CN111529625A

CN111529625A - Traditional Chinese medicine formula for preventing re-workers from infecting new coronary pneumonia and tea bag

Info

Publication number: CN111529625A
Application number: CN202010603479.3A
Authority: CN
Inventors: 廖鹏程; 黄天赐; 杨群; 胡熠; 岳会霞
Original assignee: Jiuxin Wuhan Institute Of Traditional Chinese Medicine Co ltd
Current assignee: Jiuxin Wuhan Institute Of Traditional Chinese Medicine Co ltd
Priority date: 2020-06-29
Filing date: 2020-06-29
Publication date: 2020-08-14

Abstract

The invention relates to a traditional Chinese medicine formula for preventing re-workers from infecting new coronary pneumonia, which comprises the following raw materials: 5-15 parts of radix pseudostellariae, 6-12 parts of radix ophiopogonis, 8-15 parts of lotus leaves, 7-15 parts of folium isatidis, 8-11 parts of burdock, 3-10 parts of rhizoma cimicifugae, 5-15 parts of fructus forsythiae, 4-12 parts of radix paeoniae rubra, 3-10 parts of liquorice and 8-13 parts of green tea. Meanwhile, the invention also relates to a preparation method of the tea bag comprising the formula, which comprises the following steps: pulverizing or cutting the above materials, sieving with 10-mesh and 50-mesh sieves, mixing the powders with 10-mesh and 50-mesh sieves, packaging the coarse powders into a bag tea filter bag, and sealing. The traditional Chinese medicine composition combines the medicines, has the effects of tonifying qi, moistening lung, removing dirt, eliminating turbid pathogen, effectively relieving symptoms such as fever, cough, pharyngalgia, hypodynamia, shortness of breath, lassitude and the like while improving the body resistance, has smooth and fragrant taste and strong sweet taste, and is suitable for daily health care of normal people.

Description

Traditional Chinese medicine formula for preventing re-workers from infecting new coronary pneumonia and tea bag

[ technical field ] A method for producing a semiconductor device

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a teabag for preventing neocoronary pneumonia infection of a re-worker population and a preparation method thereof.

[ background of the invention ]

2019 New coronavirus (Novel coronavirus (NCP) 'COVID-19', named by the world health organization on 1, 12 months in 2020.

With the gradual control of the epidemic situation in China, enterprises gradually carry out repeated production and rework, but still need to take protective measures, and no traditional Chinese medicine tea which has a health-care effect, is convenient to drink and can prevent repeated production and rework staff from infecting new coronary pneumonia exists at present.

[ summary of the invention ]

In order to solve the problems, the invention provides a traditional Chinese medicine formula for preventing new coronary pneumonia infection of rework population. The teabag prepared by the formula has reasonable formula, smooth and fragrant taste, strong sweet-back force and good effect of preventing the infection of the Xinguan pneumonia.

In order to achieve the aim, the invention provides a traditional Chinese medicine formula for preventing the re-workers from being infected with the new coronary pneumonia, which comprises the following components:

radix pseudostellariae, radix ophiopogonis, lotus leaves, folium isatidis, burdock, rhizoma cimicifugae, fructus forsythiae, radix paeoniae rubra, liquorice and green tea.

Further, the traditional Chinese medicine formula comprises the following components in parts by weight:

5-15 parts of radix pseudostellariae, 6-12 parts of radix ophiopogonis, 8-15 parts of lotus leaves, 7-15 parts of folium isatidis, 8-11 parts of burdock, 3-10 parts of rhizoma cimicifugae, 5-15 parts of fructus forsythiae, 4-12 parts of radix paeoniae rubra, 3-10 parts of liquorice and 8-13 parts of green tea.

Another object of the present invention is to provide a teabag for re-workers to prevent new coronary pneumonia infection based on the traditional Chinese medicine formula, wherein the preparation method comprises:

1) powdering: respectively crushing or chopping radix Pseudostellariae, radix Ophiopogonis, folium Nelumbinis, folium Isatidis, fructus Arctii, cimicifugae rhizoma, fructus forsythiae, radix Paeoniae Rubra, Glycyrrhrizae radix, and green tea, sieving with 10 mesh and 50 mesh sieves, continuously crushing or chopping coarse particles which can not pass through 10 mesh sieve, and collecting powder between 10 mesh and 50 mesh sieves;

2) mixing: mixing the coarse powders of radix Pseudostellariae, radix Ophiopogonis, folium Nelumbinis, folium Isatidis, fructus Arctii, cimicifugae rhizoma, fructus forsythiae, radix Paeoniae Rubra, Glycyrrhrizae radix, and green tea at a certain ratio;

3) packaging: quantitatively packaging the coarse powder in a bag tea filter bag in a sterile workshop, and sealing.

Further, the bag tea filter bag in the packaging step comprises a non-woven bag, a filter bag made of different materials such as nylon and corn fiber.

The invention has the beneficial effects that:

1. the formula firstly fixes the foundation and expels the evil, achieves the double functions of supplementing qi and nourishing yin by combining reinforcement and elimination, simultaneously eliminates the toxin of the exogenous evil, can recover the normal function of the organism as soon as possible and obtains good effect.

The radix pseudostellariae is sweet, slightly bitter and flat, enters spleen and lung channels, has the functions of tonifying qi and spleen, promoting the production of body fluid and moistening lung, is used for treating spleen deficiency and tiredness, inappetence, weakness after illness, deficiency of qi and yin, spontaneous perspiration and thirst, lung dryness and dry cough, is a good product for clearing and nourishing, can tonify qi without raising the body weight, has very stable medicine property, and is mainly used for relieving qi-yin injuries caused by various reasons; the dwarf lilyturf tuber is sweet, slightly bitter and slightly cold, enters heart, lung and stomach channels, has the functions of nourishing yin, promoting the secretion of saliva or body fluid, moistening lung and clearing heart, is used for treating dry cough due to lung dryness, tuberculosis cough due to yin deficiency, sore throat, body fluid consumption and thirst, internal heat, diabetes, vexation and insomnia, intestinal dryness and constipation, is biased to moistening lung and calming heart, and has the efficacies of nourishing stomach yin and relieving polydipsia; the radix pseudostellariae and the ophiopogon root are matched, the radix pseudostellariae is mainly used for tonifying qi, the ophiopogon root is mainly used for nourishing yin, and the lung-tonifying and lung-moistening effects can be achieved, so that the effects of tonifying qi, moistening lung, nourishing yin and promoting the production of body fluid are achieved, the symptoms of cough, hypodynamia, shortness of breath, lassitude and the like of warm diseases can be relieved, the dry mouth and throat, inappetence and dry cough caused by body fluid consumption and lung and stomach yin deficiency which are easily caused after warm diseases can be improved, and the radix pseudostellariae and the ophiopogon root are most suitable for treating lung deficiency cough caused by lung; the lotus leaves are bitter and neutral, enter liver, spleen and stomach channels, have the functions of clearing summer heat and resolving dampness, raising fever and clearing yang, cooling blood and stopping bleeding, are used for summer heat polydipsia, summer heat and dampness diarrhea, spleen deficiency diarrhea, blood heat and epistaxis, hematochezia and metrorrhagia and metrostaxis, are good at improving the qi clearing of the spleen and the stomach, further improve the functions of the spleen and the stomach, improve the appetite, can help the effects of tonifying the spleen of the heterophylly falsestarwort root, improve the weakness of the spleen and the stomach, the inappetence and the poor appetite due; folium isatidis is bitter and cold, enters heart and stomach channels, has the functions of clearing heat and removing toxicity, cooling blood and removing ecchymoses, is used for treating epidemic febrile disease, hyperpyrexia, coma, macula and rash, mumps, pharyngitis, erysipelas, carbuncle and swelling, and has the effect of removing exogenous pathogenic heat, is the essential drug for removing toxicity and removing ecchymoses and is good for removing blood and removing ecchymoses; the burdock is pungent, bitter and cold, enters lung and stomach channels, has the functions of dispelling wind and heat, ventilating lung and promoting eruption, detoxifying and relieving sore throat, is used for wind and heat type common cold, cough with excessive phlegm, measles, rubella, sore throat, mumps, erysipelas, carbuncle and swelling and sore toxin, has the functions of clearing and reducing in ascending and floating, can dispel wind and heat, internally releases the toxin to promote the eruption, is a good medicine for detoxifying and promoting eruption, and has the effects of clearing heat and detoxifying, relieving swelling and relieving sore throat; cimicifugae rhizoma is pungent, slightly sweet and slightly cold, enters lung, spleen, stomach and large intestine channels, has the effects of relieving exterior syndrome, promoting eruption, clearing heat and removing toxicity, and lifting yang qi, and is used for treating wind-heat headache, toothache, aphtha, sore throat, measles without adequate eruption, yang toxin macula, proctoptosis and uterine prolapse, and is good at relieving yang-heat toxin in the channels, such as swelling and pain of gum, aphtha of the mouth and tongue, swelling and pain of throat and skin sore caused by stomach fire; fructus forsythiae is bitter and slightly cold, enters lung, heart and small intestine channels, has the functions of clearing heat and detoxicating, reducing swelling and resolving masses and dispelling wind and heat, is used for treating carbuncle and cellulitis, scrofula, acute mastitis, erysipelas, wind and heat cold, early warm diseases, warm heat entering nutrient, high fever and polydipsia, coma and macula, heat stranguria and pain, is light in clearing and superficial, can reach exterior pathogens and clear away internal heat, has the efficacies of detoxifying, reducing swelling and resolving masses, and is the essential drug for treating sore and carbuncle and swelling; the red peony root is bitter and slightly cold, enters liver meridian, has the functions of clearing heat and cooling blood, and removing stasis and relieving pain, is used for heat entering nutrient-blood, warm toxicity and macula, hematemesis and epistaxis, conjunctival congestion and swelling pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrheal, abdominal mass and abdominal pain, traumatic injury, carbuncle swelling and sore and ulcer, has the advantages of clearing heat and cooling blood, and is mainly used for fever bleeding, conjunctival congestion and swelling pain, carbuncle swelling and sore toxin of pestilence heat entering blood; the liquorice is sweet and neutral, and has the effects of tonifying spleen and qi, clearing heat and removing toxicity, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the medicines, so that the liquorice is used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and excessive phlegm, abdominal and limb spasm and acute pain, carbuncle, swelling and sore toxicity, relieving the toxicity and the toxicity of the medicines, harmonizing the medicines, and having sweet and neutral temperament and tonifying, and being capable of slowly and urgently, and is called by the old; the green tea is bitter in taste and cold in nature, can clear away heat and toxic materials, resist bacteria and diminish inflammation, and is compatible with traditional Chinese medicinal materials to exert and enhance the efficacy of the medicines.

The formula has the effects of tonifying qi, moistening lung, removing dirt and eliminating turbid. In the formula, the radix pseudostellariae and the radix ophiopogonis are monarch drugs, so that the effects of tonifying qi, tonifying lung and nourishing yin and moistening lung are achieved, the effects of tonifying qi, tonifying spleen and moistening lung of the radix pseudostellariae are mainly achieved by tonifying qi, the effects of nourishing yin, promoting the secretion of saliva or body fluid and moistening lung are mainly achieved by nourishing yin, the radix pseudostellariae and the radix ophiopogonis are combined, the symptoms of qi and yin deficiency are achieved, and the traditional Chinese medicine; the lotus leaves can lift spleen and stomach, clear yang, promote diuresis, and help the radix pseudostellariae to tonify spleen and stomach, and are ministerial drugs; folium isatidis has the effects of clearing heat and removing toxicity, cooling blood and removing ecchymoses, fructus arctii has the effects of rising and floating, clearing and reducing the heat, ventilating the lung and promoting eruption, detoxifying and relieving sore throat, rhizoma cimicifugae has the effects of relieving exterior syndrome and promoting eruption, clearing heat and removing toxicity, fructus forsythiae has the effects of clearing heat and removing toxicity, relieving swelling and eliminating stagnation, radix paeoniae rubra has the effects of clearing heat and cooling blood, dissipating blood stasis and relieving; licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe, and has the effects of dispelling wind, clearing heat, dispersing lung qi, and relieving cough.

The formula is reasonable in matching, and has the double functions of tonifying qi and nourishing yin, is matched with the machine of deficiency of both qi and yin of a patient with new coronary pneumonia, is assisted with folium isatidis, burdock, fructus forsythiae and the like to detoxify and eliminate stagnation, dispel exogenous pathogens, integrally adjust the functions of internal organs such as lung and stomach and the like, improve the balance in the body, grow hair and strengthen vital qi, enhance and mobilize autoimmune function, help to eliminate exogenous toxin products and control the development of diseases, so that good effects can be obtained while the normal resistance of the body is restored.

2. Is suitable for asymptomatic infected people and normal common people to improve immunity

In view of the risk of asymptomatic infected persons developing diagnosed cases themselves and the risk of unconscious infection of normal ordinary persons, improvement of self-resistance and resistance to viral attack are often required.

In the formula composition, the radix pseudostellariae is proved to Be capable of obviously improving the immune function of an organism and enhancing the physique, wherein glycosides and polysaccharides are effective components playing a role in enhancing the immunity, a radix pseudostellariae decoction can obviously improve the rat cell immune function caused by rabbit-resistant rat lymphocyte serum (ALS), a radix pseudostellariae water-decocting alcohol precipitation agent has obvious stimulation on lymphocyte proliferation, polysaccharide crude extracts can increase the weight of immune organs of mice and promote the nonspecific immune function, the radix pseudostellariae contains a plurality of amino acid components and can improve the body resistance, the metabolic circulation can Be quicker, toxins can Be quickly discharged, and the radix pseudostellariae also contains trace elements such as Fe, Cu, Zn, Cr, Ni, Co, Sr, Mn, Pb, Li, Na, B, Be, Ti, Al, Ca, Mg, K, P, Se and the like, wherein the trace elements such as Fe, Cu, Zn, Mg, Se and the like, Zn, Cr, Ni, Co, Sr, Mn, Na, B, Ca, Mg, K, P and Se are essential elements of human body, the nourishing, strengthening and tonifying effects are closely related to the trace elements, the Fe, Mn and other elements can treat inappetence, weakness and low immune function, and Mn can stimulate the synthesis of antitoxin to improve the capability of the body to resist infectious diseases; the ophiopogon root is rich in polysaccharide, has good immune regulation and immunity promotion effects, can obviously increase the weight of the spleen of a mouse, enhance the carbon clearance effect of the mouse, stimulate the generation of hemolysin in the serum of the mouse, resist the reduction of leucocytes caused by cyclophosphamide and cobalt irradiation, and can obviously improve the erythrocyte SOD activity, serum TAA and erythrocyte immune function of a model rat by a water decoction; by combining the antiviral and anti-inflammatory effects of other folium isatidis, fructus forsythiae, radix paeoniae rubra and the like, the formula can improve immunity, accelerate metabolic cycle and quickly discharge toxin, and is suitable for asymptomatic infectors and normal common people to improve immunity and resist virus invasion.

3. Smooth and fragrant taste and strong sweet-taste

Through compatibility, the tea has the faint scent of green tea and lotus leaves, the thick fragrance of burdock is hung on the tongue surface when the tea is drunk, but the tea does not have stimulation or heavier traditional Chinese medicine flavor, and after the tea is drunk, the tea has the advantages of quick body fluid generation and strong sweet-back force due to the rich content of radix ophiopogonis, radix pseudostellariae, green tea and the like. The product is soft in tea aroma and medicine aroma, strong in freshness, smooth and fragrant in overall taste, strong in aroma and lasting in aftertaste, is a product with fresh and strong taste and sweet and refreshing aftertaste, is easy to be widely concerned by people, and is high in acceptance.

4. The teabag has the advantages of convenient carrying, short brewing time, simple process, and easy treatment of residue

The teabag is packaged into an independent small package while preventing and protecting health, is convenient to carry when going out, can be enjoyed at any time and any place, and is simple in design and conforms to the fast-paced life of the modern urban society; when the product is processed, granules which are easier to dissolve are formed, the dissolution rate is high, and compared with other decoction, the product has the advantages of simple procedure, short time and convenient obtaining; when brewing, the tea soup is separated from the medicine bag, and the medicine dregs are easy to be treated.

The composition is prepared by mixing a plurality of traditional Chinese medicines, and is prepared by using radix pseudostellariae, radix ophiopogonis, lotus leaves, folium isatidis, burdock, rhizoma cimicifugae, fructus forsythiae, radix paeoniae rubra, liquorice and green tea in a compatibility manner. The immunity is improved through the synergistic effect of the medicines, the metabolic cycle is accelerated, the toxin is quickly discharged, and the medicine is suitable for the re-working crowd in the new coronary pneumonia epidemic situation so as to achieve the purposes of improving the immunity and resisting the virus invasion.

[ detailed description ] embodiments

In order to make the objects, technical solutions and advantageous effects of the present invention more apparent, the present invention is further described in detail with reference to the following detailed description. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention.

Example 1:

a traditional Chinese medicine formula comprises the following components in parts by weight: 5 parts of radix pseudostellariae, 6 parts of radix ophiopogonis, 8 parts of lotus leaves, 7 parts of folium isatidis, 8 parts of burdock, 3 parts of rhizoma cimicifugae, 5 parts of fructus forsythiae, 4 parts of radix paeoniae rubra, 3 parts of liquorice and 8 parts of green tea.

The method for preparing the tea bag by the formula comprises the following steps:

(1) powdering: respectively crushing or chopping radix Pseudostellariae, radix Ophiopogonis, folium Nelumbinis, folium Isatidis, fructus Arctii, cimicifugae rhizoma, fructus forsythiae, radix Paeoniae Rubra, Glycyrrhrizae radix, and green tea, sieving with 10 mesh and 50 mesh sieves, continuously crushing or chopping coarse particles which can not pass through 10 mesh sieve, and collecting powder between 10 mesh and 50 mesh sieves;

(2) mixing: mixing the coarse powders of radix Pseudostellariae, radix Ophiopogonis, folium Nelumbinis, folium Isatidis, fructus Arctii, cimicifugae rhizoma, fructus forsythiae, radix Paeoniae Rubra, Glycyrrhrizae radix, and green tea at a certain ratio;

(3) packaging: quantitatively packaging the coarse powder in a bag tea filter bag in a sterile workshop, and sealing.

Example 2:

a traditional Chinese medicine formula comprises the following components in parts by weight: 15 parts of radix pseudostellariae, 12 parts of radix ophiopogonis, 15 parts of lotus leaf, 15 parts of folium isatidis, 11 parts of burdock, 10 parts of rhizoma cimicifugae, 15 parts of fructus forsythiae, 12 parts of radix paeoniae rubra, 10 parts of liquorice and 13 parts of green tea. The preparation process of the formula tea bag is the same as that of example 1.

Example 3:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of lotus leaves, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The preparation process of the bagged tea of the formula is the same as that of example 1.

Example 4:

a traditional Chinese medicine formula comprises the following components in parts by weight: 8 parts of radix pseudostellariae, 6 parts of radix ophiopogonis, 9 parts of lotus leaves, 8 parts of folium isatidis, 10 parts of burdock, 6 parts of rhizoma cimicifugae, 8 parts of fructus forsythiae, 5 parts of radix paeoniae rubra, 6 parts of liquorice and 8 parts of green tea. The preparation process of the bagged tea of the formula is the same as that of example 1.

Example 5:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 12 parts of lotus leaves, 12 parts of folium isatidis, 11 parts of burdock, 10 parts of rhizoma cimicifugae, 15 parts of fructus forsythiae, 12 parts of radix paeoniae rubra, 10 parts of liquorice and 12 parts of green tea. The preparation process of the formula tea bag is the same as that of example 1.

Comparative example 1:

a traditional Chinese medicine formula comprises the following components in parts by weight: 9 parts of radix ophiopogonis, 10 parts of lotus leaves, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of cimicifugae foetidae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, except that radix pseudostellariae is not added.

Comparative example 2:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 10 parts of lotus leaf, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of cimicifugae foetidae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, except that no radix Ophiopogonis is added.

Comparative example 3:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, except that no lotus leaf is added.

Comparative example 4:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of lotus leaf, 10 parts of burdock, 8 parts of cimicifuga foetida, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, and only differs from that of the green tea.

Comparative example 5:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of lotus leaf, 10 parts of folium isatidis, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, except that burdock is not added.

Comparative example 6:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of lotus leaves, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra and 8 parts of liquorice. The teabag preparation process of this formulation was the same as in example 3, except that no green tea was added.

Comparative example 7:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of lotus leaf, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of cimicifugae foetidae, 10 parts of fructus forsythiae, 9 parts of red paeony root, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, and only the radix pseudostellariae and the radix ophiopogonis are not added.

Comparative example 8:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The tea bag preparation process of the formula is the same as that of example 3, except that radix ophiopogonis and lotus leaves are not added.

Comparative example 9:

a traditional Chinese medicine formula comprises the following components in parts by weight: 9 parts of radix ophiopogonis, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The preparation process of the tea bag of the formula is the same as that of the example 3, and the difference is only that the radix pseudostellariae and the lotus leaf are not added.

Comparative example 10:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of lotus leaves, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The preparation process of the tea bag of the formula is the same as that in example 3, except that the medicinal materials are not crushed, and the medicinal materials are directly mixed and bagged.

Comparative example 11:

a traditional Chinese medicine formula comprises the following components in parts by weight: 10 parts of radix pseudostellariae, 9 parts of radix ophiopogonis, 10 parts of lotus leaves, 10 parts of folium isatidis, 10 parts of burdock, 8 parts of rhizoma cimicifugae, 10 parts of fructus forsythiae, 9 parts of radix paeoniae rubra, 8 parts of liquorice and 10 parts of green tea. The teabag preparation process of the formulation is the same as that of example 3, except that 50 mesh sieve powder is used.

Experimental example 1: testing of health benefits

1) Inclusion criteria were:

the age is more than or equal to 18 years and less than or equal to 60 years;

the region is limited to the re-working crowd in Wuhan city of Hubei province;

body temperature (axillary temperature) is less than or equal to 37.3 ℃;

volunteered in the study and signed an informed consent.

Patients who also met the above 4 items were included in this study.

2) Exclusion criteria:

patients with serious primary diseases such as heart, brain, liver, kidney and hematopoietic system;

those with pulmonary cachexia;

those with mental, intellectual or language handicaps;

pregnant women, lactating women and people with pregnancy requirements in about 6 months;

those who are unwilling to accept the traditional Chinese medicine tea drink or have the past history of traditional Chinese medicine allergy;

patients diagnosed with COVID-19 and healed.

Patients who met any of the above were excluded.

3) Grouping and prevention method

Random, blank control, multicenter test design methods were used.

Prevention group: the tea bags of examples 1-2 were drunk for 14 days, 1 bag each time, 2 times per day.

Blank group: the bagged tea is not drunk for 14 days.

Observation indexes are as follows: the physical condition of the subject (mainly fever) was followed for 14 days, and the prophylactic group and the blank group were subjected to nucleic acid detection of new coronary pneumonia after the end of the trial.

4) Prevention of outcome

Body condition (χ) of the preventive group compared to the placebo group²Value 7.377, 8.557, P<0.01), and nucleic acid detection (X)²Value 7.049, 7.049, P<0.01) all have significant differences; in the preventive group, the differences between example 1 and example 3 are not statistically significant (P)>0.05), the results are shown in table 1. The tea bag disclosed by the invention has a good effect on preventing the new coronary pneumonia infection, can increase the immunity of the organism, has a remarkable effect on preventing fever, and has a good prevention and health-care effect.

Table 1: comparison of prevention between groups

Experimental example 2: evaluation of Effect on viral infection pneumonia

The bagged tea of the examples 1 to 5 and the comparative examples 1 to 9 is taken, added with water and decocted for 5 minutes, filtered, concentrated into 10ml of aqueous solution, sucked, quantitatively intragastrically administered, applied to a pneumonia mouse model caused by influenza virus FM1 strain, and compared with the lung index and the change of the gamma-IFN level of lung tissues and evaluated.

Molding: the mice were infected with 0.05 ml/mouse by nasal drops of 4LD 50 influenza virus under light anesthesia with ether inhalation. The day of modeling was day 0, day 1 was started with the 1 st dose, 1 time a day, and the dose volume was 0.02mL/g for a total of 7 days.

And (3) detection: on the 2 nd day after the administration, fasting and water deprivation are carried out for more than 4h, weighing is carried out, sacrifice is carried out, lung tissues are dissected, and the lung index is calculated. After the last administration, the mouse lung is taken under aseptic condition, added with a proper amount of PBS, frozen and stored at-70 ℃, and the level of gamma-interferon (gamma-IFN) in the lung tissue is detected by adopting a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) method.

The results are given in table 2 below:

table 2: comparison of pulmonary index and lung tissue expression level of gamma-IFN in each group of infected mice

As shown in Table 2, example 3 showed the best effect, decreased pulmonary index and high levels of γ -IFN in lung tissue.

Comparative examples 1-11 are the control groups of example 3, which lack 1-2 herbal ingredients, respectively.

The lung index and the lung tissue gamma-IFN level effect of the control examples 4 and 5 respectively lacking the folium isatidis and the burdock are reduced, but the activity reduction is not obvious, which shows that the detoxifying and lung-clearing functions of the folium isatidis and the burdock are not obvious, and only play an auxiliary role; control 3, lacking green tea, did not differ significantly from the examples, indicating that green tea had no prophylactic effect in this formulation; the control examples 1, 7 and 9 lacking the radix pseudostellariae have poor prevention effect, which shows the main function of the radix pseudostellariae in the whole prevention formula; the control examples 2, 7 and 8 lacking ophiopogon root have poor prevention effect, which shows the main role of ophiopogon root in the whole prevention formula; the control example 3 lacking the lotus leaves has poor prevention effect, but has better prevention effect than the control examples 1 and 2 lacking the radix pseudostellariae and the radix ophiopogonis respectively, which indicates that the lotus leaves only play a secondary role in the formula; meanwhile, compared with the comparative examples 7-9, the comparative example 7 lacking the radix pseudostellariae and the radix ophiopogonis has the worst prevention effect, which shows that the combination application of the radix pseudostellariae and the radix ophiopogonis in the patent product is very important, and the lotus leaves are added, so that the prevention effect is further improved. The comparative examples 10-11 showed poor preventive effect, indicating that the dissolution of the active ingredient was not favored by the non-pulverization or the fine pulverization of the herbs.

Therefore, the analysis shows that the radix pseudostellariae and the radix ophiopogonis play a main role in the prevention effect, the lotus leaf plays a secondary role, and the prevention effect of the radix pseudostellariae and the radix ophiopogonis is better under the condition of coexistence of the radix pseudostellariae and the lotus leaf, so that the synergistic effect of the radix pseudostellariae and the lotus leaf is reflected, and the drug effects are not simply superposed.

Experimental example 3

The inventor chose 780 patients with pulmonary discomfort in Wuhan City, all aged between 20-60 years. The patients mainly show symptoms of cough, excessive phlegm, chest distress, short breath, unsmooth breath and the like. During the test period, all patients stop taking other medicines and health care products, live normally, and take the prevention tea bag of the embodiment twice a day, one bag at a time, and the symptoms are relieved after taking the prevention tea bag for two weeks. The patients were divided into one group per 60 th, and the blank group was not taken, and the bagged tea prepared in example 3 and comparative examples 1 to 11 was used. The results of the experiment are shown in table 3:

table 3: symptom-improving application effects of different formulas

As can be seen from Table 3, the improvement effect was significantly different from that of the blank group except for the control example 7. Example 3 is the most effective, all patients improved symptoms; the number of persons who improved significantly in comparative examples 1 to 11 was reduced and the number of persons who did not improve the effect was increased, but the improvement effect in comparative examples 4 to 6 was superior to that in the other comparative examples. Experimental data show that the formulas of the reference examples 1 and 2 which lack radix pseudostellariae and radix ophiopogonis respectively have poor improvement effects, and the radix pseudostellariae and the radix ophiopogonis in the formulas have main prevention effects; the improvement effect of the control 3 lacking lotus leaves is slightly improved, which shows that the lotus leaves play a secondary role in the formula; the improvement effects of the comparative examples 4 and 5 which lack the folium isatidis and the burdock fruit respectively are slightly reduced, which shows that the folium isatidis and the burdock fruit play an auxiliary role in the prevention of the formula; the improved effect of the comparative example 6 lacking green tea is similar to that of the example 3, which indicates that the green tea does not play a preventive role in the formula; the control example 10 and the powder teabag under the 50-mesh sieve which are directly mixed and packaged by the raw medicinal materials have poor improvement effect, which shows that the granularity of the medicinal materials influences the improvement effect of the product; meanwhile, compared with the comparative examples 7-9, the comparative example 7 lacking the radix pseudostellariae and the radix ophiopogonis has the worst improvement effect, which shows that the combination application of the radix pseudostellariae and the radix ophiopogonis in the patent product is very important, and the lotus leaves are added, so that the improvement effect is further improved.

Experimental example 4

The tea bags of example 3 and comparative examples 1-3 were placed in 500ml glass cups, respectively, and brewed with 300ml boiling water for 5min, and tasted when the temperature dropped to 35 ± 5 ℃, and the mouth feel and odor of different tea bags were compared and scored, and the results are shown in table 4.

Table 4: taste evaluation results

Grading standard: the content is preferably-4 points, more preferably-3 points, usually-2 points, and still more preferably-1 point.

As can be seen from Table 4, the taste scores of the teabag of example 3 are all higher than those of the control examples 2, 5 and 6, wherein the radix Ophiopogonis is absent in the control example 2, so that the fluid production capacity is greatly weakened, the aftertaste effect is greatly reduced, and the overall afterfeel is insufficient; in the comparison example 5, the burdock is lack, the fragrance cannot be presented, the whole fragrance is lost, and the aftertaste is not generated; in contrast 6, the tea taste and the drug flavor are not coordinated due to the lack of green tea, so that the drug flavor is concentrated, the whole is not acceptable easily, and the aftertaste is weakened. Therefore, the tea bag prepared by the formula has better taste, more fresh and concentrated taste, strong aftertaste and no bitterness, and is a tea bag with good taste.

Experimental example 5

2g of the tea bag obtained in the example 3 and the comparative examples 10 to 11 is put into a 500ml conical flask, 300ml of boiling water is added, the mixture is immediately transferred into a boiling water bath for leaching for 45min, the hot mixture is filtered under reduced pressure, the tea residue is washed for a plurality of times, the filter paper is communicated and transferred into a baking dish, the mixture is dried for 1h at the constant temperature of 120 ℃, cooled for 1h and then baked for 1h, transferred into a drier for cooling to the room temperature, and weighed. And calculating the content of the water extract. The results are given in Table 5 below.

Table 5: water extract measurement results

As can be seen from Table 5, the water extract content of the teabag of example 3 is higher than that of the control examples 10-11 and higher than that of the control examples 9% -20%, and the water extract content of the control example 10 is slightly weaker than that of the example due to the slightly larger particle size and insufficient dissolution during the extraction process; the water-soluble dissolution rate of the comparison example 11 is only 46%, and the water-soluble dissolution rate is obviously lower than that of each example in consideration of the facts that the granularity is too fine, the specific surface area of the medicinal powder is too large, the adsorption effect is enhanced, the diffusion is influenced, the thickening phenomenon is easily generated in the extraction process, the extraction efficiency is influenced, and extract is difficult to dissolve out, so that the water-soluble dissolution rate is obviously lower than that of each example.

Experimental example 6:

precisely weighing about 1.0g of the tea bag of example 3 and comparative examples 10-11, placing in a centrifuge tube with a plug, precisely adding 20ml of anhydrous ethanol, shaking with a vortex oscillator to mix well, performing ultrasonic extraction for 30min, centrifuging, discarding supernatant, washing insoluble substances with 10ml of ethanol solution, and centrifuging. Transferring the insoluble substance into round bottom flask with water, adding 50ml distilled water, extracting in boiling water bath for 1h, cooling to room temperature, filtering, transferring supernatant into 100ml volumetric flask, washing residue for 2-3 times, adding water to constant volume, and measuring content of dissolved components, as shown in Table 6.

Table 6: dissolution rate of crude polysaccharide in tea bag

As can be seen from Table 6, the dissolution rate of the crude polysaccharide in the teabag of example 3 is higher than that of the control examples 10-11, and the dissolution rate of the crude polysaccharide component is slightly lower than that of the example due to the slightly larger particle size of the control example 10 and the weak dissolution of the crude polysaccharide component during the extraction process; the dissolution rates of the crude polysaccharide in the comparison example 5 are only 43.8% and 39.6%, and the dissolution rates of the crude polysaccharide are only 43.8% and 39.6%, considering that the particle size is too fine, the specific surface area of the medicinal powder is too large, the adsorption effect is enhanced, the diffusion is influenced, the thickening phenomenon is easily generated in the extraction process, the dissolution efficiency is influenced, and the crude polysaccharide component is difficult to dissolve, so that the dissolution rates are obviously less than those in each example, and the particle size of the powder has influence on the dissolution effect of the crude polysaccharide.

The invention is not limited solely to that described in the specification and embodiments, and additional advantages and modifications will readily occur to those skilled in the art, so that the invention is not limited to the specific details, representative embodiments and experimental examples shown herein, without departing from the spirit and scope of the general concept as defined by the appended claims and their equivalents.

Claims

1. The traditional Chinese medicine formula for preventing the new crown pneumonia infection of the rework population is characterized by comprising the following components: radix pseudostellariae, radix ophiopogonis, lotus leaves, folium isatidis, burdock, rhizoma cimicifugae, fructus forsythiae, radix paeoniae rubra, liquorice and green tea.

2. The traditional Chinese medicine formula for preventing the new crown pneumonia of the rework population according to claim 1, wherein the components comprise, in parts by weight: 5-15 parts of radix pseudostellariae, 6-12 parts of radix ophiopogonis, 8-15 parts of lotus leaves, 7-15 parts of folium isatidis, 8-11 parts of burdock, 3-10 parts of rhizoma cimicifugae, 5-15 parts of fructus forsythiae, 4-12 parts of radix paeoniae rubra, 3-10 parts of liquorice and 8-13 parts of green tea.

3. The use of the traditional Chinese medicine formula of claim 1 or 2 in preventing the re-workers from infecting new coronary pneumonia.

4. The method for preparing the teabag for preventing the re-workers from being infected with the new coronary pneumonia by applying the traditional Chinese medicine formula of claim 1 or 2 is characterized by comprising the following steps:

respectively pulverizing or cutting radix Pseudostellariae, radix Ophiopogonis, folium Nelumbinis, folium Isatidis, fructus Arctii, cimicifugae rhizoma, fructus forsythiae, radix Paeoniae Rubra, Glycyrrhrizae radix, and green tea, sieving, mixing powders of 10 mesh and 50 mesh, weighing, and packaging with bag tea filter bag.

5. The teabag for preventing the contracting coronary pneumonia in the rework population according to claim 4, wherein the screening process is performed simultaneously with the screens of 10 meshes and 50 meshes, and the coarse particles which can not pass through the screen of 10 meshes are further crushed or cut.

6. The teabag for preventing re-workers from being infected with Xinguan pneumonia as claimed in claim 4, wherein the material for making the teabag filter bag is one of non-woven bag, nylon and corn fiber.