CN111512159A - 结核诊断方法 - Google Patents
结核诊断方法 Download PDFInfo
- Publication number
- CN111512159A CN111512159A CN201880083123.2A CN201880083123A CN111512159A CN 111512159 A CN111512159 A CN 111512159A CN 201880083123 A CN201880083123 A CN 201880083123A CN 111512159 A CN111512159 A CN 111512159A
- Authority
- CN
- China
- Prior art keywords
- tuberculosis
- antigen
- antibody
- treating
- diagnostic method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000008827 tuberculosis Diseases 0.000 title claims abstract description 99
- 238000002405 diagnostic procedure Methods 0.000 title claims description 14
- 239000000427 antigen Substances 0.000 claims abstract description 106
- 102000036639 antigens Human genes 0.000 claims abstract description 99
- 108091007433 antigens Proteins 0.000 claims abstract description 99
- 239000000126 substance Substances 0.000 claims abstract description 38
- 238000001514 detection method Methods 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 34
- 230000002378 acidificating effect Effects 0.000 claims abstract description 29
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 28
- 230000003472 neutralizing effect Effects 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 239000004471 Glycine Substances 0.000 claims description 14
- 239000000872 buffer Substances 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 210000002966 serum Anatomy 0.000 claims description 7
- 239000007853 buffer solution Substances 0.000 claims description 6
- 230000003248 secreting effect Effects 0.000 claims description 6
- 239000007790 solid phase Substances 0.000 claims description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims description 5
- 101710088334 Diacylglycerol acyltransferase/mycolyltransferase Ag85B Proteins 0.000 claims description 4
- 206010036790 Productive cough Diseases 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 210000003802 sputum Anatomy 0.000 claims description 4
- 208000024794 sputum Diseases 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 206010062767 Hypophysitis Diseases 0.000 claims description 3
- 239000008351 acetate buffer Substances 0.000 claims description 3
- 239000012445 acidic reagent Substances 0.000 claims description 3
- 239000007979 citrate buffer Substances 0.000 claims description 3
- 210000003635 pituitary gland Anatomy 0.000 claims description 3
- 101710088335 Diacylglycerol acyltransferase/mycolyltransferase Ag85A Proteins 0.000 claims description 2
- 101710088427 Diacylglycerol acyltransferase/mycolyltransferase Ag85C Proteins 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 210000003296 saliva Anatomy 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims 3
- 238000008157 ELISA kit Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 abstract description 35
- 230000009257 reactivity Effects 0.000 abstract 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 16
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 14
- 238000006386 neutralization reaction Methods 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 11
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 10
- 239000005018 casein Substances 0.000 description 8
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 8
- 235000021240 caseins Nutrition 0.000 description 8
- 101150079015 esxB gene Proteins 0.000 description 7
- 239000010931 gold Substances 0.000 description 7
- 229910052737 gold Inorganic materials 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000002365 anti-tubercular Effects 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- GICLSALZHXCILJ-UHFFFAOYSA-N ctk5a5089 Chemical compound NCC(O)=O.NCC(O)=O GICLSALZHXCILJ-UHFFFAOYSA-N 0.000 description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 5
- 238000003317 immunochromatography Methods 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- 101001057048 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) ESAT-6-like protein EsxB Proteins 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 239000003365 glass fiber Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- 229920004890 Triton X-100 Polymers 0.000 description 3
- 239000013504 Triton X-100 Substances 0.000 description 3
- 239000002981 blocking agent Substances 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000016359 Fibronectins Human genes 0.000 description 2
- 108010067306 Fibronectins Proteins 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- HFNQLYDPNAZRCH-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O.OC(O)=O HFNQLYDPNAZRCH-UHFFFAOYSA-N 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- ZPIRTVJRHUMMOI-UHFFFAOYSA-N octoxybenzene Chemical compound CCCCCCCCOC1=CC=CC=C1 ZPIRTVJRHUMMOI-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000012123 point-of-care testing Methods 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- IMCUVBSHZXQITN-UHFFFAOYSA-N 4-[[4-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-1,3-thiazol-2-yl]amino]-4-oxobutanoic acid Chemical compound S1C(NC(=O)CCC(O)=O)=NC(C=2C=CC(Cl)=CC=2)=C1CC(=O)OC IMCUVBSHZXQITN-UHFFFAOYSA-N 0.000 description 1
- 241000304886 Bacilli Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 206010065048 Latent tuberculosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- -1 Polyoxyethylene octyl phenyl ether Polymers 0.000 description 1
- 208000036981 active tuberculosis Diseases 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002102 nanobead Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229920002114 octoxynol-9 Polymers 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/5375—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/5695—Mycobacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2470/00—Immunochemical assays or immunoassays characterised by the reaction format or reaction type
- G01N2470/04—Sandwich assay format
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2017-0178159 | 2017-12-22 | ||
KR20170178159 | 2017-12-22 | ||
PCT/KR2018/016434 WO2019125034A1 (fr) | 2017-12-22 | 2018-12-21 | Méthode de diagnostic de la tuberculose |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111512159A true CN111512159A (zh) | 2020-08-07 |
Family
ID=66993586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880083123.2A Pending CN111512159A (zh) | 2017-12-22 | 2018-12-21 | 结核诊断方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20210072235A1 (fr) |
EP (1) | EP3726219A4 (fr) |
JP (1) | JP2021508836A (fr) |
KR (1) | KR20190076897A (fr) |
CN (1) | CN111512159A (fr) |
WO (1) | WO2019125034A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3164027A1 (fr) * | 2019-12-09 | 2021-06-17 | Versiti Blood Research Institute Foundation Inc. | Constructions bcg car et leurs procedes de preparation et d'utilisation |
KR102351951B1 (ko) * | 2020-05-06 | 2022-01-17 | 한국원자력연구원 | 결핵균을 검출하는 방법 |
KR20230102652A (ko) | 2021-12-30 | 2023-07-07 | 한국화학연구원 | 결핵균 항원 또는 항체 검출용 산화아연 나노선 어레이의 제조방법 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002062299A (ja) * | 2000-08-24 | 2002-02-28 | Kyowa Medex Co Ltd | 結核菌の検出方法及び試薬 |
CN1694725A (zh) * | 2001-08-02 | 2005-11-09 | 纽约大学 | 肽在早期检测分枝杆菌疾病中的应用 |
JPWO2009084481A1 (ja) * | 2007-12-28 | 2011-05-19 | 株式会社ビーエル | 結核菌群の免疫検出法 |
CN103864907A (zh) * | 2012-12-18 | 2014-06-18 | 中国医学科学院病原生物学研究所 | 用于结核病诊断的蛋白以及试剂盒 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5384240A (en) * | 1992-11-25 | 1995-01-24 | Akzo Nobel, N.V. | Base dissociation assay |
US20090280474A1 (en) * | 2008-05-08 | 2009-11-12 | Abbott Laboratories | Method for detecting a virus |
US8450076B2 (en) * | 2008-09-11 | 2013-05-28 | Institut Pasteur | Monitoring and inhibiting human immunodeficiency virus infection by modulating HMGB1 dependent triggering of HIV-1 replication and persistence |
SG10201600531TA (en) * | 2011-01-24 | 2016-02-26 | Univ Singapore | Pathogenic mycobacteria-derived mannose-capped lipoarabinomannan antigen binding proteins |
KR101707291B1 (ko) * | 2012-02-29 | 2017-02-15 | 오쓰까 세이야꾸 가부시키가이샤 | 항리포아라비노만난 항체 및 당해 항체를 사용한 항산균증의 이뮤노어세이 |
US20150355178A1 (en) * | 2012-09-04 | 2015-12-10 | Mbio Diagnostics, Inc. | System and method for improving biomarker assay |
KR101524109B1 (ko) | 2014-03-14 | 2015-06-02 | 충남대학교산학협력단 | 결핵균 특이항원에 대한 항체가 결합되어 있는 나노바이오센서 및 이를 이용한 결핵균 검출진단법 |
WO2016130638A1 (fr) * | 2015-02-10 | 2016-08-18 | University Of Utah Research Foundation | Procédés de détection d'analytes et de diagnostic de la tuberculose |
KR20170011200A (ko) * | 2015-07-22 | 2017-02-02 | 사단법인대한결핵협회 | 결핵 특이 항원의 융합 단백질, 이의 효율적 생산방법 및 이의 용도 |
-
2018
- 2018-12-21 KR KR1020180167278A patent/KR20190076897A/ko not_active IP Right Cessation
- 2018-12-21 JP JP2020555001A patent/JP2021508836A/ja active Pending
- 2018-12-21 WO PCT/KR2018/016434 patent/WO2019125034A1/fr unknown
- 2018-12-21 US US16/955,934 patent/US20210072235A1/en not_active Abandoned
- 2018-12-21 EP EP18892688.5A patent/EP3726219A4/fr not_active Withdrawn
- 2018-12-21 CN CN201880083123.2A patent/CN111512159A/zh active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002062299A (ja) * | 2000-08-24 | 2002-02-28 | Kyowa Medex Co Ltd | 結核菌の検出方法及び試薬 |
CN1694725A (zh) * | 2001-08-02 | 2005-11-09 | 纽约大学 | 肽在早期检测分枝杆菌疾病中的应用 |
JPWO2009084481A1 (ja) * | 2007-12-28 | 2011-05-19 | 株式会社ビーエル | 結核菌群の免疫検出法 |
CN103864907A (zh) * | 2012-12-18 | 2014-06-18 | 中国医学科学院病原生物学研究所 | 用于结核病诊断的蛋白以及试剂盒 |
Non-Patent Citations (1)
Title |
---|
A.G.KHOMENKO,ETC,: ""Serodiagnosis of tuberculosis: detection of mycobacterial antibodies and antigens"", <TUBERCLE AND LUNG DISEASE> * |
Also Published As
Publication number | Publication date |
---|---|
WO2019125034A1 (fr) | 2019-06-27 |
EP3726219A1 (fr) | 2020-10-21 |
JP2021508836A (ja) | 2021-03-11 |
US20210072235A1 (en) | 2021-03-11 |
KR20190076897A (ko) | 2019-07-02 |
EP3726219A4 (fr) | 2021-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2020233741B2 (en) | Method and device for combined detection of viral and bacterial infections | |
Mukundan et al. | Rapid detection of Mycobacterium tuberculosis biomarkers in a sandwich immunoassay format using a waveguide-based optical biosensor | |
US10379121B2 (en) | Method and device for combined detection of viral and bacterial infections | |
US6841159B2 (en) | Rapid lateral flow assay for determining exposure to Mycobacterium tuberculosis and other mycobacteria | |
US8962260B2 (en) | Method and device for combined detection of viral and bacterial infections | |
WO2019153630A1 (fr) | Kit de détection de la calprotectine dans les selles humaines et méthode de préparation | |
US20070059682A1 (en) | Method to increase specificity and/or accuracy of lateral flow immunoassays | |
CN111512159A (zh) | 结核诊断方法 | |
US10859575B2 (en) | Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates | |
RU2214835C2 (ru) | Метод обнаружения антител к трансглутаминазе для применения в диагностике целиакии | |
Bhargava et al. | Evaluation of enzyme-linked immunosorbent assay using mycobacterial saline-extracted antigen for the serodiagnosis of abdominal tuberculosis. | |
KR20170002347A (ko) | 결핵 특이적 항원에 대한 항체반응검사를 이용한 결핵 진단 방법 | |
RU181920U1 (ru) | Иммуночип для трепонема-специфической серологической диагностики сифилиса | |
RU2532352C2 (ru) | Способ проведения иммунохроматографического анализа для серодиагностики | |
RU2395092C2 (ru) | Способ определения антител к возбудителю туберкулеза | |
JP2006234627A (ja) | 体液中の結核菌抗原を検出する方法 | |
US11204351B2 (en) | Compositions and methods for identifying Ehrlichia species | |
Rivera et al. | Current and upcoming point-of-care diagnostics for schistosomiasis | |
RU2794855C1 (ru) | Способ диагностики туберкулеза | |
KR20160139888A (ko) | 결핵 특이적 항원에 대한 항체반응검사를 이용한 결핵 진단 방법 | |
Deodhar et al. | Standardization of a dot blot immunoassay for antigen detection in cases of pulmonary tuberculosis & its evaluation with respect to the conventional techniques | |
JP2024030655A (ja) | リンパ球性下垂体前葉炎及び副腎皮質刺激ホルモン単独欠損症の検査のための試薬及び検査方法 | |
KR20230139802A (ko) | 검체 유효성 확인선 및 이를 포함하는 면역진단키트 | |
JP2009288065A (ja) | Shigatoxin2e及びShigatoxin2eに対する抗体の検出方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WD01 | Invention patent application deemed withdrawn after publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200807 |