CN106620090A - Composition for reducing blood glucose, and preparation method of composition - Google Patents
Composition for reducing blood glucose, and preparation method of composition Download PDFInfo
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Abstract
The invention provides a composition for reducing blood glucose, and a preparation method of the composition. The composition is prepared from the following raw materials in parts by weight: 56-84 parts of tartary buckwheat bran (Hmong: Jiu Gaku), 120-180 parts of tartary buckwheat (Hmong: Jiu) flour, 80-120 parts of konjac refined flour and auxiliary materials. The composition is prepared by means of the combined action of konjak and a tartary buckwheat natural product, and shows a significant synergistic effect; compared with the existing composition for reducing the blood glucose, the composition provided by the invention adopts fewer medicinal materials, but gives play to a better curative effect, can remarkably reduces the blood glucose level, and can supplement protein, konjac polysaccharide, multiple vitamins and mineral elements such as potassium, phosphorus and selenium; furthermore, the composition is safe, free from toxic and side effects, less in the used raw materials, low in cost and simple in technology, thus being suitable for industrial large-scale production.
Description
Technical field
The present invention relates to pharmaceutical technology field, more particularly to a kind of hypoglycemic composition and preparation method thereof.
Background technology
Diabetes be one group because insulin active severe lacks and rises the inappropriate rising of C-21 cortico-steroid, cause blood sugar too high,
And cause sugar, fat and protein metabolism disorderly so that the multi-pathogenesis such as body water, electrolyte and acid-base imbalance cause with
The lifelong participation metabolic disease that chronic hyperglycemia is characterized.Long-term blood glucose increases, big blood vessel, capilary be damaged and jeopardize the heart, brain,
Kidney, peripheral nerve, eyes, foot etc., count according to the World Health Organization, and diabetic complication is up to kind more than 100, is to be currently known simultaneously
Send out a kind of most disease of disease.It is that caused by cardiovascular and cerebrovascular, 10% is caused by nephropathy that Diabetes Death person has more than half.Because of sugar
The patient of the sick amputation of urine is ND 10～20 times.Clinical data shows 10 years or so after onset diabetes, will there is 30%
There is a kind of complication, and complication to I haven't seen you for ages once producing in～40% patient, drug therapy is difficult to reverse, therefore emphasizes to the greatest extent
Early prevention diabetic complication.
At present treatment diabetes Western medicine is more, such as sulfonylurea drugs, biguanides, α glucosidase inhibitors, pancreas
Island element sensitizer, meglitinide Insulin secretagogues and insulin etc., hypoglycemic Western medicine has preferable in terms of blood sugar is reduced
Effect, Western medicine hypoglycemic agent can not treat diabetic complication, and large side effects, wherein typical common side effect is low blood
Sugar.Alpha-glucosidase inhibitor, biguanides and insulin sensitizer are used alone will not typically cause hypoglycemia, but and other drugs
Still may occur when being used in conjunction.Patient be possible to occur feel on an empty stomach, be in a cold sweat strongly, general weakness, palpitaition, trick are shaken, eye
Eyeball grows dim, headache, the phenomenon such as stupefied, can go into a coma when serious.Oral carbohydrate is answered or containing glucose beverage, when serious
Answer injectable dextrose monohydrate immediately.During treatment diabetes must be taken, the method laid equal stress on of doctor trained in Western medicine.The characteristics of doctor trained in Western medicine is that curative effect is strong and bright
Really, especially blood sugar reducing function, traditional Chinese medicine can be obviously improved patients clinical symptom, if any patient blood glucose control very well,
Glucose in urine is negative, but still feels that dry is not intended to drink again, and fatigue and weak, this phenomenon of the bad explanation of doctor trained in Western medicine is also special
Method is treated.And the traditional Chinese medical science then thinks that hypoglycemic Western medicine solves the problems, such as " mark ", " sheet " of kidney-yin deficiency is not changed, opinion is mended
The methods such as kidney, yin-nourishing, heat-clearing, dampness removing are effected a permanent cure.
Liuwei Dihuang Wan class medicine is such as used, good effect can be obtained really.The traditional Chinese medical science, another big advantage of Chinese medicine are exactly to control
Treatment complication, the chronic complicating diseases (such as light moderate kidney or eyeground pathological changes, diabetic neuropathy) to diabetes, the traditional Chinese medical science is then
Whole body comprehensive therapy can be taken by diagnosis and treatment, reach satisfied curative effect.Part Chinese medicine also has assistant hypoglycemic to act on.Disease
The lighter diabetes B patient of feelings, can merely take treatment by Chinese herbs on the basis of dietary therapy and physical training；For
The heavier diabetic of the state of an illness, on the basis of Western medicine plus can use treatment by Chinese herbs, can both reach the purpose of rapid hypoglycemic,
Again can comprehensively regulating patient whole body functional status.
The content of the invention
The technical problem to be solved is to provide a kind of hypoglycemic composition and preparation method thereof, said composition
With more preferable hypoglycemic effect, while providing the preparation method of said composition.
In order to solve above-mentioned technical problem, the present invention is adopted the following technical scheme that：
The invention provides a kind of hypoglycemic composition, is made up of the natural products of following weight portion：Tartary buckwheat bran (seedling
Language：Wine loud, high-pitched sound is withered) 56～84 parts, duck wheat (Miao：Wine) 120～180 parts of powder, 80～120 parts of konjaku powder and auxiliary material.
Preferably, composition of the present invention, is made up of the natural products of following weight portion：Tartary buckwheat bran (Miao：Wine
Loud, high-pitched sound is withered) 65～75 parts, duck wheat (Miao：Wine) 135～165 parts of powder, 90～110 parts of konjaku powder and auxiliary material.
It is further preferred that composition of the present invention, is made up of the natural products of following weight portion：Tartary buckwheat bran
(Miao：Wine loud, high-pitched sound is withered) 70 parts, duck wheat (Miao：Wine) 150 parts of powder, 100 parts of konjaku powder and auxiliary material.
Present invention also offers a kind of preparation method for preparing composition described in any one of claims 1 to 3, by duck wheat
Bran, tartary buckwheat powder and konjaku powder add customary adjuvant, and according to common process soft capsule, oral liquid, pill, piece are made
Agent, granule, hard capsule.
The auxiliary material of composition soft preparation of the present invention is calculated as by weight：It is 10 parts of beeswax, 108 parts of gelatin, sweet
54 parts of oil, 1.5 parts of Cacao pigment, 108 parts of compositions of purified water.
The invention provides a kind of preparation method of the composition soft, is made up of following steps：
1) when, konjaku powder, tartary buckwheat powder being heated into 60～80 DEG C, add the beeswax of formula ratio so as to melt, stir
Uniformly, 25～35 DEG C are cooled to, oily wax liquor is obtained, it is standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor, stirring is mixed
Close uniform, be evacuated to -0.06～-0.08MPa, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 60～80 DEG C, gelatin, Cacao pigment are added, is stirred
Mix and boil 1～3h, be evacuated to -0.06～-0.08MPa, take off bubble, 100 mesh screens obtain capsule hide glue gelatin, 55～65
DEG C insulation is standby；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, by capsule-core feed liquid the stock chest of pellet press is transported to
In；Capsule hide glue gelatin is transported in the storage glue groove of pellet press, pellet press is started and be can be prepared by soft capsule.
Preferably, the invention provides a kind of preparation method of the composition soft, is made up of following steps：
1) when, konjaku powder, tartary buckwheat powder being heated into 65～75 DEG C, add the beeswax of formula ratio so as to melt, stir
Uniformly, 30 DEG C are cooled to, oily wax liquor is obtained, it is standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor, stirring mixing is equal
After even, -0.06～-0.08MPa is evacuated to, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 65～75 DEG C, gelatin, Cacao pigment are added, is stirred
Mix and boil 2h, be evacuated to -0.06～-0.08MPa, take off bubble, 100 mesh screens obtain capsule hide glue gelatin, in 55～65 DEG C of guarantors
Warm standby is used；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, by capsule-core feed liquid the stock chest of pellet press is transported to
In；Capsule hide glue gelatin is transported in the storage glue groove of pellet press, pellet press is started and be can be prepared by soft capsule.
Composition weight number of the present invention can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
Duck wheat, Miao Jux (transliteration wine)；Tartary buckwheat bran, Miao Jux ghab khub (transliteration wine loud, high-pitched sound is withered)：Nature and flavor hardship,
Flat, cold, beneficial strength, continuous spirit, sharp knowledge, the effect of sending down abnormally ascending width intestines stomach invigorating, active ingredient includes bioflavonoid, Duo Zhongwei
Mineral matter and the trace element such as raw element, 18 kinds of amino acid, crude protein, chlorophyll and its selenium, zinc, magnesium, chromium, calcium, with can antioxygen
Change, remove interior free yl, anti-aging prevents and treats tumour, cancer, and blood can drop in reducing weight and beautifying features, effect of toxin-expelling and face nourishing
It is pressure, reducing blood lipid, hypoglycemic.Konjaku is cold in nature, pungent, poisonous；Can be promoting blood circulation and removing blood stasis, removing toxicity for detumescence, wide intestines defaecation, resolving phlegm and softening hard masses；Cure mainly
The disease such as hypotensive, hypoglycemic, scrofula subcutaneous nodule, the damage stasis of blood swollen, constipation stomachache, abscess of throat, swelling and aching of gum.In addition, konjaku also has
Replenish the calcium, balance the effect such as salinity, clean stomach, whole intestines, toxin expelling.Konjaku starch-containing 35%, protein 3%, and multivitamin
With the mineral matter element such as potassium, phosphorus, selenium, the SKGM also wanted containing necessary for human, i.e. glucomannans are up to 30%.Amorphophallus
Some species stem tubers be up to 50-65% rich in SKGM, especially white konjaku, elephant-foot yam kind content.
The present invention shows the effect of significant Synergistic by above konjaku and duck wheat natural products collective effect,
Compared with existing hypoglycemic composition, the present invention adopts less medicinal material, plays more preferable curative effect, can significantly hypoglycemic level,
It is starch-containing that konjaku can be supplemented simultaneously, protein, SKGM, and the mineral matter element such as multivitamin and potassium, phosphorus, selenium,
Safe without toxic side effect, raw materials used few, low cost, process is simple is adapted to the big production of industry.
Inventor has carried out pharmacodynamic experiment to hypoglycemic composition, specific as follows：
1. experiment material
1.1 instruments：Visit Anyi Ascensia Brio blood-sugar detecting instruments and blood sugar test paper, Bayer Bitterfeld GmbH (TaiWan, China company
Manufacture), automatic biochemistry analyzer (Japan is uncommon to think Meikang), (the upper grand experimental facilities of Nereid has DKZ-2 type electric heating constant temperature shaking water baths
Limit is public), LDZ5-2 types automatic centrifugal machine (Beijing Medical Centrifugal Machine Factory)
1.2 reagents and medicine：Streptozotocin (STZ) is U.S.'s SIGMA products, by the limited public affairs of Shanghai U.S. season biotechnology
Department's packing, model Sigma 0130, face the used time is made into 2% with 0.1mmol/l PH4.4 citric acid-sodium citrate buffer solutions
STZ solution；Cholesterol (CHOL), lot number 060815 is dispensed by upper sea blue season technology ＆ development Co.；Sodium taurocholate, lot number：
060915, Italy's manufacture, upper sea blue season technology ＆ development Co. packing；Glucose injection, specification 20ml: 10g, lot number
200604182, pharmaceutical factory production is forced by Jiangsu side；Cholesterol (TCHO), triglyceride (TG) kit, are held by Shanghai and contain biological
Technology Co., Ltd. provides.
Test medicine：Embodiment, comparison medicine：Melbine
1.3 animals used as test and feed Wistar rats, regular grade, all-male, 180 ± 20g of body weight, are carried by Guiyang College of Traditional Chinese Medicine
For.Common mouse feed, Guiyang College of Traditional Chinese Medicine provides.High fat mouse feed：55% basal feed, 20% sucrose, 10% lard, 10%
Egg, 4% sesame oil, 1% cholesterol, 0.2% sodium taurocholate is constituted.
2. experimental technique
It is prepared by 2.1 animal models：Reference literature, increases sugar-high lipid food and feeds with low dose of Streptozotocin (STZ),
Set up similar clinic diabetes B patient characteristic, with high body weight, high fat of blood, IGT (diabetes) feature it is big
Rat animal model.
After rat adaptability is fed one week, use high sugar-high lipid food instead and feed 4 weeks, be 350g or so in rat body weight
When, (it is made into 2% with 0.1mmol/L sodium citrate-citric acid buffer solutions by the dosage disposable celiac injection STZ of 30mg/kg
Solution, PH4.5), and while feed with high sugar-high lipid food.After 2 weeks, Rat Fast gavages 20% after 8 hours by 2g/kg body weight
D-Glucose solution, does oral glucose tolerance test.All 0 and 120min blood sugar be respectively greater than 7.0mmol/l's and 11.0mmol/l
Rat, as Glycemia Decline success rat.
2.2 packet administrations：Modeling success rat is randomly divided into 5 groups：1. model group：Give distilled water 10ml/kg；(2)
Positive controls：Give melbine 1.25g/kg；(3) embodiment I group：Embodiment 1：20g/kg；(4) embodiment II group：It is real
Apply example 2：10g/kg；(5) embodiment III group：Embodiment 3：5g/kg.The same period separately sets one group of normal group：Distilled water 10ml/kg.Respectively
Group is with the volume of 10ml/kg by the daily gastric infusion of above-mentioned dosage 1 time, successive administration 4 weeks.
2.3 observation index
(1) fasting blood-glucose and sugar tolerance：After 10 hours, eye socket takes blood to food, with determination of glucose oxidase, every 7 days
Determine once, in strict accordance with explanation operation on kit.
(2) microdose urine protein is determined：Rat 24 h urine is taken, 4 DEG C store, and assay method is according to kit specification
Carry out.
(3) drinking-water, the measure of urine volume：14 hours urine volume are determined using Metabolic cage method.
(4) changes of weight.
(5) random blood sugar is determined：
(6) change of serum C HO, TG, HDL-C, NEFA
(7)MDA、SOD；
(8) change of hemorheology；
(9) the pathological change of aortic tissue：Administration the 60th day terminate medication, put to death rat model, take sustainer,
Heart makes tissue pathological slice, and the dyeing of conventional H E carries out electron microscopic observation, photograph.Sustainer is paved after cutting open, is taken pictures, and is used in combination
Weight method measures area of aorta atherosclerotic plaque.From coronary artery porch and in, bottom, it is transversal respectively to take heart tissue
Film-making, the Atheromatosis reason index and calculating lesion vesselses for assessing the large, medium and small branch of coronary artery accounts for total blood vessel number
Percentage, is analyzed on computers using SAS statistical packages.
3. experimental result
The impact of 3.1 pairs of diabetes rat fasting blood-glucoses and sugar tolerance
After modeling, model group rats fasting blood-glucose is raised, and substantially exception occurs in sugar tolerance, has aobvious compared with blank control group
Sex differernce is write, modeling success is illustrated.
Impact of the present invention of table 1 to blood glucose in diabetic rats (N=10)
Note：Compared with blank group,▲▲P ＜ 0.01；With model group ratio,**P ＜ 0.01*P ＜ 0.05
Conclusion：Test result indicate that embodiment I group, II groups that the present invention is provided can be reduced substantially greatly compared with model group
Mouse fasting blood-glucose and improve sugar tolerance, and good dose-effect relationship be presented, show present invention offer embodiment have it is good
Hypoglycemic activity, can be used for the preventing and treating of diabetes.
Specific embodiment
Embodiment 1
Formula：Tartary buckwheat bran 56g, tartary buckwheat powder 120g, konjaku powder 80g, beeswax 10g, gelatin 108g, glycerine 54g, can
Can shell pigment 1.5g, purified water 108g composition.
Preparation method：
1) when, konjaku powder, tartary buckwheat powder being heated into 60 DEG C, the beeswax of formula ratio is added so as to melt, stirring is equal
It is even, 25 DEG C are cooled to, oily wax liquor is obtained, it is standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor, stirring mixing is equal
It is even, -0.06～-0.08MPa is evacuated to, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 60 DEG C, gelatin, Cacao pigment, stirring is added to endure
1h processed, is evacuated to -0.06～-0.08MPa, takes off bubble, and 100 mesh screens obtain capsule hide glue gelatin, standby in 55～65 DEG C of insulations
With；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, by capsule-core feed liquid the stock chest of pellet press is transported to
In；Capsule hide glue gelatin is transported in the storage glue groove of pellet press, pellet press is started and be can be prepared by soft capsule.
Usage：Orally, 2 times a day, 3 every time.
Embodiment 2
Formula：Tartary buckwheat bran 84g, tartary buckwheat powder 180g, konjaku powder 120g, beeswax 10g, gelatin 108g, glycerine 54g,
Cacao pigment 1.5g, purified water 108g composition
Preparation method：
1) when, konjaku powder, tartary buckwheat powder being heated into 80 DEG C, the beeswax of formula ratio is added so as to melt, stirring is equal
It is even, 35 DEG C are cooled to, oily wax liquor is obtained, it is standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor, stirring mixing is equal
It is even, -0.06～-0.08MPa is evacuated to, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 80 DEG C, gelatin, Cacao pigment, stirring is added to endure
3h processed, is evacuated to -0.06～-0.08MPa, takes off bubble, and 100 mesh screens obtain capsule hide glue gelatin, standby in 55～65 DEG C of insulations
With；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, by capsule-core feed liquid the stock chest of pellet press is transported to
In；Capsule hide glue gelatin is transported in the storage glue groove of pellet press, pellet press is started and be can be prepared by soft capsule.
Usage：Orally, 2 times a day, 3 every time.
Embodiment 3
Formula：Tartary buckwheat bran 84g, tartary buckwheat powder 120g, konjaku powder 80g, beeswax 10g, gelatin 108g, glycerine 54g, can
Can shell pigment 1.5g, purified water 108g composition
Preparation method：1) when, konjaku powder, tartary buckwheat powder being heated into 65～75 DEG C, the beeswax of formula ratio is added so as to
Melting, stirs, and is cooled to 30 DEG C, obtains oily wax liquor, standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor,
After being uniformly mixed, -0.06～-0.08MPa is evacuated to, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 65～75 DEG C, gelatin, Cacao pigment are added, is stirred
Mix and boil 2h, be evacuated to -0.06～-0.08MPa, take off bubble, 100 mesh screens obtain capsule hide glue gelatin, in 55～65 DEG C of guarantors
Warm standby is used；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, by capsule-core feed liquid the stock chest of pellet press is transported to
In；Capsule hide glue gelatin is transported in the storage glue groove of pellet press, pellet press is started and be can be prepared by soft capsule.
Usage：Orally, 2 times a day, 3 every time.
Embodiment 4
Formula：Tartary buckwheat bran 56g, tartary buckwheat powder 180g, konjaku powder 80g, beeswax 10g, gelatin 108g, glycerine 54g, can
Can shell pigment 1.5g, purified water 108g composition
Preparation method：
Soft capsule is prepared into by the preparation method of embodiment 2.
Usage：Orally, 2 times a day, 3 every time.
Embodiment 5
Formula：Tartary buckwheat bran 56g, tartary buckwheat powder 180g, konjaku powder 80g, beeswax 10g, gelatin 108g, glycerine 54g, can
Can shell pigment 1.5g, purified water 108g composition
Preparation method：
Soft capsule is prepared into by the preparation method of embodiment 1
Usage：Orally, 2 times a day, 3 every time.
Embodiment 6
Formula：Bitter tartary buckwheat bran 56g, tartary buckwheat powder 120g, konjaku powder 120g, beeswax 10g, gelatin 108g, glycerine
54g, Cacao pigment 1.5g, purified water 108g composition
Preparation method：
Soft capsule is prepared into by the preparation method of embodiment 3
Usage：Orally, 2 times a day, 3 every time.
Embodiment 7
Formula：Tartary buckwheat bran 84g, tartary buckwheat powder 150g, konjaku powder 100g
The preparation method of dripping pill：
Take gelatin 86g, glycerine 43g, water 86g to be well mixed, in 60～70 DEG C of heating water baths 1 hour, bitter buckwheat is added while hot
Wheat bran stirs, and is cooled to 65 DEG C, obtains rubber cement, standby in 65 DEG C of insulations, by tartary buckwheat powder and konjaku powder in 60～70 DEG C of water
After preheating in bath, lower addition 50ml water is being stirred continuously, stirring 0.5h is emulsified, and emulsion is being stirred continuously into lower addition glue
In slurry, stirring is emulsified for 4 hours, and with constant displacement pump pill dripping machine dripping, 13～15 DEG C of liquid paraffins make condensate liquid, constant pressure and dry,
Prepared pill.
Usage：Orally, 2 times a day, 3 every time.
Embodiment 8
Prescription：Tartary buckwheat bran 80g, tartary buckwheat powder 160g, konjaku powder 90g
Process for producing granula：
1) take gelatin 86g, with water 60g immersion 0.5h after, dissolve in 60～70 DEG C of water-baths gelatin solution is standby, by hardship
Buckwheat bran, tartary buckwheat powder and konjaku powder are added in gelatin solution, add 50 DEG C of distilled water to 100mL after stirring, and are stirred, so
The 60%Na of 50 DEG C of 200mL is added afterwards2SO4Solution, mixes, and keeps mixed liquor at 50 DEG C, and stirring is lower to add 35～45 DEG C
72%Na2SO4Solution 500mL, is cooled to 32～35 DEG C naturally, is placed on rapid cooling in ice-water bath and, to less than 10 DEG C, is stirred continuously,
37%HCHO solution 8mL are added, after stirring 20min, with 20%NaOH pH 9.0 is adjusted to, continue to stir 1h, centrifugation point takes micro-
Capsule, is washed to neutral formaldehydeless, freeze-drying, obtains final product dry micro-capsule.
2) in step 1) add 2 times of starch, granulation to obtain final product the granule of the present invention in gained micro-capsule.
Usage：Orally, 2 times a day, 1 bag every time.
Embodiment 9
Formula：Tartary buckwheat bran 70g, tartary buckwheat powder 130g, konjaku powder 95g
The preparation method of tablet：
Micro-capsule is prepared by step 1 method of embodiment 8, adds 1 times of starch, compressing tablet to obtain final product the tablet of the present invention.
Usage：Orally, 2 times a day, and 3 tablets once.
Embodiment 10
Formula：Tartary buckwheat bran 80g, tartary buckwheat powder 140g, konjaku powder 110g, gelatin 86g, water 130g
Capsule preparation method thereof：
Micro-capsule is prepared by step 1 method of embodiment 8, loads capsule, obtain final product the capsule of the present invention.
Usage：Orally, 2 times a day, 3 every time.
Embodiment 11
Prescription：Tartary buckwheat bran 55g, tartary buckwheat powder 240g, konjaku powder 180g, gelatin 86g, water 130g.
Oral liquor：
Micro-capsule is prepared by step 1 method of embodiment 8,3 times of pure water and 0.2 times of sweetener, mixing is added, is filled
Note, gland, sterilizing obtains final product oral liquid.
Usage：Orally, 2 times a day, 1 bottle every time.
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail
State, but on the basis of the present invention, some modifications can be made to it or be improved, this is to those skilled in the art aobvious and easy
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (7)
1. a kind of hypoglycemic composition, it is characterised in that be made up of the raw material of following weight portion：Tartary buckwheat bran (Miao：Wine loud, high-pitched sound
It is withered) 56～84 parts, duck wheat (Miao：Wine) 120～180 parts of powder, 80～120 parts of konjaku powder and auxiliary material.
2. according to the composition described in claim 1, it is characterised in that be made up of the natural products of following weight portion：Tartary buckwheat bran
(Miao：Wine loud, high-pitched sound is withered) 65～75 parts, duck wheat (Miao：Wine) 135～165 parts of powder, 90～110 parts of konjaku powder and auxiliary material.
3. composition according to claim 2, it is characterised in that be made up of the natural products of following weight portion：Duck wheat
Bran (Miao：Wine loud, high-pitched sound is withered) 70 parts, duck wheat (Miao：Wine) 150 parts of powder, 100 parts of konjaku powder and auxiliary material.
4. a kind of preparation method for preparing composition described in any one of claims 1 to 3, it is characterised in that by tartary buckwheat bran, hardship
Buckwheat and konjaku powder add customary adjuvant, and according to common process soft capsule, oral liquid, pill, tablet, particle are made
Agent, hard capsule.
5. composition according to claim 4, it is characterised in that the auxiliary material of the soft capsule is calculated as by weight：Beeswax
10 parts, 108 parts of gelatin, 54 parts of glycerine, 1.5 parts of Cacao pigment, 108 parts of purified water.
6. a kind of preparation method for preparing composition described in claim 4, it is characterised in that soft capsule is made up of following steps：
1) when, konjaku powder, tartary buckwheat powder being heated into 60～80 DEG C, the beeswax of formula ratio is added so as to melt, stirring is equal
It is even, 25～35 DEG C are cooled to, oily wax liquor is obtained, it is standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor, stirring mixing
Uniformly, -0.06～-0.08MPa is evacuated to, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 60～80 DEG C, gelatin, Cacao pigment, stirring is added to endure
1～3h of system, is evacuated to -0.06～-0.08MPa, takes off bubble, and 100 mesh screens obtain capsule hide glue gelatin, in 55～65 DEG C of guarantors
Warm standby is used；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, capsule-core feed liquid is transported in the stock chest of pellet press；Will
Capsule hide glue gelatin is transported in the storage glue groove of pellet press, is started pellet press and be can be prepared by soft capsule.
7. the preparation method of composition according to claim 6, it is characterised in that be made up of following steps：
1) when, konjaku powder, tartary buckwheat powder being heated into 65～75 DEG C, the beeswax of formula ratio is added so as to melt, stirring is equal
It is even, 30 DEG C are cooled to, oily wax liquor is obtained, it is standby；Tartary buckwheat bran is crossed into 100 mesh sieves, in adding above-mentioned oily wax liquor, is uniformly mixed
Afterwards, -0.06～-0.08MPa is evacuated to, de-bubbled obtains capsule-core feed liquid；
2), by glycerine and purified water putting into glue tank, when being heated to 65～75 DEG C, gelatin, Cacao pigment, stirring is added to endure
2h processed, is evacuated to -0.06～-0.08MPa, takes off bubble, and 100 mesh screens obtain capsule hide glue gelatin, standby in 55～65 DEG C of insulations
With；
3), 18～26 DEG C of temperature, relative humidity 45～55% indoors, capsule-core feed liquid is transported in the stock chest of pellet press；Will
Capsule hide glue gelatin is transported in the storage glue groove of pellet press, is started pellet press and be can be prepared by soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710104500.3A CN106620090A (en) | 2017-02-24 | 2017-02-24 | Composition for reducing blood glucose, and preparation method of composition |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710104500.3A CN106620090A (en) | 2017-02-24 | 2017-02-24 | Composition for reducing blood glucose, and preparation method of composition |
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| CN201710104500.3A Pending CN106620090A (en) | 2017-02-24 | 2017-02-24 | Composition for reducing blood glucose, and preparation method of composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494570A (en) * | 2020-05-14 | 2020-08-07 | 贵州神奇药物研究院 | Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof |
| CN113455612A (en) * | 2021-07-13 | 2021-10-01 | 云南云荞生物科技有限公司 | Meal-accompanying brewing powder |
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| CN1453024A (en) * | 2003-05-08 | 2003-11-05 | 上海诺金科生物科技有限公司 | Compound Chinese medicine prepn containing white mulberry bark and bitter buckwheat with hypoglycemic effect and its prepn process |
| CN1970058A (en) * | 2006-12-07 | 2007-05-30 | 崔萍 | Chinese medicinal formulation for treating diabetes |
| CN102065874A (en) * | 2008-06-12 | 2011-05-18 | 陈思成 | Compositions for reducing blood glucose level and uses thereof |
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2017
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| CN1453024A (en) * | 2003-05-08 | 2003-11-05 | 上海诺金科生物科技有限公司 | Compound Chinese medicine prepn containing white mulberry bark and bitter buckwheat with hypoglycemic effect and its prepn process |
| CN1970058A (en) * | 2006-12-07 | 2007-05-30 | 崔萍 | Chinese medicinal formulation for treating diabetes |
| CN102065874A (en) * | 2008-06-12 | 2011-05-18 | 陈思成 | Compositions for reducing blood glucose level and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111494570A (en) * | 2020-05-14 | 2020-08-07 | 贵州神奇药物研究院 | Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof |
| CN113455612A (en) * | 2021-07-13 | 2021-10-01 | 云南云荞生物科技有限公司 | Meal-accompanying brewing powder |
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