray has a first reagent injection position corresponding to the first push rod and a second reagent injection position corresponding to the second push rod.
Further, the driving mechanism comprises a motor, and an output shaft of the motor is connected with the chip tray.
Compared with the prior art, the invention has the following advantages by adopting the scheme:
according to the driving and liquid adding device for the microfluidic chip, in the process that the chip tray carries the microfluidic chip to move, the reagent is automatically injected into the detection area through the reagent injection mechanism, and the reagent can be added only by controlling the movement of the chip tray, so that the operation is convenient.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on the drawings without creative efforts.
FIG. 1 is a schematic external view of a chemiluminescent immunoassay analyzer employing a driving and liquid adding device according to an embodiment of the present invention;
FIGS. 2 and 3 are schematic views of a driving and liquid adding device, respectively;
fig. 4a to 4f show the moving process of the microfluidic chip.
Wherein,
1. a chip tray; 10. mounting grooves; 11. a front limiting block; 12. a rear limiting block;
2. a reagent injection mechanism; 21. a first push rod; 22. a second push rod; 23. mounting a plate; 24. a push rod seat; 25. an elastic member;
3. a drive mechanism; 31. a linear motor;
4. a fluorescence detection device; 41. a photomultiplier tube; 411. a detection port; 42. a counting device;
5. a housing; 51. a window; 52. a linear guide rail; 53. a control panel; 54. a power supply module; 55. a switch;
6. a microfluidic chip; 61. a detection zone; 62. a quality control port; 63. a first plunger; 64. and a second plunger.
Detailed Description
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the invention may be more readily understood by those skilled in the art. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto.
As used in this specification and the appended claims, the terms "comprises" and "comprising" are intended to only encompass the explicitly identified steps and elements, which do not constitute an exclusive list, and that a method or apparatus may include other steps or elements. As used herein, the term "and/or" includes any combination of one or more of the associated listed items.
It should be noted that, unless otherwise specified, when a feature is referred to as being "fixed" or "connected" to another feature, it may be directly fixed or connected to the other feature or indirectly fixed or connected to the other feature. Further, the description of the upper, lower, left, right, etc. used in the present invention is only with respect to the positional relationship of the respective components of the present invention with respect to each other in the drawings.
The embodiment provides a driving and liquid adding device for a microfluidic chip, which can be used for a chemiluminescence immunoassay analyzer to realize the movement of the microfluidic chip and the addition of a reagent. Referring to fig. 1, the chemiluminescence immunoassay analyzer comprises a housing 5, wherein a driving and liquid adding device is arranged in the housing 5, a window 51 is arranged on the housing 5, and the window 51 is used for assembling and disassembling the microfluidic chip 6. Referring to fig. 2 and 3, the driving and filling device includes a chip tray 1 disposed in a housing 5, a reagent injection mechanism 2, and a driving mechanism 3. The window 51 on the housing 5 is disposed opposite to the chip tray 1, and the microfluidic chip 6 enters and exits through the window 51 on the housing 5. The chip tray 1 is used for loading the microfluidic chip 6. The reagent injection mechanism 2 is used for injecting a reagent into a detection area of the microfluidic chip 6. The driving mechanism 3 is used for enabling the microfluidic chip 6 on the chip tray 1 to move relative to the reagent injection mechanism 2, and the driving mechanism 3 is connected with the chip tray 1 so as to drive the chip tray 1 to move. The chip tray 1 has a reagent injection position (as shown in fig. 4c and 4 d), when the chip tray 1 is at the reagent injection position, the reagent injection mechanism 2 is inserted into the microfluidic chip 6, and as the chip tray 1 continues to move, the reagent injection mechanism 2 moves relative to the microfluidic chip 6 to push the reagent to inject the reagent into the detection region of the microfluidic chip 6.
The driving and liquid adding device can also enable the micro-fluidic chip 6 to enter the lower part of the fluorescence detection device 4 to realize fluorescence detection. The fluorescence detection device 4 is used for detecting the fluorescence intensity of the sample in the microfluidic chip 6, and the fluorescence detection device 4 is provided with a detection port for injecting fluorescence. The chip tray 1 has a detection position (as shown in fig. 4 e), when the chip tray 1 is at the detection position, the chip tray 1 is located below the fluorescence detection device 4, the detection area of the microfluidic chip 6 loaded on the chip tray 1 can be opposite to the detection port of the fluorescence detection device 4, and further the fluorescence in the detection area can enter the fluorescence detection device 4 through the detection port.
As shown in fig. 4a, the microfluidic chip 6 has a detection region 61 and a reagent storage region, a micro-channel is provided between the detection region 61 and the reagent storage region, a plunger is provided in the reagent storage region, after the plunger is pushed by external force, the reagent in the reagent storage region is extruded by the plunger and enters the detection region 61 through the micro-channel, so as to realize incubation, reaction and the like, and the detection region 61 is used for reaction and detection after reaction. Specifically, two reagent storage areas are separately arranged in the microfluidic chip 6, a first movable plunger 63 is arranged in the first reagent storage area, and a second movable plunger 64 is arranged in the second reagent storage area. In one specific application example, a phage buffer solution is pre-stored in the first reagent storage region, and a sunflower aldehyde solution is pre-stored in the second reagent storage region, and the chemiluminescence immunoassay analyzer can detect bacteria (such as mycobacterium tuberculosis) in a biological sample. The first reagent storage area and the second reagent storage area are both located on the rear side of the microfluidic chip 6. The detection zone 61 is located substantially in the middle of the microfluidic chip 6 and has a hole for transmitting fluorescence. The micro-fluidic chip 6 is also provided with a quality control port 62, the quality control port 62 is positioned at the rear of the detection area 61, the quality control port 62 can be used for pre-placing phage solution, and reaction liquid is added into the quality control port 62 when the micro-fluidic chip is used.
As shown in fig. 3, the chip tray 1 is slidably disposed on the guide rails. The guide rail mainly comprises a pair of linear guide rails 52 arranged in parallel, the linear guide rails 52 are fixedly arranged on the shell 5, and two sides of the chip tray 1 are respectively connected with the corresponding linear guide rails 52 in a sliding fit manner. The chip tray 1 is provided with a mounting groove 10 for the micro-fluidic chip 6 to be clamped in, and the shape of the mounting groove 10 in a plan view is consistent with that of the micro-fluidic chip 6. The front side part of the chip tray 1 is provided with a front limiting block 11, the rear side part of the chip tray 1 is provided with a rear limiting block 12, and the height of the front limiting block 11 is smaller than that of the rear limiting block 12, so that the micro-fluidic chip 6 can conveniently enter and exit the mounting groove 10. The front limiting blocks 11 are two in number and arranged at intervals, so that hands and the like can clamp the microfluidic chip 6 to assemble and disassemble the microfluidic chip; the rear stoppers 12 are two in number and spaced apart to provide a space for allowing the reagent injection mechanism 2 to move in and out of the microfluidic chip 6 to push the plunger. Herein, the longitudinal direction of the linear guide 52 is defined as the front-rear direction, the side of the chip tray 1 farther from the reagent injection mechanism 2 is defined as the front side portion, and the side of the chip tray 1 closer to the reagent injection mechanism 2 is defined as the rear side portion.
As shown in fig. 2 and 3, the reagent injection mechanism 2 includes one or more push rods that can be inserted into the microfluidic chip 6. Further, after the push rod is inserted into the microfluidic chip 6, the push rod is matched with the plunger therein, and as the chip tray 1 drives the microfluidic chip 6 to move, the plunger is blocked by the push rod to extrude the reagent in front of the plunger into the detection area 61 of the microfluidic chip 6. The number of push rods corresponds to the number of plungers. Thus, the reagent injection mechanism 2 includes a first push rod 21 corresponding to the first plunger 63 and a second push rod 22 corresponding to the second plunger 64. As the microfluidic chip 6 moves backwards, the first plunger 63 abuts against the first push rod 21 to receive the resistance of the first push rod 21, and when the resistance is larger than the friction force received by the first plunger 63 in the microfluidic chip 6, the first plunger 63 moves forwards relative to the microfluidic chip 6 to squeeze the reagent in the first reagent storage region into the detection region 61; similarly, the second plunger 64 is capable of squeezing the reagent in the second reagent storage region into the detection zone 61.
Further, the first push rod 21 and the second push rod 22 do not move synchronously, and when the first push rod 21 pushes the first plunger 63, the second push rod 22 does not contact the second plunger 64 yet; after the reagent in the first reagent storage region is squeezed into the detection region 61, a reaction is required for a certain period of time (e.g., 15min after the phage buffer solution is squeezed), and then the second push rod 22 squeezes the reagent in the second reagent storage region into the detection region 61, at which time the first push rod 21 can move backward along with the microfluidic chip 6 so that the second push rod 22 can contact the second plunger 64. Specifically, the first push rod 21 and the second push rod 22 are both disposed on the mounting plate 23, and the mounting plate 23 is fixedly disposed on the housing 5. Wherein the first push rod 21 is movably arranged on the mounting plate 23, and the second push rod 22 is fixedly arranged on the mounting plate 23. The mounting plate 23 is fixedly provided with a push rod seat 24, the first push rod 21 and the second push rod 22 are parallel to each other and extend along the front-back direction, the first push rod 21 can be movably arranged on the mounting plate 23 along the length direction (i.e. the front-back direction) thereof, one end part of the first push rod 21 is movably inserted into the push rod seat 24, and an elastic part 25 is arranged between one end part (i.e. the rear end part) of the first push rod 21 and the push rod seat 24. The elastic member 25 is specifically a compression spring which is pressed between one end of the first push rod 21 and the push rod holder 24. The length of the first push rod 21 which can be inserted into the microfluidic chip 6 is longer than that of the second push rod 22 which can be inserted into the microfluidic chip 6, so that the first push rod 21 contacts the first plunger 63 first, and the second push rod 22 contacts the second plunger 64 after the reagent in the first reagent storage region is squeezed in, and the reagent in the second reagent storage region is injected in. Accordingly, the chip tray 1 has a first reagent injection position corresponding to the first push rod 21 (as shown in FIG. 4 c) and a second reagent injection position corresponding to the second push rod 22 (as shown in FIG. 4 d), the second reagent injection position being located between the first reagent injection position and the detection position (as shown in FIG. 4 e).
As shown in fig. 2 and 3, the driving mechanism 3 includes a motor, and an output shaft of the motor is connected to the chip tray 1. Specifically, the motor is a linear motor 31, the linear motor 31 is mounted on the housing 5, and an output shaft of the linear motor 31 is connected to the chip tray 1 through a connecting member. As the linear motor 31 operates, the chip tray 1 moves in the front-rear direction therewith.
As shown in fig. 2, the fluorescence detection device 4 includes a photomultiplier tube 41 and a counter 42. A photomultiplier tube 41 (PMT for short) converts a fluorescence signal incident from the detection port into an electric signal, and a counting device 42 is electrically connected to the photomultiplier tube 41 to obtain the number of the target (e.g., Mycobacterium tuberculosis) to be detected based on the electric signal output from the photomultiplier tube 41. The detection port is specifically a detection port of the photomultiplier tube 41, and is used for providing fluorescence inside the photomultiplier tube 41. In this embodiment, the photomultiplier 41 is disposed above the chip tray 1, and the counter 42 is disposed beside the chip tray 1.
Referring to fig. 2 and 3, the chemiluminescence immunoassay analyzer further includes a control board 53, a power supply module 54, and a switch 55 for controlling the power supply module 54. The control board 53 is electrically connected to the linear motor 31 to send a control signal for controlling the start and stop of the linear motor 31 according to a preset detection program. The control board 53 is also electrically connected to the counting device 42 to obtain the detection information obtained by the counting device 42, and display, output, etc. The power supply module 54 is used for supplying power to the linear motor 31, the photomultiplier tube 41, the counting unit, the control board 53, and the like, and the power supply module 54 may be a power line used for being connected to an external power source such as commercial power, and may also be a battery (e.g., a rechargeable battery).
The process that the driving and liquid adding device drives the micro-fluidic chip to move is as follows:
1. as shown in fig. 4a, the chip tray 1 is located at the front side of the guide rail, and even part of the chip tray can be located outside the housing 5 through the window 51, and the microfluidic chip 6 is loaded on the chip tray 1;
2. when the linear motor 31 operates, the chip tray 1 carrying the microfluidic chip 6 moves backwards along the linear guide rail 52 until the quality control port 62 of the microfluidic chip 6 faces the detection port 411 of the photomultiplier 41, as shown in fig. 4 b; and in this process, the front part of the first push rod 21 is inserted into the microfluidic chip 6, but the first plunger 63 is not yet pushed;
3. the linear motor 31 continues to operate, the chip tray 1 carries the microfluidic chip 6 to continue moving backwards along the linear guide rail 52, and in the moving process of the microfluidic chip 6, the first plunger 63 abuts against the first push rod 21 to be blocked, so that the reagent (such as phage buffer) in the first reagent storage region is squeezed into the detection region 61, as shown in fig. 4 c; the linear motor 31 stops running, and the chip tray 1 keeps the first reagent injection position shown in fig. 4c for a period of time to perform reaction, incubation, etc., for example, 15min after extruding phage buffer;
4. after the incubation is completed, the linear motor 31 continues to operate, the chip tray 1 carrying the microfluidic chip 6 further moves backwards along the linear guide rail 52, in the process that the microfluidic chip 6 continues to move, the second push rod 22 is inserted into the microfluidic chip 6 and abuts against the second plunger 64, the second plunger 64 is subjected to the resistance of the second push rod 22 to squeeze the reagent (such as the sunflower aldehyde solution) in the second reagent storage region into the detection region 61, and the second reagent injection position is shown in fig. 4 d; in this process, the pushing force of the first plunger 63 exerted on the first push rod 21 increases and pushes the first push rod 21 to move backward together, and the elastic member 25 is compressively deformed;
5. the linear motor 31 runs in reverse direction, and the chip tray 1 with the microfluidic chip 6 moves forward until the detection area 61 of the microfluidic chip 6 faces the detection port 411 of the photomultiplier 41, as shown in fig. 4 e;
6. after the detection is finished, the linear motor 31 continues to move reversely, the chip tray 1 carrying the microfluidic chip 6 exits the window 51, and the microfluidic chip 6 is dismounted from the chip tray 1.
During the reverse operation of the linear motor 31, the pushing force exerted by the first plunger 63 on the first push rod 21 is reduced until the pushing force disappears, and the restoring force of the elastic element 25 drives the first push rod 21 to restore for the next detection.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and are preferred embodiments, which are intended to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the scope of the present invention. All equivalent changes or modifications made according to the principles of the present invention should be covered within the protection scope of the present invention.
Claims (10)
1. A drive and liquid feeding device for a microfluidic chip is characterized by comprising:
a chip tray for loading a microfluidic chip;
the reagent injection mechanism is used for injecting a reagent pre-stored in the microfluidic chip into a detection area of the microfluidic chip; and
a driving mechanism for moving the microfluidic chip on the chip tray relative to the reagent injection mechanism, the driving mechanism being connected to the chip tray;
wherein the chip tray has a reagent injection position for inserting the reagent injection mechanism into the microfluidic chip to push the reagent.
2. The driving and charging device according to claim 1, characterized in that: the chip tray is slidably disposed on the guide rail.
3. The driving and charging device according to claim 1, characterized in that: the reagent injection mechanism comprises one or more push rods capable of being inserted into the microfluidic chip.
4. The driving and charging device according to claim 3, characterized in that: the reagent injection mechanism comprises a movable first push rod and a fixedly arranged second push rod.
5. The driving and charging device according to claim 4, characterized in that: the reagent injection mechanism further comprises a mounting plate, the first push rod is movably arranged on the mounting plate, and the second push rod is fixedly arranged on the mounting plate.
6. The driving and charging device according to claim 5, characterized in that: the fixed push rod seat that is provided with on the mounting panel, first push rod can wear to locate along its length direction removal on the mounting panel, just a tip of first push rod is movably inserted in the push rod seat, first push rod a tip with be provided with the elastic component between the push rod seat.
7. The driving and charging device according to claim 6, characterized in that: the elastic piece is a pressure spring which is arranged between the end part of the first push rod and the push rod seat in a propping mode.
8. The driving and charging device according to claim 4, characterized in that: the length of the first push rod which can be inserted into the microfluidic chip is longer than that of the second push rod which can be inserted into the microfluidic chip.
9. The driving and charging device according to any one of claims 4 to 8, characterized in that: the chip tray has a first reagent injection position corresponding to the first push rod and a second reagent injection position corresponding to the second push rod.
10. The driving and charging device according to claim 1, characterized in that: the driving mechanism comprises a motor, and an output shaft of the motor is connected with the chip tray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010467273.2A CN111558405A (en) | 2020-05-28 | 2020-05-28 | Driving and liquid adding device for micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010467273.2A CN111558405A (en) | 2020-05-28 | 2020-05-28 | Driving and liquid adding device for micro-fluidic chip |
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| Publication Number | Publication Date |
|---|---|
| CN111558405A true CN111558405A (en) | 2020-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010467273.2A Pending CN111558405A (en) | 2020-05-28 | 2020-05-28 | Driving and liquid adding device for micro-fluidic chip |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112916061A (en) * | 2021-01-29 | 2021-06-08 | 绿叶诊断产品技术(广东)有限公司 | Liquid transfer driving device and method of micro-fluidic chip and detection equipment |
| CN113083388A (en) * | 2021-04-26 | 2021-07-09 | 苏州德运康瑞生物科技有限公司 | Automatic interfacing apparatus of chip of dyeing appearance is caught to blood cell |
| CN113155580A (en) * | 2021-04-26 | 2021-07-23 | 苏州德运康瑞生物科技有限公司 | Tumor blood cell capturing and dyeing instrument |
-
2020
- 2020-05-28 CN CN202010467273.2A patent/CN111558405A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112916061A (en) * | 2021-01-29 | 2021-06-08 | 绿叶诊断产品技术(广东)有限公司 | Liquid transfer driving device and method of micro-fluidic chip and detection equipment |
| CN113083388A (en) * | 2021-04-26 | 2021-07-09 | 苏州德运康瑞生物科技有限公司 | Automatic interfacing apparatus of chip of dyeing appearance is caught to blood cell |
| CN113155580A (en) * | 2021-04-26 | 2021-07-23 | 苏州德运康瑞生物科技有限公司 | Tumor blood cell capturing and dyeing instrument |
| CN113155580B (en) * | 2021-04-26 | 2024-05-31 | 苏州德运康瑞生物科技有限公司 | Tumor blood cell capturing staining instrument |
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