CN111544562A - 一种新型的治疗鸡球虫病中药丸 - Google Patents
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Abstract
本发明公开了一种新型的治疗鸡球虫病中药丸,将称重后的青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷混合粉碎后过40筛网备用;将过筛后的药物粉末放入容器中,将容器放入蒸锅中蒸1小时,待冷却后放入制粒机中制成药丸,制得治疗鸡球虫病中药丸,本发明采用中药制剂,对治疗鸡球虫病具有良好的治疗效果,经济环保,不会造成对养鸡场的化学污染,提升鸡的免疫力,减少生病,具有推广应用的价值。
Description
技术领域
本发明涉及兽用药物领域,尤其涉及一种新型的治疗鸡球虫病中药丸。
背景技术
鸡球虫病是鸡常见且危害十分严重的寄生虫病,是由一种或多种球虫引起的急性流行性寄生虫病。它造成的经济损失是惊人的。10~30日龄的雏鸡或35~60日龄的青年鸡的发病率和致死率可高达80%。病愈的雏鸡生长受阻,增重缓慢;成年鸡一般不发病,但为带虫者,增重和产蛋能力降低,是传播球虫病的重要病源。现有技术中,对于鸡球虫病治疗效果较差,疗效缓慢,因此,存在改进空间。
发明内容
本发明的目的就在于为了解决上述问题而提供一种新型的治疗鸡球虫病中药丸。
本发明通过以下技术方案来实现上述目的:
本发明由青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷制作而成。
进一步,按重量比,每份含所述青蒿6-10%、所述黄柏4-7%、所述柴胡5-8%、所述苦参4-6%、所述玄参5-8%、所述常山8-12%、所述生地黄6-9%、所述地榆碳2-4%、所述木香6-10%、所述大枣12-18%、所述黄芪7-9%、所述干姜8-15%、所述薄荷4-8%。
优选的,按重量比,每份含所述青蒿8%、所述黄柏5%、所述柴胡7%、所述苦参5%、所述玄参7%、所述常山10%、所述生地黄8%、所述地榆碳3%、所述木香8%、所述大枣15%、所述黄芪8%、所述干姜10%、所述薄荷6%。
本发明一种新型的治疗鸡球虫病中药丸制备方法,包括以下步骤:
S1:将青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷按重量比每份含所述青蒿8%、所述黄柏5%、所述柴胡7%、所述苦参5%、所述玄参7%、所述常山10%、所述生地黄8%、所述地榆碳3%、所述木香8%、所述大枣15%、所述黄芪8%、所述干姜10%、所述薄荷6%进行称重备用;
S2:将称重后的青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷混合粉碎后过40筛网备用;
S3:将过筛后的药物粉末放入容器中,将容器放入蒸锅中蒸1小时,待冷却后放入制粒机中制成药丸,制得治疗鸡球虫病中药丸。
本发明的有益效果在于:
本发明是一种新型的治疗鸡球虫病中药丸,与现有技术相比,本发明采用中药制剂,对治疗鸡球虫病具有良好的治疗效果,经济环保,不会造成对养鸡场的化学污染,提升鸡的免疫力,减少生病,具有推广应用的价值。
具体实施方式
下面对本发明作进一步说明:
本发明由青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷制作而成。
进一步,按重量比,每份含所述青蒿6-10%、所述黄柏4-7%、所述柴胡5-8%、所述苦参4-6%、所述玄参5-8%、所述常山8-12%、所述生地黄6-9%、所述地榆碳2-4%、所述木香6-10%、所述大枣12-18%、所述黄芪7-9%、所述干姜8-15%、所述薄荷4-8%。
优选的,按重量比,每份含所述青蒿8%、所述黄柏5%、所述柴胡7%、所述苦参5%、所述玄参7%、所述常山10%、所述生地黄8%、所述地榆碳3%、所述木香8%、所述大枣15%、所述黄芪8%、所述干姜10%、所述薄荷6%。
本发明治疗鸡球虫病中药丸制备方法,包括以下步骤:
S1:将青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷按重量比每份含所述青蒿8%、所述黄柏5%、所述柴胡7%、所述苦参5%、所述玄参7%、所述常山10%、所述生地黄8%、所述地榆碳3%、所述木香8%、所述大枣15%、所述黄芪8%、所述干姜10%、所述薄荷6%进行称重备用;
S2:将称重后的青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷混合粉碎后过40筛网备用;
S3:将过筛后的药物粉末放入容器中,将容器放入蒸锅中蒸1小时,待冷却后放入制粒机中制成药丸,制得治疗鸡球虫病中药丸。
临床试验:药丸大小为2mm直径颗粒,每天与饲料混合喂一次,每公斤饲料添加100g药丸,连续用药4天。以100只鸡统计,死亡率:3%;治愈率:用药后,临床症状完全消失,治愈数占88%。无效率:用药后,临床症状未见减轻,甚至出现恶化或死亡为无效,无效数占5%。有效率:用药后,临床症状减轻但并未完全消失,有效数占95%。
以上显示和描述了本发明的基本原理和主要特征及本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的只是说明本发明的原理,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (4)
1.一种新型的治疗鸡球虫病中药丸,其特征在于:由青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷制作而成。
2.根据权利要求1所述的新型的治疗鸡球虫病中药丸,其特征在于:按重量比,每份含所述青蒿6-10%、所述黄柏4-7%、所述柴胡5-8%、所述苦参4-6%、所述玄参5-8%、所述常山8-12%、所述生地黄6-9%、所述地榆碳2-4%、所述木香6-10%、所述大枣12-18%、所述黄芪7-9%、所述干姜8-15%、所述薄荷4-8%。
3.根据权利要求2所述的新型的治疗鸡球虫病中药丸,其特征在于:按重量比,每份含所述青蒿8%、所述黄柏5%、所述柴胡7%、所述苦参5%、所述玄参7%、所述常山10%、所述生地黄8%、所述地榆碳3%、所述木香8%、所述大枣15%、所述黄芪8%、所述干姜10%、所述薄荷6%。
4.一种新型的治疗鸡球虫病中药丸制备方法,其特征在于,包括以下步骤:
S1:将青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷按重量比每份含所述青蒿8%、所述黄柏5%、所述柴胡7%、所述苦参5%、所述玄参7%、所述常山10%、所述生地黄8%、所述地榆碳3%、所述木香8%、所述大枣15%、所述黄芪8%、所述干姜10%、所述薄荷6%进行称重备用;
S2:将称重后的青蒿、黄柏、柴胡、苦参、玄参、常山、生地黄、地榆碳、木香、大枣、黄芪、干姜、薄荷混合粉碎后过40筛网备用;
S3:将过筛后的药物粉末放入容器中,将容器放入蒸锅中蒸1小时,待冷却后放入制粒机中制成药丸,制得治疗鸡球虫病中药丸。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102100788A (zh) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | 一种预防及治疗鸡球虫病的中药制剂 |
CN104887784A (zh) * | 2015-05-04 | 2015-09-09 | 霍邱县科瑞达禽业有限公司 | 一种治疗商品鸡球虫病的中药及其制备方法 |
CN104982667A (zh) * | 2015-06-19 | 2015-10-21 | 安徽牧翔禽业有限公司 | 一种防治麻黄种鸡养殖过程中患球虫病的饲料添加剂及其制备方法 |
CN110934920A (zh) * | 2018-09-22 | 2020-03-31 | 浠水县散花镇大横厢养鸡专业合作社 | 一种用于治疗蛋鸡球虫病的中药组合物 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102100788A (zh) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | 一种预防及治疗鸡球虫病的中药制剂 |
CN104887784A (zh) * | 2015-05-04 | 2015-09-09 | 霍邱县科瑞达禽业有限公司 | 一种治疗商品鸡球虫病的中药及其制备方法 |
CN104982667A (zh) * | 2015-06-19 | 2015-10-21 | 安徽牧翔禽业有限公司 | 一种防治麻黄种鸡养殖过程中患球虫病的饲料添加剂及其制备方法 |
CN110934920A (zh) * | 2018-09-22 | 2020-03-31 | 浠水县散花镇大横厢养鸡专业合作社 | 一种用于治疗蛋鸡球虫病的中药组合物 |
Non-Patent Citations (2)
Title |
---|
刘传敏等: "几种中草药复方对柔嫩艾美耳球虫感染鸡的防治效果 ", 《河南畜牧兽医(综合版)》 * |
李宁等: "中西药防治鸡球虫病临床效果对比", 《中兽医学杂志》 * |
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