CN111467281A

CN111467281A - Anti-allergy moisturizing facial mask prepared from active polypeptide and hyaluronic acid and preparation method of anti-allergy moisturizing facial mask

Info

Publication number: CN111467281A
Application number: CN202010472700.6A
Authority: CN
Inventors: 蒋艳伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-29
Filing date: 2020-05-29
Publication date: 2020-07-31

Abstract

The invention provides an anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid and a preparation method thereof, wherein hyaluronic acid with large molecular weight is selected as a skeleton, cellulose and starch high molecular substances rich in hydroxyl are added, and a porous mask cloth which is easy to degrade and strong in rigidity is formed by utilizing the hydrogen bond action and the subsequent crosslinking action between the hyaluronic acid and the cellulose; meanwhile, the essence which is rich in active polypeptide and hyaluronic acid with different molecular weights and is used as an active ingredient is prepared, the natural plant anti-allergy active ingredient perilla leaf alcohol extract is added, and the anti-allergy active ingredient perilla leaf alcohol extract and the mask base cloth are combined to form the mask with anti-allergy moisturizing effects.

Description

Anti-allergy moisturizing facial mask prepared from active polypeptide and hyaluronic acid and preparation method of anti-allergy moisturizing facial mask

Technical Field

The invention belongs to the technical field of mask materials, and particularly relates to an anti-allergy moisturizing mask with active polypeptide compounded with hyaluronic acid and a preparation method thereof.

Background

The facial mask is one of important cosmetics for cleaning and nursing facial skin, when the facial mask is applied to a face, moisture and nutritional ingredients in the facial mask can compact and wrap the skin, so that water can fully permeate into the horny layer of the epidermis of the skin, meanwhile, nutritional or functional substances can fully permeate into the deep layer of the skin, the skin is softened, the elasticity of the skin is enhanced, the telangiectasia is promoted, dust, chemical pollutants, bacteria and grease dirt in pores are removed, the blood microcirculation of the deep layer of the skin is accelerated, the activity of cells of each layer of the epidermis is enhanced, the fatigue and the aging of the skin are eliminated, and the young state is maintained.

The facial mask comprises essence and facial mask cloth, and is prepared by soaking the essence, adsorbing on the facial mask cloth, and sealing and packaging with aluminum foil bag or plastic bag. At present, chemical synthetic fiber non-woven fabrics or artificial fiber non-woven fabrics are mostly adopted as mask fabrics, and although the non-woven fabrics mask bring certain beauty and skin care effects for consumers, the mask fabrics also have defects in beauty, such as: the degradation problem exists, and the regeneration and the utilization can not be realized; the long-term soaking of the soaking solution can cause the fibers and the adhesive of the non-woven fabric to be partially dissolved, the using effect of the mask is reduced, the phenomenon of allergy of consumers is easily caused, and the skin permeation capability is weak. In addition, the existing essence is added with excessive chemical components, so that the sensitive skin is easy to generate allergic phenomena, and skin diseases such as flushing, erythra and the like are caused.

For this reason, various types of masks have been proposed in the prior art to solve the allergic phenomenon caused by mask cloths and essences, such as: CN2019114145526 discloses a dissolving facial mask for whitening and removing freckles and a preparation method thereof. The components in the facial mask have small molecular weight, can be completely absorbed by skin, and can be cleaned after use, and the components synergistically play a role in whitening and removing freckles. CN201911392018X discloses an aseptic mask and a preparation method thereof, wherein a mask base material is selected from graphene-biological cellulose-oligopeptide-piperine base material, and the base material has the advantages of good absorptivity, strong penetration promotion and good fitting performance. However, the mask cloth still has the defects of poor permeability, insufficient rigidity, easy dissolution and allergy.

Therefore, a novel facial mask which is easily degradable, not easy to dissolve and allergic and is matched with preferred essence to achieve the long-term anti-allergy and moisturizing effects is needed in the field.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide the anti-allergy moisturizing facial mask compounded by the active polypeptide and the hyaluronic acid and the preparation method thereof, and the facial mask can effectively moisturize the surface layer of the skin through compounding the active polypeptide and the hyaluronic acid, and further permeate into the skin to provide sufficient moisture for dry skin; meanwhile, hyaluronic acid is used as a skeleton, and the mask base cloth is prepared through electrostatic spinning, so that the mask base cloth has good degradability, rigidity and permeability, is easy to attach to skin, and synergistically enhances the moisturizing and water-holding performances of the mask base cloth.

In order to solve the technical problems, the invention provides a preparation method of an anti-allergy moisturizing facial mask prepared by compounding active polypeptide with hyaluronic acid, which comprises the following steps:

1. preparation of mask cloth

1.1 dissolving hyaluronic acid, a polymer and a pore-foaming agent in a mixed solvent consisting of water, formic acid and N, N-dimethylformamide to prepare a solution with the weight percentage of 6-8 wt%, and performing ultrasonic treatment to obtain a transparent mixed solution;

the polymer is selected from one or more of hydroxymethyl cellulose, hydroxyethyl cellulose, ethyl starch and methyl starch; the pore-foaming agent is selected from one or more than two of polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone;

1.2, performing electrostatic spinning on the transparent mixed solution prepared in the step 1.1 to obtain a fiber membrane, and soaking the fiber membrane into a cross-linking agent for treatment for 30-60 min; the cross-linking agent is selected from more than two of glutaraldehyde, carbodiimide and epichlorohydrin;

1.3 soaking the fiber membrane obtained in the step 1.2 in water for 1-2 hours to obtain mask cloth;

2. preparation of essence

2.1 pulverizing folium Perillae, sieving with 100 mesh sieve, adding 70-75% ethanol solution according to the material-liquid ratio of 1:30-50, heating to 40-50 deg.C, refluxing for 1-2h, filtering, and oven drying the filtrate to obtain folium Perillae ethanol extract;

2.2 weighing 0.2-0.6 part of perilla leaf alcohol extract, 2-5 parts of macromolecular hyaluronic acid, 3-6 parts of micromolecular hyaluronic acid, 0.5-3 parts of active polypeptide, 5-8 parts of water-soluble micromolecule, 0.5-0.8 part of microcrystalline cellulose, 1-2 parts of guar gum, 0.6-0.8 part of chondroitin sulfate and 60-80 parts of water in the step 2.1 for later use;

2.3, uniformly mixing 20-40 parts of water, 2-5 parts of macromolecular hyaluronic acid and 0.6-0.8 part of chondroitin sulfate, adding 0.2-0.6 part of perilla leaf alcohol extract, 3-6 parts of micromolecular hyaluronic acid, 0.5-3 parts of active polypeptide and 5-8 parts of water-soluble micromolecule, continuously uniformly mixing, and finally adding 1-2 parts of guar gum, 0.5-0.8 part of microcrystalline cellulose and the rest water, and uniformly mixing to obtain essence;

3. preparation of facial mask

And (3) soaking the mask cloth obtained in the step (1) in the essence obtained in the step (2), treating for 10-20min, sterilizing by adopting microwave, and packaging to obtain the anti-allergy moisturizing mask with the active polypeptide compounded with hyaluronic acid.

Preferably, the molecular weight of the hyaluronic acid in step 1.1 is 1600-1800kda, the weight ratio of hyaluronic acid: the weight ratio of the polymer to the pore-foaming agent is 10-15:8-10:1-2, and the weight ratio of water, formic acid and N, N-dimethylformamide in the mixed solvent is 20-40:40-60: 20-40;

preferably, the specific method of electrostatic spinning in the step 1.3 is that a spinning outlet is a No. 6 needle head, the voltage is 15-25 kV, the distance from a spray head to a receiver is 20-25 cm, the spray flow is 0.5-0.8 ml/h, and the relative humidity is lower than 40%;

preferably, the molecular weight of the macromolecular hyaluronic acid is 1200-1500kda, and the molecular weight of the small molecular hyaluronic acid is 500-800 kda; the active polypeptide is selected from one or more than two of palmitoyl tripeptide-8, acetyl tetrapeptide-9, acetyl tetrapeptide-15, hexapeptide-3, copper peptide and oligopeptide-1; the water-soluble micromolecules are one or more than two of glycerol, ethylene glycol and propylene glycol.

The invention also aims to provide the facial mask prepared by the method, which has good anti-allergy moisturizing effect.

The invention has the following beneficial effects:

(1) according to the invention, hyaluronic acid with large molecular weight is selected as a skeleton, cellulose and starch high-molecular substances rich in hydroxyl are added, and a facial mask cloth base material which is easy to degrade and strong in rigidity is formed by utilizing the hydrogen bond effect and the subsequent crosslinking effect between the hyaluronic acid and the cellulose and the starch high-molecular substances; meanwhile, in the preparation process, pore-forming agents are added, most of the pore-forming agents are removed through soaking water in the subsequent process to form a porous structure, so that the capacity of the facial mask cloth for adsorbing essence can be enhanced, the essence can flow freely in the facial mask cloth, the permeability is enhanced, and the skin surface can be reached quickly;

(2) hyaluronic acid is one of the constituents of human skin, is an acidic mucosaccharide which is most widely distributed in human bodies, exists in a matrix of connective tissues, has good water replenishing and moisturizing effects, slightly expands capillary vessels by utilizing the skin tightening effect of macromolecular hyaluronic acid and the skin permeability of small molecular hyaluronic acid, promotes small molecular active polypeptides and other components to be soaked in the skin, increases the skin elasticity and delays the skin aging;

(3) the perilla alcohol extract has good anti-allergy performance, is not easy to cause allergic reaction of skin, is a good natural plant anti-allergy component, and can play a good anti-allergy effect by adding a certain amount of perilla alcohol extract into the facial mask;

(4) the mask cloth and the essence of the mask are simple in preparation method and low in cost, have good anti-allergy moisturizing effects, delay skin aging and have good market prospects.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

All of the starting materials of the present invention, without particular limitation as to their source, may be purchased commercially or prepared according to conventional methods well known to those skilled in the art.

Example 1

A preparation method of an anti-allergy moisturizing mask with active polypeptide compounded with hyaluronic acid comprises the following steps:

1. preparation of mask cloth

1.1 dissolving hyaluronic acid, a polymer and a pore-foaming agent in a mixed solvent consisting of water, formic acid and N, N-dimethylformamide to prepare a solution with the weight percentage of 8 wt%, and performing ultrasonic treatment to obtain a transparent mixed solution;

the polymer is a mixture of hydroxymethyl cellulose and methyl starch in a weight ratio of 1: 1; the pore-forming agent is selected from polyethylene glycol; the molecular weight of the hyaluronic acid is 1600kda, and the ratio of hyaluronic acid: the weight ratio of the polymer to the pore-foaming agent is 10:8:1, and the weight ratio of water, formic acid and N, N-dimethylformamide in the mixed solvent is 40:40: 20;

1.2, performing electrostatic spinning on the transparent mixed solution prepared in the step 1.1 to obtain a fiber membrane, and soaking the fiber membrane into a cross-linking agent for treatment for 60 min; the cross-linking agent is selected from glutaraldehyde; the specific method of electrostatic spinning is that a spinning outlet is a No. 6 needle head, the voltage is 15kV, the distance from a spray head to a receiver is 25cm, the jet flow is 0.8ml/h, and the relative humidity is lower than 40%;

1.3, soaking the fiber membrane obtained in the step 1.2 in water for 1.5 hours to obtain mask cloth;

2. preparation of essence

2.1 pulverizing folium Perillae, sieving with 100 mesh sieve, adding 70% ethanol solution according to the material-liquid ratio of 1:30, heating to 50 deg.C, refluxing for 1h, filtering, and oven drying the filtrate to obtain folium Perillae ethanol extract;

2.2 weighing 0.2 part of perilla leaf alcohol extract, 4 parts of macromolecular hyaluronic acid, 5 parts of micromolecular hyaluronic acid, 2 parts of active polypeptide, 5 parts of water-soluble micromolecule, 0.6 part of microcrystalline cellulose, 2 parts of guar gum, 0.8 part of chondroitin sulfate and 80 parts of water in the step 2.1 for later use;

2.3, uniformly mixing 40 parts of water, 4 parts of macromolecular hyaluronic acid and 0.8 part of chondroitin sulfate, adding 0.2 part of perilla leaf alcohol extract, 5 parts of micromolecular hyaluronic acid, 2 parts of active polypeptide and 5 parts of water-soluble micromolecule, continuously uniformly mixing, and finally adding 2 parts of guar gum, 0.6 part of microcrystalline cellulose and the rest water, and uniformly mixing to obtain essence;

the molecular weight of the macromolecular hyaluronic acid is 1500kda, and the molecular weight of the small molecular hyaluronic acid is 800 kda; the active polypeptide is selected from a mixture of palmitoyl tripeptide-8 and acetyl tetrapeptide-9 in a weight ratio of 1: 1; the water-soluble micromolecules are a mixture of glycerol and propylene glycol in a weight ratio of 1: 2;

3. preparation of facial mask

And (3) soaking the mask cloth obtained in the step (1) in the essence obtained in the step (2), treating for 15min, sterilizing by adopting microwave, and packaging to obtain the anti-allergy moisturizing mask of the active polypeptide composite hyaluronic acid.

Example 2

1. preparation of mask cloth

1.1 dissolving hyaluronic acid, a polymer and a pore-foaming agent in a mixed solvent consisting of water, formic acid and N, N-dimethylformamide to prepare a solution with the weight percentage of 6 wt%, and performing ultrasonic treatment to obtain a transparent mixed solution;

the polymer is selected from a mixture of hydroxymethyl cellulose and hydroxyethyl cellulose in a weight ratio of 2:1, and the pore-foaming agent is selected from a mixture of polyethylene glycol and polyvinyl alcohol in a weight ratio of 1: 1; the molecular weight of the hyaluronic acid is 1800kda, the molecular weight of the hyaluronic acid: the weight ratio of the polymer to the pore-foaming agent is 15:8:1, and the weight ratio of water, formic acid and N, N-dimethylformamide in the mixed solvent is 30: 60: 20;

1.2, performing electrostatic spinning on the transparent mixed solution prepared in the step 1.1 to obtain a fiber membrane, and soaking the fiber membrane into a cross-linking agent for treatment for 40 min; the crosslinking agent is epichlorohydrin, and the specific method of electrostatic spinning is that a filament outlet is a No. 6 needle, the voltage is 25kV, the distance from a spray head to a receiver is 25cm, the spray flow is 0.8ml/h, and the relative humidity is lower than 40%;

2. preparation of essence

2.1 pulverizing folium Perillae, sieving with 100 mesh sieve, adding 75% ethanol solution according to the material-liquid ratio of 1: 50, heating to 50 deg.C, refluxing for 2 hr, filtering, and oven drying the filtrate to obtain folium Perillae ethanol extract;

2.2 weighing 0.6 part of perilla leaf alcohol extract, 5 parts of macromolecular hyaluronic acid, 6 parts of micromolecular hyaluronic acid, 3 parts of active polypeptide, 8 parts of water-soluble micromolecule, 0.5 part of microcrystalline cellulose, 2 parts of guar gum, 0.8 part of chondroitin sulfate and 60 parts of water in the step 2.1 for later use;

2.3, uniformly mixing 20 parts of water, 5 parts of macromolecular hyaluronic acid and 0.8 part of chondroitin sulfate, adding 0.6 part of perilla leaf alcohol extract, 6 parts of micromolecular hyaluronic acid, 3 parts of active polypeptide and 8 parts of water-soluble micromolecule, continuously uniformly mixing, and finally adding 2 parts of guar gum, 0.5 part of microcrystalline cellulose and the rest water, and uniformly mixing to obtain essence;

the molecular weight of the macromolecular hyaluronic acid is 1500kda, and the molecular weight of the small molecular hyaluronic acid is 800 kda; the active polypeptide is selected from palmitoyl tripeptide-8, acetyl tetrapeptide-9 and acetyl tetrapeptide-15 in a weight ratio of 1:1: 1; the water-soluble small molecule is glycerol;

3. preparation of facial mask

And (3) soaking the mask cloth obtained in the step (1) in the essence obtained in the step (2), treating for 20min, sterilizing by adopting microwave, and packaging to obtain the anti-allergy moisturizing mask of the active polypeptide composite hyaluronic acid.

Example 3

1. preparation of mask cloth

1.1 dissolving hyaluronic acid, a polymer and a pore-foaming agent in a mixed solvent consisting of water, formic acid and N, N-dimethylformamide to prepare a solution with the weight percentage of 7 wt%, and performing ultrasonic treatment to obtain a transparent mixed solution;

the polymer is selected from a mixture of hydroxyethyl cellulose and methyl starch in a weight ratio of 1: 3; the pore-foaming agent is selected from a mixture of polyethylene glycol and polyvinylpyrrolidone in a weight ratio of 3: 1; the molecular weight of the hyaluronic acid is 1600kda, and the ratio of hyaluronic acid: the weight ratio of the polymer to the pore-foaming agent is 15: 10: 2, and the weight ratio of water, formic acid and N, N-dimethylformamide in the mixed solvent is 40:50: 40;

1.2, performing electrostatic spinning on the transparent mixed solution prepared in the step 1.1 to obtain a fiber membrane, and soaking the fiber membrane into a cross-linking agent for treatment for 40 min; the cross-linking agent is selected from a mixture of carbodiimide and epichlorohydrin in a weight ratio of 2: 3; the specific method of electrostatic spinning is that a spinning outlet is a No. 6 needle head, the voltage is 20kV, the distance from a spray head to a receiver is 22cm, the jet flow is 0.6ml/h, and the relative humidity is lower than 40%;

1.3 soaking the fiber membrane obtained in the step 1.2 in water for 1 hour to obtain mask cloth;

2. preparation of essence

2.1 pulverizing folium Perillae, sieving with 100 mesh sieve, adding 75% ethanol solution according to the material-liquid ratio of 1:40, heating to 40 deg.C, refluxing for 1h, filtering, and oven drying the filtrate to obtain folium Perillae ethanol extract;

2.2 weighing 0.4 part of perilla leaf alcohol extract, 4 parts of macromolecular hyaluronic acid, 3 parts of micromolecular hyaluronic acid, 1 part of active polypeptide, 6 parts of water-soluble micromolecule, 0.6 part of microcrystalline cellulose, 1.5 parts of guar gum, 0.7 part of chondroitin sulfate and 70 parts of water in the step 2.1 for later use;

2.3, uniformly mixing 40 parts of water, 4 parts of macromolecular hyaluronic acid and 0.7 part of chondroitin sulfate, adding 0.4 part of perilla leaf alcohol extract, 3 parts of micromolecular hyaluronic acid, 1 part of active polypeptide and 6 parts of water-soluble micromolecule, continuously uniformly mixing, and finally adding 1.5 parts of guar gum, 0.6 part of microcrystalline cellulose and the rest water, and uniformly mixing to obtain essence;

the molecular weight of the macromolecular hyaluronic acid is 1400kda, and the molecular weight of the small molecular hyaluronic acid is 700 kda; the active polypeptide is selected from hexapeptide-3, copper peptide and oligopeptide-1 in a weight ratio of 2:3: 1; the water-soluble micromolecules are a mixture of glycerol and propylene glycol in a weight ratio of 1: 2;

3. preparation of facial mask

Example 4

1. preparation of mask cloth

the polymer is selected from methyl starch; the pore-forming agent is selected from polyethylene glycol; molecular weight of hyaluronic acid is 1800kda, the molecular weight of hyaluronic acid: the weight ratio of the polymer to the pore-foaming agent is 12:9:1, and the weight ratio of water, formic acid and N, N-dimethylformamide in the mixed solvent is 40: 60: 30;

1.2, performing electrostatic spinning on the transparent mixed solution prepared in the step 1.1 to obtain a fiber membrane, and soaking the fiber membrane into a cross-linking agent for treatment for 60 min; the cross-linking agent is selected from glutaraldehyde, and the specific method of electrostatic spinning is that a filament outlet is a No. 6 needle, the voltage is 15kV, the distance from a spray head to a receiver is 25cm, the spray flow is 0.8ml/h, and the relative humidity is lower than 40%;

1.3 soaking the fiber membrane obtained in the step 1.2 in water for 2 hours to obtain mask cloth;

2. preparation of essence

2.1 pulverizing folium Perillae, sieving with 100 mesh sieve, adding 75% ethanol solution according to the material-liquid ratio of 1: 50, heating to 50 deg.C, refluxing for 1h, filtering, and oven drying the filtrate to obtain folium Perillae ethanol extract;

2.2 weighing 0.6 part of perilla leaf alcohol extract, 5 parts of macromolecular hyaluronic acid, 4 parts of micromolecular hyaluronic acid, 3 parts of active polypeptide, 8 parts of water-soluble micromolecule, 0.7 part of microcrystalline cellulose, 2 parts of guar gum, 0.8 part of chondroitin sulfate and 80 parts of water in the step 2.1 for later use;

2.3, uniformly mixing 30 parts of water, 5 parts of macromolecular hyaluronic acid and 0.8 part of chondroitin sulfate, adding 0.6 part of perilla leaf alcohol extract, 4 parts of micromolecular hyaluronic acid, 3 parts of active polypeptide and 8 parts of water-soluble micromolecule, continuously uniformly mixing, and finally adding 2 parts of guar gum, 0.7 part of microcrystalline cellulose and the rest water, and uniformly mixing to obtain essence; the molecular weight of the macromolecular hyaluronic acid is 1300kda, and the molecular weight of the small molecular hyaluronic acid is 800 kda; the active polypeptide is selected from oligopeptide-1, and the water-soluble micromolecule is ethylene glycol;

3. preparation of facial mask

Comparative example 1

The procedure is as in example 1 except that no polymer is added;

comparative example 2

The procedure is as in example 2 except that no polymer is added;

comparative example 3

The procedure was the same as in example 1 except that no perilla leaf alcohol was added;

comparative example 4

Only macromolecular hyaluronic acid is added, and small molecular hyaluronic acid is not added, and the rest steps are the same as the example 1;

comparative example 5

Only small hyaluronic acid molecules were added, and no large hyaluronic acid molecules were added, and the remaining procedure was the same as in example 1.

The masks prepared in examples 1 to 4 and comparative examples 1 to 5 were subjected to the following performance tests:

(1) the results of the performance test of the mask cloth are shown in Table 1

TABLE 1

The data in table 1 show that the rigidity, breaking strength, air permeability, liquid absorption amount and the like of the mask cloth are obviously improved by adding the polymer into the mask cloth, and a good effect is achieved.

(2) Moisture retention test

The invention adopts a human body test to evaluate the moisturizing effect, and the specific experimental process comprises the following steps of firstly, selecting 50 subjects, defining 2 areas (5 m × 5 m) with the same area on the left forearm as a use area at the position 5cm away from the base of the palm on the inner side of the left arm and the right arm of the subject, using a point at the same position of the right forearm as a blank control area, and simultaneously testing the corresponding areas of the left arm and the right arm, secondly, circularly applying the samples of examples 1-4 and comparative examples 1-5 on the two test areas of the arm by the subject in sequence, testing the hydration state of the skin by using a skin moisture measuring instrument 1, 2, 4, 6 and 8h after application, measuring for 3 times, and taking an average value, wherein the larger the moisture content is the larger, and on the contrary, the smaller the moisture content is the smaller the moisture content of the test part of the:

TABLE 2

As can be seen from the data in table 2, the moisturizing effect of the facial mask can be improved by applying a polymer rich in hydroxyl groups to the facial mask cloth and compounding hyaluronic acids with different molecular weights.

(3) Anti-allergy test

The anti-allergy effect of the facial mask is tested by adopting a human skin patch test, and the anti-allergy test is respectively carried out on the facial masks prepared in example 1 and comparative example 3 according to a method of the human skin patch test in 2015 edition of cosmetic safety technical Specification.

The test method comprises the following steps: 40 subjects were selected and the masks of example 1 and comparative example 3 were cut to an area of 50mm²The round shape of (1) was attached to the face of the subject, the blank group was coated with purified water, the mask was removed after 24 hours, the skin reaction of the subject was observed at 0.5 hour, 24 hours and 48 hours after the removal, respectively, and the results of the skin reaction scale were recorded.

And (4) judging the standard:

the test results are shown in Table 3

Therefore, the perilla leaf alcohol extract is added into the facial mask to improve the anti-allergy effect of the facial mask, and the facial mask prepared by the invention has good anti-allergy effect and is safe and non-irritant to use.

It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. A preparation method of an anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid is characterized by comprising the following steps: the method comprises the following steps:

1. preparation of mask cloth

1.1 dissolving hyaluronic acid, a polymer and a pore-foaming agent in a mixed solvent consisting of water, formic acid and N, N-dimethylformamide to prepare a solution with the weight percentage of 6-8 wt%, and performing ultrasonic treatment to obtain a transparent mixed solution; the polymer is selected from one or more of hydroxymethyl cellulose, hydroxyethyl cellulose, ethyl starch and methyl starch;

1.2, performing electrostatic spinning on the transparent mixed solution prepared in the step 1.1 to obtain a fiber membrane, and soaking the fiber membrane into a cross-linking agent for treatment for 30-60 min;

2. preparation of essence

3. preparation of facial mask

2. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 1, wherein the method comprises the following steps: the pore-forming agent is selected from one or more of polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone.

3. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 1, wherein the method comprises the following steps: the cross-linking agent is one or more than two of glutaraldehyde, carbodiimide and epichlorohydrin.

4. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 1, wherein the method comprises the following steps: the molecular weight of hyaluronic acid in step 1.1 is 1600-1800 kda.

5. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 4, wherein the method comprises the following steps: the hyaluronic acid: the weight ratio of the polymer to the pore-foaming agent is 10-15:8-10:1-2, and the weight ratio of water, formic acid and N, N-dimethylformamide in the mixed solvent is 20-40:40-60: 20-40.

6. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 1, wherein the method comprises the following steps: the specific method of electrostatic spinning in the step 1.3 is that a spinning outlet is a No. 6 needle head, the voltage is 15-25 kV, the distance from a spray head to a receiver is 20-25 cm, the spray flow is 0.5-0.8 ml/h, and the relative humidity is lower than 40%.

7. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 1, wherein the method comprises the following steps: the molecular weight of the macromolecular hyaluronic acid is 1200-1500kda, and the molecular weight of the small molecular hyaluronic acid is 500-800 kda.

8. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 7, wherein the method comprises the following steps: the active polypeptide is selected from one or more than two of palmitoyl tripeptide-8, acetyl tetrapeptide-9, acetyl tetrapeptide-15, hexapeptide-3, copper peptide and oligopeptide-1.

9. The method for preparing the anti-allergy moisturizing mask of active polypeptide compounded hyaluronic acid according to claim 7, wherein the method comprises the following steps: the water-soluble micromolecules are one or more than two of glycerol, ethylene glycol and propylene glycol.

10. An anti-allergic moisture-keeping facial mask prepared according to the method of claims 1-9 and containing active polypeptide compounded hyaluronic acid.