CN111375453A - Automatic change micro-fluidic device - Google Patents
Automatic change micro-fluidic device Download PDFInfo
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- CN111375453A CN111375453A CN201811608194.8A CN201811608194A CN111375453A CN 111375453 A CN111375453 A CN 111375453A CN 201811608194 A CN201811608194 A CN 201811608194A CN 111375453 A CN111375453 A CN 111375453A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1861—Means for temperature control using radiation
Abstract
The invention discloses an automatic micro-fluidic device which comprises a supporting base, a sample containing plate, a micro-fluidic box body and a rotary servo motor, wherein supporting legs are arranged below the supporting base, a positioning tool is arranged on one side above the supporting base, the sample containing plate is arranged on the positioning tool, and a sample containing bottle is arranged on the sample containing plate. Has the advantages that: the device can simultaneously carry out a large number of detection items by arranging the circular base plate, the rotary servo motor and the mechanical arm, manpower and material resources are saved, the amount of added reaction liquid and sample solution can be controlled by the controller by arranging the metering sampling pump and the metering liquid pump, the operation is simple, the metering is accurate, the detection efficiency is improved, and meanwhile, the device can finish dozens of previous detection operations once in the aspects of food virus detection and the like, thereby reducing unnecessary labor, saving time and greatly improving the detection efficiency.
Description
Technical Field
The invention relates to the technical field of biological detection and analysis, and relates to an automatic microfluidic device.
Background
At present, the detection means used in various fields are still the traditional method, namely, firstly, samples are manually extracted, a series of complex biochemical reactions are carried out in a test tube by purchasing a commercial kit according to a product specification or preparing a reaction system, and then the experimental results are analyzed, so that a large amount of repeated work is repeated, a large amount of time is consumed, and redundant materials are wasted. Therefore, there is a need for an automated inspection system that integrates these operations together to be performed automatically by a machine to reduce manual operations, avoid the risk of misoperations, and increase analysis speed and inspection throughput.
Disclosure of Invention
It is an object of the present invention to provide an automated microfluidic device that solves the above problems.
The invention realizes the purpose through the following technical scheme:
an automatic micro-fluidic device comprises a supporting base, a sample containing plate, a micro-fluidic box body and a rotary servo motor, wherein supporting legs are arranged below the supporting base, a positioning tool is arranged on one side above the supporting base, the sample containing plate is arranged on the positioning tool, sample containing bottles are arranged on the sample containing plate, a mechanical arm is arranged on one side of the positioning tool, a sample pumping pipe is arranged on the mechanical arm, the micro-fluidic box body is arranged on one side of the mechanical arm, a controller is arranged on one side wall of the micro-fluidic box body, a liquid discharge pipe is arranged on the other side wall of the micro-fluidic box body, a liquid discharge control valve is arranged on the liquid discharge pipe, a metering sampling pump is arranged on one side above the micro-fluidic box body, a sample guide hose is arranged between the metering sampling pump and the sample pumping pipe, a metering sampling pump is arranged on one side of, the metering liquid pump is provided with a reaction liquid inlet pipe, one side of the metering liquid pump is provided with a cleaning pump, a cleaning liquid inlet pipe is arranged on the cleaning pump, a supporting box body is arranged below the inner part of the micro-fluidic box body, the rotary servo motor is arranged in the supporting box body, a circular slide rail is arranged on the periphery of the upper end of the supporting box body, a sliding block is arranged on the circular sliding rail, a rotating base is arranged on the sliding block, a supporting shaft is arranged above the rotating base, a circular base plate is arranged on the supporting shaft, a micro-flow hole is formed on the circular base plate, a circular diversion supporting plate is arranged above the circular base plate, a through hole is formed on the circular diversion support plate, a cleaning liquid detector is arranged below the circular diversion support plate, and a data analysis processor is arranged on one side above the circular diversion support plate, and an excitation light source is arranged below the data analysis processor.
Furthermore, circular water conservancy diversion supporting disk with the micro-fluidic box passes through the screw connection, circular water conservancy diversion supporting disk is including setting gradually add appearance district, liquid feeding district, detection zone and washing district on the circular water conservancy diversion supporting disk.
Furthermore, the supporting base is connected with the supporting legs through bolts, the supporting base is connected with the positioning tool through screws, and the positioning tool is connected with the sample containing plate through a clamping groove.
Furthermore, the mechanical arm is connected with the supporting base through a screw, the sampling pipe is connected with the mechanical arm through a screw, and the model of the mechanical arm is VS-060.
Further, the controller is connected with the microfluidic box body through screws, the microfluidic box body is connected with the liquid discharge pipe through a flange, the liquid discharge pipe is connected with the liquid discharge control valve through threads, and the type of the liquid discharge control valve is WJ41F-16DN 15.
Furthermore, the metering sampling pump, the metering liquid pump and the cleaning pump are all connected with the microfluidic box body through screws, the models of the metering sampling pump and the metering liquid pump are P056-398TI, and the model of the cleaning pump is FL-35.
Furthermore, the sampling pipe with the measurement sampling pump passes through threaded connection, the reaction liquid inlet pipe with the measurement drawing pump passes through threaded connection, the washing liquid inlet pipe with the washing pump passes through threaded connection.
Further, the controller is connected with the microfluidic box body through screws, the supporting box body is connected with the microfluidic box body through screws, the circular slide rail is connected with the slide block in a sliding mode, the rotary servo motor is connected with the rotary base through a key, the type of the rotary servo motor is JSMA-SC04ABK01, and the type of the controller is MAM-330.
Furthermore, the supporting base is connected with the sliding block through a screw, and the circular base plate is connected with the rotating base through the supporting shaft.
Furthermore, the data analysis processor is connected with the microfluidic box body through a screw, the excitation light source is connected with the data analysis processor through a screw, and the cleaning liquid detector is connected with the circular diversion support plate through a screw.
The specific working principle is as follows: when the device is used, an external power supply is connected with the controller, the cleaning liquid inlet pipe is connected with an external cleaning liquid pipeline, the reaction liquid inlet pipe is connected with an external reaction liquid pipeline, the sample containing plate containing a test sample is fixed on the positioning tool, equipment can be opened by the controller to enable the sample containing plate to operate, the controller controls the action of the mechanical arm to pump the sample solution in the sample containing bottle on the sample containing plate to the inside of the micro-flow hole in the circular base plate below the sample adding area on the circular diversion supporting plate through the metering sampling pump, then the controller controls the rotary servo motor to work, the rotary servo motor drives the circular base plate to rotate to sequentially enter the sample adding area, and the metering pump pumps the external reaction liquid to the inside of the micro-flow hole containing the sample through the reaction liquid inlet pipe, after reacting for a period of time, enter into the detection zone below, then under excitation light source with data analysis processor's combined action, judge the detection item through the fluorescence signal who collects, enter into after the detection finishes the washing district opens clap liquid control valve under the effect of scavenging pump, it is right to pass through outside washing liquid admission pipe the micropore hole washs, the washing liquid detector can detect whether the downthehole portion of microflow washs totally, and then improves the purity of sample splendid attire process, improves the precision of detected data circular base plate rotatory in-process, control gradually robotic arm passes through on the sampling pipe holds the board with the sample the inside sample of lofting bottle is taken out inside the micropore hole, realizes circulation detection work, improves the efficiency of detection.
The invention has the beneficial effects that:
1. by arranging the circular base plate, the rotary servo motor and the mechanical arm, a large number of detection items can be simultaneously developed by the device, and manpower and material resources are saved;
2. by arranging the metering sampling pump and the metering liquid pump, the amount of the added reaction liquid and the amount of the added sample solution can be controlled by the controller, the operation is simple, the metering is accurate, and the detection efficiency is improved;
3. the invention can finish dozens of previous detection operations in aspects of food virus detection and the like at one time, reduces unnecessary labor, saves time and greatly improves detection efficiency.
Drawings
FIG. 1 is a front view of an automated microfluidic device according to the present invention;
FIG. 2 is a front cross-sectional view of a microfluidic housing of an automated microfluidic device according to the present invention;
FIG. 3 is a top view of a circular base plate in an automated microfluidic device according to the present invention;
fig. 4 is a top view of a circular flow directing support disk in an automated microfluidic device according to the present invention;
fig. 5 is a block circuit diagram of a controller in an automated microfluidic device according to the present invention.
The reference numerals are explained below:
1. a support base; 2. supporting legs; 3. positioning a tool; 4. a sample holding plate; 5. placing a sample bottle; 6. a robot arm; 7. a sampling tube; 8. a sample guide hose; 9. a microfluidic box body; 10. a metering sampling pump; 11. a metering liquid pump; 12. introducing the reaction liquid into a pipe; 13. cleaning the pump; 14. a cleaning liquid inlet pipe; 15. a controller; 16. a liquid discharge pipe; 17. a drain control valve; 18. supporting the box body; 19. rotating the servo motor; 20. a circular slide rail; 21. a slider; 22. rotating the base; 23. a support shaft; 24. a circular base plate; 25. a circular diversion support plate; 2501. a sample adding area; 2502. a liquid feeding area; 2503. a detection zone; 2504. a washing zone; 26. a data analysis processor; 27. an excitation light source; 28. a micro-orifice; 29. a via hole; 30. and a cleaning liquid detector.
Detailed Description
The invention will be further described with reference to the accompanying drawings in which:
as shown in fig. 1-5, an automatic microfluidic device comprises a supporting base 1, a sample holding plate 4, a microfluidic box 9 and a rotary servo motor 19, wherein supporting legs 2 are arranged below the supporting base 1, a positioning tool 3 is arranged on one side above the supporting base 1, the positioning tool 3 can play a role of positioning, so that the alignment time in secondary detection can be greatly shortened, the detection efficiency is improved, the sample holding plate 4 is arranged on the positioning tool 3, a sample bottle 5 is arranged on the sample holding plate 4, the sample bottle 5 is used for holding sample solution, a mechanical arm 6 is arranged on one side of the positioning tool 3, a sampling tube 7 is arranged on the mechanical arm 6, the sample bottle 5 and the sampling tube 7 can be detached from the sample holding plate 4 and the mechanical arm 6 respectively for holding a blood sampling tube, the blood sample analyzer is convenient for detecting blood, the mechanical arm 6 can control the sampling tube 7 to sequentially complete the transfer work of sample solution in the sample placing bottle 5, one side of the mechanical arm 6 is provided with the microfluidic box 9, one side wall of the microfluidic box 9 is provided with the controller 15, the other side wall of the microfluidic box 9 is provided with the liquid discharge tube 16, the liquid discharge tube 16 is used for discharging cleaning liquid, the liquid discharge tube 16 is provided with the liquid discharge control valve 17, one side above the microfluidic box 9 is provided with the metering sampling pump 10, the metering sampling pump 10 is used for metering the amount of the added sample solution, a sample guide hose 8 is arranged between the metering sampling pump 10 and the sampling tube 7, one side of the metering sampling pump 10 is provided with the metering liquid pump 11, the metering liquid pump 11 is used for metering the amount of the added reaction solution, the metering liquid pump 11 is provided with the reaction solution inlet tube 12, a cleaning pump 13 is arranged on one side of the metering liquid pump 11, the cleaning pump 13 is used for pumping cleaning liquid, a cleaning liquid inlet pipe 14 is arranged on the cleaning pump 13, a supporting box 18 is arranged below the inner part of the microfluidic box 9, the rotary servo motor 19 is arranged in the supporting box 18, a circular slide rail 20 is arranged on the periphery of the upper end of the supporting box 18, a slide block 21 is arranged on the circular slide rail 20, a rotary base 22 is arranged on the slide block 21, a supporting shaft 23 is arranged above the rotary base 22, a circular base disc 24 is arranged on the supporting shaft 23, the rotary servo motor 19 provides power for the rotation of the circular base disc 24, the circular slide rail 20 and the slide block 21 provide guidance for the rotation of the circular base disc 24, a micro-flow hole 28 is formed on the circular base disc 24, and a circular guide supporting disc 25 is arranged above the circular base disc 24, the round diversion supporting disc 25 is formed with a via hole 29, a cleaning liquid detector 30 is arranged below the round diversion supporting disc 25, the cleaning liquid detector 30 is used for detecting whether a micro-flow hole 28 is clear or not, a data analysis processor 26 is arranged on one side above the round diversion supporting disc 25, an excitation light source 27 is arranged below the data analysis processor 26, and the excitation light source 27 and the data analysis processor 26 jointly act to judge detection items through collected fluorescent signals.
In this embodiment, the circular diversion support plate 25 is connected to the microfluidic box 9 by screws, and the circular diversion support plate 25 includes a sample adding region 2501, a liquid adding region 2502, a detection region 2503 and a washing region 2504, which are sequentially disposed on the circular diversion support plate 25.
In this embodiment, support base 1 with supporting leg 2 passes through bolted connection, support base 1 with location frock 3 passes through the screw connection, location frock 3 can play the effect of repeated location, shortens the adjustment time of secondary detection, location frock 3 with sample holding plate 4 passes through the draw-in groove and connects.
In this embodiment, the mechanical arm 6 is connected to the support base 1 through a screw, the sampling tube 7 is connected to the mechanical arm 6 through a screw, and the type of the mechanical arm 6 is VS-060.
In this embodiment, the controller 15 is connected to the microfluidic box 9 by screws, the microfluidic box 9 is connected to the drain pipe 16 by flanges, the drain pipe 16 is connected to the drain control valve 17 by threads, the drain control valve 17 controls a cleaning and draining process, and the drain control valve 17 is WJ41F-16DN 15.
In this embodiment, the measurement sampling pump 10, the measurement pumping liquid pump 11, and the cleaning pump 13 are all connected to the microfluidic tank 9 by screws, the measurement sampling pump 10 and the measurement pumping liquid pump 11 are used to measure the amounts of the added sample solution and reaction solution, the measurement sampling pump 10 and the measurement pumping liquid pump 11 are both P056-398TI, and the cleaning pump 13 is FL-35.
In this embodiment, the sampling tube 7 is connected to the metering sampling pump 10 by a screw, the reaction liquid inlet tube 12 is connected to the metering liquid pump 11 by a screw, and the cleaning liquid inlet tube 14 is connected to the cleaning pump 13 by a screw.
In this embodiment, the controller 15 is connected to the microfluidic box 9 by screws, the support box 18 is connected to the microfluidic box 9 by screws, the circular slide rail 20 is connected to the slide block 21 in a sliding manner, the rotary servo motor 19 is connected to the rotary base 22 by a key, the circular slide rail 20 and the slide block 21 provide guidance for rotation of the circular base plate 24, the rotary servo motor 19 is JSMA-SC04ABK01, and the controller 15 is MAM-330.
In this embodiment, the supporting base 1 is connected to the sliding block 21 by screws, and the circular base plate 24 is connected to the rotating base 22 by the supporting shaft 23.
In this embodiment, the data analysis processor 26 is connected to the microfluidic box 9 by screws, the excitation light source 27 is connected to the data analysis processor 26 by screws, the cleaning solution detector 30 is connected to the circular diversion support plate 25 by screws, and the excitation light source 27 and the data analysis processor cooperate to determine the detection items through the collected fluorescence signals.
The specific working principle is as follows: when the device is used, firstly, an external power supply is connected with the controller 15, the cleaning liquid inlet pipe 14 is connected with an external cleaning liquid pipeline, the reaction liquid inlet pipe 12 is connected with an external reaction liquid pipeline, then the sample containing plate 4 containing a test sample is fixed on the positioning tool 3, then the device can be opened by the controller 15 to operate, the controller 15 controls the mechanical arm 6 to act, the sample solution in the sample containing bottle 5 on the sample containing plate 4 is pumped into the micro-flow hole 28 on the circular base plate 24 below the sample adding area 2501 on the circular diversion supporting plate 25 through the metering sampling pump 10, then the controller 15 controls the rotary servo motor 19 to work, the rotary servo motor 19 drives the circular base plate 24 to rotate, and the circular base plate 24 sequentially enters the liquid adding area 2502, the measuring and pumping liquid pump 11 delivers an external reaction liquid to the interior of the microflow hole 28 containing a sample through the reaction liquid inlet tube 12, after a reaction period, the reaction liquid enters the detection area 2503, then under the combined action of the excitation light source 27 and the data analysis processor 26, the detection items are judged through the collected fluorescence signals, after the detection is finished, the reaction liquid enters the washing area 2504, the drainage control valve 17 is opened, under the action of the cleaning pump 13, the external cleaning liquid is cleaned to the microflow hole 28 through the cleaning liquid inlet tube 14, the cleaning liquid detector 30 can detect whether the interior of the microflow hole 28 is cleaned, so as to improve the purity of the sample containing process and the accuracy of the detection data, and in the process of rotating the circular base plate 24, the mechanical arm 6 is sequentially controlled to take the sample inside the sample containing bottle 5 on the sample containing plate 4 through the sampling tube 7, the micro-flow hole 28 is pumped to the inside, so that the circular detection work is realized, and the detection efficiency is improved.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (10)
1. An automated microfluidic device, comprising: the device comprises a supporting base (1), a sample containing plate (4), a micro-fluidic box body (9) and a rotary servo motor (19), wherein supporting legs (2) are arranged below the supporting base (1), a positioning tool (3) is arranged on one side above the supporting base (1), the sample containing plate (4) is arranged on the positioning tool (3), a sample containing bottle (5) is arranged on the sample containing plate (4), a mechanical arm (6) is arranged on one side of the positioning tool (3), a sample pumping pipe (7) is arranged on the mechanical arm (6), the micro-fluidic box body (9) is arranged on one side of the mechanical arm (6), a controller (15) is arranged on one side wall of the micro-fluidic box body (9), a liquid discharge pipe (16) is arranged on the other side wall of the micro-fluidic box body (9), and a liquid discharge control valve (17) is arranged on the liquid discharge pipe (16), the device is characterized in that a metering sampling pump (10) is arranged on one side above the micro-fluidic box body (9), a sample guiding hose (8) is arranged between the metering sampling pump (10) and the sampling pipe (7), a metering liquid pump (11) is arranged on one side of the metering sampling pump (10), a reaction liquid inlet pipe (12) is arranged on the metering liquid pump (11), a cleaning pump (13) is arranged on one side of the metering liquid pump (11), a cleaning liquid inlet pipe (14) is arranged on the cleaning pump (13), a supporting box body (18) is arranged below the inside of the micro-fluidic box body (9), a rotary servo motor (19) is arranged inside the supporting box body (18), a circular slide rail (20) is arranged on the periphery of the upper end of the supporting box body (18), a slide block (21) is arranged on the circular slide rail (20), and a rotary base (22) is arranged on the slide, rotating base (22) top is provided with back shaft (23), be provided with circular base plate (24) on back shaft (23), the shaping has micropore hole (28) on circular base plate (24), circular base plate (24) top is provided with circular water conservancy diversion supporting disk (25), the shaping has via hole (29) on circular water conservancy diversion supporting disk (25), circular water conservancy diversion supporting disk (25) below is provided with washing liquid detector (30), circular water conservancy diversion supporting disk (25) top one side is provided with data analysis treater (26), data analysis treater (26) below is provided with excitation light source (27).
2. An automated microfluidic device according to claim 1 wherein: circular water conservancy diversion supporting disk (25) with micro-fluidic box (9) pass through the screw connection, circular water conservancy diversion supporting disk (25) are including setting gradually add appearance district (2501), liquid feeding district (2502), detection zone (2503) and washing district (2504) on circular water conservancy diversion supporting disk (25).
3. An automated microfluidic device according to claim 1 wherein: the supporting base (1) is connected with the supporting legs (2) through bolts, the supporting base (1) is connected with the positioning tool (3) through screws, and the positioning tool (3) is connected with the sample containing plate (4) through a clamping groove.
4. An automated microfluidic device according to claim 1 wherein: the mechanical arm (6) is connected with the supporting base (1) through screws, the sampling tube (7) is connected with the mechanical arm (6) through screws, and the type of the mechanical arm (6) is VS-060.
5. An automated microfluidic device according to claim 1 wherein: the controller (15) is connected with the microfluidic box body (9) through screws, the microfluidic box body (9) is connected with the liquid discharge pipe (16) through a flange, the liquid discharge pipe (16) is connected with the liquid discharge control valve (17) through threads, and the type of the liquid discharge control valve (17) is WJ41F-16DN 15.
6. An automated microfluidic device according to claim 1 wherein: the metering sampling pump (10), the metering liquid pump (11) and the cleaning pump (13) are connected with the microfluidic box body (9) through screws, the types of the metering sampling pump (10) and the metering liquid pump (11) are P056-TI 398, and the type of the cleaning pump (13) is FL-35.
7. An automated microfluidic device according to claim 1 wherein: the sampling pipe (7) is in threaded connection with the metering sampling pump (10), the reaction liquid inlet pipe (12) is in threaded connection with the metering liquid pump (11), and the cleaning liquid inlet pipe (14) is in threaded connection with the cleaning pump (13).
8. An automated microfluidic device according to claim 1 wherein: the controller (15) with micro-fluidic box (9) pass through the screw connection, supporting box (18) with micro-fluidic box (9) pass through the screw connection, circular slide rail (20) with slider (21) sliding connection, rotatory servo motor (19) with rotating base (22) pass through the key-type connection, the model of rotatory servo motor (19) is JSMA-SC04ABK01, controller (15) model is MAM-330.
9. An automated microfluidic device according to claim 1 wherein: the supporting base (1) is connected with the sliding block (21) through screws, and the circular base plate (24) is connected with the rotating base (22) through the supporting shaft (23).
10. An automated microfluidic device according to claim 1 wherein: the data analysis processor (26) is connected with the microfluidic box body (9) through screws, the excitation light source (27) is connected with the data analysis processor (26) through screws, and the cleaning liquid detector (30) is connected with the circular diversion support plate (25) through screws.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811608194.8A CN111375453A (en) | 2018-12-27 | 2018-12-27 | Automatic change micro-fluidic device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811608194.8A CN111375453A (en) | 2018-12-27 | 2018-12-27 | Automatic change micro-fluidic device |
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| CN111375453A true CN111375453A (en) | 2020-07-07 |
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| CN201811608194.8A Pending CN111375453A (en) | 2018-12-27 | 2018-12-27 | Automatic change micro-fluidic device |
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| EP0087028A1 (en) * | 1982-02-13 | 1983-08-31 | Kabushiki Kaisha Toshiba | Automatic chemical analyzer |
| US20090308746A1 (en) * | 2008-06-11 | 2009-12-17 | Samsung Electronics Co., Ltd. | Analyzing apparatus using rotatable microfluidic disk |
| CN202101998U (en) * | 2011-06-16 | 2012-01-04 | 深圳市国赛生物技术有限公司 | Full-automatic chemiluminescence test device |
| CN205991942U (en) * | 2016-08-26 | 2017-03-01 | 深圳市库贝尔生物科技股份有限公司 | A kind of reaction cup rotating mechanism of chemical luminescence detector |
| CN106568696A (en) * | 2016-11-14 | 2017-04-19 | 江苏大学 | Preventive detection apparatus and method for fungal diseases of crops based on micro-fluidic chip |
| CN206362757U (en) * | 2016-12-09 | 2017-07-28 | 中储粮成都粮食储藏科学研究所 | A kind of fatty acid value automatic tester |
| CN106906137A (en) * | 2017-03-19 | 2017-06-30 | 北京化工大学 | A kind of high-throughput nucleic acid analysis device based on micro-fluidic chip |
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