CN111481617A

CN111481617A - Inhalant for treating herpes zoster and preparation method thereof

Info

Publication number: CN111481617A
Application number: CN202010552829.8A
Authority: CN
Inventors: 石婷
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-17
Filing date: 2020-06-17
Publication date: 2020-08-04

Abstract

The invention belongs to the technical field of medicines, relates to an inhalant for treating herpes zoster and also relates to a preparation method of the inhalant. The invention provides an inhalant for treating herpes zoster, which is prepared from the following raw materials: 10g to 30g of snake slough, 15g to 50g of croton, 30g to 60g of scallion, 30g to 60g of Chinese date, and 500ml to 1000ml of white spirit (more than 50 degrees). The weight ratio of each component is as follows: snake slough, croton, scallion and Chinese date are 1: 0.6-3: 1-3. According to the invention, according to the pathogenesis principle of herpes zoster, the medicament is ground by the volatile principle of alcohol and then is put into white spirit to be processed so as to maximize the efficacy of the medicament, and the medicament can be put into nasal cavities to achieve the effects of inducing resuscitation, removing heat, strengthening body resistance, eliminating dampness, tonifying middle-jiao and Qi, nourishing blood, soothing nerves and improving immunity.

Description

Inhalant for treating herpes zoster and preparation method thereof

The technical field is as follows:

the invention belongs to the technical field of medicines, relates to an inhalant for treating herpes zoster and also relates to a preparation method of the inhalant.

Background art:

herpes zoster is a clinically common viral skin disease and is called herpes zoster, herpes zoster or herpes zoster erysipelas in traditional Chinese medicine. Shingles is primarily due to clustered blisters and intense pain along the peripheral innervated area following varicella-zoster virus infection. The clinical characteristics of the onset of herpes zoster are that the elderly are more and people with low immunity are easy to get herpes zoster, and the bigger the age is, the more pain is, and the higher the probability of postherpetic neuralgia is. The virus can be latent in neurons of spinal nerve posterior root ganglia for a long time after invading nerve infection, and can grow and propagate to cause diseases when the resistance is low or the nerve is tired and infected, the cold is fever, and the vital energy is generated and the disease is developed. The traditional Chinese medicine considers that the liver-qi stagnation and the fire transformation are caused by the accumulation of damp-heat in the spleen channel and the overflow of the damp-heat out of the skin, or the liver-qi stagnation and the fire transformation are caused by the accumulation of damp-heat and toxin in the skin due to accidental infection. The elderly and infirm can usually have severe pain due to blood deficiency, liver hyperactivity, damp-heat toxicity and stagnation of qi and blood, and can disappear after a long time. The invention relates to a traditional Chinese medicine for treating herpes zoster, which is prepared by the steps of adding medicines into a nasal cavity to assist the healthy energy of a human body, wherein the healthy energy is sufficient, so that cold-dampness and air leakage cannot invade the human body, inducing resuscitation and transforming heat, diminishing inflammation and easing pain, strengthening the body resistance and clearing damp, promoting blood circulation and removing obstruction in channels, astringing dampness and promoting tissue regeneration and healing sore, tonifying middle-jiao and Qi, and improving immunity.

Most of the existing medicines for treating herpes zoster are antiviral medicines and nerve-nourishing medicines, such as acyclovir ointment, acyclovir tablets and pregabalin capsules (lerecan), the side effect is mainly the damage of the functions of the liver and the kidney, the analgesic medicines are central analgesics such as carbamazepine, amitriptyline and the like, although the central analgesics have better curative effect at that time and temporarily stop pain, the postherpetic neuralgia is prolonged at the later stage, and many central analgesics have dependence.

The invention content is as follows:

the invention aims to overcome the defects of the prior art and provide an inhalant for treating herpes zoster, which is applied through a nasal cavity without touching the body, not only can achieve the exact curative effect of treating herpes zoster, but also has the characteristic of reducing toxic and side effects.

The invention is realized by the following technical scheme:

the invention provides an inhalant for treating herpes zoster, which is prepared from the following raw materials:

10g to 30g of snake slough, 15g to 50g of croton, 30g to 60g of scallion, 30g to 60g of Chinese date, and 500ml to 1000ml of white spirit (more than 50 degrees).

Wherein the weight ratio of each component is as follows: snake slough, croton, shallot and Chinese date are 1: 0.6-3: 1-3, preferably 1: 1-3: 3, more preferably 1: 2: 3.

Further, the invention is preferably prepared from the following raw materials:

10g to 20g of snake slough, 15g to 30g of croton, 30g to 60g of scallion, 30g to 60g of Chinese date, and 500ml to 1000ml of white spirit (more than 50 degrees).

The weight ratio of each component is as follows: snake slough, croton, shallot and Chinese date are 1: 0.6-3: 1-3, preferably 1: 1-3: 3, more preferably 1: 2: 3.

Wherein, in the inhalant for treating herpes zoster, the components have the following functions:

snake slough: dispelling pathogenic wind, arresting convulsion, removing nebula, relieving swelling, and killing parasite; inducing resuscitation and dissipating heat, strengthening body resistance and eliminating dampness: "Yi Lin Du" (treatise on medilin) says that snake slough: "removing toxic heat and wind-damp", Snake slough is sweet and salty in flavor, sweet in flavor and capable of removing toxicity, salty in flavor can soften hardness and dissipate nodulation, enter liver and spleen meridians and enter blood system, so it can remove toxicity and relieve swelling.

Croton seed: removing blood stasis, resolving food stagnation, relieving pain, and resolving hard mass; astringe dampness, promote granulation, heal wound, diminish inflammation and relieve pain: croton, fructus crotonis, pungent in flavor and strongly toxic in property, enters stomach and large intestine meridians. For external use, it can corrode sore, and is suitable for treating malignant boil, scabies, tinea, and wart and nevus. Has effects in inhibiting bacterial growth, relieving pain, and treating carbuncle, cellulitis, malignant sore, furuncle, and sore.

Scallion: inducing sweat, relieving exterior syndrome, activating yang, and promoting urination; the scallion is pungent in flavor and slightly warm in nature, and has the effects of relieving exterior syndrome, activating yang, and detoxifying, and has the antibacterial, bactericidal and antiviral effects.

Chinese date: invigorating spleen and replenishing qi, nourishing blood and tranquillizing mind, and relieving drug property; tonify middle-jiao and qi, nourish blood and tranquilize: the Chinese dates are sweet in taste and warm in nature, enter spleen and stomach channels, have the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and relieving drug properties, and saccharides in the Chinese dates mainly comprise glucose, fructose, cane sugar, oligosaccharide consisting of glucose and fructose, araban and galactan, contain a large amount of vitamin C, thiamine, carotene, nicotinic acid, riboflavin and other vitamins, have a strong nourishing effect, and can help a human body to improve the immunity and enhance the disease resistance.

The invention also provides a preparation method of the smelling agent, which comprises the following steps: cleaning the above Chinese medicinal materials, air drying, oven drying, pulverizing the Chinese medicinal materials with a Chinese medicinal pulverizer under aseptic and dustless conditions, sieving with 12 mesh sieve, mixing, adding into Chinese liquor, stirring, and sealing for 15-30 days.

According to the invention, according to the pathogenesis principle of herpes zoster, the medicament is ground by the volatile principle of alcohol and then is put into white spirit to be processed so as to maximize the efficacy of the medicament, and the medicament can be put into nasal cavities to achieve the effects of inducing resuscitation, removing heat, strengthening body resistance, eliminating dampness, tonifying middle-jiao and Qi, nourishing blood, soothing nerves and improving immunity.

The snuff takes 5 days as a treatment course, and is respectively smelled once every morning, noon and evening, and each time lasts for 20-30 minutes.

After the snake slough, the croton, the onion and the Chinese date are ground and soaked in the white spirit with the alcohol content of more than 50 degrees, the main active ingredients of the snake slough, the croton, the onion and the Chinese date are extracted and absorbed by nasal mucosa through the volatilization principle of alcohol, thereby playing a role. When the ratio of snake slough to croton, shallot to jujube is 1: 0.6-3: 1-3, its effective rate is above 50%, and when the ratio of snake slough to croton, shallot to jujube is 1: 1-3: 3, its effective rate is above 60%, and when the ratio of snake slough to croton, shallot to jujube is 1: 2: 3, its effective rate can be above 90%. The method is safe, nontoxic, effective and suitable for long-term administration. The traditional Chinese medicine composition is simple to prepare, has the effects of inducing resuscitation and dissipating heat, diminishing inflammation and easing pain, strengthening body resistance and eliminating dampness, promoting blood circulation and removing obstruction in channels, eliminating dampness and promoting tissue regeneration and healing sore, and fundamentally repairs neuralgia caused by herpes zoster.

The specific implementation mode is as follows:

example 1:

screening the components of the prescription:

and (3) prescription test:

according to the prescription, the maximum efficacy of the prescription is ensured, the best treatment effect on the herpes zoster is achieved, and two bottles of samples (the sample is divided into a sample b and a sample c) are compared and verified with a sample of the original formula a

1. a, sample: snake slough 10g-30g croton 15g-50g onion 30g-60g Chinese date 30g-60g white spirit (above 50 degree) 500ml-1000ml

2. b, sample preparation: snake slough 10g-30g onion 30g-60g Chinese date 30g-60g white spirit (above 50 degree) 500ml-1000ml

3. c, sample preparation: 15g to 50g of croton, 30g to 60g of scallion, 30g to 60g of Chinese date, 500ml to 1000ml of white spirit (more than 50 degrees)

a, sample: the weight ratio of snake slough, croton, shallot and Chinese date is 1: 2: 3;

b, sample preparation: the weight ratio of the snake slough to the scallion to the Chinese date is 1: 3;

c, sample preparation: the weight ratio of the croton, the onion and the Chinese date is 2: 3;

the components are mixed and mixed evenly according to the proportion, then the mixture is put into the white spirit and is stirred evenly and sealed for 30 days.

1. And (3) firstly, the patient performs a trial smelling on the sample b for 5 days, wherein the trial smelling times are respectively one time in the morning, at noon and at night, the trial smelling time is 20 minutes each time, and the detection result shows that the herpes zoster is obviously reduced after 5 days, but the reaction neuralgia of the patient is slightly reduced but is not obvious, and the phenomenon of herpes zoster neuralgia attack still occurs.

2. And (3) the patient performs examination and smelling on the sample c for 5 days, wherein the examination and smelling times are respectively one time in the morning, the noon and the evening, the examination and smelling time is 20 minutes each time, and the examination result shows that the herpes zoster is slightly reduced after 5 days, but the herpes zoster is not obvious, the pain of the patient in response to the herpes zoster neuralgia outbreak is relieved, and the outbreak frequency is reduced.

3. Finally, the patient performs trial smelling on the sample a for 5 days, wherein the trial smelling times are respectively one time in the morning, at noon and at night, the trial smelling time is 20 minutes each time, and the patient has a very satisfactory effect on the sample after 5 days, so that the herpes zoster is obviously reduced, the pain feeling of the herpes zoster neuralgia outbreak is obviously relieved, and the outbreak frequency is obviously reduced.

The result shows that the inhalant has the functions of inducing resuscitation, dissipating heat, strengthening body resistance, eliminating dampness, promoting granulation, healing sore, diminishing inflammation, relieving pain, strengthening the middle-jiao, benefiting qi, nourishing blood, tranquilizing mind, inducing sweat, relieving exterior syndrome, activating yang and promoting urination, and has obvious treatment effect on herpes zoster.

Example 2:

in order to further prove the medicine property of the smelling agent, the maximum treatment effect of the medicine is determined by adjusting the medicine proportion of the smelling agent:

a, sample: the weight ratio of the snake slough to the croton, the scallion to the Chinese date is 1.5: 1: 1.5

b, sample preparation: the weight ratio of snake slough, croton, scallion and Chinese date is as follows: 1: 1.5

c, sample preparation: the weight ratio of snake slough, croton, scallion and Chinese date is as follows: 1: 2: 3

d, sample: the weight ratio of snake slough, croton, scallion and Chinese date is as follows: 1: 3

e, sample preparation: the weight ratio of snake slough, croton, scallion and Chinese date is as follows: 1: 3

In the test, 100 herpes zoster patients are selected to test 20 persons in each group of 5 groups of samples including a sample a, a sample b, a sample c, a sample d and a sample e, 5 days are taken as 1 test period, the test frequency is respectively one time in the morning, the evening and the test time is 20 minutes each time, and the test results are as follows:

a, sample: the number of patients with significantly reduced herpes zoster status was 10, 50% of the trial population in group a

b, sample preparation: the number of patients with significantly reduced herpes zoster status was 8, 40% of the test population in group b

c, sample preparation: the number of patients with significantly reduced herpes zoster status was 18, 90% of the test population in group c

d, sample: the number of patients with significantly reduced herpes zoster status was 12, accounting for 60% of the d groups tested

e, sample preparation: the number of patients with significantly reduced herpes zoster status was 13, 65% of the test subjects in group e

The 5 groups of experiments prove that the optimum preparation ratio of the snake slough, the croton, the onion and the Chinese date in the weight ratio of 1: 2: 3 can maximize the drug potency of the inhalant and has the most obvious curative effect on herpes zoster.

Claims

1. An inhalant for treating herpes zoster is characterized by being prepared from the following raw materials:

10g to 30g of snake slough, 15g to 50g of croton, 30g to 60g of scallion, 30g to 60g of Chinese date, and 500ml to 1000ml of white spirit with the alcohol degree of more than 50.

2. The snuff for treating herpes zoster according to claim 1, wherein the snuff is prepared from the following raw materials:

10g to 20g of snake slough, 15g to 30g of croton, 30g to 60g of scallion, 30g to 60g of Chinese date, and 500ml to 1000ml of white spirit with the alcohol degree of more than 50.

3. The inhalant for treating herpes zoster according to claim 1 or 2, wherein the weight ratio of snake slough, croton, shallot and Chinese date is 1: 0.6-3: 1-3.

4. The inhalant for treating herpes zoster according to claim 1 or 2, wherein the weight ratio of snake slough, croton, shallot and Chinese date is 1: 1-3: 3.

5. An inhalant for treating herpes zoster according to claim 1 or 2, wherein the weight ratio of snake slough, croton, shallot and Chinese date is 1: 2: 3.

6. The method for preparing the snuff for treating herpes zoster according to any one of claims 1-5, wherein snake slough, croton, shallot and Chinese date are cleaned, air-dried, oven-dried, respectively pulverized by a Chinese medicinal pulverizer under aseptic and dustless conditions, mixed uniformly according to a certain proportion, put into white spirit, stirred uniformly and sealed for 15-30 days.

7. Use of an olfactory agent for the treatment of herpes zoster according to any one of claims 1 to 5 in the manufacture of a medicament for the treatment of herpes zoster.

8. The use of claim 7, wherein the composition is administered once a day, 20-30 minutes each time, in the morning, in the evening.