CN111480836A - 一种雨生红球藻破壁藻片 - Google Patents
一种雨生红球藻破壁藻片 Download PDFInfo
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 48
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 27
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Abstract
本发明公开了一种雨生红球藻破壁藻片,涉及保健药品技术领域。本发明由以下重量份的组分制成:雨生红球藻破壁粉60~75份、柠檬酸1~3份、壳寡糖3~8份、赤藓糖醇1~3份、微晶纤维素15~18份、硬脂酸镁5~8份。本发明片剂由破壁后的雨生红球藻粉制备,使得制得的藻片产品易保存,使用者易吸收,扩大了产品市场的应用,通过添加辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁,综合各组分的功效,可改善片剂口味,提高吸收效果。
Description
技术领域
本发明属于保健药品技术领域,特别是涉及一种雨生红球藻破壁藻片。
背景技术
红球藻是一种淡水单胞绿藻,隶属绿藻门、团藻目、红球藻科、红球藻属,该藻能大量累积虾青素而呈现红色,故名红球藻,又称雨生红球藻,红球藻是目前科学界发现的继螺旋藻、小球藻之后,富含营养价值和药用价值的藻类食品,雨生红球藻是一种主要生长在淡水中的单细胞绿藻,在海洋中分布很少,但海水中的盐度有利于藻体中虾青素的累积,雨生红球藻是公认的在自然界中生产天然虾青素的最理想来源,虾青素作为目前发现的一种最高效的纯天然抗氧化剂,在清除自由基、保护皮肤、维持心血管系统健康、保护眼睛健康、维护关节和缔结组织健康、抗衰老、抗肿瘤和免疫调节等方面显示出良好的生物活性,被广泛应用于功能性食品、医药以及化妆品领域,世界上现已有多家公司生产雨生红球藻粉及其功能制品,雨生红球藻中虾青素含量为1.5%~10.0%,被看作是天然虾青素的“浓缩品”。
由雨生红球藻制得的各类供人体食用的产品中,其中,雨生红球藻片是由雨生红球藻粉干燥而得,呈深红色薄片,产品的市场较大,但是现有的雨生红球藻片由于雨生红球藻粉具有较厚的细胞壁,使用者难吸收,因此有必要对现有技术进行改进,以解决上述问题。
发明内容
本发明的目的在于提供一种雨生红球藻破壁藻片,本发明片剂由破壁后的雨生红球藻粉制备,使得制得的藻片产品易保存,使用者易吸收,扩大了产品市场的应用,通过添加辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁,综合各组分的功效,可改善片剂口味,提高吸收效果,解决了雨生红球藻粉具有较厚的细胞壁,使用者难吸收的问题。
为解决上述技术问题,本发明是通过以下技术方案实现的:
本发明为一种雨生红球藻破壁藻片,由以下重量份的组分制成:雨生红球藻破壁粉60~75份、柠檬酸1~3份、壳寡糖3~8份、赤藓糖醇1~3份、微晶纤维素15~18份、硬脂酸镁5~8份。
进一步地,由以下重量份的组分制成:雨生红球藻破壁粉60份、柠檬酸3份、壳寡糖8份、赤藓糖醇3份、微晶纤维素18份、硬脂酸镁8份。
进一步地,由以下重量份的组分制成:雨生红球藻破壁粉68份、柠檬酸2份、壳寡糖5份、赤藓糖醇2份、微晶纤维素16份、硬脂酸镁7份。
进一步地,由以下重量份的组分制成:雨生红球藻破壁粉75份、柠檬酸1份、壳寡糖3份、赤藓糖醇1份、微晶纤维素15份、硬脂酸镁5份。
进一步地,所述雨生红球藻破壁藻片的制备工艺包括以下步骤:
步骤一:通过雨生红球藻粉制备雨生红球藻破壁粉;
步骤二:对辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁进行粉碎过筛,并同雨生红球藻破壁粉沸腾混合;
步骤三:对沸腾混合后的物料进行喷雾制粒,并将颗粒通过干燥设备进行干燥;
步骤四:干燥后的颗粒经过筛处理后,合格的颗粒中加入压片润滑剂并混合均匀;
步骤五:通过压片机直接进行压片,然后再依次进行包衣、包装操作,得到雨生红球藻破壁片。
进一步地,所述雨生红球藻破壁粉的具体制备步骤包括:
S1:将筛分后的合格雨生红球藻粉投入搅拌罐内,并加入5倍体积70%乙醇溶液,开启其内的搅拌机A,对悬浮液进行搅拌3小时;
S2:开启送料阀门和送料泵A,将搅拌后呈均匀悬浮液状态的藻液由搅拌罐转移至破碎罐,同时开启其内的搅拌机B;
S3:将破碎罐内的破碎压力调至200bar,待压力上升至200bar后,再将压力调整至破碎需要的压力1000bar左右;
S4:破碎机运行正常后等待2分钟,打开取样口阀门,放出1L藻液后取样30ml,立即送分析科做相关检测,循环直到破碎率达到90%以上后,等待干燥;
S5:开启干燥用的蒸汽发生器,将蒸汽压力调整至0.18Mpa,开启排风机,频率调整至36Hz,开启干燥滚筒,频率调整至12.2Hz,开启蒸汽阀;
S6:预热1.5~2h后,测量干燥滚筒的温度,使之达到110~125℃,并检查进风口温度和出风口温度,进风口温度达到55~70℃,排风口温度达到50~60℃,经过调整使得各部分运行正常后方可供藻液进行干燥;
S7:开启送料阀门及送料泵B,送料泵B的频率调整至35~45Hz,通过观察口观察产品干燥情况,根据经验判断干燥情况是否良好;
S8:在干燥设备正常运行10min左右,取5g样品检测水分含量,在确保水分小于5%的情况下,持续干燥,干燥后的藻粉装入藻粉收集桶内,直到藻液干燥完毕,干燥完毕后,关闭干燥滚筒,排风机,蒸汽阀,蒸汽发生器,将接料容器与出料口分离。
进一步地,所述S1中筛分后的合格藻粉的目数设置为80~120目。
进一步地,所述S8中破碎干燥后的藻粉的目数设置为400目以上。
本发明具有以下有益效果:
1、本发明片剂由破壁后的雨生红球藻粉制备,使得制得的藻片产品易保存,使用者易吸收,扩大了产品市场的应用,解决了雨生红球藻粉具有较厚的细胞壁,使用者难吸收的问题,且雨生红球藻粉的破壁工艺完善,破壁效果以及效率均较好。
2、本发明通过添加辅料柠檬酸、壳寡糖、赤藓糖醇,综合各组分的功效,可改善片剂口味,提高吸收效果,通过添加微晶纤维素和硬脂酸镁,进一步提高片剂被人体吸收的能力。
当然,实施本发明的任一产品并不一定需要同时达到以上所述的所有优点。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
本发明为一种雨生红球藻破壁藻片,由以下重量份的组分制成:雨生红球藻破壁粉60份、柠檬酸3份、壳寡糖8份、赤藓糖醇3份、微晶纤维素18份、硬脂酸镁8份。
雨生红球藻破壁藻片的制备工艺包括以下步骤:
步骤一:通过雨生红球藻粉制备雨生红球藻破壁粉;
步骤二:对辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁进行粉碎过筛,按配方配比称量柠檬酸3g、壳寡糖8g、赤藓糖醇3g、微晶纤维素18g、硬脂酸镁8g,并同按配方配比称量的雨生红球藻破壁粉60g沸腾混合;
步骤三:对沸腾混合后的物料进行喷雾制粒,并将颗粒通过干燥设备进行干燥;
步骤四:干燥后的颗粒经过筛处理后,合格的颗粒中加入压片润滑剂并混合均匀;
步骤五:通过压片机直接进行压片,然后再依次进行包衣、包装操作,得到雨生红球藻破壁片。
实施例2
本发明为一种雨生红球藻破壁藻片,由以下重量份的组分制成:雨生红球藻破壁粉68份、柠檬酸2份、壳寡糖5份、赤藓糖醇2份、微晶纤维素16份、硬脂酸镁7份。
雨生红球藻破壁藻片的制备工艺包括以下步骤:
步骤一:通过雨生红球藻粉制备雨生红球藻破壁粉;
步骤二:对辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁进行粉碎过筛,按配方配比称量柠檬酸2g、壳寡糖5g、赤藓糖醇2g、微晶纤维素16g、硬脂酸镁7g,并同按配方配比称量的雨生红球藻破壁粉68g沸腾混合;
步骤三:对沸腾混合后的物料进行喷雾制粒,并将颗粒通过干燥设备进行干燥;
步骤四:干燥后的颗粒经过筛处理后,合格的颗粒中加入压片润滑剂并混合均匀;
步骤五:通过压片机直接进行压片,然后再依次进行包衣、包装操作,得到雨生红球藻破壁片。
实施例3
本发明为一种雨生红球藻破壁藻片,由以下重量份的组分制成:雨生红球藻破壁粉75份、柠檬酸1份、壳寡糖3份、赤藓糖醇1份、微晶纤维素15份、硬脂酸镁5份。
雨生红球藻破壁藻片的制备工艺包括以下步骤:
步骤一:通过雨生红球藻粉制备雨生红球藻破壁粉;
步骤二:对辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁进行粉碎过筛,按配方配比称量柠檬酸1g、壳寡糖3g、赤藓糖醇1g、微晶纤维素15g、硬脂酸镁5g,并同按配方配比称量的雨生红球藻破壁粉75g沸腾混合;
步骤三:对沸腾混合后的物料进行喷雾制粒,并将颗粒通过干燥设备进行干燥;
步骤四:干燥后的颗粒经过筛处理后,合格的颗粒中加入压片润滑剂并混合均匀;
步骤五:通过压片机直接进行压片,然后再依次进行包衣、包装操作,得到雨生红球藻破壁片。
其中,上述实施例1-3中的雨生红球藻破壁粉的具体制备步骤包括:
S1:将筛分后的合格雨生红球藻粉投入搅拌罐内,筛分目数设置为80~120目,并加入5倍体积70%乙醇溶液,开启其内的搅拌机A,对悬浮液进行搅拌3小时;
S2:开启送料阀门和送料泵A,将搅拌后呈均匀悬浮液状态的藻液由搅拌罐转移至破碎罐,同时开启其内的搅拌机B;
S3:将破碎罐内的破碎压力调至200bar,待压力上升至200bar后,再将压力调整至破碎需要的压力1000bar左右;
S4:破碎机运行正常后等待2分钟,打开取样口阀门,放出1L藻液后取样30ml,立即送分析科做相关检测,循环直到破碎率达到90%以上后,等待干燥;
S5:开启干燥用的蒸汽发生器,将蒸汽压力调整至0.18Mpa,开启排风机,频率调整至36Hz,开启干燥滚筒,频率调整至12.2Hz,开启蒸汽阀;
S6:预热1.5~2h后,测量干燥滚筒的温度,使之达到110~125℃,并检查进风口温度和出风口温度,进风口温度达到55~70℃,排风口温度达到50~60℃,经过调整使得各部分运行正常后方可供藻液进行干燥;
S7:开启送料阀门及送料泵B,送料泵B的频率调整至35~45Hz,通过观察口观察产品干燥情况,根据经验判断干燥情况是否良好;
S8:在干燥设备正常运行10min左右,取5g样品检测水分含量,在确保水分小于5%的情况下,持续干燥,干燥后的藻粉装入藻粉收集桶内,破碎干燥后的藻粉的目数设置为400目以上,直到藻液干燥完毕,干燥完毕后,关闭干燥滚筒,排风机,蒸汽阀,蒸汽发生器,将接料容器与出料口分离。
本发明片剂由破壁后的雨生红球藻粉制备,使得制得的藻片产品易保存,使用者易吸收,扩大了产品市场的应用,解决了雨生红球藻粉具有较厚的细胞壁,使用者难吸收的问题,且通过添加辅料柠檬酸、壳寡糖、赤藓糖醇,赤藓糖醇具有甜味,且含有较低的卡路里,同时不会导致龋齿,此外赤藓糖醇相比其他糖醇口感更好,它没有其他糖醇的涩味和刺激性,柠檬酸具有螯合作用和调节pH值得特性,在食品的加工中能增加抗氧剂的性能,抑制酶活性,延长食品保存期,壳寡糖可调节肠道微生态,改善肠道组织形态,增强免疫功能,作为食品添加剂促进肠蠕动,促进营养物质的吸收,综合各组分的功效,可改善片剂口味,提高吸收效果,通过添加微晶纤维素和硬脂酸镁,进一步提高片剂被人体吸收的能力。
在本说明书的描述中,参考术语“一个实施例”、“示例”、“具体示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不一定指的是相同的实施例或示例。而且,描述的具体特征、结构、材料或者特点可以在任何的一个或多个实施例或示例中以合适的方式结合。
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节,也不限制该发明仅为所述的具体实施方式。显然,根据本说明书的内容,可作很多的修改和变化。本说明书选取并具体描述这些实施例,是为了更好地解释本发明的原理和实际应用,从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。
Claims (8)
1.一种雨生红球藻破壁藻片,其特征在于:由以下重量份的组分制成:雨生红球藻破壁粉60~75份、柠檬酸1~3份、壳寡糖3~8份、赤藓糖醇1~3份、微晶纤维素15~18份、硬脂酸镁5~8份。
2.根据权利要求1所述的一种雨生红球藻破壁藻片,其特征在于,由以下重量份的组分制成:雨生红球藻破壁粉60份、柠檬酸3份、壳寡糖8份、赤藓糖醇3份、微晶纤维素18份、硬脂酸镁8份。
3.根据权利要求1所述的一种雨生红球藻破壁藻片,其特征在于,由以下重量份的组分制成:雨生红球藻破壁粉68份、柠檬酸2份、壳寡糖5份、赤藓糖醇2份、微晶纤维素16份、硬脂酸镁7份。
4.根据权利要求1所述的一种雨生红球藻破壁藻片,其特征在于,由以下重量份的组分制成:雨生红球藻破壁粉75份、柠檬酸1份、壳寡糖3份、赤藓糖醇1份、微晶纤维素15份、硬脂酸镁5份。
5.基于上述权利要求1~4任意一项所述的一种雨生红球藻破壁藻片,其特征在于,所述雨生红球藻破壁藻片的制备工艺包括以下步骤:
步骤一:通过雨生红球藻粉制备雨生红球藻破壁粉;
步骤二:对辅料柠檬酸、壳寡糖、赤藓糖醇、微晶纤维素和硬脂酸镁进行粉碎过筛,并同雨生红球藻破壁粉沸腾混合;
步骤三:对沸腾混合后的物料进行喷雾制粒,并将颗粒通过干燥设备进行干燥;
步骤四:干燥后的颗粒经过筛处理后,合格的颗粒中加入压片润滑剂并混合均匀;
步骤五:通过压片机直接进行压片,然后再依次进行包衣、包装操作,得到雨生红球藻破壁片。
6.根据权利要求1-5中任意一项所述的一种雨生红球藻破壁藻片,其特征在于,所述雨生红球藻破壁粉的具体制备步骤包括:
S1:将筛分后的合格雨生红球藻粉投入搅拌罐内,并加入5倍体积70%乙醇溶液,开启其内的搅拌机A,对悬浮液进行搅拌3小时;
S2:开启送料阀门和送料泵A,将搅拌后呈均匀悬浮液状态的藻液由搅拌罐转移至破碎罐,同时开启其内的搅拌机B;
S3:将破碎罐内的破碎压力调至200bar,待压力上升至200bar后,再将压力调整至破碎需要的压力1000bar左右;
S4:破碎机运行正常后等待2分钟,打开取样口阀门,放出1L藻液后取样30ml,立即送分析科做相关检测,循环直到破碎率达到90%以上后,等待干燥;
S5:开启干燥用的蒸汽发生器,将蒸汽压力调整至0.18Mpa,开启排风机,频率调整至36Hz,开启干燥滚筒,频率调整至12.2Hz,开启蒸汽阀;
S6:预热1.5~2h后,测量干燥滚筒的温度,使之达到110~125℃,并检查进风口温度和出风口温度,进风口温度达到55~70℃,排风口温度达到50~60℃,经过调整使得各部分运行正常后方可供藻液进行干燥;
S7:开启送料阀门及送料泵B,送料泵B的频率调整至35~45Hz,通过观察口观察产品干燥情况,根据经验判断干燥情况是否良好;
S8:在干燥设备正常运行10min左右,取5g样品检测水分含量,在确保水分小于5%的情况下,持续干燥,干燥后的藻粉装入藻粉收集桶内,直到藻液干燥完毕,干燥完毕后,关闭干燥滚筒,排风机,蒸汽阀,蒸汽发生器,将接料容器与出料口分离。
7.根据权利要求6所述的一种雨生红球藻破壁藻片,其特征在于,所述S1中筛分后的合格藻粉的目数设置为80~120目。
8.根据权利要求6所述的一种雨生红球藻破壁藻片,其特征在于,所述S8中破碎干燥后的藻粉的目数设置为400目以上。
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