CN111467458A - Traditional Chinese medicine composition for treating cold in uterus, preparation method and application - Google Patents
Traditional Chinese medicine composition for treating cold in uterus, preparation method and application Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating cold in uterus, a preparation method and application thereof, wherein the pungent and warm cassia twig is adopted to warm yang qi and dispel cold evil; sour and sweet white peony root, radix Paeoniae alba nourishes nutrient-yin, relieves liver urgency and relieves abdominal pain. The ginger is used for warming the stomach and dispelling cold, and the Chinese date is used for tonifying the spleen and replenishing qi. Prepared licorice root, radix Glycyrrhizae Praeparata, as an adjuvant drug, has the effects of replenishing qi to regulate the middle warmer, and harmonizing the effects of the other drugs in the recipe. Wherein cassia twig, pungent and sweet in flavor and capable of resolving yang and warming middle-jiao to tonify spleen deficiency; peony root combined with licorice root, sour and sweet, acts to relieve liver urgency and relieve abdominal pain. The combination of the ingredients can warm the middle-jiao and tonify deficiency and relieve urgency, and has the meaning of nourishing liver and regulating spleen, and benefiting yin and yang, so that the composition can strengthen the middle-jiao and activate yin-yang and qi and blood. The Chinese patent medicine is prepared by extracting, concentrating, mixing thick paste with sucrose powder and dextrin, preparing into granules, and subpackaging into small bags for use. The production process is simple, the production amount is large, and the period is short. The product is dissolved by boiled water when being taken, is taken at a low temperature, has good taste, obvious effect and strong practicability, is not easy to relapse, and is suitable for being widely popularized.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating cold in uterus, a preparation method and application.
Background
In recent years, the occurrence of cold in the uterus is caused by the reasons that women are weak in constitution, invade the human body by exogenous cold evil, have poor appetite and malnutrition, stay in air-conditioned rooms and pay little attention to warm, have a cold day and are lovely and beautiful, pay no attention to self-maintenance and the like.
The symptoms of cold in the uterus include: during menstrual period, dysmenorrhea and blood clots occur, and the color of menstrual blood also appears dark; infertility is likely to occur; abnormal menstruation appears; the hands and feet are cold, or the whole body is cold, and the leucorrhea is usually clear and thin. The invention discloses a method for treating cold in uterus, for example, the invention patent with the publication number of CN108524635A, discloses a traditional Chinese medicine for treating cold in uterus and a preparation method thereof, wherein the traditional Chinese medicine is prepared from the following traditional Chinese medicines as raw materials in parts by weight: 2-5 parts of angelica, 4-7 parts of rhynohophylla root, 5-9 parts of scutellaria baicalensis, 1-3 parts of abrus cantoniensis hance, 2-9 parts of codonopsis pilosula, 3-6 parts of Chinese mesona herb, 2-5 parts of artemisia anomala and 3-7 parts of garden balsam stem. The traditional Chinese medicine has certain effect on treating the uterine cold syndrome caused by leukorrhagia, dysmenorrhea, menoxenia, deep and tight pulse, thin white tongue fur and much saliva. The preparation method is complex, the raw materials are divided into three groups for decoction in different time, the first decoction, the second decoction and the third decoction are combined and filtered to obtain filtrate, and the filtrate is decompressed and concentrated to obtain clear paste, so the required production period is long. In addition, the traditional Chinese medicine has poor taste when being taken.
Also, as the invention patent with publication number CN109833374A, a plaster for treating cold womb and a preparation method thereof are disclosed, the plaster is prepared from active components, plant essential oil, finished plaster seasoning and non-woven fabric; the active component comprises the following raw materials in parts by weight: 15-40 parts of motherwort, 10-30 parts of astragalus, 5-15 parts of angelica, 5-15 parts of poria cocos, 10-20 parts of liquorice, 10-15 parts of ligusticum wallichii, 5-10 parts of wolfberry fruit, 5-10 parts of red paeony root, 1-5 parts of red ginseng, 5-10 parts of pilose antler, 5-15 parts of rehmannia, 5-13 parts of costus root and 3-8 parts of achyranthes bidentata; the plaster disclosed by the invention also has a certain treatment effect on female cold uterus, but in the preparation process of the plaster, part of the raw material medicines are required to be processed firstly and then prepared into the plaster, so that the production period is too long.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating cold womb, a preparation method and application, and solves the problem that the production period is too long because part of raw material medicines are required to be processed and then prepared into ointment in the preparation process of the ointment.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a traditional Chinese medicine composition for treating cold in uterus is prepared from the following raw materials or extracts thereof in parts by weight: 42-78 parts of white peony root, 21-39 parts of Chinese date, 21-39 parts of cassia twig, 14-26 parts of honey-fried licorice root, 21-39 parts of ginger, 60-112 parts of cane sugar and 36-68 parts of dextrin.
The Chinese patent medicine of the invention has the following drug effects of the raw materials or the extracts:
white peony root: calming the liver, relieving pain, nourishing blood, regulating menstruation, astringing yin and arresting sweating; the main treatment is as follows: can be used for treating headache, dizziness, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat.
Chinese date: invigorating spleen, replenishing qi, nourishing blood, and tranquilizing; the main treatment is as follows: can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.
Cassia twig: inducing sweat to relieve muscles, warming and dredging channels, supporting yang to transform qi, and calming the adverse-rising energy; the main treatment is as follows: can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping.
Honey-fried licorice root: invigorating spleen and regulating stomach function, benefiting qi and recovering pulse; the main treatment is as follows: can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse.
Ginger: relieving exterior syndrome, dispelling cold, warming middle energizer, relieving vomiting, eliminating phlegm, and relieving cough; the main treatment is as follows: can be used for treating wind-cold type common cold, stomach cold type emesis, cold phlegm cough.
Preferably, the composition is prepared from the following raw materials or extracts thereof in parts by weight: 60 parts of white paeony root, 30 parts of Chinese date, 30 parts of cassia twig, 20 parts of honey-fried licorice root, 30 parts of ginger, 86 parts of cane sugar and 52 parts of dextrin.
A traditional Chinese medicine preparation for treating cold in uterus comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
Preferably, the traditional Chinese medicine preparation is a tablet, a capsule, a granule or an oral liquid.
Preferably, the auxiliary materials are sucrose and dextrin.
Preferably, the composition is prepared from the following raw materials or extracts thereof in parts by weight: 42-78 parts of white paeony root, 21-39 parts of Chinese date, 21-39 parts of cassia twig, 14-26 parts of honey-fried licorice root, 21-39 parts of ginger, 60-112 parts of cane sugar and 36-68 parts of dextrin;
preferably, the composition is prepared from the following raw materials or extracts thereof in parts by weight: 60 parts of white paeony root, 30 parts of Chinese date, 30 parts of cassia twig, 20 parts of honey-fried licorice root, 30 parts of ginger, 86 parts of cane sugar and 52 parts of dextrin.
A preparation method of the traditional Chinese medicine preparation specifically comprises the following steps:
the method comprises the following steps: adding water 2.5 times the amount of ramulus Cinnamomi and rhizoma Zingiberis recens, distilling with multifunctional extraction tank to obtain volatile oil, and collecting the distilled water solution;
step two: decocting the residue with radix Paeoniae alba, fructus Jujubae and radix Glycyrrhizae Preparata with 5 times of water for 1 hr for three times, mixing decoctions, and filtering with 80 mesh sieve;
step three: mixing the filtrate with the distilled water solution, and concentrating with double-effect external circulation concentrator to relative density of 1.10-1.12 at 65 deg.C;
step four: adding ethanol to make ethanol content reach 50%, stirring, standing for 6-8 hr, filtering with 80 mesh sieve;
step five: recovering ethanol from filtrate, and concentrating with double-effect external circulation concentrator to obtain soft extract with relative density of 1.28-1.32 at 65 deg.C;
step six: and D, adding a proper amount of sucrose powder into the thick paste obtained in the fifth step, uniformly mixing the thick paste and the dextrin by using a universal pulverizer, a 100-mesh screen and a trough type mixer to prepare a soft material.
Preferably, the granulation is carried out by a rocking granulator with a granulation screen: 14 meshes, drying by a boiling drying granulator at the air inlet temperature of 90 +/-5 ℃ for 45 +/-5 minutes.
Preferably, the screening is performed by a vibration screening machine, and the screen specification is as follows: top screen No. 1 screen, bottom screen No. 5 screen. Spraying volatile oil on the granules while sieving;
and/or, the total mixing of all the particles is carried out by a pyramid mixer for 30 +/-2 minutes;
and/or, the sub-packaging with a particle packaging machine: each bag is filled with 15g, and the filling quantity difference is less than or equal to +/-4.5 percent, thus obtaining the product.
The application of a traditional Chinese medicine composition in preparing a medicine for treating cold in uterus comprises the following raw materials or extracts thereof: white peony root, Chinese date, cassia twig, honey-fried licorice root and ginger;
preferably, the feed comprises the following raw materials or extracts thereof in parts by weight: 42-78 parts of white peony root, 21-39 parts of Chinese date, 21-39 parts of cassia twig, 14-26 parts of honey-fried licorice root and 21-39 parts of ginger;
further preferably, the feed comprises the following raw materials or extracts thereof in parts by weight: 60 parts of white peony root, 30 parts of Chinese date, 30 parts of cassia twig, 20 parts of honey-fried licorice root and 30 parts of ginger.
(III) advantageous effects
The invention provides a traditional Chinese medicine composition for treating cold in uterus, a preparation method and application. The method has the following beneficial effects: the invention adopts the pungent and warm cassia twig to warm yang qi and dispel cold evil; sour and sweet white peony root, radix Paeoniae alba nourishes nutrient-yin, relieves liver urgency and relieves abdominal pain. The ginger is used for warming the stomach and dispelling cold, and the Chinese date is used for tonifying the spleen and replenishing qi. Prepared licorice root, radix Glycyrrhizae Praeparata, as an adjuvant drug, has the effects of replenishing qi to regulate the middle warmer, and harmonizing the effects of the other drugs in the recipe. Wherein Gui Zhi, pungent and sweet in flavor and capable of resolving yang, warms middle-jiao and tonifies spleen deficiency; peony root combined with licorice root, sour and sweet, acts to relieve liver urgency and relieve abdominal pain. The combination of the ingredients can warm the middle-jiao and tonify deficiency and relieve urgency, and has the meaning of nourishing liver and regulating spleen, and benefiting yin and yang, so that the composition can strengthen the middle-jiao and activate yin-yang and qi and blood.
The Chinese patent medicine is prepared by extracting, concentrating, mixing thick paste with sucrose powder and dextrin, preparing into granules, and subpackaging into small bags for use. The production process is simple, the production amount is large, and the period is short. The product is dissolved by boiled water when being taken, is taken at a low temperature, has good taste, obvious effect and strong practicability, is not easy to relapse, and is suitable for being widely popularized.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, belong to the protection scope of the present invention.
Example 1
A traditional Chinese medicine composition for treating cold in uterus is prepared from the following raw materials or extracts thereof in parts by weight.
The formula I is as follows: 42 g of white peony root, 21 g of Chinese date, 21 g of cassia twig, 26 g of honey-fried licorice root and 39 g of ginger.
And a second formula: 78 g of white peony root, 39 g of Chinese date, 39 g of cassia twig, 14 g of honey-fried licorice root and 21 g of ginger.
And the formula III: 60 g of white peony root, 30 g of Chinese date, 30 g of cassia twig, 20 g of honey-fried licorice root and 30 g of ginger.
The formula four: 60 g of white peony root, 30 g of Chinese date, 30 g of cassia twig, 20 g of astragalus root and 30 g of ginger.
And a fifth formula: 60 g of prepared rhizome of rehmannia, 30 g of Chinese date, 30 g of cassia twig, 20 g of liquorice and 30 g of ginger.
And the formula six: white peony root 60 g, cassia twig 30 g, honey-fried licorice root 20 g.
Example 2
Traditional Chinese medicine composition granules for treating cold in uterus
The formulations of example 1 were prepared as follows:
the invention also discloses a preparation method of the traditional Chinese medicine preparation, which specifically comprises the following steps:
the method comprises the following steps: adding water 2.5 times the amount of ramulus Cinnamomi and rhizoma Zingiberis recens, distilling with multifunctional extraction tank to obtain volatile oil, and collecting the distilled water solution;
step two: decocting the residue with radix Paeoniae alba, fructus Jujubae and radix Glycyrrhizae Preparata with 5 times of water for 1 hr for three times, mixing decoctions, and filtering (80 mesh screen).
Step three: the filtrate is combined with the distilled aqueous solution and concentrated by a double-effect external circulation concentrator to a relative density of 1.10-1.12(65 ℃).
Step four: adding ethanol to make ethanol content reach 50%, stirring, standing for 6-8 hr, and filtering (80 mesh screen).
Step five: recovering ethanol from filtrate, and concentrating with double-effect external circulation concentrator to obtain soft extract (relative density 1.28-1.32g (65 deg.C)).
Step six: adding appropriate amount of sucrose powder (using universal pulverizer, 100 mesh screen) and dextrin into the thick paste obtained in step five, and mixing uniformly by using trough type mixer to obtain soft material.
Making into granule (granulation screen: 14 mesh) with swing type granulator, and drying with boiling drying granulator at air inlet temperature of 90 + -5 deg.C for 45 + -5 min.
Sieving with a vibration screening machine, wherein the specification of the screen is as follows: top screen No. 1 screen, bottom screen No. 5 screen. Spraying volatile oil on the granules while sieving.
All particles were mixed together using a square cone mixer for 30. + -. 2 minutes.
Subpackaging by using a particle packaging machine: each bag is filled with 15g, and the filling quantity difference is less than or equal to +/-4.5 percent, thus obtaining the product.
Examples of the experiments
Subject: women of childbearing age who suffer from cold womb infertility in the Chinese traditional medicine syndrome diagnosis curative effect standard published by the State administration of traditional Chinese medicine in 1994 are a group of cold womb infertility, and women with congenital uterine malformation, hysteromyoma, ovarian cyst, polycystic ovary and other diseases are excluded. Healthy women who have born birth are used as a control group. All sign an informed consent.
The experimental method comprises the following steps: the preparation is administered 3 times daily, and each bag contains 15g (10 g crude drug) of the granule.
Granular starch was used as placebo.
The detection method comprises the following steps: subjects were examined on both day 10 (follicular phase) and day 14 (ovulatory phase) of the menstrual cycle at TVS-3D, observed for endometrial morphology and measured for thickness. Measured at months 1, 2, 3, 6, 9, 12.
The rating method comprises the following steps:
and (3) curing: pregnancy within 1 year;
has the following effects: within 6 months, the thickness of the endometrium in the ovulatory period of the follicular phase has no obvious difference (P <0.05) with the control group.
The results are shown in Table 1.
TABLE 1 therapeutic Effect
| Percent cure rate/%) | Start efficiency/%) | |
| Formulation I | 80 | 85 |
| Formulation II | 80 | 90 |
| Formulation III | 85 | 95 |
| Formulation IV | 5 | 10 |
| Recipe five | 10 | 15 |
| Formula six | 10 | 10 |
| Placebo group | 5 | 10 |
Typical case
Wangzhi, woman, age 35, clerical, three years infertile after marriage, complaining oneself of mental fatigue, loss of appetite, watery stool, and watery menstruation. After the granule prepared from the traditional Chinese medicine composition of the formula III is taken, the thickness of the endometrium is recovered to be normal within 6 months, and pregnancy is carried out within 9 months.
Zhangqi, female, age 32, civilians, three years of infertility after marriage, complaint about soreness of waist, aversion to cold, clear and long urine, watery stool and frequent urination at night. After the granule prepared from the traditional Chinese medicine composition of the formula III is taken, the thickness of the endometrium is recovered to be normal within 3 months, and the pregnancy is performed within 6 months.
The above description is only for the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating cold in uterus is characterized by being prepared from the following raw materials or extracts thereof in parts by weight: 42-78 parts of white peony root, 21-39 parts of Chinese date, 21-39 parts of cassia twig, 14-26 parts of honey-fried licorice root and 21-39 parts of ginger.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the composition is prepared from the following raw materials or extracts thereof in parts by weight: 60 parts of white peony root, 30 parts of Chinese date, 30 parts of cassia twig, 20 parts of honey-fried licorice root and 30 parts of ginger.
3. A traditional Chinese medicine preparation for treating cold in uterus is characterized by comprising the traditional Chinese medicine composition 1 or 2 and pharmaceutically acceptable auxiliary materials.
4. The Chinese medicinal preparation according to claim 3, wherein the Chinese medicinal preparation is a tablet, a capsule, a granule or an oral liquid.
5. The Chinese medicinal preparation according to claim 3, wherein the adjuvants are sucrose and dextrin.
6. The traditional Chinese medicine preparation according to claim 3, which is prepared from the following raw materials or extracts thereof in parts by weight: 42-78 parts of white paeony root, 21-39 parts of Chinese date, 21-39 parts of cassia twig, 14-26 parts of honey-fried licorice root, 21-39 parts of ginger, 60-112 parts of cane sugar and 36-68 parts of dextrin;
preferably, the composition is prepared from the following raw materials or extracts thereof in parts by weight: 60 parts of white paeony root, 30 parts of Chinese date, 30 parts of cassia twig, 20 parts of honey-fried licorice root, 30 parts of ginger, 86 parts of cane sugar and 52 parts of dextrin.
7. A method of preparing a Chinese medicinal preparation according to claims 3-6, wherein the method comprises the steps of: the method specifically comprises the following steps:
the method comprises the following steps: adding water 2.5 times the amount of ramulus Cinnamomi and rhizoma Zingiberis recens, distilling with a multifunctional extraction tank to obtain volatile oil, and collecting the water solution after distillation;
step two: decocting the residue with radix Paeoniae alba, fructus Jujubae and radix Glycyrrhizae Preparata with 5 times of water for three times (1 hr each time), mixing decoctions, and filtering with 80 mesh sieve;
step three: mixing the filtrate with the distilled water solution, and concentrating with double-effect external circulation concentrator to relative density of 1.10-1.12 at 65 deg.C;
step four: adding ethanol to make ethanol content reach 50%, stirring, standing for 6-8 hr, filtering with 80 mesh sieve;
step five: recovering ethanol from filtrate, and concentrating with double-effect external circulation concentrator to obtain soft extract with relative density of 1.28-1.32 at 65 deg.C;
step six: and D, adding a proper amount of sucrose powder into the thick paste obtained in the fifth step, uniformly mixing the thick paste and the dextrin by using a universal pulverizer, a 100-mesh screen and a trough type mixer to prepare a soft material.
8. The method of claim 7, wherein: the granulation is made by using a swing granulator, and a granulation screen: 14 meshes, drying by a boiling drying granulator at the air inlet temperature of 90 +/-5 ℃ for 45 +/-5 minutes.
9. The method of claim 7, wherein: sieving by using a vibration screening machine, wherein the specification of a screen is as follows: top screen No. 1 screen, bottom screen No. 5 screen. Spraying volatile oil on the granules while sieving;
and/or, the total mixing of all the particles is carried out by a pyramid mixer for 30 +/-2 minutes;
and/or, the sub-packaging with a particle packaging machine: each bag is filled with 15g, and the filling quantity difference is less than or equal to +/-4.5 percent, thus obtaining the product.
10. An application of a traditional Chinese medicine composition in preparing a medicine for treating cold in uterus is characterized in that: the pharmaceutical composition comprises the following raw materials or extracts thereof: radix paeoniae alba, Chinese date, cassia twig, radix glycyrrhizae preparata and ginger;
preferably, the feed comprises the following raw materials or extracts thereof in parts by weight: 42-78 parts of white peony root, 21-39 parts of Chinese date, 21-39 parts of cassia twig, 14-26 parts of honey-fried licorice root and 21-39 parts of ginger;
further preferably, the feed comprises the following raw materials or extracts thereof in parts by weight: 60 parts of white peony root, 30 parts of Chinese date, 30 parts of cassia twig, 20 parts of honey-fried licorice root and 30 parts of ginger.
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| CN108524635A (en) * | 2018-05-28 | 2018-09-14 | 胡聪 | A kind of Chinese medicine and preparation method thereof for treating palace cold |
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