CN111447955A - 99mTc-替马诺塞和相关的分子构建体用于鉴定和诊断恶性肿瘤和用于监测治疗性抗肿瘤干预的用途 - Google Patents
99mTc-替马诺塞和相关的分子构建体用于鉴定和诊断恶性肿瘤和用于监测治疗性抗肿瘤干预的用途 Download PDFInfo
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
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- A—HUMAN NECESSITIES
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- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
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| CA3127487A1 (en) * | 2019-01-25 | 2020-07-30 | Navidea Biopharmaceuticals, Inc. | Compositions and methods for assessing macrophage mediated pathology |
| US20210052639A1 (en) * | 2019-08-19 | 2021-02-25 | Navidea Biopharmaceuticals, Inc. | Compositions and related methods for the ablation of m2 macrophages and myeloid derived suppressor cells |
| US20210145989A1 (en) * | 2019-09-30 | 2021-05-20 | Navidea Biopharmaceuticals, Inc. | Compositions and related methods for blocking off-target localization of mannosylated dextrans and other cd206 ligands |
| EP4076540A4 (en) * | 2020-07-08 | 2024-02-21 | Navidea Biopharmaceuticals, Inc. | Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof |
| CA3192041A1 (en) * | 2020-08-21 | 2022-02-24 | Resolute Science, Inc. | Compositions and methods for targeting tumor-associated macrophages |
| EP4472643A1 (en) | 2022-02-04 | 2024-12-11 | Navidea Biopharmaceuticals, Inc. | Altering net charge on mannosylated dextrans to maximize target tissue uptake and off target competitive blocking |
| US20230302041A1 (en) * | 2022-03-25 | 2023-09-28 | Navidea Biopharmaceuticals, Inc. | Competitive Self-Blocking with Unlabeled Manocept Imaging Agents |
Citations (7)
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|---|---|---|---|---|
| US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| JP2005226021A (ja) * | 2004-02-16 | 2005-08-25 | Nihon Medi Physics Co Ltd | マンノース受容体親和性化合物 |
| WO2016011419A1 (en) * | 2014-07-17 | 2016-01-21 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis |
| WO2016011415A2 (en) * | 2014-07-17 | 2016-01-21 | Ohio State Innovation Foundation | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
| CN105764529A (zh) * | 2013-07-22 | 2016-07-13 | 纳维迪亚生物制药有限公司 | 用于诊断和治疗与表达cd206的细胞相关的病症的组合物、方法和药盒 |
| US20160206763A1 (en) * | 2015-01-21 | 2016-07-21 | Navidea Biopharmaceuticals, Inc. | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
| US20170202969A1 (en) * | 2014-07-17 | 2017-07-20 | Larry Schlesinger | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4671256A (en) * | 1984-05-25 | 1987-06-09 | Lemelson Jerome H | Medical scanning, monitoring and treatment system and method |
| US10806803B2 (en) * | 2014-07-17 | 2020-10-20 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis |
| WO2018067751A1 (en) * | 2016-10-04 | 2018-04-12 | Navidea Biopharmaceuticals, Inc. | Compositions and methods for diagnosing and treating macrophage-related disorders using carbohydrate-based macromolecular carrier |
| MX2019004029A (es) * | 2016-10-07 | 2019-09-27 | Navidea Biopharmaceuticals Inc | Compuestos y metodos para diagnosis y tratamiento de infecciones virales. |
| EP3522899A4 (en) * | 2016-10-07 | 2020-05-06 | Navidea Biopharmaceuticals, Inc. | Compounds and compositions for treating leishmaniasis and methods of diagnosis and treating using same |
-
2018
- 2018-07-20 WO PCT/US2018/043176 patent/WO2019018815A1/en not_active Ceased
- 2018-07-20 JP JP2020502669A patent/JP2020528059A/ja active Pending
- 2018-07-20 US US16/041,673 patent/US20190022259A1/en not_active Abandoned
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- 2018-07-20 CN CN201880061342.0A patent/CN111447955A/zh active Pending
- 2018-07-20 EP EP18834762.9A patent/EP3655107A4/en not_active Withdrawn
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2020
- 2020-01-19 IL IL272123A patent/IL272123A/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
| JP2005226021A (ja) * | 2004-02-16 | 2005-08-25 | Nihon Medi Physics Co Ltd | マンノース受容体親和性化合物 |
| CN105764529A (zh) * | 2013-07-22 | 2016-07-13 | 纳维迪亚生物制药有限公司 | 用于诊断和治疗与表达cd206的细胞相关的病症的组合物、方法和药盒 |
| WO2016011419A1 (en) * | 2014-07-17 | 2016-01-21 | Ohio State Innovation Foundation | Compositions for targeting macrophages and other cd206 high expressing cells and methods of treating and diagnosis |
| WO2016011415A2 (en) * | 2014-07-17 | 2016-01-21 | Ohio State Innovation Foundation | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
| US20170202969A1 (en) * | 2014-07-17 | 2017-07-20 | Larry Schlesinger | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
| US20160206763A1 (en) * | 2015-01-21 | 2016-07-21 | Navidea Biopharmaceuticals, Inc. | Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same |
Non-Patent Citations (6)
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| US20190022259A1 (en) | 2019-01-24 |
| CA3070494A1 (en) | 2019-01-24 |
| WO2019018815A1 (en) | 2019-01-24 |
| EP3655107A4 (en) | 2021-04-28 |
| IL272123A (en) | 2020-03-31 |
| JP2020528059A (ja) | 2020-09-17 |
| EP3655107A1 (en) | 2020-05-27 |
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