CN111420063A - A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method - Google Patents

A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method Download PDF

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CN111420063A
CN111420063A CN202010243213.2A CN202010243213A CN111420063A CN 111420063 A CN111420063 A CN 111420063A CN 202010243213 A CN202010243213 A CN 202010243213A CN 111420063 A CN111420063 A CN 111420063A
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traditional chinese
ionized calcium
chinese medicine
weight
therapeutic effect
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杨淑
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Shilin Daoshang Biological Technology Co ltd
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Shilin Daoshang Biological Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

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  • Chemical & Material Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention discloses a traditional Chinese medicine preparation containing ionized calcium and having improved drug effect and a preparation method thereof, wherein the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 30-45% of ionized calcium; 5-15% of drinking water; 2-3% of a synergist; 12-22% of a blending agent; 1-3% of edible organic acid; 0.5-2% of compound vitamin; 0.8-2% of edible quillajasaponins; 2-4% of pumpkin pectin, the traditional Chinese medicine decoction method has the advantages that the complexity of traditional decoction of traditional Chinese medicines is reduced, the problem that the medicine property of the traditional Chinese medicines is evaporated through steam when the traditional Chinese medicines are repeatedly decocted is solved, the effective components of the traditional Chinese medicines are reserved, and the effective utilization of the traditional Chinese medicines is improved; by adding the traditional Chinese medicine preparation, only 20-30% of the components of the normally-open traditional Chinese medicine prescription are needed, so that the cost is saved, and the traditional Chinese medicine preparation is simple and convenient; the active ingredients of the traditional Chinese medicine can be fully exerted and utilized by utilizing the strong permeability of the ionized calcium to activate the performance of the medicine.

Description

A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method
Technical Field
The invention relates to the technical field of dry tablet preparations, in particular to a traditional Chinese medicine preparation containing ionized calcium and having the effect of improving the drug effect and a preparation method thereof.
Background
Traditional chinese medicine decocting device is the casserole, traditional chinese medicine jar etc, boil the in-process, need the people for stirring, make the active ingredient of traditional chinese medicine fully appear, prevent simultaneously that traditional chinese medicine from pasting in the device bottom, consequently, the system efficiency of stewing of current traditional chinese medicine decocting device is lower, the user uses and experiences the sense also very poorly, some medicinal materials are in system in-process in addition, should be high breakage, through filtering, the drug effect has appeared reducing, it can fall the unable this demand of satisfying of property of a medicine through steam evaporation obviously to decoct repeatedly current traditional chinese medicine, user experience is poor, current traditional chinese medicine system boils and all needs manual water of adding in addition, then heat through indirect heating mode, so heating time is longer, user experience has also been reduced, consequently, current traditional chinese medicine exists to boil inefficiency and user experience the poor defect of sense.
Disclosure of Invention
The invention provides a traditional Chinese medicine preparation containing ionized calcium and having improved drug effect and a preparation method thereof.
The scheme of the invention is as follows:
a traditional Chinese medicine preparation containing ionized calcium and having efficacy improving function comprises the following raw materials in parts by weight:
Figure BDA0002433248430000011
the preferable technical scheme comprises the following raw materials in parts by weight:
Figure BDA0002433248430000012
Figure BDA0002433248430000021
as a preferred technical scheme, the synergist is concretio silicea bambusae.
As a preferred technical scheme, the blender is grape juice or grapefruit juice.
Preferably, the edible organic acid comprises malic acid and citric acid.
Preferably, the nutritional agent comprises collagen peptide.
The invention also provides a preparation method of the traditional Chinese medicine preparation containing ionized calcium, which has the effect of improving the drug effect, and comprises the following steps:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use;
2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid;
3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
As a preferable technical scheme, the pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
According to a preferable technical scheme, the synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
Due to the adoption of the technical scheme, the traditional Chinese medicine preparation containing ionized calcium and having the effect of improving the drug effect and the preparation method thereof comprise the following steps:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use; 2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid; 3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The invention has the advantages that:
1. the complexity of traditional decoction of the traditional Chinese medicine is reduced, the problem that the property of the traditional Chinese medicine is evaporated by steam when the traditional Chinese medicine is repeatedly decocted is solved, the effective components of the traditional Chinese medicine are reserved, and the effective utilization of the components of the traditional Chinese medicine is improved;
2. by adding the traditional Chinese medicine preparation, the effect can be achieved only by 20-30% of the weight of the normally-open traditional Chinese medicine formula, so that the cost is saved, and the traditional Chinese medicine preparation is simple and convenient;
3. the active ingredients of the traditional Chinese medicine can be fully exerted and utilized by utilizing the strong permeability of the ionized calcium to activate the performance of the medicine.
4. The absorption rate of the traditional Chinese medicine prescription after the traditional Chinese medicine prescription is used by a user can be effectively improved, and the absorption capacity of traditional Chinese medicine components of the user is improved after the traditional Chinese medicine prescription is used by the user, so that the drug effect is enhanced;
5. through mouse experiments, after the traditional Chinese medicine composition is used with a prescription, toxic and side effects of the prescription containing cinnabar and realgar can be reduced.
Detailed Description
In order to make up for the above deficiencies, the present invention provides a traditional Chinese medicine preparation containing ionized calcium with improved drug effect and a preparation method thereof to solve the problems in the background art.
A Chinese medicinal preparation containing ionized calcium with improved drug effect and its preparation method are provided, which comprises the following steps:
a traditional Chinese medicine preparation containing ionized calcium and having efficacy improving function comprises the following raw materials in parts by weight:
Figure BDA0002433248430000031
comprises the following raw materials in parts by weight:
Figure BDA0002433248430000032
Figure BDA0002433248430000041
the synergist is concretio silicea Bambusae seu Schizostachyi.
The blending agent is grape juice or grapefruit juice.
The edible organic acid comprises malic acid and citric acid.
The nutritional agent includes collagen peptides.
The invention also provides a preparation method of the traditional Chinese medicine preparation containing ionized calcium, which has the effect of improving the drug effect, and comprises the following steps:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use;
2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid;
3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1:
1) stirring and mixing 0.2% of pumpkin pectin, 0.8% of edible quillaja saponin, 0.5% of compound vitamin and 2% of synergist by weight, and mixing the mixture for later use;
2) mixing 30% of ionized calcium and 5% of drinking water by weight to obtain a mixed liquid;
3) mixing 1% of edible organic acid and 12% of blending agent by weight, then adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture at the same time, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The pumpkin pectin in the step 1) is heated to 35 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
Example 2:
1) stirring and mixing 0.6% of pumpkin pectin, 2% of edible quillaja saponin, 2% of multivitamin and 3% of synergist by weight, and mixing the mixture for later use;
2) blending 45% of ionized calcium and 15% of drinking water by weight to obtain a mixed liquid;
3) mixing 3% of edible organic acid and 22% of blending agent by weight, then adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture at the same time, and stirring the mixture to obtain the traditional Chinese medicine preparation containing ionized calcium with improved efficacy.
The pumpkin pectin in the step 1) is heated to 40 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
Example 3:
1) stirring and mixing 0.4% of pumpkin pectin, 1.2% of edible quillaja saponin, 1% of compound vitamin and 2.5% of synergist by weight, and mixing the mixture for later use;
2) blending 40% of ionized calcium and 10% of drinking water by weight to obtain mixed liquid;
3) mixing 2% of edible organic acid and 18% of blending agent by weight, then adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture at the same time, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
The pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
The synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
The ionic calcium-containing Chinese medicinal preparation prepared in example 3 was used in the following experiments
The method comprises the following steps of stirring 500 ml of water and 20 g of medlar in a control group for 2 minutes, boiling for 1 hour, fishing out the medlar, concentrating the boiled medlar water into 100 ml of medlar water, taking 100 ml of the traditional Chinese medicine preparation containing ionized calcium prepared in the embodiment 3 in the test group, adding 20 g of medlar, stirring for 2 minutes, fishing out the medlar, and then measuring the content of effective components of the medlar in the control group and the test group respectively, wherein the content of the effective components of the medlar in the control group is 5 times of the content of the effective components of the medlar in the test group.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (9)

1. A traditional Chinese medicine preparation containing ionized calcium with efficacy improvement function is characterized by comprising the following raw materials in parts by weight:
Figure FDA0002433248420000011
2. the traditional Chinese medicine preparation containing ionized calcium with efficacy improving function of claim 1, which is characterized by comprising the following raw materials in parts by weight:
Figure FDA0002433248420000012
3. the pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the synergist is concretio silicea Bambusae seu Schizostachyi.
4. The pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the blending agent is grape juice or grapefruit juice.
5. The pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the edible organic acid comprises malic acid and citric acid.
6. The pharmaceutical composition of claim 1 or 2, comprising ionized calcium for enhancing therapeutic effect, wherein: the nutritional agent includes collagen peptides.
7. A method for preparing the pharmaceutical preparation of claim 1 or 2, comprising ionized calcium for improving the efficacy, comprising the steps of:
1) stirring and mixing 0.2-0.6% by weight of pumpkin pectin, 0.8-2% by weight of edible quillaja saponin, 0.5-2% by weight of multivitamin and 2-3% by weight of synergist, and mixing the mixture for later use;
2) blending 30-45% of ionized calcium and 5-15% of drinking water by weight to obtain a mixed liquid;
3) mixing 1-3% of edible organic acid and 12-22% of blending agent by weight, adding the mixture obtained in the step 1) and the mixed liquid obtained in the step 2) into the mixture, and stirring to obtain the traditional Chinese medicine preparation containing ionized calcium with improved drug effect.
8. The method for preparing the pharmaceutical preparation of claim 7, which comprises ionized calcium for improving the therapeutic effect, wherein the pharmaceutical preparation comprises the following steps: the pumpkin pectin in the step 1) is heated to 35-40 ℃ for use.
9. The method for preparing the pharmaceutical preparation of claim 7, which comprises ionized calcium for improving the therapeutic effect, wherein the pharmaceutical preparation comprises the following steps: the synergist is tabasheer, the blending agent is grape juice or grapefruit juice, the edible organic acid comprises malic acid and citric acid, and the nutritional agent comprises collagen peptide.
CN202010243213.2A 2020-03-31 2020-03-31 A Chinese medicinal preparation containing ionized calcium for improving drug effect, and its preparation method Pending CN111420063A (en)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102351958A (en) * 2011-08-22 2012-02-15 河南中医学院 Preparation method and application of astragalus polysaccharide-calcium complex
CN102716154A (en) * 2012-06-28 2012-10-10 舒文一 Processing method and product of ionized calcium water-solubility preparation
CN107349227A (en) * 2016-05-10 2017-11-17 赵建国 A kind of new medicine concocting method
CN108567867A (en) * 2018-07-18 2018-09-25 李青 A kind of Chinese medicine composition that treating chronic nephritis and its application
CN108939610A (en) * 2018-07-21 2018-12-07 安溪县凤城建金产品外观设计服务中心 The efficient extraction process of effective component in a kind of Primula obconica Hance
CN109641021A (en) * 2017-08-04 2019-04-16 赵建国 A kind of calcium base solion processes the method and its application of Chinese medicine
CN111972578A (en) * 2020-08-28 2020-11-24 山东道道生物工程有限公司 Cold extraction essence reagent and production method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102351958A (en) * 2011-08-22 2012-02-15 河南中医学院 Preparation method and application of astragalus polysaccharide-calcium complex
CN102716154A (en) * 2012-06-28 2012-10-10 舒文一 Processing method and product of ionized calcium water-solubility preparation
CN107349227A (en) * 2016-05-10 2017-11-17 赵建国 A kind of new medicine concocting method
CN109641021A (en) * 2017-08-04 2019-04-16 赵建国 A kind of calcium base solion processes the method and its application of Chinese medicine
CN108567867A (en) * 2018-07-18 2018-09-25 李青 A kind of Chinese medicine composition that treating chronic nephritis and its application
CN108939610A (en) * 2018-07-21 2018-12-07 安溪县凤城建金产品外观设计服务中心 The efficient extraction process of effective component in a kind of Primula obconica Hance
CN111972578A (en) * 2020-08-28 2020-11-24 山东道道生物工程有限公司 Cold extraction essence reagent and production method thereof

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* Cited by examiner, † Cited by third party
Title
张兆旺等: "麻杏石甘汤2种提取方法的成分比较", 《中国中药杂志》 *
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Application publication date: 20200717