CN111388585A - Calcium-supplementing medicinal food essence product and preparation method thereof - Google Patents

Calcium-supplementing medicinal food essence product and preparation method thereof Download PDF

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Publication number
CN111388585A
CN111388585A CN202010121927.6A CN202010121927A CN111388585A CN 111388585 A CN111388585 A CN 111388585A CN 202010121927 A CN202010121927 A CN 202010121927A CN 111388585 A CN111388585 A CN 111388585A
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percent
product
calcium
medicinal
food
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邓玉林
辛念
孙俐丽
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Beijing Ligong Genshu Technology Co ltd
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Beijing Ligong Genshu Technology Co ltd
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Abstract

The invention relates to the field of food, functional food and health food, and discloses a medicinal diet vegetarian product with a calcium supplementing function and a preparation method thereof. The medicated diet vegetarian product consists of the following raw materials in percentage by weight: 15 to 30 percent of oyster, 27 to 45 percent of yam, 15 to 30 percent of black sesame seed and 15 to 25 percent of white hyacinth bean, wherein the sum of the components is 100 percent. The invention takes medicinal and edible medicinal materials such as oyster, Chinese yam, black sesame and white hyacinth bean as the basis, and forms a series of medicinal and dietary vegetarian products which take nourishing and health preserving as the main functions and have the using characteristics of seasonings through compatibility, extraction, seasoning and forming. The medicated diet vegetable product can be added into dishes or soup as a seasoning, and can also be directly brewed and drunk as a tea drink. The food provided by the invention can supplement calcium, invigorate spleen, harmonize yin and yang, astringe and secure essence, tonify liver and kidney, induce diuresis to reduce edema, and relieve bone and muscle weakness, and osteoporosis caused by deficiency of liver and kidney.

Description

Calcium-supplementing medicinal food essence product and preparation method thereof
Technical Field
The invention relates to the field of foods, functional foods and health-care foods, in particular to a calcium-supplementing medicinal food product of oysters, Chinese yams and black sesames and a preparation method thereof.
Background
The first kind is inorganic calcium, also called first generation calcium supplement product, such as calcium carbonate, calcium phosphate and calcium oxide, or from mechanically processed animal shell skeleton, the second kind is organic calcium, i.e. second generation calcium agent, such as calcium gluconate, calcium lactate, calcium citrate, calcium acetate, etc., the third kind is organic calcium, i.e. third generation calcium agent, such as amino acid chelated calcium, L-threonic acid calcium.
With the increasing requirements of people on the living standard of substances, people pay more attention to the body maintenance through diet. China has the theory of homology of medicine and food, all things are medicine, food and medicine are homologous and used together, and food with homology of medicine and food is more and more valued at home and abroad. The medicated diet is prepared by matching traditional Chinese medicines with certain foods with medicinal values under the guidance of traditional Chinese medicine, culinary science and nutriology theories according to a medicated diet formula and adopting unique diet cooking technology and modern scientific methods in China, and has certain colors, fragrance, taste and shape and the efficacies of preventing and treating diseases, protecting health, building body and prolonging life. The drugs depend on food power and food-assisted drugs complement each other to complement each other
The medicinal diet vegetarian product takes medicinal and edible medicinal materials such as oyster, Chinese yam, black sesame and white hyacinth bean as raw materials, and forms the medicinal diet which can be brewed by drinking and cooked and has the functions of supplementing calcium, tonifying spleen, astringing to arrest spontaneous emission and tonifying liver and kidney by compatibility, seasoning and forming. The oyster is rich in zinc, calcium and various proteins, the Chinese yam is rich in almost all amino acids, the white hyacinth bean is rich in calcium, the black sesame is also rich in calcium and trace elements, and the combination of the four ingredients is beneficial to the intake, synthesis, absorption and utilization of calcium, can prevent and treat osteoporosis, can regulate yin and yang, tonify liver and kidney, invigorate spleen and promote diuresis.
Disclosure of Invention
The invention aims to provide a medicinal food vegetarian product of oyster, Chinese yam, black sesame and white hyacinth bean and a preparation method thereof.
The invention provides a medicated diet vegetable product which is prepared from the following raw materials: oyster, Chinese yam, black sesame and white hyacinth bean.
Wherein, the weight percentage of the ingredients are 15 percent to 30 percent of oyster, 27 percent to 45 percent of yam, 15 percent to 30 percent of black sesame, 15 percent to 25 percent of white hyacinth bean, and the sum of the ingredients is 100 percent.
In particular to a medicinal food vegetarian product which comprises,
(1) 22% of oyster, 35% of Chinese yam, 22% of black sesame and 21% of white hyacinth bean;
or, (2) oyster 30%, rhizoma Dioscoreae 40%, semen Sesami Niger 15%, semen lablab album 15%;
or (3) oyster 26%, Chinese yam 28%, black sesame 30% and white hyacinth bean 16%.
Square solution:
oyster shell: liver-calming and wind-calming herbs; yin-nourishing herbs. Has astringent, tranquilizing, toxic materials clearing away, and analgesic effects. Modern researches show that oyster contains 80-95% of calcium carbonate, calcium phosphate and calcium sulfate, magnesium, aluminum, silicon, iron oxide and the like, and a plurality of dosage forms of oyster are clinically used for treating osteoporosis and other calcium-deficient patients.
Chinese yam: tonify spleen and stomach, promote the production of body fluid and nourish lung, tonify kidney and astringe essence. Can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat.
Black sesame seed: tonify liver and kidney, nourish essence and blood, moisten intestine and dry. Can be used for treating deficiency of essence and blood, dizziness, dim eyesight, tinnitus, deafness, premature gray hair, alopecia after illness, and constipation due to intestinal dryness.
White hyacinth bean: sweet in property, slightly warm in nature, entering spleen and stomach meridians. Invigorate spleen, resolve dampness, promote the middle-jiao and relieve summer-heat. Can be used for treating weakness of spleen and stomach, anorexia, loose stool, leukorrhagia, summer-heat, dampness, vomiting and diarrhea, chest distress, and abdominal distention.
The formulation of the medicated diet element takes oyster as a monarch drug to regulate yin and yang and supplement calcium; the Chinese yam with the effects of tonifying spleen and nourishing stomach is selected as the ministerial drug, so that yin is calm and yang is secret, and primordial qi is kept in the interior; black sesame is added, so that the liver and kidney are benefited, and the intestine is loosened to relieve constipation; the sweet white hyacinth bean is added to strengthen the spleen and remove dampness, so the tonifying effect is not sufficient. The compatibility of the four medicines can supplement calcium and spleen, and tonify liver and kidney, and is mainly used for treating the symptoms of muscle and bone weakness and osteoporosis caused by spleen and stomach weakness.
The invention also provides a preparation method of the medicinal food vegetarian product, which comprises the following steps:
mixing Concha Ostreae, rhizoma Dioscoreae, semen Sesami Niger and semen lablab album according to formula weight percentage, pulverizing, sieving, mixing well, and drying; the oyster, the Chinese yam, the black sesame and the white hyacinth bean are all medicinal decoction pieces thereof.
In the step of crushing the raw materials, the mesh number of the crushed powder is 80-100 meshes; specifically, the mesh size is 80.
The raw material powder can be packaged directly without seasoning and then sterilized;
or adding corresponding flavoring and food additive according to taste requirement for flavoring, adding forming adjuvants for process forming, packaging, and sterilizing to obtain the medicated diet vegetable products with various tastes;
a series of formulas with various flavor characteristics can be developed according to market positioning and demand of products, marketing strategies, future market distribution geographical characteristics and the like, wherein the taste is specifically selected from at least one of fresh and fragrant, spiced, garlic, sauce, sour and sweet, sour and refreshing, spicy, hot and sour, curry, seafood and tomatoes;
the sterilization adopts an irradiation sterilization method.
Specifically, the packaged medicinal food extract product is subjected to radiation sterilization by adopting a radioactive element Co60 with the dose of 3 kGy.
The medicated diet product can also be made into various forms, such as solid (powder, granule, block), liquid, and paste.
The application of the medicated diet vegetable product in the products for tonifying spleen and calcium, nourishing yin and suppressing hyperactive yang, and tonifying liver and kidney also belongs to the protection scope of the invention.
The invention also aims to provide a using method of the medicinal food vegetarian product.
The use method of the medicated food vegetarian product provided by the invention comprises the following steps:
the medicinal food vegetarian product is taken as seasoning and is directly added into dishes or soup for eating, or is taken as tea beverage for direct brewing and drinking.
Specifically, the food is put in before being taken out of the pot during cooking, soup cooking and stewing; or directly adding stuffing, cold dish, and cooked wheaten food, and stirring.
The daily maximum dosage of adult is 2 g/time, 3 times/day, and total 6 g/day, wherein the weight of adult is 70 kg.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Example 1 preparation of medicated diet vegetarian product
Weighing the medicinal slices according to the following weight: oyster 44g, Chinese yam 70g, black sesame 44g, white hyacinth bean 42 g. Pulverizing the weighed medicinal material decoction pieces, sieving with 100 mesh sieve, and mixing well to obtain medicated diet extract product 1.
Example 2 preparation of medicated diet vegetarian product
Weighing the medicinal slices according to the following weight: 60g of oyster, 80g of Chinese yam, 30g of black sesame and 30g of white hyacinth bean. Pulverizing the weighed medicinal material decoction pieces, sieving with 100 mesh sieve, and mixing well to obtain medicated diet extract product 2.
Example 3 preparation of medicated diet product
Weighing the medicinal slices according to the following weight: 52g of oyster, 56g of Chinese yam, 60g of black sesame and 32g of white hyacinth bean. Pulverizing the weighed medicinal material decoction pieces, sieving with 100 mesh sieve, and mixing well to obtain medicated diet vegetable product 3.
Example 4 acute toxicity test
In order to investigate the acute toxicity of the product, a sample of the product is dissolved in water and then subjected to an acute toxicity test to evaluate the safety of the product and provide a basis for application, development and research.
4.1 Experimental materials
4.1.1 animals
ICR mice, SPF grade, weight 18 ± 2g, sex half each, provided by sbefu (beijing) biotechnology limited, animal license number: SCXK (Kyoto) 2016-.
4.1.2 drugs
A formula 1 of a medicated diet vegetarian product is taken as a test sample.
4.1.3 Experimental Environment
Experimental animal barrier system of Life academy of sciences of Beijing university of Rich Engineers.
4.2 Experimental methods
4.2.1 preliminary experiments
8 ICR mice were selected and randomly divided into two groups, i.e., control and test sample groups, each group consisting of 4 mice, each half male and female. Taking a tested sample to prepare a liquid medicine with the maximum concentration of 45 percent (mass volume ratio), carrying out intragastric administration for 3 times at intervals of 4h, wherein the intragastric volume of each time is 0.4ml/10g, and the equivalent amount of distilled water is that of the intragastric administration of a control group. Fasting before gavage is not prohibited for 12h, feeding is carried out regularly after administration, and continuous observation is carried out for 7 d. No mouse death and toxic reactions were seen, and the maximum dose experiments were performed in view of the limitations imposed by the concentration and volume of the test samples.
4.2.2 maximum dose assay
24 ICR mice are taken and randomly divided into two groups, namely a control group and a test sample group, wherein each group comprises 12 mice, the mice are half male and female, before the experiment, the mice are fasted and not forbidden for 12 hours, and the mice are not fed during the interval period. Each mouse of the tested sample group is filled with 45 percent (mass volume ratio) of maximum concentration liquid medicineThe test samples were administered to the stomach 3 times at 4h intervals, and the gavage volume was 0.4ml/10g, and the control group was administered with the same volume of distilled water. Continuously observing for 14d after intragastric administration, observing mice appearance action, reflex action, water intake, defecation, and appetite, measuring for mice on days 1, 3, 5, 7 and 14 after administration, and measuring for mice food intake and body weight respectively
Figure BSA0000202763930000047
Results are shown statistically processed using SPSS17.0 software. After the observation, gross dissection was performed, and changes in volume, color, texture, and the like of each organ were observed.
4.3 results of the experiment
The results of the acute toxicity test are shown in tables 1, 2, 3 and 4.
TABLE 1 weight change of mice in the case of acute toxicity test with herbal diet: (
Figure BSA0000202763930000041
n＝6)
Figure BSA0000202763930000042
TABLE 2 dietary meal essence acute toxicity Experimental mice food intake variation: (
Figure BSA0000202763930000043
g/10g body weight, n ═ 6)
Figure BSA0000202763930000044
TABLE 3 change in water intake of mice in acute toxicity experiment with herbal diet: (
Figure BSA0000202763930000045
ml/10g body weight, n ═ 6)
Figure BSA0000202763930000046
TABLE 4 acute toxicity test of the herbal remedies
Figure BSA0000202763930000051
Note: "-": and (4) normal.
After the experiment, 2 groups of mice were dissected and observed with naked eyes, and it was found that all the mice had normal organs such as liver, kidney, spleen, intestine, stomach, pancreas, and genital organ, and the test sample group had no abnormality compared with the blank.
The experimental result shows that the animals do not die within 14 days after the administration, the general condition is good, the stool is normal, the appearance, fur, behavior and breathing are normal, abnormal secretion does not exist in the nose, eyes and oral cavity, and the weight gain of the tested sample group and the control group has no obvious difference. The food intake has no significant difference, and each organ is normal without other obvious abnormal reactions. The test samples were administered to the mice by gavage in a 1-day three-time maximum dose of 38g/kg, corresponding to 440 times the clinical daily maximum dose for an adult (maximum daily dose for a human: 2 g/time, 3 times/day, total 6 g/day, for a human, calculated on a 70kg body weight basis). Therefore, the test samples were considered safe and non-toxic.
Example 5 Regulation of castrated osteoporosis rats by medicated diet product 1
The natural product composition has the function of calcium supplement, and is proved by the following experiments. The composition is mainly used for investigating the influence of the composition on the bone density of the rat femur and the bone index of the rat femur, the influence on serum calcium and serum phosphorus of the rat, and the influence on ash content, bone calcium and bone phosphorus of the rat femur.
Taking a medicinal diet vegetarian product formula 1 as a test sample, taking 50 SD rats with half each of male and female, and feeding the SD rats for one week according to a standard diet before a test. After one week of pre-feeding, surgery was performed, anesthetized with 3% pentobarbital, sterilized conventionally, bilateral testicles or bilateral ovaries were removed under aseptic conditions, and incisions were sutured randomly. The sham group was only sterilized and incised by abdominal surgery and then sutured (without removal of testis and ovary). The groups were randomized one week after surgery, 10 individuals per group, and the groups are shown in Table 5. The administration is performed by intragastric administration once a day for 60 days.
According to the invention, the recommended dosage of the human body is 2 g/time and 3 times/day, the total dosage is 6 g/day, the human body calculates according to 70kg body weight, the dosage is converted into rat dosage, the dosages of the low, medium and high dosage groups of the tested sample are respectively 0.6g/kg body weight, 1.2g/kg body weight and 2.4g/kg body weight, and the rat mice of the blank control group and the model control group are filled with the corresponding solvents with the same volume every time.
TABLE 5 Experimental groups
Figure BSA0000202763930000052
Breaking the head of the animal after the administration, collecting blood, separating serum, measuring S/Ca and S/P contents with the kit, collecting the clean meat and other tissues of the femur on two sides of the rat, scanning the femur on one side with a dual-energy X-ray bone densitometer to measure the bone density (g/cm)2) Weighing femur W (g), measuring femur length L (cm), oven drying at 110 deg.C for 1h, ashing in muffle furnace at 200 deg.C, 400 deg.C, 600 deg.C and 800 deg.C for two hours, cooling after ashing, weighing ash, and adding 6N HNO3After extraction, the content of Ca and P in the bone ash is measured and expressed by the gram of calcium ions or P in 100g of bone ash. The results were compared between the experimental group and the model group, and between the model group and the blank control group.
TABLE 6 Effect of dietary supplement product formula 1 on rat femoral bone Density and femoral index: (
Figure BSA0000202763930000061
n＝10)
Figure BSA0000202763930000062
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
TABLE 7 Effect of dietary supplement product formula 1 on rat serum calcium and serum phosphorus: (
Figure BSA0000202763930000063
n＝10)
Figure BSA0000202763930000064
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
TABLE 8 influence of the formula 1 of the herbal dietary supplement on ash, calcium and phosphorus in rat femur bone: (
Figure BSA0000202763930000065
n＝10)
Figure BSA0000202763930000066
Figure BSA0000202763930000071
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
The results show that the formula 1 of the medicinal dietary supplement composition can obviously increase the weight of the femur bone, the bone density, the bone ash weight, the bone calcium, the bone phosphorus and the serum calcium of the calcium-deficient rats, and has no obvious influence on the serum phosphorus. The medicinal diet composition 1 can increase the bone density and improve the calcium deficiency and the osteoporosis.
Example 6 Regulation of castrated osteoporosis rats by medicated diet product 2
The test samples were prepared according to the method described in example 1, using formula 2 as the dietary supplement, and the results are shown in tables 9, 10 and 11.
TABLE 9 Effect of the formula 2 of the herbal diet product on bone density and femoral index of rat femur: (
Figure BSA0000202763930000072
n＝10)
Figure BSA0000202763930000073
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
TABLE 10 Effect of dietary supplement product formula 2 on rat serum calcium and serum phosphorus: (
Figure BSA0000202763930000074
n＝10)
Figure BSA0000202763930000075
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
TABLE 11 influence of the formula 2 of the herbal diet extract on ash, calcium and phosphorus in rat femur bone: (
Figure BSA0000202763930000081
n＝10)
Figure BSA0000202763930000082
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
The results show that the formula 1 of the medicinal dietary supplement composition can obviously increase the weight of the femur bone, the bone density, the bone ash weight, the bone calcium, the bone phosphorus and the serum calcium of the calcium-deficient rats, and has no obvious influence on the serum phosphorus. The medicinal food composition 2 is probably effective in increasing bone density and improving calcium deficiency and osteoporosis, but the effect is not as obvious as that of the formula 1.
Example 7 Regulation of castrated osteoporosis rats by medicated diet product 3
The test samples were prepared according to the method described in example 1, using the formula 3 of the herbal diet product, and the results are shown in tables 12, 13 and 14.
TABLE 12 Effect of formula 3 of herbal remedies for bone density and femoral index of rat femur: (
Figure BSA0000202763930000083
n＝10)
Figure BSA0000202763930000084
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
TABLE 13 Effect of dietary supplement product formula 3 on rat serum calcium and serum phosphorus: (
Figure BSA0000202763930000085
n＝10)
Figure BSA0000202763930000086
Figure BSA0000202763930000091
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
TABLE 14 Effect of the formula 3 of the herbal diet product on rat femur bone ash, bone calcium and bone phosphorus: (
Figure BSA0000202763930000092
n＝10)
Figure BSA0000202763930000093
Note: compared to the a blank control group: "#": p is less than 0.05; "# #": p < 0.01, "###": p is less than 0.001.
Compared to the model B control group: "*": p < 0.05, "+": p < 0.01, "+": p is less than 0.001.
The results show that the formula 3 of the medicinal dietary supplement composition can obviously increase the weight of the femur bone, the bone density, the bone ash weight, the bone calcium, the bone phosphorus and the serum calcium of the calcium-deficient rats, and has no obvious influence on the serum phosphorus. The medicinal food composition 3 is probably effective in increasing bone density, and improving calcium deficiency and osteoporosis.

Claims (7)

1. A medicated diet vegetable product is prepared from the following raw materials: concha Ostreae, rhizoma Dioscoreae, semen Sesami Niger, and semen lablab album; wherein, the weight percentage of the ingredients are 15 percent to 30 percent of oyster, 27 percent to 45 percent of yam, 15 percent to 30 percent of black sesame, 15 percent to 25 percent of white hyacinth bean, and the sum of the ingredients is 100 percent.
2. The dietary supplement product of claim 1, wherein: the ginseng, the angelica, the liquorice and the tuckahoe are all medicinal decoction pieces.
3. The dietary supplement product of claim 1, wherein: packaging without flavoring, and sterilizing to obtain final medicated diet product; or adding corresponding flavoring agent and food additive according to taste requirement for flavoring, adding forming adjuvants for process forming, packaging, and sterilizing to obtain medicated diet vegetable products with various tastes;
wherein the taste comprises fresh and fragrant, spiced, garlic, sauce, sour and sweet, spicy, hot, sour and spicy, curry, seafood, tomato and other tastes;
the medicated diet vegetable product can also be made into various forms, solid, liquid or paste.
4. A dietary supplement product according to any one of claims 1 to 3, wherein: and (3) carrying out radiation sterilization on the packaged medicinal food extract product by adopting a radioactive element Co60 with the dose of 3 kGy.
5. The use of the dietary supplement of claim 1 for calcium supplementation and osteoporosis alleviation.
6. The use of the dietary supplement product of claim 1 in the preparation of a calcium supplement product.
7. The method of using the dietary supplement product of claim 1, comprising: the medicated diet vegetable product is taken as a seasoning and is directly added into dishes and soup for eating; or directly used as tea for brewing and drinking.
CN202010121927.6A 2020-02-26 2020-02-26 Calcium-supplementing medicinal food essence product and preparation method thereof Pending CN111388585A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107616461A (en) * 2017-10-30 2018-01-23 东莞珍其道健康食品科技有限公司 Replenish the calcium the health-care soup base of invigorating the spleen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107616461A (en) * 2017-10-30 2018-01-23 东莞珍其道健康食品科技有限公司 Replenish the calcium the health-care soup base of invigorating the spleen

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Title
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