CN111491578B - 组合的无创和微创机械能靶向 - Google Patents

组合的无创和微创机械能靶向 Download PDF

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Publication number
CN111491578B
CN111491578B CN201880079368.8A CN201880079368A CN111491578B CN 111491578 B CN111491578 B CN 111491578B CN 201880079368 A CN201880079368 A CN 201880079368A CN 111491578 B CN111491578 B CN 111491578B
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wave
mechanical
directing device
directing
orientation
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CN201880079368.8A
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Chinese (zh)
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CN111491578A (zh
Inventor
马丁·布鲁耶特
史蒂文·迪昂
路易斯-菲力浦·里尔
史蒂文·阿莱斯
马尔旺·阿博德
达斯汀·阿莱斯
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Macao One Person Co
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Les Solutions Medicales Soundbite Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/225—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00274—Prostate operation, e.g. prostatectomy, turp, bhp treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
    • A61B2017/00411—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like actuated by application of energy from an energy source outside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00535—Surgical instruments, devices or methods pneumatically or hydraulically operated
    • A61B2017/00557—Surgical instruments, devices or methods pneumatically or hydraulically operated inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B2017/22014—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B2017/22024—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement with a part reflecting mechanical vibrations, e.g. for focusing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0052—Ultrasound therapy using the same transducer for therapy and imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/006—Lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0069—Reflectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)
CN201880079368.8A 2017-12-08 2018-12-10 组合的无创和微创机械能靶向 Active CN111491578B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762596200P 2017-12-08 2017-12-08
US62/596,200 2017-12-08
PCT/IB2018/059831 WO2019111239A1 (en) 2017-12-08 2018-12-10 Combined non-invasive and minimally-invasive mechanical energy targeting

Publications (2)

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CN111491578A CN111491578A (zh) 2020-08-04
CN111491578B true CN111491578B (zh) 2023-11-21

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Country Status (5)

Country Link
US (1) US12279783B2 (cg-RX-API-DMAC7.html)
EP (1) EP3720370B1 (cg-RX-API-DMAC7.html)
JP (1) JP7411549B2 (cg-RX-API-DMAC7.html)
CN (1) CN111491578B (cg-RX-API-DMAC7.html)
WO (1) WO2019111239A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2969535A1 (en) 2014-11-03 2016-05-12 Cagent Vascular, Llc Serration balloon
US11311454B2 (en) * 2019-03-28 2022-04-26 Softwave Tissue Regeneration Technologies, Llc Handheld acoustic shock wave or pressure pulse application device and methods of use
US20230241422A1 (en) * 2019-05-24 2023-08-03 John F. Warlick Methods to treat cancer, inflammations and tumors
US10792054B1 (en) 2019-07-11 2020-10-06 Eduardo Lorenzo Catheter for thromboembolic disease with mechanic waves, injection and ejection
US20210171887A1 (en) * 2019-11-11 2021-06-10 Vivax Bio, Llc Apparatus and method for levitational biofabrication of organ and tissue engineered constructs using tissue spheroids and magnetoacoustic bifield
WO2022147375A1 (en) 2020-12-31 2022-07-07 Cagent Vascular, Inc. Balloon catheter and methods of use
US12303721B2 (en) * 2022-07-25 2025-05-20 Softwave Tissue Regeneration Technologies, Llc Acoustic shock wave treatment and devices for appendages
US20260020869A1 (en) * 2022-07-29 2026-01-22 Deerfield Catalyst, Llc Venoarterial shockwave therapy

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930600A1 (de) * 1989-09-07 1991-04-04 Schubert Werner Dilitationssonde und aehnliche/zusaetzliche vorrichtungen
US5595178A (en) * 1994-10-02 1997-01-21 Hmt High Medical Technologies Gmbh System, method and apparatus for treatment of degenerative bone
CN1216910A (zh) * 1996-04-24 1999-05-19 加利福尼亚大学董事会 光-声血栓溶解方法
CN101686830A (zh) * 2007-07-11 2010-03-31 皇家飞利浦电子股份有限公司 具有可调整的流体透镜的超声组件
CN101683549A (zh) * 2008-09-28 2010-03-31 重庆海扶(Hifu)技术有限公司 一种超声波发生装置及含有该装置的超声治疗系统
WO2011094379A1 (en) * 2010-01-28 2011-08-04 Cook Medical Technologies Llc Apparatus and method for destruction of vascular thrombus

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3068730B2 (ja) * 1993-06-03 2000-07-24 アロカ株式会社 超音波治療装置
US5676692A (en) * 1996-03-28 1997-10-14 Indianapolis Center For Advanced Research, Inc. Focussed ultrasound tissue treatment method
EP1091787A4 (en) * 1998-06-30 2004-06-16 Intec Res Company APPARATUS AND METHOD FOR INDUCING VIBRATION IN THE BODY OF A LIVING BEING
US20130197555A1 (en) * 2002-07-01 2013-08-01 Recor Medical, Inc. Intraluminal devices and methods for denervation
US20050070961A1 (en) * 2003-07-15 2005-03-31 Terumo Kabushiki Kaisha Energy treatment apparatus
US8750983B2 (en) * 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
DK3287170T3 (en) * 2004-10-06 2019-02-04 Guided Therapy Systems Llc HUMAN SURFACE TREATMENT CONTROLLED HEAT TREATMENT SYSTEM
WO2007021958A2 (en) * 2005-08-12 2007-02-22 University Of Washington Method and apparatus for preparing organs and tissues for laparoscopic surgery
US8979776B2 (en) * 2008-05-02 2015-03-17 Daniel Gelbart Lithotripsy system with automatic 3D tracking
EP3461438B1 (en) * 2009-07-08 2021-02-17 Sanuwave, Inc. Combined intracorporeal and extracorporeal shock wave treatment system
US8617150B2 (en) * 2010-05-14 2013-12-31 Liat Tsoref Reflectance-facilitated ultrasound treatment
WO2013119662A1 (en) * 2012-02-06 2013-08-15 Cornell University Catheter based system and method for thrombus removal using time reversal acoustics
US20140350401A1 (en) * 2012-06-30 2014-11-27 Yegor D. Sinelnikov Carotid body ablation via directed energy
US20140221828A1 (en) * 2013-02-05 2014-08-07 Muffin Incorporated Non-linear echogenic markers
US10322178B2 (en) * 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10080906B2 (en) * 2015-09-30 2018-09-25 Btl Holdings Limited Methods and devices for tissue treatment using mechanical stimulation and electromagnetic field
US9974983B2 (en) * 2015-11-12 2018-05-22 SonaCare Medical, LLC Tissue stabilization for therapeutic ultrasound

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930600A1 (de) * 1989-09-07 1991-04-04 Schubert Werner Dilitationssonde und aehnliche/zusaetzliche vorrichtungen
US5595178A (en) * 1994-10-02 1997-01-21 Hmt High Medical Technologies Gmbh System, method and apparatus for treatment of degenerative bone
CN1216910A (zh) * 1996-04-24 1999-05-19 加利福尼亚大学董事会 光-声血栓溶解方法
CN101686830A (zh) * 2007-07-11 2010-03-31 皇家飞利浦电子股份有限公司 具有可调整的流体透镜的超声组件
CN101683549A (zh) * 2008-09-28 2010-03-31 重庆海扶(Hifu)技术有限公司 一种超声波发生装置及含有该装置的超声治疗系统
WO2011094379A1 (en) * 2010-01-28 2011-08-04 Cook Medical Technologies Llc Apparatus and method for destruction of vascular thrombus

Also Published As

Publication number Publication date
US20200383692A1 (en) 2020-12-10
CA3084914A1 (en) 2019-06-13
CN111491578A (zh) 2020-08-04
WO2019111239A1 (en) 2019-06-13
US12279783B2 (en) 2025-04-22
EP3720370A4 (en) 2021-01-13
JP2021505271A (ja) 2021-02-18
EP3720370B1 (en) 2022-12-07
JP7411549B2 (ja) 2024-01-11
EP3720370A1 (en) 2020-10-14

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