CN111494570A - Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof Download PDFInfo
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- CN111494570A CN111494570A CN202010405896.7A CN202010405896A CN111494570A CN 111494570 A CN111494570 A CN 111494570A CN 202010405896 A CN202010405896 A CN 202010405896A CN 111494570 A CN111494570 A CN 111494570A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
The invention relates to the technical field of biological medicines, and discloses a traditional Chinese medicine composition for treating diabetes, which is prepared from the following raw materials: quinoa, tartary buckwheat, oat, coix seed and konjak. The invention also discloses a preparation method and application of the traditional Chinese medicine composition. The medicine prepared based on the traditional Chinese medicine composition has the advantages of obvious effect, convenient use and long persistence.
Description
Technical Field
The invention relates to the technical field of biological medicines, in particular to a traditional Chinese medicine composition for treating diabetes, a preparation method and application thereof.
Background
Diabetes mellitus is a chronic endocrine metabolic disease which causes disorder of metabolism of sugar, fat and protein due to insufficient secretion of insulin in a body, causes increase of blood sugar in the body and excretes diabetes. The clinical manifestations are polydipsia, diuresis, polyphagia, fatigue and emaciation. If further development is carried out, complications such as atherosclerosis, microangiopathy, nervous system and the like can be caused, and the health and the life of the human are threatened.
Diabetes is divided into two types, i.e., type I and type II. Type I is insulin dependent, and type II is non-insulin dependent. Among them, type II patients account for about 90% of the total number of diabetic patients, seriously threaten the health and life of people, and at present, there is no ideal medicine for treating both symptoms and root causes at home and abroad.
At present, most of the medicines for treating diabetes have certain curative effect, but most of the western medicines used clinically have large adverse reactions, such as rebound after stopping taking the medicines, liver and kidney damage of patients, rhabdomyolysis and other side effects, and are used for treating symptoms and not treating the root causes. The traditional Chinese medicine has unique advantages in the aspect of treating diabetes, has a plurality of traditional Chinese medicine prescriptions for preventing and treating diabetes, has a long-lasting curative effect, and mostly has no obvious toxic or side effect, but the traditional Chinese medicine for treating diabetes is mostly preferred to a single prescription and an proved prescription at present, and lacks of the clinical pharmacodynamic study with complete system. Therefore, based on the theory of traditional Chinese medicine and traditional Chinese medicine, the method has important significance in actively searching and making efforts to develop traditional Chinese medicines for treating diabetes (especially for treating type II diabetes) and preventing and treating various complications caused by diabetes according to the pathogenesis of diabetes.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating diabetes, a preparation method and application thereof.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating diabetes comprises the following raw materials: quinoa, tartary buckwheat, oat, coix seed and konjak.
Preferably, the traditional Chinese medicine composition for treating diabetes is prepared from the following raw materials in parts by weight: 5-12 parts of quinoa, 8-14 parts of tartary buckwheat, 2-5 parts of oat, 6-10 parts of coix seed and 1-3 parts of konjak.
More preferably, the traditional Chinese medicine composition for treating diabetes is prepared from the following raw materials in parts by weight: 8 parts of quinoa, 11 parts of tartary buckwheat, 3 parts of oat, 8 parts of coix seed and 2 parts of konjak.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating or preventing diabetes.
In the invention, the medicine is powder, decoction, dripping pills, micro pills, granules, tablets, hard capsules, soft capsules, mixture, syrup, control preparation or sustained release preparation.
Preferably, the medicament is a pellet.
The invention also provides a preparation method of the medicine, which comprises the following steps:
(1) curing the quinoa, the tartary buckwheat, the oat and the coix seed in parts by weight, removing bran, and respectively reserving seeds and bran for later use;
(2) puffing quinoa, tartary buckwheat, oat and coix seed without bran by using microwave, then crushing the puffed quinoa, the tartary buckwheat, the oat and the coix seed together with konjak, sieving and mixing;
(3) extracting the mixed powder in the step (2) with water or ethanol, filtering, combining the extracting solutions, and concentrating to obtain a concentrated solution;
(4) diluting the concentrated solution in the step (3) with water, uniformly stirring to obtain a drug-containing solution, and then spraying the drug-containing solution onto the blank pellet cores by adopting a centrifugal spray dryer to obtain drug-containing pellet cores;
(5) crushing the bran in the step (1), sieving, uniformly mixing with talcum powder to obtain mixed powder, placing the drug-containing pellet core and the mixed powder in the step (4) into a fluidized bed pot, adding pharmaceutically acceptable auxiliary materials, uniformly mixing until a layer of uniform powder layer is formed on the surface of the drug-containing pellet core to obtain drug-containing pellets, and finally coating the drug-containing pellets by using a coating liquid to obtain the target pellets.
Wherein the mass ratio of the medicine-containing solution in the step (4) to the mixed powder in the step (5) is 4-5: 1.
wherein in the mixed powder, the weight ratio of bran to the talcum powder is 1: 3.
more preferably, the mixed powder is sieved through a 800 mesh sieve.
The invention provides a traditional Chinese medicine composition which contains quinoa, tartary buckwheat, oat, coix seed and konjak components, has a good blood sugar reduction effect, and can be used for preparing a medicine for treating or preventing diabetes. The medicine prepared based on the traditional Chinese medicine composition has the advantages of obvious effect, convenient use and long persistence.
Detailed Description
The present invention is further illustrated by the following specific examples, which are not intended to limit the scope of the invention as claimed herein, in regard to the particular data and operations involved.
Example 1 preparation of target pellet 1
Consists of the following components: 50g of quinoa, 80g of tartary buckwheat, 20g of oat, 60g of coix seed and 10g of konjak.
The preparation method comprises the following steps:
(1) curing the quinoa, the tartary buckwheat, the oat and the coix seed in parts by weight, removing bran, and respectively reserving seeds and bran for later use;
(2) puffing quinoa, tartary buckwheat, oat and coix seed without bran by using microwave, then crushing the puffed quinoa, the tartary buckwheat, the oat and the coix seed together with konjak, sieving and mixing;
(3) extracting the mixed powder in the step (2) with water or ethanol, filtering, combining the extracting solutions, and concentrating to obtain a concentrated solution;
(4) diluting the concentrated solution in the step (3) with water, uniformly stirring to obtain a drug-containing solution, and then spraying the drug-containing solution onto the blank pellet cores by adopting a centrifugal spray dryer to obtain drug-containing pellet cores;
(5) crushing the bran in the step (1), sieving, uniformly mixing with talcum powder to obtain mixed powder, and sieving with an 800-mesh sieve, wherein the weight ratio of the bran to the talcum powder in the mixed powder is 1: and 3, placing the pill-containing core obtained in the step 4 and the mixed powder into a fluidized bed pan, wherein the mass ratio of the medicine-containing solution obtained in the step 4 to the mixed powder is (4-5): 1, preferably 4.5:1, adding pharmaceutically acceptable auxiliary materials, uniformly mixing until a layer of uniform powder layer is formed on the surface of the drug-containing pellet core to obtain the drug-containing pellet, and finally coating the drug-containing pellet by using a coating solution to obtain the target pellet 1.
Example 2 preparation of target pellets 2
Consists of the following components: 80g of quinoa, 110g of tartary buckwheat, 30g of oat, 80g of coix seed and 20g of konjak.
The preparation method comprises the following steps:
(1) curing the quinoa, the tartary buckwheat, the oat and the coix seed in parts by weight, removing bran, and respectively reserving seeds and bran for later use;
(2) puffing quinoa, tartary buckwheat, oat and coix seed without bran by using microwave, then crushing the puffed quinoa, the tartary buckwheat, the oat and the coix seed together with konjak, sieving and mixing;
(3) extracting the mixed powder in the step (2) with water or ethanol, filtering, combining the extracting solutions, and concentrating to obtain a concentrated solution;
(4) diluting the concentrated solution in the step (3) with water, uniformly stirring to obtain a drug-containing solution, and then spraying the drug-containing solution onto the blank pellet cores by adopting a centrifugal spray dryer to obtain drug-containing pellet cores;
(5) crushing the bran in the step (1), sieving, uniformly mixing with talcum powder to obtain mixed powder, and sieving with an 800-mesh sieve, wherein the weight ratio of the bran to the talcum powder in the mixed powder is 1: and 3, placing the pill-containing core obtained in the step 4 and the mixed powder into a fluidized bed pan, wherein the mass ratio of the medicine-containing solution obtained in the step 4 to the mixed powder is (4-5): 1, preferably 4.5:1, adding pharmaceutically acceptable auxiliary materials, uniformly mixing until a layer of uniform powder layer is formed on the surface of the drug-containing pellet core to obtain the drug-containing pellet, and finally coating the drug-containing pellet by using a coating solution to obtain the target pellet 2.
Example 3 preparation of target pellets 3
Consists of the following components: 120g of quinoa, 140g of tartary buckwheat, 50g of oat, 100g of coix seed and 30g of konjak.
The preparation method comprises the following steps:
(1) curing the quinoa, the tartary buckwheat, the oat and the coix seed in parts by weight, removing bran, and respectively reserving seeds and bran for later use;
(2) puffing quinoa, tartary buckwheat, oat and coix seed without bran by using microwave, then crushing the puffed quinoa, the tartary buckwheat, the oat and the coix seed together with konjak, sieving and mixing;
(3) extracting the mixed powder in the step (2) with water or ethanol, filtering, combining the extracting solutions, and concentrating to obtain a concentrated solution;
(4) diluting the concentrated solution in the step (3) with water, uniformly stirring to obtain a drug-containing solution, and then spraying the drug-containing solution onto the blank pellet cores by adopting a centrifugal spray dryer to obtain drug-containing pellet cores;
(5) crushing the bran in the step (1), sieving, uniformly mixing with talcum powder to obtain mixed powder, and sieving with an 800-mesh sieve, wherein the weight ratio of the bran to the talcum powder in the mixed powder is 1: and 3, placing the pill-containing core obtained in the step 4 and the mixed powder into a fluidized bed pan, wherein the mass ratio of the medicine-containing solution obtained in the step 4 to the mixed powder is (4-5): 1, preferably 4.5:1, adding pharmaceutically acceptable auxiliary materials, uniformly mixing until a layer of uniform powder layer is formed on the surface of the drug-containing pellet core to obtain the drug-containing pellet, and finally coating the drug-containing pellet by using a coating solution to obtain the target pellet 3.
Test example 1 selection of powder layer
And (3) placing the drug-containing pellet core prepared in the step (4) in a fluidized bed pan, then scattering the following powder layers shown in the table 1 into the pan, uniformly mixing to form a layer of uniform powder layer on the surface of the drug-containing pellet core to obtain a drug-containing pellet, and finally coating the drug-containing pellet by using a coating liquid to obtain the target pellet.
Table 1: material for powder layer
It can be seen from the above data that when bran is completely selected as the powder layer, coating cannot be smoothly performed, meanwhile, the coating time is too long, and when talc powder is completely selected or the ratio of bran to talc powder exceeds 1:3, a sticky phenomenon occurs when the powder layer is prepared, so that bran is selected: the talc powder in the ratio of 1:3 can obtain better pellet yield, and the coating time is also suitable.
Test example 2: influence on the hypoglycemic function of rats
1. Material
Rats with combined male and female weight of 1800-250g were supplied from the experimental animal center of Guiyang medical school.
The reagent Streptomycin (STZ) available from Sigma company, usa;
glibenclamide: hebei Sanshi pharmaceuticals GmbH;
2. method of producing a composite material
(1) Molding method
Rats are fasted and are not forbidden to be watered for 12-16h, STZ solution (fresh preparation) prepared by 0.1 mol/L and PH4.2 sodium citrate buffer solution (refrigeration) is injected into abdominal cavity for 1 time, blood sugar is detected after 7 days of modeling, and random blood sugar value is larger than 13.1 mmol/L, so that the model is successful.
(2) Animal grouping and administration
Grouping: rats were divided into groups of 10 rats (male and female) according to the weight random average, and the groups were divided into: blank control group, model control group, positive control group, test drug group (refer to pellets prepared by the method of example 2).
Administration experiment:
blank control group: eating basic feed and freely drinking water;
model control group: eating basic feed and freely drinking water;
positive control group: the glibenclamide is given on the basis of model-making rats, and during the administration period, basic feed is eaten and water is freely drunk;
test drug groups: the pellets prepared by the method of example 2 of the present invention (the pellets were pulverized and diluted with water to prepare a drug solution containing 1.59g/ml of the crude drug) were administered to model rats, during which time the basic feed was consumed and the water was freely drunk;
animals of the positive control group and the tested drug group are dosed for 1 time every day, and are continuously dosed for one month, and are fasted for 12 hours after the last dosing, and a blood glucose monitor and a test strip are adopted to measure the fasting blood glucose value by taking blood from the tail vein.
Table 2: mean + -SD of the effects of the test drug on blood glucose of the animals of each group one month later
| Group of | Blank control group | Model control group | Positive control group | Test drug group |
| Blood sugar (mmol/L) | 5.28±0.59 | 30.15±6.24 | 11.01±2.78 | 12.32±3.05 |
From the above results, it can be seen that the drug of the present invention has a good hypoglycemic effect.
In order to examine the influence of bran on the blood sugar of each group of animals, the target pellets were prepared according to the weight of the medicinal materials given in example 2, and the powder materials given in table 1 were respectively selected as the tested drug group a, the tested drug group b, the tested drug group c, the tested drug group d, the tested drug group e, the tested drug group f and the tested drug group g in the preparation process. The hypoglycemic effects thereof are shown in table 3 below.
Table 3: mean + -SD of the effect of bran content on blood glucose of various groups of animals
It can be seen from the above table that the bran of the traditional Chinese medicine raw material medicine is directly selected as a part of the powder layer, so that the medicinal material can be fully utilized, and the bran can obviously improve the blood sugar reducing effect.
To examine the persistence and rebound effect of the drug effect, the blood glucose values of the animals in each group were measured after the test drug group (pellet prepared by the method of example 2 of the present invention) and the positive control group were stopped for one week, and the results are shown in table 4:
TABLE 4 blood glucose values (mmol/L) for each group of animals after one week of withdrawal
| Group of | Test drug group | Positive control group |
| Blood sugar (mmol/L) | 15.77±3.14 | 20.69±4.52 |
From the above results, the tested drug group has a better continuous hypoglycemic effect than the positive control group.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A traditional Chinese medicine composition for treating diabetes is characterized by comprising the following raw materials: quinoa, tartary buckwheat, oat, coix seed and konjak.
2. The traditional Chinese medicine composition for treating diabetes according to claim 1, which is prepared from the following raw materials in parts by weight: 5-12 parts of quinoa, 8-14 parts of tartary buckwheat, 2-5 parts of oat, 6-10 parts of coix seed and 1-3 parts of konjak.
3. The traditional Chinese medicine composition for treating diabetes according to claim 1, which is prepared from the following raw materials in parts by weight: 8 parts of quinoa, 11 parts of tartary buckwheat, 3 parts of oat, 8 parts of coix seed and 2 parts of konjak.
4. Use of the Chinese medicinal composition according to any one of claims 1 to 3 in the preparation of a medicament for the treatment or prevention of diabetes.
5. Use according to claim 4, characterized in that: the medicine is powder, decoction, dripping pill, pellet, granule, tablet, hard capsule, soft capsule, mixture, syrup, controlled preparation or sustained release preparation.
6. Use according to claim 5, characterized in that: the medicine is a pellet.
7. A process for the preparation of a medicament according to claim 6, characterized in that: the method comprises the following steps:
(1) curing the quinoa, the tartary buckwheat, the oat and the coix seed in parts by weight, removing bran, and respectively reserving seeds and bran for later use;
(2) puffing quinoa, tartary buckwheat, oat and coix seed without bran by using microwave, then crushing the puffed quinoa, the tartary buckwheat, the oat and the coix seed together with konjak, sieving and mixing;
(3) extracting the mixed powder in the step (2) with water or ethanol, filtering, combining the extracting solutions, and concentrating to obtain a concentrated solution;
(4) diluting the concentrated solution in the step (3) with water, uniformly stirring to obtain a drug-containing solution, and then spraying the drug-containing solution onto the blank pellet cores by adopting a centrifugal spray dryer to obtain drug-containing pellet cores;
(5) crushing the bran in the step (1), sieving, uniformly mixing with talcum powder to obtain mixed powder, placing the drug-containing pellet core and the mixed powder in the step (4) into a fluidized bed pot, adding pharmaceutically acceptable auxiliary materials, uniformly mixing until a layer of uniform powder layer is formed on the surface of the drug-containing pellet core to obtain drug-containing pellets, and finally coating the drug-containing pellets by using a coating liquid to obtain the target pellets.
8. The method of claim 7, wherein: the mass ratio of the medicine-containing solution in the step (4) to the mixed powder in the step (5) is 4-5: 1.
9. the method of claim 7, wherein: in the mixed powder, the weight ratio of the bran to the talcum powder is 1: 3.
10. the production method according to any one of claims 7 to 9, characterized in that: the mixed powder is sieved by a 800-mesh sieve.
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| CN202010405896.7A CN111494570A (en) | 2020-05-14 | 2020-05-14 | Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof |
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Citations (5)
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| CN101416760A (en) * | 2007-10-22 | 2009-04-29 | 陶顺海 | The production method of mountain delicacies giantarum paste |
| CN106620090A (en) * | 2017-02-24 | 2017-05-10 | 贵州神奇老年病研究院 | Composition for reducing blood glucose, and preparation method of composition |
| CN109925296A (en) * | 2017-12-19 | 2019-06-25 | 四川济生堂药业有限公司 | A kind of coating method of traditional Chinese medicine pellet |
| CN110367526A (en) * | 2019-08-14 | 2019-10-25 | 甘肃省轻工研究院有限责任公司 | A kind of low sugar content and high fiber content nutritional meal replacement powder |
| CN110771880A (en) * | 2019-11-08 | 2020-02-11 | 国家半干旱农业工程技术研究中心 | Blood sugar-reducing quinoa meal replacement powder and preparation process thereof |
-
2020
- 2020-05-14 CN CN202010405896.7A patent/CN111494570A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416760A (en) * | 2007-10-22 | 2009-04-29 | 陶顺海 | The production method of mountain delicacies giantarum paste |
| CN106620090A (en) * | 2017-02-24 | 2017-05-10 | 贵州神奇老年病研究院 | Composition for reducing blood glucose, and preparation method of composition |
| CN109925296A (en) * | 2017-12-19 | 2019-06-25 | 四川济生堂药业有限公司 | A kind of coating method of traditional Chinese medicine pellet |
| CN110367526A (en) * | 2019-08-14 | 2019-10-25 | 甘肃省轻工研究院有限责任公司 | A kind of low sugar content and high fiber content nutritional meal replacement powder |
| CN110771880A (en) * | 2019-11-08 | 2020-02-11 | 国家半干旱农业工程技术研究中心 | Blood sugar-reducing quinoa meal replacement powder and preparation process thereof |
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