CN1114409C - Injection for curing hemorrhoid complicated by anal fistula and its preparation method - Google Patents
Injection for curing hemorrhoid complicated by anal fistula and its preparation method Download PDFInfo
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- CN1114409C CN1114409C CN 99120795 CN99120795A CN1114409C CN 1114409 C CN1114409 C CN 1114409C CN 99120795 CN99120795 CN 99120795 CN 99120795 A CN99120795 A CN 99120795A CN 1114409 C CN1114409 C CN 1114409C
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- injection
- anal fistula
- hemorrhoid complicated
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Abstract
The present invention relates to an injection for curing hemorrhoid complicated by anal fistula and a preparation method thereof. 10 to 100 parts of phenol, 100 to 700 parts of medical glycerol and 0.1 to 8 parts of methylene blue are taken according to weight proportion, mixed, dissolved and uniformly stirred to obtain a product, and lidocaine can be added. The present invention has simple preparation method and low production cost. The present invention can corrode and desquamate the tissue affected with hemorrhoid complicated by anal fistula, realize that the normal tissue is unwounded and has sharp limits, and treat the symptoms of internal hemorrhoids, external hemorrhoids, mixed hemorrhoids, anus fistula, anus fissure, bowel polypus, anal itch, etc. The present invention has the advantages of convenient use, no need of operation, high safety, low medical cost, no pain, sequela or complication, less dosage and short curing period, and the cure rate can reach more than 97.25%.
Description
The present invention relates to a kind of medical injection agent and preparation method thereof, particularly treat the injection and the preparation method of hemorrhoid complicated by anal fistula.
Hemorrhoid complicated by anal fistula be clinical in common multiple disease.In the prior art, adopt the operation method treatment more.Because wound healing is slow, the general treatment cycle is long, and patient's misery is bigger, and medical expense is also higher.For this reason, also adopt injection downright bad agent (as Sodium Humate) or sclerosing agent means such as (as xiaozhiling injections) treatment hemorrhoid complicated by anal fistula in clinical.The mechanism of injecting downright bad agent is to make the focus mummification necrosis, and that injection of sclerosing agent can play is antibacterial, convergence, hardened effect.The operation of above-mentioned two kinds of Therapeutic Method is all more loaded down with trivial details, is suitable for the disease narrow range, also very easily occurs complication such as massive hemorrhage after the injection.
The object of the invention is to provide the injection and the preparation method of a kind of curative effect height, short treating period, the uncomplicated treatment hemorrhoid complicated by anal fistula of safety, overcomes above-mentioned shortcoming of the prior art.
The object of the invention can be achieved through the following technical solutions, and the preparation method of the injection of treatment hemorrhoid complicated by anal fistula comprises the steps:
A. get the raw materials ready (weight ratio: part, down together)
Phenol 10-100 glycerol concentration expressed in percentage by weight is the medical glycerol 70-700 of 20%-88%
Methylene blue 0.1-8
B. the preparation: the said medicine after will weighing be mixed, dissolve and stir after promptly make the injection that the present invention treats hemorrhoid complicated by anal fistula.
The injection that the present invention treats hemorrhoid complicated by anal fistula is a kind of caustic, and its mechanism is: utilize the stronger corrosivity of phenol, make it to act on pathological tissues, its burn into is come off, thereby reach clinical therapeutic efficacy.Glycerol has the effect that improves plasma osmotic pressure and reach dehydration, can be again solvent with the local organization pitting, and the corrosivity of phenol is reduced, and reduces its toxic and side effects.The antidote methylene blue can reduce the toxicity of phenol on the one hand, can play painted effect simultaneously, is convenient to accurately grasp dosage and degree when clinical manipulation, can also bring out the hidden danger pathological changes and make its exposure reach the purpose of thorough healing.
For when treating, reaching analgesic activity, can in the injection component of above-mentioned treatment hemorrhoid complicated by anal fistula, add the anesthetis lignocaine, addition is to be advisable below 8 parts.The cooperation of lignocaine and methylene blue can not only be blocked nerve, can also reach long-acting anesthetic action.Like this, can utilize lignocaine to have stronger anesthetic action and strong penetrance, diffusible characteristics and make the diseased region pain relieving immediately of pain, the coming off of whole therapeutic process such as blood stasis, the growth of new granulation tissue, meeting such as healing of wound obtain healing in painless.
Substitute lignocaine with anaesthetics such as equivalent procaine, tetracaine, tetracaine, also can play better therapeutic effect.
Drug component of the present invention has very strong intermiscibility and synergism, can make hemorrhoid complicated by anal fistula organize burn into to come off and normal structure is excellent, and boundary is clearly demarcated.In the pathological tissues that is corroded came off process, new tissue was constantly grown, thereby reached the purpose of healing fully.Use injection of the present invention can treat diseases such as internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anus fistula, anal fissure, all kinds of anorectal polyp, pruritus ani, easy to use, need not operation, safety, no pain.Consumption is little, medical expense is low, and the healing cycle is short, and cure rate can reach more than 97.25%, and no sequel and complication are equipped with.Injection manufacture method of the present invention is simple, and cost is low.
Below in conjunction with embodiment, the invention will be further described:
The preparation method that the present invention treats the hemorrhoid complicated by anal fistula injection may further comprise the steps:
A. get the raw materials ready (weight for gram) respectively by the component of listed embodiment 1-12 in the table and weight, concentration take by weighing, standby.The medical glycerol (the accurate word 1993001102 of medicine is defended in Zhejiang) that can select for use Nanchang, Zhejiang Province white clouds medication chemistry factory to produce, phenol and methylene blue, lignocaine, procaine are analytical pure, and also can use commercially available concentration is lignocaine, the procaine preparations of/100 milliliters of 2 grams.
B. preparation: the said medicine after will weighing is mixed, dissolves and the back packing that stirs promptly makes the injection product that the present invention treats hemorrhoid complicated by anal fistula.
The component of embodiment 1-12 sees Table 1 (% is the concentration expressed in percentage by weight number in the table).
During use,, can select the 1ml needle tubing for use for ease of grasping the injected dose and the degree of depth,
Number syringe needle to the local patholoic change tissue injection, is observed the change color of medication lesion simultaneously.When whole pathological tissues all becomes navy blue (according to treatment disease difference, generally using injection consumption of the present invention to be 0.2ml-8ml), pathological tissues hardening after about 5 minutes, 3-7 days are promptly tear-away, healing in 7-14 days.To the pathological tissues beyond the tooth trace, can after local anaesthesia, inject.
Table 1
| The real example that gives of group | Phenol | Methylene blue | Lignocaine | Procaine | 22% glycerol | 45% glycerol | 65% glycerol | 87% glycerol | ||||||||
| Gram | ％ | Gram | ％ | Gram | ％ | Gram | ％ | Gram | Glycerol % | Gram | Glycerol % | Gram | Glycerol % | Gram | Glycerol % | |
| 1 | 10 | 12.0 | 3.0 | 3.6 | 70 | 54.8 | ||||||||||
| 2 | 30 | 7.7 | 8.0 | 2.1 | 350 | 40.6 | ||||||||||
| 3 | 99 | 12.4 | 5.5 | 0.7 | 695 | 75.5 | ||||||||||
| 4 | 75 | 42.8 | 0.1 | 0.06 | 100 | 12.6 | ||||||||||
| 5 | 50 | 24.8 | 1.5 | 0.74 | 150 | 33.5 | ||||||||||
| 6 | 25 | 4.0 | 0.8 | 0.13 | 0.2 | 0.03 | 600 | 43.1 | ||||||||
| 7 | 80 | 13.5 | 6.0 | 1.0 | 6.0 | 1.0 | 500 | 18.6 | ||||||||
| 8 | 100 | 17.9 | 0.2 | 0.03 | 7.8 | 1.4 | 450 | 70.2 | ||||||||
| 9 | 40 | 5.7 | 4.5 | 0.64 | 2.0 | 0.3 | 650 | 20.5 | ||||||||
| 10 | 60 | 12.8 | 2.0 | 0.4 | 8 | 1.7 | 400 | 38.3 | ||||||||
| 11 | 70 | 25.6 | 0.5 | 0.18 | 3 | 1.1 | 200 | 47.5 | ||||||||
| 12 | 90 | 37.2 | 1.0 | 0.41 | 1 | 0.41 | 150 | 53.9 | ||||||||
Claims (6)
1. an injection for the treatment of hemorrhoid complicated by anal fistula comprises phenol, medical glycerol, methylene blue in it is characterized in that forming, and the weight proportion of said components is:
Phenol 10-100 glycerol concentration is the medical glycerol 100-700 methylene blue 0.1-8 of 20%-88%.
2. according to the injection of the described treatment hemorrhoid complicated by anal fistula of claim 1, it is characterized in that also comprising lignocaine in the said component, the ratio of each component is:
Phenol 10-100 glycerol concentration is medical glycerol 100-700 methylene blue 0.1-8 lignocaine＜8 of 20%-88%.
3. a preparation method for the treatment of the hemorrhoid complicated by anal fistula injection is characterized in that comprising the steps:
A. get the raw materials ready (weight ratio: part)
Phenol 10-100 glycerol concentration is the medical glycerol 100-700 methylene blue 0.1-8 of 20%-88%
B. preparation: the said medicine after will weighing is mixed, dissolves and stirs.
4. according to the preparation method of the described treatment hemorrhoid complicated by anal fistula injection of claim 3, it is characterized in that adding lignocaine below 8 parts in the injection component of above-mentioned treatment hemorrhoid complicated by anal fistula.
5. according to the preparation method of the described treatment hemorrhoid complicated by anal fistula injection of claim 3, it is characterized in that adding procaine below 8 parts in the injection component of above-mentioned treatment hemorrhoid complicated by anal fistula.
6. according to the preparation method of claim 3 or 4 described treatment hemorrhoid complicated by anal fistula injections, the concentration that it is characterized in that glycerol in the said medical glycerol is 65%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99120795 CN1114409C (en) | 1999-10-15 | 1999-10-15 | Injection for curing hemorrhoid complicated by anal fistula and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99120795 CN1114409C (en) | 1999-10-15 | 1999-10-15 | Injection for curing hemorrhoid complicated by anal fistula and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1253778A CN1253778A (en) | 2000-05-24 |
| CN1114409C true CN1114409C (en) | 2003-07-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99120795 Expired - Fee Related CN1114409C (en) | 1999-10-15 | 1999-10-15 | Injection for curing hemorrhoid complicated by anal fistula and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1114409C (en) |
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1999
- 1999-10-15 CN CN 99120795 patent/CN1114409C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1253778A (en) | 2000-05-24 |
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