CN111514216A - Traditional Chinese medicine composition and preparation for treating hyperplasia of mammary glands - Google Patents
Traditional Chinese medicine composition and preparation for treating hyperplasia of mammary glands Download PDFInfo
- Publication number
- CN111514216A CN111514216A CN202010315351.7A CN202010315351A CN111514216A CN 111514216 A CN111514216 A CN 111514216A CN 202010315351 A CN202010315351 A CN 202010315351A CN 111514216 A CN111514216 A CN 111514216A
- Authority
- CN
- China
- Prior art keywords
- parts
- hyperplasia
- chinese medicine
- treating
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition and a preparation for treating hyperplasia of mammary glands. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-50 parts of red salvia root, 10-50 parts of ligusticum wallichii, 5-30 parts of tangerine pith, 5-30 parts of radix clematidis, 10-40 parts of spina gleditsiae, 1-10 parts of saffron crocus, 10-50 parts of ginseng, 0.1-0.5 part of borneol, 5-30 parts of semen brassicae and 5-30 parts of rhizoma corydalis preparata. The Chinese medicinal composition has the functions of promoting blood circulation, removing blood stasis, dredging collaterals, relieving pain, relieving swelling, resolving hard mass, improving microcirculation environment of breast tissue, promoting blood circulation of breast, dredging channels and collaterals of breast, and repairing breast tissue, so as to relieve breast pain caused by hyperplasia of mammary glands, and soften and eliminate breast lump; when in use, the traditional Chinese medicine composition has good curative effect without adopting other auxiliary treatment means, and a patient can independently perform treatment at home, so that the treatment cost is reduced; the traditional Chinese medicine composition has a treatment course of 1 month and a short treatment period.
Description
Technical Field
The invention belongs to the technical field of treatment of hyperplasia of mammary glands, and particularly relates to a traditional Chinese medicine composition and a preparation for treating hyperplasia of mammary glands.
Background
The mammary gland hyperplasia is a common breast disease of women, the clinical symptoms of the mammary gland hyperplasia mainly comprise breast lumps and breast pain, the symptoms are heavier in the early period of menstruation generally, and the symptoms are relieved after the menstruation. Although the mild hyperplasia of mammary glands does not affect the normal life and work of women greatly, the probability of hyperplasia of mammary glands to be worsened into breast cancer is 2 to 4 times that of the condition without hyperplasia of mammary glands, so that the active treatment is required in the early stage of the disease of hyperplasia of mammary glands.
The traditional Chinese medicines for treating hyperplasia of mammary glands at present can be divided into two types of oral administration and external application. Wherein, the oral Chinese traditional medicine preparation is a Chinese traditional medicine composition for treating hyperplasia of mammary glands disclosed in the Chinese patent of the invention with the publication number CN103142902B, and the Chinese traditional medicine composition comprises the following raw material medicines in parts by weight: 10-30 parts of angelica sinensis, 9-27 parts of kudzu root, 7.5-22.5 parts of semen cuscutae, 7.5-22.5 parts of cowherb seed, 6-18 parts of malt, 6-18 parts of kelp, 7.5-22.5 parts of corydalis tuber and 5-15 parts of ricepaperplant pith. Wherein, the angelica is a monarch drug for enriching and nourishing blood, promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, coordinating Chong and ren meridians, soothing liver and astringing yin. Radix Puerariae has effects of clearing heat and eliminating dampness, relieving restlessness, quenching thirst, removing blood stasis, and resolving hard mass; the dodder seed has the effects of tonifying liver and kidney, benefiting essence, walking thoroughfare and conception vessels and strengthening cell and organ; the kudzu root and the dodder have estrogen-like effects, can promote the absorption of hyperplasia of mammary glands and improve the atrophy state of mammary glands, and are used as ministerial drugs. The cowherb seed can promote blood circulation to remove meridian obstruction, promote lactation to reduce swelling, dissipate stagnation and relieve pain, carry medicine to move upwards, evacuate blood in breasts and dredge channels and collaterals in breasts; the malt strengthens the spleen, harmonizes the stomach and promotes lactation; thallus laminariae can soften hardness and dissipate stagnation; yanhu is a good herb for activating qi to alleviate pain, activating blood and dispelling stasis, because it can cure the pain of qi stagnation and blood stasis of the whole body; the four medicines are used together to achieve the effects of dissipating stagnation, reducing swelling and relieving pain, and promoting the softening and dissipation of the hyperplastic breast lumps, and are used as adjuvant medicines together. Medulla Tetrapanacis has the effects of promoting qi circulation, promoting lactation, clearing away heat, dredging channels and collaterals, and dredging channels and collaterals.
The traditional Chinese medicine composition has the effects of nourishing blood and liver, tonifying kidney and spleen, removing blood stasis and resolving masses, and regulating qi to alleviate pain, but people generally reject and contradict psychology to internal medicines, so that audiences of the internal medicines are narrow, and external medicines are more popular compared with the internal medicines. For example, the Chinese patent with the publication number of CN103550442B discloses a traditional Chinese medicine external preparation for treating hyperplasia of mammary glands, which is prepared from the following raw material medicines in parts by weight: 15 parts of ligusticum wallichii, 12 parts of red paeony root, 10 parts of rhizoma alismatis, 10 parts of radix clematidis, 10 parts of semen brassicae, 15 parts of frankincense, 15 parts of myrrh, 20 parts of glossy privet fruit, 30 parts of spina gleditsiae, 30 parts of herba epimedii, 20 parts of pangolin, 30 parts of beautiful sweetgum fruit, 30 parts of eucommia bark and 15 parts of borneol.
However, the traditional Chinese medicine external preparation has the following defects: (1) TDP irradiation is simultaneously assisted in the using process to increase the microcirculation of the breasts and eliminate inflammation and pain, and the TDP lamp is difficult to be equipped at home, so that a patient needs to continuously carry out treatment to a specific medical institution during the treatment period, the treatment cost is increased, and meanwhile, great inconvenience is caused to the life of the patient; (2) the traditional Chinese medicine external preparation has the following using treatment course: 14 days is a treatment course, each treatment course is followed by 3 days of rest, 3 months of treatment, and the treatment period is long.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition and a preparation for treating hyperplasia of mammary glands, which are convenient to use, short in treatment period and low in treatment cost.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition for treating hyperplasia of mammary glands comprises the following raw materials in parts by weight: 10-50 parts of red salvia root, 10-50 parts of ligusticum wallichii, 5-30 parts of tangerine pith, 5-30 parts of radix clematidis, 10-40 parts of spina gleditsiae, 1-10 parts of saffron crocus, 10-50 parts of ginseng, 0.1-0.5 part of borneol, 5-30 parts of semen brassicae and 5-30 parts of rhizoma corydalis preparata.
In the traditional Chinese medicine composition, the salvia miltiorrhiza bunge has the effects of activating blood and removing stasis, nourishing blood and soothing nerves, and is a monarch drug; the saffron has the functions of promoting blood circulation to remove blood stasis, cooling blood and relieving pain, the ligusticum wallichii has the functions of removing stasis and relieving pain, and the ginseng has the functions of tonifying qi and soothing nerves, and the saffron, the ligusticum wallichii and the ginseng are combined into a ministerial drug; semen Sinapis Albae has effects of eliminating phlegm, promoting qi circulation, resolving hard mass, and relieving swelling, tangerine pith has effects of eliminating phlegm, regulating qi-flowing, and dredging collaterals, spina Gleditsiae has effects of relieving swelling, removing toxic substances, and expelling pus, rhizoma corydalis Preparata has effects of promoting blood circulation, activating qi-flowing, and relieving pain, Borneolum Syntheticum has effects of relieving swelling and relieving pain, and five of them are as adjuvant drugs; clematis chinensis has the functions of pungent and dispersing, promoting the circulation of qi, warming and smoothing the nature, dredging collaterals and relieving pain, and is used as a guiding drug. The traditional Chinese medicine composition has the functions of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, and reducing swelling and resolving masses, and can improve the microcirculation environment of breast tissues, promote the blood circulation of breasts, dredge the channels and collaterals of breasts, and repair the breast tissues, thereby achieving the purposes of relieving breast distending pain caused by hyperplasia of mammary glands, softening and eliminating breast lumps.
When the traditional Chinese medicine composition is used, auxiliary treatment means such as TDP irradiation and the like are not needed, so that the traditional Chinese medicine composition has good curative effect, a patient can perform treatment at home, and the time cost of the patient during treatment is greatly reduced; the traditional Chinese medicine composition has the treatment course of 1 month, and greatly shortens the treatment period while ensuring the curative effect.
Preferably, in the above traditional Chinese medicine composition for treating hyperplasia of mammary glands, the raw materials comprise, by weight: 24-45 parts of red salvia root, 26-36 parts of ligusticum wallichii, 10-20 parts of tangerine pith, 15-20 parts of radix clematidis, 20-30 parts of spina gleditsiae, 4-7 parts of saffron crocus, 30-40 parts of ginseng, 0.3-0.4 part of borneol, 15-20 parts of semen brassicae and 18-25 parts of rhizoma corydalis preparata.
Preferably, the traditional Chinese medicine composition for treating hyperplasia of mammary glands comprises the following raw materials in parts by weight: 36 parts of red sage root, 30 parts of szechuan lovage rhizome, 13 parts of tangerine pith, 17 parts of clematis root, 24 parts of spina gleditsiae, 6 parts of saffron crocus, 35 parts of ginseng, 0.4 part of borneol, 18 parts of white mustard seed and 21 parts of prepared corydalis tuber.
The traditional Chinese medicine preparation for treating hyperplasia of mammary glands is prepared from the traditional Chinese medicine composition for treating hyperplasia of mammary glands.
The traditional Chinese medicine preparation for treating hyperplasia of mammary glands is an external preparation, and the external preparation can be: the externally applied cataplasm, the externally applied cataplasm or the externally applied smearing preparation. Among them, the external cataplasm is preferable from the viewpoint of convenience in use. The cataplasm is convenient to use, and a patient does not need to vacate a specific time for sticking the membrane, can still carry out other production and living activities during the membrane sticking period, and does not need to be cleaned immediately after use.
In the traditional Chinese medicine preparation for treating hyperplasia of mammary glands, the external cataplasm sequentially comprises a bearing substrate layer, a hydrophilic gel layer and a release layer, wherein the hydrophilic gel layer contains effective extracts of the traditional Chinese medicine composition for treating hyperplasia of mammary glands.
In the above traditional Chinese medicine preparation for treating hyperplasia of mammary glands, the preparation method of the hydrophilic gel layer comprises the following steps:
(1) taking saffron crocus according to the preset weight part, performing reflux extraction for 1-4 times by using 40-90% ethanol, combining all extracting solutions, and concentrating into an extract;
preferably, the time of each reflux extraction is 0.5-3h, and the relative density of the extract is kept between 1.01-1.30.
(2) Mixing red sage root, ligusticum wallichii, tangerine pith, clematis root, spina gleditsiae, ginseng, white mustard seed and prepared rhizoma corydalis according to preset weight parts, adding water for decocting at least twice, combining all decoctions, precipitating the decoctions with ethanol, filtering, concentrating and drying the filtrate to obtain dry paste, and preparing the dry paste into powder;
preferably, the amount of water added is 5-15 times of the amount of the medicine in each decoction, and each decoction lasts for 0.5-2 h.
(3) Taking borneol according to a preset weight part, and dissolving the borneol with 50-95% ethanol to obtain a borneol solution;
(4) mixing the Borneolum Syntheticum solution, the extract, and the dry extract powder, adding gelatin into the mixture, and making into gel solution;
the gelatin is added in an amount such that the gel liquid can be cooled to form a viscous and elastic solid.
(5) And uniformly coating the gel liquid on a carrier, and cooling to form the hydrophilic gel layer.
Cutting the hydrophilic gel layer into required size and shape, adhering the hydrophilic gel layer to the bearing base layer, and covering the hydrophilic gel layer with a release layer to obtain the external cataplasm.
Compared with the prior art, the invention has the beneficial effects that:
(1) the traditional Chinese medicine composition has the functions of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, and reducing swelling and resolving masses, and can improve the microcirculation environment of breast tissues, promote the blood circulation of breasts, dredge the channels and collaterals of breasts, and repair the breast tissues, thereby achieving the purposes of relieving breast distending pain caused by hyperplasia of mammary glands, softening and eliminating breast lumps.
(2) When the traditional Chinese medicine composition is used, auxiliary treatment means such as TDP irradiation and the like are not needed, so that the traditional Chinese medicine composition has good curative effect, a patient can perform treatment at home, and the time cost of the patient during treatment is greatly reduced; the traditional Chinese medicine composition has the treatment course of 1 month, and greatly shortens the treatment period while ensuring the curative effect.
Detailed Description
The technical means of the present invention will be described in further detail below with reference to specific embodiments.
Example 1
The embodiment of the invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 36 parts of red sage root, 30 parts of szechuan lovage rhizome, 13 parts of tangerine pith, 17 parts of clematis root, 24 parts of spina gleditsiae, 6 parts of saffron crocus, 35 parts of ginseng, 0.4 part of borneol, 18 parts of white mustard seed and 21 parts of prepared corydalis tuber.
The embodiment of the invention relates to a traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which is an externally applied cataplasm and the preparation method comprises the following steps:
(1) taking saffron crocus according to the preset weight part, carrying out reflux extraction for 3 times by using 75% ethanol, extracting for 2 hours each time, combining all extracting solutions, filtering, and concentrating the filtrate into an extract with the relative density of 1.24 at the temperature of 40-70 ℃;
(2) mixing red sage root, ligusticum wallichii, tangerine pith, clematis root, spina gleditsiae, ginseng, white mustard seed and prepared rhizoma corydalis according to preset weight parts, adding 15 times of water for decocting for 3 times, decocting for 1.5h each time, merging all decoction liquids, adding ethanol into the decoction liquid until the final concentration of the ethanol in the decoction liquid is 80%, precipitating with ethanol for 24h, filtering, concentrating the filtrate to an extract with the temperature of 50-60 ℃ and the relative density of 1.21, drying the extract to obtain dry paste, and preparing the dry paste into fine powder;
(3) taking borneol according to a preset weight part, and dissolving the borneol with 95% ethanol to obtain a borneol solution;
(4) uniformly mixing the extract prepared in the step (1), the dry extract powder prepared in the step (2) and the borneol solution prepared in the step (3), and adding gelatin into the mixture to prepare gel liquid;
the addition amount of the gelatin is preferably that the gel liquid can present a viscous and elastic solid state after being cooled;
(5) uniformly coating the gel liquid on a carrier, and cooling to form a hydrophilic gel layer;
(6) cutting the hydrophilic gel layer into a required size and shape, adhering the hydrophilic gel layer to the bearing base layer, and covering the hydrophilic gel layer with a release layer to obtain the traditional Chinese medicine preparation of the embodiment.
The bearing base layer can be made of non-woven fabrics, and one surface of the non-woven fabrics is uniformly coated with pressure-sensitive adhesive; the release layer can be a plastic film.
Example 2
The embodiment of the invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 45 parts of red sage root, 26 parts of szechuan lovage rhizome, 20 parts of tangerine pith, 20 parts of clematis root, 20 parts of spina gleditsiae, 4 parts of saffron crocus, 40 parts of ginseng, 0.4 part of borneol, 20 parts of white mustard seed and 25 parts of prepared corydalis tuber.
The same procedure as in example 1 was used to prepare a cataplasm for external use for treating hyperplasia of mammary glands.
Example 3
The embodiment of the invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 24 parts of red sage root, 36 parts of szechuan lovage rhizome, 10 parts of tangerine pith, 15 parts of clematis root, 30 parts of spina gleditsiae, 7 parts of saffron crocus, 30 parts of ginseng, 0.3 part of borneol, 15 parts of white mustard seed and 18 parts of prepared corydalis tuber.
The same procedure as in example 1 was used to prepare a cataplasm for external use for treating hyperplasia of mammary glands.
Example 4
The embodiment of the invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 50 parts of red sage root, 10 parts of szechuan lovage rhizome, 30 parts of tangerine pith, 30 parts of clematis root, 10 parts of spina gleditsiae, 1 part of saffron crocus, 50 parts of ginseng, 0.5 part of borneol, 5 parts of white mustard seed and 30 parts of prepared corydalis tuber.
The same procedure as in example 1 was used to prepare a cataplasm for external use for treating hyperplasia of mammary glands.
Example 5
The embodiment of the invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 10 parts of red sage root, 50 parts of szechuan lovage rhizome, 5 parts of tangerine pith, 5 parts of clematis root, 40 parts of spina gleditsiae, 10 parts of saffron crocus, 10 parts of ginseng, 0.1 part of borneol, 30 parts of white mustard seed and 5 parts of prepared corydalis tuber.
The same procedure as in example 1 was used to prepare a cataplasm for external use for treating hyperplasia of mammary glands.
Clinical cases: wu XX, female, 28 years old, outer-jiao Gao guan, now hong Kong, consciously had a hard mass in the left breast, and B-ultrasound examination found that the mammary gland hyperplasia diameter of the left breast was 1.5cm, and the mood change and premenstrual breast distending pain were significant. Administering the cataplasm for external use for treating hyperplasia of mammary glands (hereinafter referred to as mammary gland patch) of example 1 in 2016, 8 months and 25 days, tearing off the release layer, attaching the mammary gland patch to the affected breast, and removing the mammary gland patch after the hydrophilic gel layer becomes thin and dries (about 20-30 min); the pain disappears every other day when the breast patch is used, the breast patch is applied every day, the breast patch is applied once a day and is continuously used for one month, the subjective mass is reduced and softened, and the hyperplasia diameter of the left breast mammary glands is only 0.8cm as found by B ultrasonic examination.
500 mammary gland hyperplasia patients were recruited and randomly divided into five groups, and were administered to the mammary gland patches prepared in examples 1-5, respectively, to further judge the clinical treatment effect of the mammary gland patch of the present invention.
The application method of the breast paste comprises the following steps: tearing off the release layer, sticking the mammary gland patch on the affected side of breast, and taking off the mammary gland patch after the hydrophilic gel layer becomes thin and dry (about 20-30 min); the plaster is applied once a day and is continuously used for one month; after one month of use, if effective, can be used continuously
The method described in the Chinese patent with the publication number of CN103550442B is adopted to grade and score the texture, distribution range and size of the breast lumps of the patient before and after the breast patch is used, and the curative effect of the breast patch is judged according to the curative effect judgment standard described in the breast patch, and the judgment result is shown in Table 1.
TABLE 1 therapeutic Effect of the Breast Patches of the examples on hyperplasia of mammary glands
| Breast paste | Healing examples | Working examples | Cure rate | High efficiency |
| Example 1 | 93 | 96 | 93％ | 96％ |
| Example 2 | 91 | 94 | 91％ | 94％ |
| Example 3 | 89 | 95 | 89％ | 95％ |
| Example 4 | 86 | 92 | 86％ | 92％ |
| Example 5 | 85 | 93 | 85％ | 93％ |
Claims (10)
1. A traditional Chinese medicine composition for treating hyperplasia of mammary glands is characterized by comprising the following raw materials in parts by weight: 10-50 parts of red salvia root, 10-50 parts of ligusticum wallichii, 5-30 parts of tangerine pith, 5-30 parts of radix clematidis, 10-40 parts of spina gleditsiae, 1-10 parts of saffron crocus, 10-50 parts of ginseng, 0.1-0.5 part of borneol, 5-30 parts of semen brassicae and 5-30 parts of rhizoma corydalis preparata.
2. The traditional Chinese medicine composition for treating hyperplasia of mammary glands according to claim 1, wherein the raw materials comprise, in parts by weight: 24-45 parts of red salvia root, 26-36 parts of ligusticum wallichii, 10-20 parts of tangerine pith, 15-20 parts of radix clematidis, 20-30 parts of spina gleditsiae, 4-7 parts of saffron crocus, 30-40 parts of ginseng, 0.3-0.4 part of borneol, 15-20 parts of semen brassicae and 18-25 parts of rhizoma corydalis preparata.
3. The traditional Chinese medicine composition for treating hyperplasia of mammary glands according to claim 2, wherein the raw materials comprise, in parts by weight: 36 parts of red sage root, 30 parts of szechuan lovage rhizome, 13 parts of tangerine pith, 17 parts of clematis root, 24 parts of spina gleditsiae, 6 parts of saffron crocus, 35 parts of ginseng, 0.4 part of borneol, 18 parts of white mustard seed and 21 parts of prepared corydalis tuber.
4. A Chinese medicinal preparation for treating hyperplasia of mammary glands, which is characterized by being prepared from the Chinese medicinal composition for treating hyperplasia of mammary glands according to any one of claims 1 to 3.
5. The Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 4, which is externally applied cataplasm.
6. The Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 5, wherein the external cataplasm comprises a bearing substrate layer, a hydrophilic gel layer and a release layer in sequence, wherein the hydrophilic gel layer contains effective extracts of the Chinese medicinal composition for treating mammary gland hyperplasia according to any one of claims 1 to 3.
7. The Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 6, wherein the preparation method of the hydrophilic gel layer comprises the following steps:
(1) taking saffron crocus according to the preset weight part, performing reflux extraction for 1-4 times by using 40-90% ethanol, combining all extracting solutions, and concentrating into an extract;
(2) mixing red sage root, ligusticum wallichii, tangerine pith, clematis root, spina gleditsiae, ginseng, white mustard seed and prepared rhizoma corydalis according to preset weight parts, adding water for decocting at least twice, combining all decoctions, precipitating the decoctions with ethanol, filtering, concentrating and drying the filtrate to obtain dry paste, and preparing the dry paste into powder;
(3) taking borneol according to a preset weight part, and dissolving the borneol with 50-95% ethanol to obtain a borneol solution;
(4) mixing the Borneolum Syntheticum solution, the extract, and the dry extract powder, adding gelatin into the mixture, and making into gel solution;
(5) and uniformly coating the gel liquid on a carrier, and cooling to form the hydrophilic gel layer.
8. The Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 7, wherein in the step (1), the time for each reflux extraction is 0.5-3 h.
9. The Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 7, wherein in the step (2), the amount of water added is 5-15 times of the amount of the medicament per decoction, and each decoction is carried out for 0.5-2 h.
10. The Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 4, which is an external application or an external smearing agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010315351.7A CN111514216A (en) | 2020-04-21 | 2020-04-21 | Traditional Chinese medicine composition and preparation for treating hyperplasia of mammary glands |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010315351.7A CN111514216A (en) | 2020-04-21 | 2020-04-21 | Traditional Chinese medicine composition and preparation for treating hyperplasia of mammary glands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111514216A true CN111514216A (en) | 2020-08-11 |
Family
ID=71903620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010315351.7A Pending CN111514216A (en) | 2020-04-21 | 2020-04-21 | Traditional Chinese medicine composition and preparation for treating hyperplasia of mammary glands |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111514216A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274450A (en) * | 2010-06-09 | 2011-12-14 | 买建修 | Breast pain syndrome dispersing paste |
| CN104306439A (en) * | 2014-10-27 | 2015-01-28 | 安丘市金铠甲医药研发有限公司 | Plaster for treating tumor and preparation method of plaster |
| CN105943670A (en) * | 2016-06-15 | 2016-09-21 | 曲宝锋 | Formula for medicine of bra insertion pieces and preparing technology of bra insertion pieces |
-
2020
- 2020-04-21 CN CN202010315351.7A patent/CN111514216A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274450A (en) * | 2010-06-09 | 2011-12-14 | 买建修 | Breast pain syndrome dispersing paste |
| CN104306439A (en) * | 2014-10-27 | 2015-01-28 | 安丘市金铠甲医药研发有限公司 | Plaster for treating tumor and preparation method of plaster |
| CN105943670A (en) * | 2016-06-15 | 2016-09-21 | 曲宝锋 | Formula for medicine of bra insertion pieces and preparing technology of bra insertion pieces |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1217681C (en) | Externally applied paste for treating fracture and injured tendons | |
| CN106236854B (en) | Traditional Chinese medicine composition for treating arthritis and application thereof | |
| CN1323699C (en) | Externally applied plaster for treating Bi syndrome and preparation method thereof | |
| CN100473402C (en) | Medicine for treating protrusion of intervetebral disc and cervical vertebra disease | |
| CN109453288B (en) | Pharmaceutical composition and traditional Chinese medicine raw material composition for treating plasma cell mastitis | |
| CN101057942A (en) | External applied medicine ointment for treating diabetes foot and its preparing method | |
| CN111514216A (en) | Traditional Chinese medicine composition and preparation for treating hyperplasia of mammary glands | |
| CN109432203B (en) | Pharmaceutical composition and traditional Chinese medicine raw material composition for treating non-lactation mastitis | |
| CN1112208C (en) | Chinese medicine for treating intraocular hemorrhage | |
| CN1557445A (en) | Chinese prepared medicine for treating cervical spondylopathy | |
| CN115463205A (en) | Traditional Chinese medicine composition with hair blackening, hair growing and hair caring effects, traditional Chinese medicine preparation, and preparation method and application thereof | |
| CN1302803C (en) | External use liquid formulation for dermatosis | |
| CN116459303B (en) | Chinese medicinal preparation for treating vitiligo and preparation method thereof | |
| CN101953943A (en) | Traditional Chinese medicine for treating chronic aplastic anemia | |
| CN101919978A (en) | Traditional Chinese medicine composition, preparation method and application thereof | |
| CN108126165A (en) | The preparation method of puerperal blood clot dispersing particle | |
| CN101496841A (en) | Chinese medicinal composition for promoting bone fracture healing and preparation method thereof | |
| CN1403123A (en) | Notoginseng medicine for treating traumatic injury and its prepn | |
| CN114949151A (en) | External product for treating neck, shoulder, waist and leg pain and production process thereof | |
| CN1049594C (en) | Rubber plaster for hyperosteogeny | |
| CN110721229A (en) | Formula essential oil for treating hyperplasia of mammary glands | |
| CN104383205A (en) | Muscle relaxing and blood circulation stimulating medicine liquor externally used for treating orthopedic diseases | |
| CN105168722A (en) | Tissue regeneration and mark removal ointment and preparation method thereof | |
| CN116617352A (en) | External traditional Chinese medicine composition for improving naked eyes and preparation process thereof | |
| CN116870054A (en) | Traditional Chinese medicine composition, application, gel and preparation method of gel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200811 |