CN111388583A - Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps and using method thereof - Google Patents
Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps and using method thereof Download PDFInfo
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- CN111388583A CN111388583A CN202010164651.XA CN202010164651A CN111388583A CN 111388583 A CN111388583 A CN 111388583A CN 202010164651 A CN202010164651 A CN 202010164651A CN 111388583 A CN111388583 A CN 111388583A
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- 241000252233 Cyprinus carpio Species 0.000 title claims abstract description 61
- 241000411851 herbal medicine Species 0.000 title claims abstract description 43
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- 244000045947 parasite Species 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims description 9
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- OVIILQQKQPCQTF-UHFFFAOYSA-N ivalin Natural products C1C2OC(=O)C(=C)C2CC2C(=C)CC(O)CC21C OVIILQQKQPCQTF-UHFFFAOYSA-N 0.000 description 2
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- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
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- 235000011570 Artemisia caruifolia var apiacea Nutrition 0.000 description 1
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- YNQLUTRBYVCPMQ-UHFFFAOYSA-N alpha-methyl toluene Natural products CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
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- 235000003891 ferrous sulphate Nutrition 0.000 description 1
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- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
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- 239000002075 main ingredient Substances 0.000 description 1
- FDZZZRQASAIRJF-UHFFFAOYSA-M malachite green Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](C)C)C=C1 FDZZZRQASAIRJF-UHFFFAOYSA-M 0.000 description 1
- 229940107698 malachite green Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 description 1
- 229960003439 mebendazole Drugs 0.000 description 1
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/10—Culture of aquatic animals of fish
- A01K61/13—Prevention or treatment of fish diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Environmental Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Biodiversity & Conservation Biology (AREA)
- Endocrinology (AREA)
- Animal Husbandry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps, which containsThe components with the following parts by weight: 25-40 parts of common carpesium fruit, 20-35 parts of betel nut, 20-30 parts of chinaberry, 5-10 parts of dried alum, 10-20 parts of pomegranate bark, 10-20 parts of brucea javanica and 10-15 parts of artemisinin. When in use, the Chinese herbal medicine formula is soaked in culture water, and the dosage of the Chinese herbal medicine formula is 6.25-125g/m3The fancy carp is cultivated in the cultivation water soaked with the Chinese herbal medicine formula for 6-12 days. The Chinese herbal medicine formula provided by the invention is safe, reliable and efficient, can effectively improve the inflammatory index and lysozyme content in the fancy carp, has the effects of obviously improving the inherent immunity of the fancy carp, resisting bacteria and diminishing inflammation and preventing parasites, does not influence the growth of the fancy carp, is also beneficial to uterine smooth muscle contraction and promotes ovulation of female fancy carps.
Description
Technical Field
The invention belongs to the technical field of aquaculture, and particularly relates to a Chinese herbal medicine formula for expelling parasites and improving immunity of koi and a using method thereof.
Background
The fancy carp has bright color and beautiful appearance, and is one of the popular high-grade ornamental fish varieties in the market. In order to obtain a fancy carp with good appearance, farmers continuously enlarge the cultivation scale, which causes the deterioration of the cultivation environment. In the raising process of the koi, if the culture water environment is deteriorated, the disease resistance of fish bodies is reduced, and parasitic diseases, bacterial diseases, virus diseases and the like are easy to occur, wherein the parasitic diseases are the most common. When a large number of parasites parasitize in the fancy carp, the pathological changes of increasing mucus on the surface of the fish body, red swelling on the body surface, scale falling, ulceration of gill silk, red swelling at the tail end of gill silk and the like can be caused, so that the fish is only dull or restless, has reduced or even no ingestion, seriously influences the growth and reproduction of the fancy carp, and more seriously causes the death of the fancy carp due to the secondary infection of bacteria caused by parasite infection of the fancy carp, thereby bringing great economic loss to farmers.
At present, the parasitic diseases of the koi are mostly treated by using chemical drugs, such as copper sulfate, a mixture of copper sulfate and ferrous sulfate, mebendazole, malachite green, methylene blue and the like, and the drugs have good effects on treating the parasitic diseases of the koi. However, during the use process, the koi is often poisoned by the chemical medicines due to improper operation, so that the growth of the koi is slowed down, and even the koi dies. Part of medicines such as copper sulfate can easily cause algae death in the using process, cause water quality deterioration and indirectly cause fancy carp death. In addition, the use of chemicals is generally in the treatment phase, while the use of chemicals in the prevention phase is not suitable, and not only is it toxic to koi, but also it can cause resistance to parasites. How to design a safe and reliable middle-prevention medicine for expelling parasites and improving immunity of fancy carps is a technical problem to be solved at present.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps.
The technical scheme of the invention is realized as follows:
a Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps comprises the following components in parts by weight: 25-40 parts of common carpesium fruit, 20-35 parts of betel nut, 20-30 parts of chinaberry, 5-10 parts of dried alum, 10-20 parts of pomegranate bark, 10-20 parts of brucea javanica and 10-15 parts of artemisinin.
The fructus Carpesii is fruit of Dicotyledoneae, Compositae, contains lactone compounds such as valeric acid, n-hexanoic acid, oleic acid, D-linolenic acid, methylene, stigmasterol, carpesin lactone, carpesin ketone, etc., and has effects in killing parasite (hookworm, ascaris), clearing away heat and toxic materials, invigorating spleen and regulating stomach. Areca is a fruit of Areca catechu L of Palmae, and contains arecoline and arecaidine as main ingredients, which are used as Taenia anthelmintic by folk. The Melia azedarach is a deciduous tree plant of Meliaceae, and its application parts include cortex Meliae, folium Meliae, fructus Toosendan, and flos Meliae, and is a pollution-free plant pesticide for expelling ascaris and hookworm. Calcined alum, also known as calcined alum, roasted alum, calcined alum, has the actions of detoxification and disinsection. Pomegranate rind, the dried pericarp of pomegranate of the family Punicaceae, has antibacterial, antiviral, and anthelmintic effects. Brucea javanica, also known as brucea javanica, sophora flavescens and brucea javanica, contains alkaloids (brucea javanica, brucea javanica and the like), glycosides (brucea javanica, brucea javanica glycosides and the like), phenolic components (brucea javanica phenol and the like) and hydroxycarboxylic acid (called brucea javanica acid) and the like, can expel intestinal nematodes and tapeworm and enhance immunity. The artemisinin is a novel sesquiterpene lactone substance extracted from the artemisia apiacea leaves, is easy to dissolve in chloroform, acetone, ethyl acetate and benzene, has quick-acting and low-toxicity characteristics, and a large number of practical applications show that the artemisinin has obvious effects of improving pathological changes and inflammatory reactions caused by parasitic diseases and has good antiparasitic effect. After the components are mixed according to the proportion, the components have synergistic effect, can obviously enhance the inherent immunity of the fancy carp, also has the effects of sterilization and desinsectization, and has safe and reliable drug effect.
Preferably, the Chinese herbal medicine formula contains the following components in parts by weight: 30-35 parts of common carpesium fruit, 30-35 parts of betel nut, 25-30 parts of chinaberry, 8-10 parts of dried alum, 13-15 parts of pomegranate bark, 15-18 parts of brucea javanica and 12-15 parts of artemisinin.
The use method of the Chinese herbal medicine formula for expelling parasites and improving immunity of koi comprises the following steps: soaking the Chinese herbal medicine formula in the culture water, wherein the dosage of the Chinese herbal medicine formula in the culture water is 6.25-125g/m3The fancy carp is cultivated in the cultivation water soaked with the Chinese herbal medicine formula for 6-12 days.
In order to facilitate soaking and taking out, the Chinese herbal medicine formula is firstly crushed and then packed in a fine gauze bag for use, and the preferable crushed particle size is 60-100 meshes. When the Chinese herbal medicine formula is soaked in the culture water, the drug effect is slowly released to the culture water, and numerous creative experiments show that: culturing Cyprinus Carpio in the culture water soaked with Chinese herbal medicine formula for 6-12 days, wherein the content of complement fragment 3a (C3a) and prostaglandin E2 (PGE) in Cyprinus Carpio serum2) The content of the lysozyme (L ZM) in the fancy carp is increased, so that the Chinese herbal medicine formula provided by the invention has the effects of obviously improving the inherent immunity of the fancy carp, resisting bacteria, diminishing inflammation and preventing parasites, does not influence the growth of the fancy carp, and also has the advantages ofHelps uterine smooth muscle to shrink and promotes ovulation of female koi.
Preferably, the Chinese herbal medicine formula is soaked in the culture water, the drug effect and the use cost are balanced, and the optimal dosage of the Chinese herbal medicine formula in the culture water is 12.5g/m3The optimal time for culturing the fancy carp in the culture water soaked with the Chinese herbal medicine formula is 9 days, and C3a and PGE are firstly cultured2L ZM content increased with the time of soaking the herbal formulation in the aquaculture water and peaked on day 9 after soaking and then decreased.
The Chinese herbal medicine formula provided by the invention is safe, reliable and efficient, has the effects of obviously improving the immunity of the fancy carp and preventing the generation of parasites, does not influence the growth of the fancy carp, and is also beneficial to uterine smooth muscle contraction and promoting ovulation of female fancy carps.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples test experiments the fancy carps were obtained from Tianjin Longjin Aquaculture Co., Ltd, initial average body weight (55 + -1.25) g, average body length (15.00 + -0.5) cm. were sterilized before cultivation, and placed in a water tank for 3 days for temporary cultivation so that the test fish were acclimatized and interference of stress reaction with the test results was avoided, hi the experiments, the fancy carps were randomly distributed into blue boxes (blue boxes containing 110L water, dissolved oxygen of not less than 5 mg/L, pH 7.5-8.4, water temperature controlled at about 25 ℃ and ZM 20 test fish were fed twice daily (9: 00 in the morning, 16:30 in the afternoon), daily feeding amount of ZM 20 test fish was about 1% of the body weight of the test fish weight), ZM 20 test fish was not fed on the same day as each ZM 20 test group, 5 fish were sampled per concentration group, measured (average weight after measurement), blood was sampled from the tail handle, kept in the abdominal region, blood collected at room temperature for 20min, and the PG5635 min, purified blood was collected from Nanjing Bioelements (PGA) and assayed by centrifugation at room temperature of PG5635C 3, 365635, 3, PGA, PG8, PGA, PG3, PGA was collected from Nanjing, and assayed by a technologies.
Example 1
A Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps comprises the following components in parts by weight: 25 parts of common carpesium fruit, 30 parts of betel nut, 30 parts of chinaberry, 5 parts of dried alum, 15 parts of pomegranate bark, 20 parts of brucea javanica and 10 parts of artemisinin.
The products obtained in example 1 were each formulated to a final concentration of 0g/m3、6.25g/m3、12.5g/m3、125g/m3The dosage of (2) and a bag hanging medicated bath test. Samples were taken on days 0, 3, 6, 9, 12, 15, respectively, and the entire experiment was for 15 days. The test results are shown below:
TABLE 1 influence of soaking in the Chinese herbal medicine formulation of example 1 on the C3R content in the serum of koi (unit: ng/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 28.01 | 30.14 | 31.73 | 31.69 | 31.04 | 26.61 |
| 6.25g/m3 | 27.57 | 30.6 | 35.32 | 58.31 | 38.99 | 28.43 |
| 12.5g/m3 | 27.31 | 33.75 | 41.45 | 63.98 | 41.07 | 32.48 |
| 125g/m3 | 28.14 | 35.3 | 47.53 | 87.53 | 50.76 | 35.89 |
TABLE 2 soaking of Cyprinus carpiod serum PGE in the Chinese herbal medicine formulation of example 12Effect of content (Unit: pg/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 599.46 | 683.17 | 712.50 | 700.38 | 705.36 | 685.12 |
| 6.25g/m3 | 579.43 | 728.94 | 1061.31 | 1435.24 | 832.74 | 745.83 |
| 12.5g/m3 | 604.04 | 951.79 | 1163.33 | 1575.60 | 1118.06 | 788.69 |
| 125g/m3 | 593.37 | 945.83 | 1369.65 | 1779.17 | 1222.57 | 906.55 |
TABLE 3 influence of the immersion of the Chinese herbal formulation of example 1 on the levels of serum L ZM in koi (unit: U/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 9.97 | 11.42 | 10.38 | 10.98 | 10.25 | 11.25 |
| 6.25g/m3 | 9.84 | 15.70 | 36.95 | 70.76 | 39.81 | 20.32 |
| 12.5g/m3 | 9.88 | 25.37 | 67.19 | 73.27 | 43.30 | 34.48 |
| 125g/m3 | 9.49 | 29.51 | 68.34 | 77.44 | 70.29 | 36.83 |
Example 2
A Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps comprises the following components in parts by weight: 30 parts of common carpesium fruit, 35 parts of betel nut, 20 parts of chinaberry, 8 parts of dried alum, 20 parts of pomegranate bark, 10 parts of brucea javanica and 12 parts of artemisinin.
The product obtained in example 1 was divided intoRespectively preparing the final concentration of 0g/m3、6.25g/m3、12.5g/m3、125g/m3The dosage of (2) and a bag hanging medicated bath test. Samples were taken on days 0, 3, 6, 9, 12, 15, respectively, and the entire experiment was for 15 days. The test results are shown below:
TABLE 4 influence of soaking in the herbal formulation of example 2 on the C3R level in the serum of koi (unit: ng/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 27.36 | 28.36 | 31.35 | 31.15 | 32.14 | 25.14 |
| 6.25g/m3 | 26.78 | 31.25 | 34.98 | 57.64 | 39.45 | 29.15 |
| 12.5g/m3 | 27.65 | 33.89 | 41.49 | 74.51 | 41.26 | 33.45 |
| 125g/m3 | 28.12 | 37.3 | 53.21 | 88.12 | 54.21 | 36.82 |
TABLE 5 soaking of Cyprinus carpiod serum PGE in the herbal formulation of example 22Effect of content (Unit: pg/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 574.35 | 614.56 | 654.23 | 681.45 | 700.14 | 640.21 |
| 6.25g/m3 | 564.12 | 741.23 | 1089.23 | 1315.32 | 1106.58 | 847.36 |
| 12.5g/m3 | 570.21 | 941.23 | 1215.63 | 1524.02 | 1032.54 | 769.23 |
| 125g/m3 | 584.45 | 989.23 | 1265.35 | 1874.36 | 1352.32 | 897.12 |
TABLE 6 influence of soaking in the Chinese herbal formula of example 2 on the level of serum L ZM in koi carp (unit: U/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 9.53 | 10.32 | 10.45 | 10.88 | 9.54 | 9.25 |
| 6.25g/m3 | 9.01 | 15.02 | 34.25 | 68.65 | 38.14 | 19.58 |
| 12.5g/m3 | 9.68 | 24.21 | 63.25 | 71.32 | 41.23 | 32.56 |
| 125g/m3 | 9.42 | 28.35 | 67.12 | 78.12 | 69.54 | 34.16 |
Example 3
A Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps comprises the following components in parts by weight: 40 parts of common carpesium fruit, 35 parts of betel nut, 25 parts of chinaberry, 10 parts of dried alum, 10 parts of pomegranate bark, 15 parts of brucea javanica and 13 parts of artemisinin.
The products obtained in example 3 were each formulated to a final concentration of 0g/m3、6.25g/m3、12.5g/m3、125g/m3The dosage of (2) and a bag hanging medicated bath test. Samples were taken on days 0, 3, 6, 9, 12, 15, respectively, and the entire experiment was for 15 days. The test results are shown below:
TABLE 7 influence of soaking in the herbal formulation of example 3 on the C3R level in the serum of koi (unit: ng/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 26.41 | 27.65 | 29.45 | 30.28 | 31.45 | 27.89 |
| 6.25g/m3 | 26.78 | 31.33 | 35.12 | 57.89 | 39.32 | 30.12 |
| 12.5g/m3 | 27.89 | 35.21 | 41.45 | 75.45 | 41.26 | 33.45 |
| 125g/m3 | 28.34 | 37.32 | 48.45 | 93.12 | 54.21 | 36.82 |
TABLE 8 serum PGE of koi soaked in the herbal formulation of example 32Effect of content (Unit: pg/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 584.56 | 677.24 | 725.35 | 765.22 | 687.12 | 645.21 |
| 6.25g/m3 | 567.87 | 712.32 | 1087.36 | 1354.89 | 745.21 | 694.25 |
| 12.5g/m3 | 589.21 | 987.23 | 1214.36 | 1578.36 | 945.26 | 700.12 |
| 125g/m3 | 593.54 | 995.83 | 1225.24 | 1874.25 | 1189.45 | 845.36 |
TABLE 9 influence of immersion in the herbal formulation of example 3 on the level of serum L ZM in koi carp (unit: U/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 9.78 | 11.24 | 10.65 | 11.24 | 10.98 | 9.89 |
| 6.25g/m3 | 10.25 | 15.24 | 35.98 | 70.12 | 39.14 | 19.25 |
| 12.5g/m3 | 9.87 | 25.14 | 65.87 | 72.45 | 42.03 | 33.61 |
| 125g/m3 | 10.01 | 29.14 | 68.96 | 76.58 | 68.97 | 36.97 |
Example 4
A Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps comprises the following components in parts by weight: 35 parts of common carpesium fruit, 20 parts of betel nut, 28 parts of chinaberry, 7 parts of dried alum, 13 parts of pomegranate bark, 18 parts of brucea javanica and 15 parts of artemisinin.
The products obtained in example 4 were each formulated to a final concentration of 0g/m3、6.25g/m3、12.5g/m3、125g/m3The dosage of (2) and a bag hanging medicated bath test. Samples were taken on days 0, 3, 6, 9, 12, 15, respectively, and the entire experiment was for 15 days. The test results are shown below:
TABLE 10 influence of soaking in the herbal formulation of example 4 on the C3R level in the serum of koi carp (unit: ng/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 28.12 | 29.65 | 32.45 | 33.25 | 31.22 | 28.89 |
| 6.25g/m3 | 28.14 | 31.14 | 35.54 | 58.84 | 40.12 | 30.12 |
| 12.5g/m3 | 29.12 | 34.87 | 42.15 | 72.04 | 42.51 | 33.45 |
| 125g/m3 | 29.35 | 37.37 | 47.65 | 94.01 | 55.31 | 36.45 |
TABLE 11 soaking of Cyprinus carpiod serum PGE in the herbal formulation of example 42Effect of content (Unit: pg/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 584.23 | 597.35 | 704.56 | 768.24 | 702.21 | 697.12 |
| 6.25g/m3 | 600.14 | 768.21 | 1130.45 | 1345.28 | 987.12 | 800.15 |
| 12.5g/m3 | 598.24 | 1032.22 | 1345.27 | 1645.67 | 1032.15 | 914.21 |
| 125g/m3 | 604.32 | 968.78 | 1245.78 | 2103.24 | 1234.56 | 1031.61 |
TABLE 12 influence of immersion in the herbal formula of example 4 on the levels of serum L ZM in koi carp (unit: U/m L)
| 0d | 3d | 6d | 9d | 12d | 15d | |
| 0g/m3 | 9.69 | 11.34 | 10.58 | 11.18 | 11.04 | 9.14 |
| 6.25g/m3 | 10.37 | 15.68 | 36.74 | 52.14 | 40.15 | 20.68 |
| 12.5g/m3 | 9.67 | 26.58 | 70.06 | 75.69 | 45.32 | 36.54 |
| 125g/m3 | 9.68 | 30.12 | 70.89 | 78.33 | 70.35 | 38.95 |
The test tests of the combined examples 1-4 show that: the higher the concentration of the Chinese herbal medicine formula is, the higher the content of C3R and the PGE2The more obvious the improvement effect of the content and L ZM content is, but the improvement is limited, the optimal concentration of the Chinese herbal medicine formula is considered by combining the efficacy and the costIs 12.5g/m3L ZM content shows a trend of increasing first and then decreasing with the increase of soaking time and reaches the highest value on the 9 th day, namely the nonspecific immunity peak of the body fluid of the koi is on the 9 th day after the Chinese herbal medicine formula is soaked, and the soaking time of the Chinese herbal medicine formula is preferably 9 days.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (4)
1. A Chinese herbal medicine formula for expelling parasites and improving immunity of fancy carps is characterized in that: the Chinese herbal medicine formula comprises the following components in parts by weight: 25-40 parts of common carpesium fruit, 20-35 parts of betel nut, 20-30 parts of chinaberry, 5-10 parts of dried alum, 10-20 parts of pomegranate bark, 10-20 parts of brucea javanica and 10-15 parts of artemisinin.
2. The Chinese herbal medicine formula for repelling insects and improving immunity of koi according to claim 1, is characterized in that: the Chinese herbal medicine formula comprises the following components in parts by weight: 30-35 parts of common carpesium fruit, 30-35 parts of betel nut, 25-30 parts of chinaberry, 8-10 parts of dried alum, 13-15 parts of pomegranate bark, 15-18 parts of brucea javanica and 12-15 parts of artemisinin.
3. A method of using the herbal formulation for repelling parasites and enhancing immunity of koi according to claim 1, which comprises: soaking the Chinese herbal medicine formula in aquaculture water, wherein the dosage of the Chinese herbal medicine formula in the aquaculture water is 6.25-125g/m3The fancy carp is cultivated in the cultivation water soaked with the Chinese herbal medicine formula for 6-12 days.
4. The use method of the Chinese herbal medicine formula for repelling insects and improving immunity of koi according to claim 3, is characterized in that: soaking the Chinese herbal medicine formula in aquaculture water, wherein the dosage of the Chinese herbal medicine formula in the aquaculture water is 12.5g/m3The brocade carp is soaked with the Chinese herbal medicineThe breeding water of the formula is cultured for 9 days.
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| CN107969445A (en) * | 2016-10-21 | 2018-05-01 | 鼎正动物药业（天津）有限公司 | A kind of Chinese herbal medicine pesticide |
| CN108567869A (en) * | 2018-07-16 | 2018-09-25 | 资兴市泰坤农林生态产业有限公司 | A kind of Chinese medicine composition, preparation method and application for treating chicken roundworm disease |
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Application publication date: 20200710 |