CN111458321A - Diagnostic system based on lesion site fluorescence feedback - Google Patents
Diagnostic system based on lesion site fluorescence feedback Download PDFInfo
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- CN111458321A CN111458321A CN202010441713.7A CN202010441713A CN111458321A CN 111458321 A CN111458321 A CN 111458321A CN 202010441713 A CN202010441713 A CN 202010441713A CN 111458321 A CN111458321 A CN 111458321A
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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Abstract
The invention discloses a diagnostic system based on lesion site fluorescence feedback, which comprises a light source, a light filtering device, a sample accommodating device, a slide rail, an injection device, a first detection device, a second detection device and an information processing device, wherein the light filtering device is used for filtering light rays emitted from the light source; the light source, the filtering device, the sample accommodating device, the sliding rail, the injection device, the first detection device and the second detection device are in signal connection with the information processing device; the diagnosis system based on the lesion site fluorescence feedback occupies small space, is easy to operate, can find whether the tracer in a lesion site sample is sufficient or not and whether the illumination intensity is sufficient or not in time, and corrects the tracer to improve the detection efficiency.
Description
Technical Field
The invention relates to the field of medical treatment, in particular to a diagnosis system based on lesion site fluorescence feedback.
Background
Traditional tumor detection means, such as X-ray imaging, nuclear magnetic resonance imaging and the like, have a certain diagnosis rate, but instrument and equipment are heavy, the manufacturing cost is high, and the diagnosis cost is high, so that the methods are difficult to become effective means for tumor general investigation, and detection technologies such as B-ultrasonic and X-ray are more unknowable damages to human bodies and cannot be used as daily detection methods; therefore, a diagnosis system based on the fluorescence feedback of the lesion part, which occupies less space, has low cost and is convenient to operate, is needed.
Disclosure of Invention
The invention aims to provide a diagnostic system based on lesion site fluorescence feedback, and aims to solve the problems of large occupied space and difficulty in operation in the prior art.
In order to realize the purpose, the invention adopts the following technical scheme:
a diagnostic system based on lesion site fluorescence feedback comprises a light source, a light filtering device, a sample accommodating device, a sliding rail, an injection device, a first detection device, a second detection device and an information processing device, wherein the light filtering device is used for filtering light rays emitted from the light source, the sample accommodating device is used for accommodating a lesion site sample and is fixedly connected with the sliding rail, the injection device is used for accommodating a tracer and injecting the tracer into the lesion site sample, the first detection device is used for detecting the content of the tracer in the lesion site sample, and the second detection device is used for detecting the fluorescence intensity generated by the lesion site sample; the light source, the filter device, the sample containing device, the sliding rail, the injection device, the first detection device and the second detection device are in signal connection with the information processing device.
Preferably, the device further comprises a motor, and the motor is used for driving the sliding rail.
Preferably, the motor is in signal connection with the information processing device.
Preferably, the information processing apparatus is a microprocessor.
Preferably, the first detection device and the second detection device are both in signal connection with the information processing device through data lines.
Preferably, the first detection means comprises a probe for accessing the lesion sample.
Preferably, the second detection device is a photoelectric sensor.
Preferably, the light source is a laser with an adjustable incident angle.
Preferably, the wavelength of the laser is between 781-789 nm.
Preferably, the tracer is indocyanine green.
Compared with the prior art, the invention has the advantages that:
the diagnosis system based on the lesion site fluorescence feedback has the advantages of small occupied space and easy operation, can find whether the tracer in a lesion site sample is sufficient or not and whether the illumination intensity is sufficient or not in time, and corrects in time to improve the detection efficiency.
Drawings
FIG. 1 is a schematic diagram of a lesion site fluorescence feedback-based diagnostic system of the present invention.
The reference numbers in the figures illustrate:
1. a diagnostic system based on lesion site fluorescence feedback; 2. a light source; 3. a light filtering means; 4. a sample containment device; 5. a slide rail; 6. an injection device; 7. a first detection device; 8. a probe; 9. a second detection device; 10. a lesion site sample; 11. an information processing apparatus.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise specifically stated or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are used in a broad sense, and for example, "connected" may be a fixed connection, a detachable connection, an integral connection, a mechanical connection, an electrical connection, a direct connection, an indirect connection through an intermediate medium, and a communication between two elements.
Referring to fig. 1, a diagnostic system 1 based on fluorescence feedback of a lesion site comprises a light source 2, a filter device 3, a sample container 4, a slide rail 5, an injection device 6, a first detection device 7, a second detection device 9 and an information processing device 11, wherein the filter device 3 is used for filtering light emitted from the light source 2, the sample container 4 is used for containing a lesion site sample 10, the sample container 4 is fixedly connected with the slide rail 5, the injection device 6 contains a tracer and is used for injecting the tracer into the lesion site sample 10, the first detection device 7 is used for detecting the content of the tracer in the lesion site sample 10, and the second detection device 9 is used for detecting the intensity of fluorescence generated by the lesion site sample 10; the light source 2, the filter device 3, the sample container 4, the slide rail 5, the injection device 6, the first detection device 7 and the second detection device 9 are all in signal connection with the information processing device 11.
The light source 2 is laser, the directivity of the laser is good, the divergence angle after emission is very small, the monochromaticity is good, the wavelength of the laser is between 781-789 nm, and the coherence is good; the laser can adjust the incident angle according to the requirement; the laser emitted from the light source 2 can be irradiated to the surface of the lesion part sample 10 after being filtered by the filter device 3; the sample containing device 4 is a tray, and the tray is fixedly connected with the slide rail 5, so that the position of the tray can be adjusted through the slide rail 5, or the incident angle of laser is adjusted, so that the incident light and the lesion part sample 10 are in the optimal position; after the sample 10 of the lesion part is irradiated by the laser, the fluorescence is generated due to the tracer, the fluorescence of the normal part is different from that of the product of the lesion part, and the condition of the lesion part can be judged by analyzing the fluorescence generated by the sample 10 of the lesion part.
In addition, after the first detection device 7 detects the content of the tracer in the lesion sample 10, the related information is sent to the information processing device 11, and after the information processing device 11 processes the related information, if the content of the tracer in the lesion sample 10 is found to be insufficient, a signal is sent to the injection device 6 to supplement and inject the tracer into the lesion sample 10; similarly, after the second detecting device 9 detects the fluorescence intensity of the surface of the lesion sample 10, it sends the relevant information to the information processing device 11, if the fluorescence intensity is found to be insufficient, it can send a signal to the light source 2 to increase the power of the laser, so that the fluorescence intensity of the lesion sample 10 can meet the requirement; if the tracer and the fluorescence intensity both meet the detection requirements, the lesion site sample 10 can be detected.
In order to improve the detection efficiency, the system is further provided with a motor which is in signal connection with the information processing device 11, the motor is used for driving the sliding rail 5, the information processing device 11 drives the sliding rail 5 through the motor so as to rapidly convey the tray to a specified position, and the sample 10 of the pathological change part is detected.
Preferably, the information processing device 11 is a microprocessor; meanwhile, in order to exchange information with the microprocessor stably and quickly, the first detection device 7 and the second detection device 9 are in signal connection with the microprocessor through data lines.
Preferably, the first detecting device 7 comprises a probe 8, and the probe 8 can enter the lesion sample 10 to detect the content of the tracer in the lesion sample 10, and send related data to the microprocessor, or receive signals sent by the microprocessor to detect the content of the tracer in different regions.
The second detecting device 9 is a photoelectric sensor, preferably a CCD, which is made of a semiconductor material with high light sensitivity, converts light into electric charges, converts the electric charges into digital signals through an analog-to-digital converter chip, and sends the digital signals to a microprocessor for processing, and receives instructions from the microprocessor to detect fluorescence; the tracer is indocyanine green, a common tracer.
By adopting the diagnostic system 1 based on the lesion part fluorescence feedback, the occupied space is small, the operation is easy, whether the tracer in the lesion part sample 10 is sufficient or not and whether the illumination intensity is sufficient or not can be found in time, and the microprocessor can correct the content and the illumination intensity of the tracer in time according to the detected data so as to improve the detection efficiency.
The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.
Claims (10)
1. A diagnostic system based on lesion site fluorescence feedback, characterized by: the device comprises a light source, a light filtering device, a sample accommodating device, a slide rail, an injection device, a first detection device, a second detection device and an information processing device, wherein the light filtering device is used for filtering light rays emitted from the light source, the sample accommodating device is used for accommodating a sample of a lesion part, the sample accommodating device is fixedly connected with the slide rail, the injection device is accommodated with a tracer and is used for injecting the tracer into the sample of the lesion part, the first detection device is used for detecting the content of the tracer in the sample of the lesion part, and the second detection device is used for detecting the intensity of fluorescence generated by the sample of the lesion part; the light source, the filter device, the sample containing device, the sliding rail, the injection device, the first detection device and the second detection device are in signal connection with the information processing device.
2. The lesion site fluorescence feedback-based diagnostic system of claim 1, wherein: still include the motor, this motor is used for driving the slide rail.
3. The lesion site fluorescence feedback-based diagnostic system of claim 2, wherein: the motor is in signal connection with the information processing device.
4. The lesion site fluorescence feedback-based diagnostic system of claim 3, wherein: the information processing device is a microprocessor.
5. The lesion site fluorescence feedback-based diagnostic system of claim 1, wherein: and the first detection device and the second detection device are in signal connection with the information processing device through data lines.
6. The lesion site fluorescence feedback-based diagnostic system of claim 5, wherein: the first detection device includes a probe for accessing the lesion sample.
7. The lesion site fluorescence feedback-based diagnostic system of claim 6, wherein: the second detection device is a photoelectric sensor.
8. The lesion site fluorescence feedback-based diagnostic system of claim 1, wherein: the light source is laser with adjustable incident angle.
9. The lesion site fluorescence feedback-based diagnostic system of claim 8, wherein: the wavelength of the laser is between 781-789 nm.
10. The lesion site fluorescence feedback-based diagnostic system of claim 1, wherein: the tracer is indocyanine green.
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Cited By (3)
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| CN112051250A (en) * | 2020-09-09 | 2020-12-08 | 南京诺源医疗器械有限公司 | Medical fluorescence imaging image light supplement adjusting system and adjusting method |
| CN112057046A (en) * | 2020-09-10 | 2020-12-11 | 南京诺源医疗器械有限公司 | Tumor fluorescence imaging spectrum diagnostic apparatus |
| CN116705215A (en) * | 2023-08-04 | 2023-09-05 | 南京诺源医疗器械有限公司 | Fluorescent marking system for detecting ventricle |
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| CN116705215A (en) * | 2023-08-04 | 2023-09-05 | 南京诺源医疗器械有限公司 | Fluorescent marking system for detecting ventricle |
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