CN111375040A

CN111375040A - Pain-relieving traditional Chinese medicine nano-emulsion dispersion liquid, preparation method and application

Info

Publication number: CN111375040A
Application number: CN201811640878.6A
Authority: CN
Inventors: 周书繁; 马振元; 苑鹏翀; 杨玉; 王辉; 赵立新; 罗红
Original assignee: Liaoning Herbpex Pharmaceutical Group Co ltd
Current assignee: Liaoning Herbpex Pharmaceutical Group Co ltd
Priority date: 2018-12-29
Filing date: 2018-12-29
Publication date: 2020-07-07

Abstract

The invention belongs to the technical field of plant extracts, and particularly relates to an analgesic nanoemulsion dispersion liquid, a preparation method and application thereof. Aiming at the technical problems that in the traditional fumigation treatment in the prior art, the patient compliance is poor, and the traditional fumigation instrument cannot meet the market demand, the application provides a preparation method and application of a nanoemulsion dispersion liquid used for warming channel to dispel cold, and activating blood to stop pain in combination with a traditional Chinese medicine fumigation instrument. The invention relates to a nano-emulsion dispersion bath lotion which is prepared by extracting, squeezing and nano-homogenizing raw materials such as red ginseng, ginger, argyi leaf, angelica, red peony root, ligusticum, divaricate saposhnikovia root, cinnamon, cibot rhizome, drynaria rhizome, native copper, yam rhizome, paniculate swallowwort root and the like and has the functions of warming channels, dispelling cold, promoting blood circulation and relieving pain. Through the investigation of the preparation process, the nano-emulsion dispersed liquid medicine with stable property, good smell, good effect and high comfort level is provided.

Description

Pain-relieving traditional Chinese medicine nano-emulsion dispersion liquid, preparation method and application

Technical Field

The invention belongs to the technical field of traditional Chinese medicine extracts, and particularly relates to a nano-emulsion dispersion liquid with the effects of warming channels for dispelling cold, and activating blood circulation to stop pain, and a preparation method and application thereof.

Background

Chinese medicated bath culture is a popular health-preserving way for people from ancient times. Under the guidance of the theory of traditional Chinese medicine, proper Chinese herbal medicines are selected, steam is generated after boiling, and the Chinese herbal medicines are fumigated, or the Chinese herbal medicines are processed into Chinese herbal medicine bath liquid to be used for bath of the whole body and the half body or local dipping bath such as hip bath, foot bath, arm bath, face bath, eye bath and the like, so as to achieve the purpose of preventing and treating diseases. The medicated bath utilizes water temperature, heat and medicine effects, and through stimulation to skin, meridian and acupoint and transdermal absorption of medicine, has effects of relaxing muscles and tendons, promoting blood circulation, regulating viscera function, etc., and can regulate yin and yang balance of human body, so as to achieve the purpose of treating and preventing diseases, and promoting health.

The traditional medicated bath mode needs the patient to soak the affected part in the medicated bath basin, needs to constantly add hot water to keep the temperature of the medicated bath, and the medicine can only rely on the hot water to dissolve out the active ingredients, so that the treatment efficiency is not high. Most of the medicines are placed in a Chinese herbal medicine bag, the efficacy of the medicines is dissipated by soaking in hot water, the soaking time of the medicines is limited, the effective components in the medicines cannot be completely leached, and the utilization rate of the medicines is low. In addition, most of the medicines used in the medicated bath are aromatic and pungent in smell, contain more volatile oil components, and the volatile oil components leached by hot water are difficult to permeate through skin barriers and mostly stay on the skin surface of an affected part, so that the effect of the medicines is not good, and the skin surface of a patient has sticky feeling and heavy smell.

Along with the update iteration of the medicated bath product, the fumigation instrument gradually replaces the medicated bath soaking. The traditional fumigation instrument mostly adopts steam heating, and the medicine steam brought out by the steam is utilized to fumigate the body part, so that the targeted application can be carried out on the body part. With the development of modern technology, the requirements of people on the quality of life are continuously improved, and certain defects are gradually exposed in the traditional fumigation: if the safety is not high, the skin is easily burnt due to inaccurate temperature control caused by steam heating; the bioavailability of the medicine is not high, the steam is heated, most of the liquid medicine obtained by fumigation is steam or volatile oily substances, and most of the active ingredients are left in the fumigation box; complex operation, low comfort level, etc.

Based on the defects, the traditional fumigation form cannot meet the market demand, and aiming at the current situation of medicated bath treatment, the composition suitable for medicated bath and the traditional Chinese medicine extract suitable for fumigation are provided, and are matched with corresponding fumigation instruments, so that the treatment effect of medicated bath fumigation can be improved, and the market demand can be met.

Disclosure of Invention

Based on the defects in the prior art, the invention provides a composition which is suitable for medicated bath and has the effects of warming channel to dispel cold, activating blood and relieving pain, further provides effective components of the composition, obtains a traditional Chinese medicine nano-dispersion medicated bath liquid, prepares a nano-grade dispersion liquid medicine by homogenizing volatile oil components in the medicine, is applied to fumigation and medicated bath forms, can effectively permeate skin barriers, and has better treatment effect.

In order to achieve the technical purpose, the application provides the following technical scheme:

in a first aspect of the invention, a composition with effects of warming channel for dispelling cold, promoting blood circulation and relieving pain is provided, the composition comprises the following raw material medicaments: radix Ginseng Rubra, rhizoma Zingiberis recens, folium Artemisiae Argyi, radix Angelicae sinensis, radix Paeoniae Rubra, rhizoma Ligustici, radix Saposhnikoviae, cortex Cinnamomi, rhizoma Cibotii, rhizoma Drynariae, Pyritum, rhizoma Dioscoreae Septemlobae, and radix Cynanchi Paniculati.

Red ginseng: ginseng radix Rubri is cooked product of Ginseng radix. Has the effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating qi, and regulating blood. Red ginseng is warmer than ginseng, has the characteristics of large and powerful fire and strong efficacy, and is good at tonifying primordial qi, restoring yang and rescuing from collapse, and tonifying qi and controlling blood. Has effects in invigorating qi, nourishing yin, tonifying blood, promoting salivation, tonifying heart, invigorating stomach, tranquilizing mind, and tranquilizing mind. Is a good tonifying product for people with deficiency of qi and blood and yang deficiency. Can relieve the symptoms of aversion to cold, unhealthy hands and feet, vertigo, listlessness, debilitation of limbs, easy fatigue, short breath, dyspnea, short breath, frequent cold in stomach, chronic diarrhea, insomnia, dreaminess, impotence, frequent micturition, etc. For soreness of waist, knees, shoulders, neck and legs of a patient, most of the pain is related to cold of joints, cold qi stagnates at affected parts, and long-term qi and blood circulation is different, so that internal organs of the five zang-organs are weak, and pain is difficult to endure. Aiming at the symptoms of arthralgia, analgesic drugs are mostly adopted as monarch drugs in general drug compositions, the application provides a different drug composition idea, red ginseng is taken as the monarch drug, the characteristic of strong fire is utilized, the effect of enhancing the immunity of the organism is the primary effect, the weak constitution caused by the content is taken, the essence is fundamentally supplemented, and the recovery effect of the organism is accelerated.

Ginger: the ginger has the effects of sweating, relieving exterior syndrome, warming middle energizer, arresting vomiting, warming lung, relieving cough and detoxifying. The ginger mainly contains volatile oil, gingerol, diphenyl heptane, flavone and other ingredients. Volatile oil components in the ginger are rich in fragrance, slightly lemon-like, fragrant, pungent and thick, have certain physiological activity and skin nutritive value, play a role in relaxing bodies and soothing nerves, have strong antifungal activity and are applied to the cosmetic industry as spices.

The topical rhizoma Zingiberis recens can also dispel rheumatism and cause cold qi of all channels, and can be used for treating rheumatic diseases such as arthritis and ankylosing spondylitis.

Folium artemisiae argyi: the folium artemisiae argyi has the effects of warming channels, stopping bleeding, dispelling cold, relieving pain, preventing miscarriage and relieving itching, and can regulate qi and blood and expel cold and dampness. The traditional Chinese medicine composition is mainly used for treating irregular menstruation, cold pain in lower abdomen, congealing cold in meridians, miscarriage prevention, killing parasites and relieving itching in clinic and the like. The chemical components of the folium artemisiae argyi mainly comprise volatile oil, flavone, tannin, triterpene, eudesmane, polysaccharide, trace elements and the like. The folium Artemisiae Argyi volatile oil has effects of relieving pain, inhibiting bacteria, enhancing immunity, and killing parasite. The polysaccharide and flavonoid components have good antioxidant activity.

The folium artemisiae argyi has a long medicinal history, is a common clinical medicine from ancient times, and has higher medicinal value no matter oral administration or external application. The "materia medica summary" records: folium Artemisiae Argyi, herbs that warm blood and warm meridians, move qi and relieve depression are also used. Opening the orifices and waking up all the things to dry and stagnate and block the interior. For diseases such as qi and blood, phlegm retention and accumulation, asthma adverse qi, bone steaming and distension and fullness, paralysis, superficial infection, scrofula and tuberculosis, the old disease after moxibustion is known. And moxibustion is the growth of mugwort leaves, and can remove stubborn diseases and fix diseases by oral administration, external washing and external application. The patients suffering from joint ache due to cold often have many years of illness experience, and the folium artemisiae argyi is added as a monarch drug, so that a good treatment effect can be achieved for the patients suffering from the diseases for many years.

The Chinese angelica volatile oil is one of main active ingredients of the Chinese angelica, contains a great number of chemical substances, including butylphthalide, β -phellandrene, α -cedrene, ligusticum chuanxiong lactone, angelone, phenol, o-cresol, iso-eugenol, vanillin, p-ethylphenol and the like, and is a main chemical ingredient in angelica.

Ligusticum: warm in nature and pungent in flavor, enters bladder meridian, has the effects of dispelling wind and cold, removing dampness and relieving pain, and is clinically commonly used for common cold due to wind-cold, rheumatic arthralgia, parietal headache and the like. The main active part of the ligusticum is volatile oil containing terpenes, coumarins, phthalides, allylbenzene and the like. The ligusticum ethanol extract and the water extract can obviously reduce the times of mouse writhing reaction caused by glacial acetic acid or antimony potassium tartrate, prolong the incubation period of mouse tail-shrinking reaction and prompt that the ligusticum contains water-soluble and fat-soluble analgesic components. There are studies showing that: the pain-relieving effect of Liaoning ligusticum is stronger than that of ligusticum.

Cinnamon: the traditional Chinese medicine is usually used for treating kidney-yang deficiency syndrome, congealing cold pain syndrome, irregular menstruation, dysmenorrheal amenorrhea, deficient yang floating and the like. Recent studies have shown that the chemical constituents in cinnamon are divided into volatile and non-volatile constituents, with the volatile constituent (the volatile oil) being the major active ingredient. The content of volatile oil in cinnamon is about 2%, wherein the relative mass fraction of cinnamaldehyde is up to 87%. Cinnamic aldehyde is yellow viscous liquid, is a natural active ingredient, and has antioxidant, antiinflammatory, antipyretic, analgesic, antitumor, antibacterial, blood sugar lowering, anti-obesity and neuroprotective effects.

Red peony root: bitter taste and slightly cold nature, entering liver meridian, and has effects of clearing heat, cooling blood, removing blood stasis and relieving pain. Peony was originally from Shen nong Ben Cao Jing and listed as a high-quality product. Before Tang Dynasty, radix Paeoniae alba and radix Paeoniae Rubra are collectively called as peony; after Tang and Song dynasties, they are classified into Bai Shao and Chi Shao due to their different indications. The compendium of materia Medica distinguishes the efficacy of the two herbs, and looks like "Bai Bu and Fu you, Chi san and Xie". In the cloud from Jingyue quan Shu, the white one is sweet in flavor and rich in tonic effect. Red blood is bitter in flavor and purgative. The living being is cooler. Recorded in the records of Yi Xue Zhong Can xi Lu that it can remove blood stasis and red blood is preferred … … for it can remove toxic heat and blood stasis without causing pus collapse. Therefore, the application of red peony root and white peony root has been distinguished.

Wind prevention: pungent, slightly sweet and warm in nature, and has the effects of relieving exterior syndrome, dispelling pathogenic wind, relieving spasm and eliminating dampness. The history of the medicine of the divaricate saposhnikovia root is listed as the first grade in Shen nong's herbal Jing, and the divaricate saposhnikovia root is mainly used for treating the symptoms of exogenous wind-cold, body pain, headache, blurred vision, arthralgia due to wind-cold-dampness, bone joint pain and the like, is one of the most commonly used traditional Chinese medicinal materials, and the divaricate saposhnikovia root has an analgesic effect. Experiments of mouse acetic acid writhing method for populus and the like show that all dosage groups of volatile oil components of the divaricate saposhnikovia root supercritical extract have analgesic effect. Studies such as Benxiang cai show that the analgesic and anti-inflammatory effects of the radix Saposhnikoviae are superior to those of the rhizome, and the difference of antipyretic effects is not obvious.

Rhizoma cibotii: it is a common Chinese medicine accepted in the Chinese pharmacopoeia all the year round, has bitter and sweet taste and warm nature, has the efficacies of dispelling wind-damp, tonifying liver and kidney, strengthening waist and knees and the like, is often combined with other medicinal materials to treat symptoms such as soreness and pain of waist and back, arthralgia due to wind-cold-dampness, numbness of hands and feet, hemiplegia and the like. The Ju Chengkou and the like adopt a hot plate method, a twisting method, a capillary glass tube method and a tail breaking method to research the analgesic and hemostatic effects of the rhizoma cibotii, and the results show that the low-dose rhizoma cibotii and the sand-scald rhizoma cibotii do not show obvious analgesic effect, and the high-dose rhizoma cibotii and the sand-scald rhizoma cibotii have obvious analgesic effect; the rhizoma cibotii and the sand-burned rhizoma cibotii have no hemostatic effect, which indicates that the rhizoma cibotii and the processed products thereof have analgesic effect and hemostatic effect with different degrees.

Drynaria rhizome, namely the rhizoma houttuyniae, the drynaria rhizome recorded in Tang 'materia medica Shiyi' records that the broken bone supplements the life of monkey ginger and kaiyuangdi mainly fracture and supplement the broken bone, so the drynaria rhizome is used as the name, has warm property and bitter taste, enters kidney and liver channels, has the effects of treating injury, relieving pain, tonifying kidney and strengthening bone, externally eliminates wind and removes spots, is used for treating traumatic injury, sudden strain and contusion, fracture and injury of bones and muscles, lumbago due to kidney deficiency, flaccidity of bones and muscles, tinnitus, deafness, tooth looseness and the like, and is a Chinese pharmacopoeia which contains Chinese medicine varieties, Zhou Rong Kui and other clinical researches find that the drynaria total flavonoids not only obviously improve the knee joint pain symptoms of osteoarthritis patients before medication, enhance the joint movement function, but also obviously reduce the serum inflammatory.

Native copper: pyritum is a commonly used drug for promoting blood circulation, removing blood stasis and relieving pain, and is reported in Rihuazi Ben Cao: expel pus, remove blood stasis, reunite tendons and bones, treat postpartum blood pathogen, calm heart and stop palpitation. It is taken after grinding with wine. The book of Kaibao Ben Cao: treat fracture, disperse blood and alleviate pain, break accumulation. Jade mountain ash Yao Jie (Yao Jie): it is different from unknown in the actions of breaking blood and removing goiter and treating rheumatic paralysis. Supplement to the Yanyi of Ben Cao (supplement to the Yan Yi of materia Medica): pyritum is a bone-knitting medicine in the world, but the herbs are mostly used in this way. Fracture is mainly due to its actions of tonifying qi, enriching blood and stomach, while Cu is not calcined, if there is a new fire, it is accompanied by toxic fire and golden poison, and herbs with heat-toxin and fragrance, though it has the action of setting bone, it is more suitable for knife, sword and abstinence. Compendium of materia Medica: pyritum, like Cu Xie, is used for setting bone, it is not used for falsely accuse. However, after setting bones, it should not be taken frequently, even if it can regulate qi and activate blood. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): pyritum is also a herb for promoting blood circulation and reuniting bones. Pain is caused by blood stasis in the fracture, pain is relieved by pungent actions of dissipating blood stasis and breaking accumulated qi, and the pain is also caused by self-mixing.

Rhizoma Dioscoreae Septemlobae: bi Xie is a commonly used herb, has a long history of application, and is recorded in Shen nong's herbal Jing, listed as a middle-grade product, and later generations of herbal medicine. Bitter in taste, neutral in nature, entering kidney and stomach meridians. The traditional Chinese medicine considers that the traditional Chinese medicine has the effects of removing dampness and turbidity, dispelling wind and removing paralysis. The clinical application is mainly used for treating symptoms such as chylous, whitish and turbid urine, leukorrhagia, rheumatic arthralgia, joint discomfort, waist and knee pain and the like, the research shows that the traditional Chinese medicine mainly contains various chemical components such as steroid saponin components, diarylheptanoids, lignans and the like, the main component steroid saponin components have obvious effects on reducing uric acid, resisting inflammation, relieving pain, resisting osteoporosis and the like, and the research of feilong and the like shows that the aqueous extract of yam rhizome is 10, 20 g.kg.kg.g. of crude drugs^-1Under the dosage, the foot swelling degree of rats and mice induced by sodium urate can be obviously reduced, and the pain sensation value is reduced. The royal xylol and the like consider that the total saponin of the yam rhizome can inhibit the assembly and activation of an NALP3 inflammatory body and inhibit the expression of inflammatory cytokines so as to prevent and treat acute gouty arthritis.

Paniculate swallowwort root: it is warm in nature and pungent in flavor, enters liver and stomach meridians, and can dispel wind, resolve dampness, alleviate pain and relieve itching. It is indicated for arthralgia due to wind-dampness, stomach-ache and distention, toothache, traumatic injury, urticaria and eczema in Shen nong Ben Cao Jing (Shen nong's herbal). Previous researches have clarified that the main effective component of the paniculate swallowwort root is paeonol, and the paniculate swallowwort root contains various aglycones, flavone, amino acid and iso-paeonol, and also determines the chemical structure of polysaccharide substances. The research shows that: the paniculate swallowwort root decoction can obviously relieve the quality of mouse granuloma, obviously prolong the pain threshold of 2h, prolong the latency period of writhing reaction and obviously reduce the writhing frequency. The cynanchum paniculatum extract (5, 10 and 15g per kg of body weight) is used for intragastric administration, and has remarkable inhibitory effect on rat plantar swelling and cotton ball granuloma caused by cobra venom.

Preferably, the composition is prepared from the following raw material medicaments in parts by weight: 7-11 parts of red ginseng, 8-12 parts of ginger, 8-12 parts of folium artemisiae argyi, 2-4 parts of angelica sinensis, 2-4 parts of radix paeoniae rubra, 2-4 parts of ligusticum, 2-4 parts of radix saposhnikoviae, 2-4 parts of cinnamon, 2-4 parts of rhizoma cibotii, 2-4 parts of rhizoma drynariae, 2-4 parts of native copper, 2-4 parts of rhizoma dioscoreae hypoglaucae and 2-4 parts of paniculate swallowwort root.

Preferably, the composition is prepared from the following raw material medicaments in parts by weight: 8-10 parts of red ginseng, 9-11 parts of ginger, 8-10 parts of folium artemisiae argyi, 2-4 parts of angelica sinensis, 2-4 parts of radix paeoniae rubra, 2-4 parts of ligusticum, 2-4 parts of radix saposhnikoviae, 2-4 parts of cinnamon, 2-4 parts of rhizoma cibotii, 2-4 parts of rhizoma drynariae, 2-4 parts of native copper, 2-4 parts of rhizoma dioscoreae hypoglaucae and 2-4 parts of paniculate swallowwort root.

Further, the composition is prepared from the following raw material medicaments in parts by weight: 9 parts of red ginseng, 10 parts of ginger, 9 parts of folium artemisiae argyi, 3 parts of angelica, 3 parts of red peony root, 3 parts of ligusticum, 3 parts of divaricate saposhnikovia root, 3 parts of cinnamon, 3 parts of rhizoma cibotii, 3 parts of rhizoma drynariae, 3 parts of native copper, 3 parts of rhizoma dioscoreae hypoglaucae and 3 parts of paniculate swallowwort root.

When the medicines in the composition are combined according to the proportion, the effects of strengthening the body resistance and banking up the elements, strengthening the muscles and bones, warming channels and dispelling cold, and activating blood and relieving pain can be realized, aiming at the arthralgia caused by the old and the cold, the combination provides a medicine which takes replenishing vital essence elements as the first part and enhances the intrinsic activity of a patient, and simultaneously adopts the raw materials of ginger and folium artemisiae argyi with pungent and strong flavor to dredge the channels and collaterals, so that the cold qi stagnated at the affected parts is evacuated and removed, and in addition, the medicine with the effects of activating blood and relieving pain is used for realizing the pain relieving effect.

In a second aspect of the invention, the invention provides a nano dispersion liquid with the effects of warming channel to dispel cold, and activating blood to stop pain, which is characterized in that the nano dispersion liquid is prepared from the composition and one or more pharmaceutically acceptable auxiliary materials.

The nano emulsion is also called microemulsion, is formed by water, oil, surfactant, cosurfactant and the like spontaneously, is a thermodynamic stable system with 1-100nm particle size and can not be layered after hot-pressing sterilization or centrifugation by virtue of the emulsifying capacity of the emulsifier and the cosurfactant, and the oil phase and the water phase are fully mixed without adding more chemical components, thereby improving the stability of the product. The nano-emulsion system contains a water phase and an oil phase simultaneously, has a structure similar to a biological membrane, is easy to be compatible with a skin stratum corneum, has good transdermal absorption characteristic, has negative charges on the skin, can improve the permeability and the permeation rate of medicaments, changes the permeability of biological macromolecular medicament components, promotes the transdermal absorption of hydrophilic biological macromolecular medicaments, and solves the key problem that the biological macromolecular hydrophilic medicaments pass through skin barriers. Is beneficial to the absorption of the medicinal components and improves the bioavailability of the medicament. And can reduce the irritation and toxic and side effects of the medicine.

The preparation method comprises preparing the above materials into nanoemulsion, combining the volatile oil and water soluble components in the medicine, improving stability of the medicine, and eliminating unpleasant odor.

The traditional Chinese medicine nano-emulsion medicated bath liquid can be used together with fumigation and bubble washing equipment, and a complete experience process of firstly fumigating and then bathing is carried out. During fumigation, high-temperature steam enables other active ingredients of volatile oil in the medicinal bath liquid to be distilled out along with water vapor, meanwhile, the traditional Chinese medicine nanoemulsion is atomized into small liquid drops by utilizing ultrasonic atomization equipment and reaches the fumigation equipment which is relatively closed along with the water vapor, pores are opened through the stimulation of temperature and medicines, so that medicinal ingredients enter the human body through skin pores and are absorbed by the human body, the perspiration of the human body is promoted, and toxins in the human body are discharged along with sweat. And the medicine volatile oil of the aromatic pungent powder can relax the body and relieve the nerves. After 30-40 minutes of fumigation, the bath is carried out on the whole body or the part, so that the medicine components are absorbed through the skin, the absorption of the medicine through a digestive system and the liver is reduced, the stimulation to the digestive tract and the damage of the liver metabolism to the medicine components are avoided, the curative effect is better exerted, and the aims of conditioning the body and curing the diseases are fulfilled.

In a third aspect of the present invention, there is provided a method for preparing the above nanodispersion, comprising the steps of:

(1) adding water into Ginseng radix Rubri, distilling to collect Ginseng radix Rubri volatile oil and steamed Ginseng radix water, pulverizing Ginseng radix Rubri, adding steamed Ginseng radix water, grinding, filtering to obtain Ginseng radix Rubri slurry, mixing Ginseng radix Rubri volatile oil and Ginseng radix Rubri slurry, homogenizing to obtain Ginseng radix Rubri homogeneous nanometer dispersion;

(2) grinding rhizoma Zingiberis recens with water, squeezing, centrifuging, and homogenizing to obtain rhizoma Zingiberis recens nanometer dispersion;

(3) directly steaming folium Artemisiae Argyi, radix Angelicae sinensis, rhizoma Ligustici, and cortex Cinnamomi for a certain period to extract volatile oil, and filtering to obtain extractive solution A;

(4) adding red paeony root, divaricate saposhnikovia root, rhizoma cibotii, rhizoma drynariae, pyrite, yam rhizome and paniculate swallowwort root into the residue of the artemisia leaf, the angelica, the ligusticum and the cinnamon extracted in the step (3), adding water for decoction to obtain an extracting solution B, combining the extracting solution B and the extracting solution A, concentrating the extracting solution B into thick paste, adding the volatile oil A, homogenizing the thick paste to obtain mixed nano dispersion liquid, and uniformly mixing the mixed nano dispersion liquid with the red ginseng homogenized nano dispersion liquid and the ginger nano dispersion liquid to obtain the nano dispersion liquid.

Preferably, in the above preparation method, the specific operation of step (1) is as follows: adding water into Ginseng radix Rubri, distilling, collecting Ginseng radix Rubri volatile oil and steamed Ginseng radix water, respectively, crushing Ginseng radix Rubri, adding steamed Ginseng radix water, grinding, filtering to obtain Ginseng radix Rubri slurry, mixing Ginseng radix Rubri volatile oil, Ginseng radix seed oil and Ginseng radix Rubri slurry, and homogenizing with dynamic ultrahigh pressure micro jet homogenizer to obtain Ginseng radix Rubri homogeneous nanometer dispersion.

More preferably, the red ginseng is ground and crushed for 30-50 min by a colloid mill.

Along with the extension of the grinding time, the grinding degree is deepened, and the effective components in the medicine are continuously dissolved out.

Preferably, in the above preparation method, the specific operation of step (2) is as follows: weighing ginger with a compatible dose, adding 1-3 parts of water, grinding, squeezing, filtering and centrifuging to obtain ginger slurry, and homogenizing by using a dynamic ultrahigh-pressure micro-jet homogenizer to obtain a ginger nano dispersion liquid;

preferably, the ginger is ground for 20-40 min by a colloid mill.

The main effective component in the ginger is a volatile oil component, the volatile oil is continuously dissolved out along with the grinding, but the volatile substance can be naturally dispersed to cause waste when the grinding time is further prolonged, and the grinding time is favorable for obtaining higher extraction efficiency.

Preferably, in the step (3), directly introducing steam of folium artemisiae argyi, angelica sinensis, ligusticum sinensis and cinnamon into the reactor for 6-10 hours to extract volatile oil, and filtering to obtain an extracting solution A for later use;

further preferably, the steam temperature is 100-.

The extraction temperature is favorable for extracting effective components in the medicine to the maximum extent, the steam temperature is too low, the xylem in the angelica is difficult to destroy, the temperature is properly increased, the damage to the plant structure of the woody herbal medicine is favorable, the polysaccharide component can be degraded to a proper degree, the viscosity degree of the medicine is reduced, and the preparation difficulty is reduced.

Preferably, in the step (4), the red peony root, the divaricate saposhnikovia root, the cibotium rhizome, the drynaria rhizome, the native copper, the yam rhizome and the paniculate swallowwort root are added into the residue of the artemisia leaf, the angelica, the ligusticum and the cinnamon which is extracted in the step (3), and the mixture is decocted twice by adding water, wherein the amount of the water added in the first time is 9-11 times that of the mixture and is decocted for 2-3 hours, and the amount of the water added in the second time is 9-11 times that.

Preferably, in the step (4), the extract B and the extract A are combined, the mixture is concentrated into thick paste, the volatile oil A is added, and then a dynamic ultrahigh pressure micro-jet homogenizer is used for homogenizing treatment to obtain the mixed nano dispersion liquid.

The medicines are extracted separately, and because the volatile oil components in the folium artemisiae argyi, the angelica, the ligusticum and the cinnamon are more, the volatile oil components in the medicines are firstly extracted, which is beneficial to obtaining an extracting solution and concentrating the extracting solution into a paste in the later period.

In the fourth aspect of the invention, the gel preparation with the effects of warming channel, dispelling cold, promoting blood circulation and relieving pain is provided, and the gel preparation is prepared from the nano dispersion liquid and one or more pharmaceutically acceptable auxiliary materials.

Preferably, the gel preparation is prepared from the nano dispersion liquid, carbomer 940, tween-80, glycerol, triethanolamine aqueous solution and water.

Further preferably, the preparation method of the gel preparation is as follows: grinding 2-5g of carbomer 940, 50-160ml of water, 1-5g of tween 80 and 10-30g of glycerol in a mortar for swelling for 2-3h, and mixing uniformly to obtain a transparent product; dropwise adding triethanolamine water solution, neutralizing to obtain transparent gel matrix with pH of 6-7, adding 5-15g nanometer dispersion, and stirring to obtain analgesic nanometer dispersion gel.

In a fifth aspect of the invention, a combined medicine package with effects of warming channel for dispelling cold, promoting blood circulation and relieving pain is provided, the combined medicine package comprises the gel preparation and the nano dispersion, when in use, the gel preparation is coated on an affected part, and then the nano dispersion is used for fumigating the affected part.

Preferably, the gel preparation is applied to the affected part and then the flap method is applied to make the gel absorbed.

Through this application research discovery, to the patient of extravasated blood, painful symptom, wash the affected part skin after with gel coat in the affected part, follow-up through stifling appearance with nanometer dispersion liquid medicine to fumigating the affected part, the medicine absorption effect improves, the gel matrix is under the prerequisite of guaranteeing the medicine absorption effect, can also realize keeping the balanced efficiency of skin moisture, improves and feels the comfort level.

The invention has the advantages of

1. According to the first aspect of the application, the composition has the effects of warming channels, dispelling cold, promoting blood circulation and relieving pain, the ginseng which can tonify primordial qi, recover pulse and relieve depletion, the ginger which is spicy and fragrant and has the effect of sweating and relieving exterior syndrome and the folium artemisiae argyi which can warm channels, dispel cold and relieve pain are used as monarch medicine components in the composition, so that the composition has good effects of dredging channels and collaterals, tonifying qi and controlling blood while dispelling cold and relieving exterior syndrome, and has good effects of relieving pain caused by cold and cool people; in addition, angelica, red peony root, native copper, ligusticum, cinnamon, radix sileris, paniculate swallowwort root, yam rhizome, rhizoma dioscoreae, rhizoma cibotii, rhizoma drynariae, muscles and bones and waist strengthening knees which have the functions of enriching the blood and promoting the blood circulation are added in the external preparation, and the effects of warming channels and expelling cold, promoting blood circulation and relieving pain, dispelling wind and relieving the exterior syndrome and strengthening the muscles and bones are realized under the combined action of the compatibility of medicines.

2. The preparation uses aromatic and pungent herbs such as folium Artemisiae Argyi and rhizoma Zingiberis recens as principal drugs, and improves the penetrating force of the whole drugs and the skin texture effect of the drugs in the form of medicated bath. Further, the application provides a nanoemulsion product of the composition, and the effective ingredients in the medicine are reserved to the greatest extent. Meanwhile, the traditional fumigating method aims at solving the problems that the volatile oil component stays on the surface of the skin to cause residual bad smell and sticky skin feeling. According to the application, the water extract and the volatile oil in the raw material extract are prepared into the form of the nano-emulsion through high-pressure homogenization, and the nano-emulsion obtained through the preparation method has good stability and drug extraction rate, and is better in fumigation effect.

3. The application also provides a gel preparation taking the nano dispersion liquid as a main active ingredient, when a patient is inconveniently treated by adopting a fumigation mode, the gel preparation can be conveniently used for administration, and the pain relieving effect is realized. In addition, the application also provides a mode of combined use of the gel preparation and the nano dispersion liquid, and through research, the combined use mode can effectively improve the treatment effect on pain, can also improve the comfort level of skin and increase the cold resistance of a body.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

As described in the background art, the application efficiency of the medicated bath form in the prior art to the medicine is low, and the volatile oil in the medicine remains on the skin surface to cause inconvenience to the patient. In order to solve the technical problems, the application provides a nano dispersion liquid, which is a Chinese medicinal nano dispersion medicinal bath liquid with the effects of warming channels, dispelling cold, promoting blood circulation and relieving pain, and is prepared by extracting, squeezing, nano homogenizing and other processes of red ginseng, ginger, folium artemisiae argyi, angelica, red paeony root, ligusticum sinense, divaricate saposhnikovia root, cinnamon, rhizoma cibotii, rhizoma drynariae, native copper, yam rhizome, paniculate swallowwort root and the like.

In order to make the technical solutions of the present application more clearly understood by those skilled in the art, the technical solutions of the present application will be described in detail below with reference to specific examples and comparative examples.

Example 1

1) Taking 9g of red ginseng rootlets, crushing for 3min by using a chopper mixer, adding 18g of steamed ginseng water, grinding for 40min by using a colloid mill, squeezing, filtering to obtain 23.6g of slurry, adding 0.02ml of volatile oil and 0.5ml of ginseng seed oil into the slurry, and processing by using a dynamic ultrahigh pressure micro-jet homogenizer to obtain the red ginseng nano dispersion liquid.

2) Taking 10g of ginger, crushing for 3min by using a chopper mixer, adding 20g of purified water, grinding for 30min by using a colloid mill, squeezing, filtering to obtain 25.4g of slurry, and treating the slurry by using a dynamic ultrahigh pressure micro-jet homogenizer to obtain the ginger nano dispersion liquid.

3) Taking 9g of folium artemisiae argyi, 3g of angelica sinensis, 3g of ligusticum sinensis and 3g of cinnamon, directly introducing high-temperature steam at 100 ℃ to extract volatile oil (the opening degree of a valve is 0.2 percent), extracting for 8 hours, collecting the volatile oil to obtain 0.55ml of volatile oil for later use, and concentrating the extracting solution to 9g for later use;

4) adding 3g of red peony root, 3g of divaricate saposhnikovia root, 3g of rhizoma cibotii, 3g of rhizoma drynariae, 3g of native copper, 3g of yam rhizome and 3g of paniculate swallowwort root into the dregs of the volatile oil extraction, adding water for extraction for 2 times, 10 times of the amount of the water for each time, extracting for 2 hours, concentrating the extracting solution to 10.5g, mixing the two thick pastes, adding 0.55ml of volatile oil, and treating by using a dynamic ultrahigh-pressure microjet homogenizer to obtain a mixed nano dispersion liquid.

5) Mixing the obtained Ginseng radix Rubri nanometer dispersion, rhizoma Zingiberis recens nanometer dispersion, and mixed nanometer dispersion to obtain Chinese medicinal nanometer dispersion bath liquid.

Example 2

1) Taking 11g of red ginseng rootlets, crushing for 4min by using a chopper mixer, adding 22g of steamed ginseng water, grinding for 45min by using a colloid mill, squeezing, filtering to obtain 24.5g of slurry, adding 0.02ml of volatile oil and 0.5ml of ginseng seed oil into the slurry, and processing by using a dynamic ultrahigh pressure micro-jet homogenizer to obtain the red ginseng nano dispersion liquid.

2) Taking 12g of ginger, crushing for 3.5min by using a chopper mixer, adding 24g of purified water, grinding for 32min by using a colloid mill, squeezing, filtering to obtain 26.1g of slurry, and treating the slurry by using a dynamic ultrahigh-pressure micro-jet homogenizer to obtain the ginger nano dispersion.

3) Taking 9g of folium artemisiae argyi, 3g of angelica sinensis, 3g of ligusticum sinensis and 3g of cinnamon, directly introducing high-temperature water vapor at 120 ℃ to extract volatile oil (the opening degree of a valve is 0.2 percent), extracting for 8.5 hours, collecting the volatile oil to obtain 0.65ml of volatile oil for later use, and concentrating the extracting solution to 10g for later use;

4) adding 3g of red peony root, 3g of divaricate saposhnikovia root, 3g of rhizoma cibotii, 3g of rhizoma drynariae, 3g of native copper, 3g of yam rhizome and 3g of paniculate swallowwort root into the dregs of the volatile oil extraction, adding water for extraction for 2 times, 11 times of the amount of the water for each time, extracting for 3 hours, concentrating the extracting solution to 11.5g, mixing the two thick pastes, adding 0.59ml of volatile oil, and treating by using a dynamic ultrahigh-pressure microjet homogenizer to obtain a mixed nano dispersion liquid.

5) Mixing the obtained Ginseng radix Rubri nanometer dispersion, rhizoma Zingiberis recens nanometer dispersion, and mixed nanometer dispersion to obtain Chinese medicinal nanometer dispersion.

Example 3

Grinding 5g of carbomer 940, 160ml of water, 5g of tween 80 and 30g of glycerol in a mortar for swelling for 3 hours, and fully and uniformly mixing to obtain a transparent product; and dropwise adding triethanolamine aqueous solution, neutralizing to obtain a transparent gel matrix with the pH value of 6.5, adding 15g of the nano dispersion liquid in the example 1, and uniformly stirring to obtain the analgesic nano dispersion gel.

Example 4

2g of carbomer 940, 50ml of water, 1g of tween 80 and 30g of glycerol are taken to be ground and swelled in a mortar for 2 hours, so that the carbomer 940, the water, the tween 80 and the glycerol are fully and uniformly mixed and are transparent; and dropwise adding triethanolamine aqueous solution, neutralizing to obtain a transparent gel matrix with the pH value of 7, adding 15g of the nano dispersion liquid in the example 1, and uniformly stirring to obtain the analgesic nano dispersion gel.

Example 5

Taking 4.5g of carbomer 940, 110ml of water, 2.5g of tween 80 and 20g of glycerol, grinding and swelling in a mortar for 2.5 hours, and fully and uniformly mixing to obtain a transparent product; and dropwise adding triethanolamine aqueous solution, neutralizing to obtain a transparent gel matrix with pH of 6, adding 15g of the nano dispersion liquid in the embodiment 1, and uniformly stirring to obtain the analgesic nano dispersion gel.

Example 6

1. Product composition

9g of red ginseng, 10g of ginger, 9g of argy wormwood leaf, 3g of angelica, 3g of red peony root, 3g of ligusticum, 3g of divaricate saposhnikovia root, 3g of cinnamon, 3g of cibot rhizome, 3g of drynaria rhizome, 3g of native copper, 3g of yam rhizome and 3g of paniculate swallowwort root

2. The process route is as follows:

1) crushing Ginseng radix Rubri fibrous root, adding steamed Ginseng radix water, grinding, squeezing, filtering, centrifuging to obtain Ginseng radix Rubri fibrous root slurry, adding appropriate amount of volatile oil collected during steaming Ginseng radix Rubri, and homogenizing with dynamic ultrahigh pressure micro jet homogenizer to obtain Ginseng radix Rubri nanometer dispersion;

2) crushing ginger, adding water, grinding, squeezing, filtering and centrifuging to obtain ginger slurry, and homogenizing by using a dynamic ultrahigh-pressure micro-jet homogenizer to obtain ginger nano dispersion liquid;

3) directly extracting volatile oil from folium Artemisiae Argyi, radix Angelicae sinensis, rhizoma Ligustici, and cortex Cinnamomi for 8 hr, collecting volatile oil, and filtering extractive solution;

4) extracting volatile oil residues from folium artemisiae argyi, angelica sinensis, ligusticum sinense and cinnamon, adding red paeony root, divaricate saposhnikovia root, rhizoma cibotii, rhizoma drynariae, native copper, yam rhizome and paniculate swallowwort root, adding water for decocting twice, adding 10 times of water for decocting for 2.5 hours for the first time, adding 10 times of water for decocting for 2 hours for the second time, mixing the obtained extracting solution with the residual extracting solution of the volatile oil extracted from the folium artemisiae argyi, the angelica sinensis, the ligusticum sinense and the cinnamon, concentrating the extracting solution into thick paste, adding 3) volatile oil, and homogenizing the thick paste by using a dynamic;

3. and (3) screening:

1) taking 9g of red ginseng rootlets, crushing by a chopper mixer for 3min, adding 18g of steamed ginseng water, grinding by a colloid mill for 40min, squeezing, filtering to obtain 23.6g of slurry, adding 0.02ml of volatile oil and 0.5ml of ginseng seed oil into the slurry, and treating by a dynamic ultrahigh pressure micro-jet homogenizer to obtain the red ginseng nano dispersion liquid.

2) Taking 10g of ginger, crushing by using a chopper mixer for 3min, adding 20g of purified water, grinding for 30min by using a colloid mill, squeezing, filtering to obtain 25.4g of slurry, and treating the slurry by using a dynamic ultrahigh-pressure micro-jet homogenizer to obtain the ginger nano dispersion liquid.

3) Taking 9g of folium artemisiae argyi, 3g of angelica, 3g of ligusticum and 3g of cinnamon, directly introducing 100-120 ℃ high-temperature steam to extract volatile oil (the opening degree of a valve is 0.2 percent), extracting for 8 hours, collecting the volatile oil to obtain 0.55ml of volatile oil for later use, concentrating the extracting solution to 9g for later use,

Examination of extraction methods

3.1 Ginseng extraction mode investigation:

taking red ginseng fibrous roots, chopping and mixing by a chopper mixer, adding 6 times of water, extracting for 2 hours, adding 4 times of water for the second time, extracting for 2 hours, combining the obtained extracting solutions, filtering, and filtering to obtain the extracting solution for later use.

Taking red ginseng fibrous roots, chopping and mixing the fibrous roots by a chopper mixer, adding 10 times of pure water, grinding the mixture for 60 minutes by a colloid mill, centrifuging the mixture for 30 minutes to obtain slurry for later use, squeezing the dregs of a decoction by a squeezer, combining the obtained slurry, filtering the combined slurry, and filtering the filtered slurry for later use.

Extraction method	Total saponins yield (%)	Total saponins transfer rate (%)
			Extraction of	0.38	68.77
Beating	0.45	82.05

And (4) conclusion: the experimental result shows that the total saponin yield and the transfer rate are taken as indexes, and the total saponin yield and the transfer rate of the ginseng in the pulping process are obviously higher than those in the traditional extraction process, so the pulping and squeezing process is selected as the extraction mode, and the parameters are further optimized and screened.

3.2 inspecting the ginger extraction mode:

taking ginger, chopping and mixing the ginger by a chopper mixer, adding 6 times of water for extraction for 2 hours, adding 4 times of water for the second time for extraction for 2 hours, combining the obtained extracting solutions, filtering, and filtering to obtain the extracting solution for later use.

Taking ginger, chopping and mixing the ginger by a chopper mixer, adding 10 times of pure water, grinding the mixture for 60 minutes by a colloid mill, centrifuging the mixture for 30 minutes to obtain slurry for later use, squeezing the decoction dregs by a squeezer, combining the obtained slurry, filtering the slurry, and filtering the filtered slurry for later use.

Extraction method	Yield of gingerol (%)	Yield of volatile oil (%)
			Extraction of	0.26	0.11
Beating	0.43	0.35

And (4) conclusion: the experimental result shows that the yield of gingerol and volatile oil is used as an index, and the yield of total ginsenoside and volatile oil in the pulping process is obviously higher than that in the traditional extraction process, so the pulping and squeezing process is selected as the extraction mode, and the parameters are further optimized and screened.

3.3 investigation of grinding time and Water addition

The water adding amount and the grinding time during grinding are considered: the optimal water addition amount and grinding time are respectively inspected by taking the contents of the total ginsenoside and the gingerol as indexes.

3.3.1 inspection of grinding time and water addition of red ginseng:

note: the grinding effect of 1 time of water is also investigated in the experiment, but the consistency is too high, the colloid mill can discharge materials in a circulating way, and the grinding is not sufficient by naked eyes, so that the important investigation is not carried out.

And (4) conclusion: taking the yield and the transfer rate of the total ginsenoside as indexes, the difference of experiments 6, 7 and 8 is small, the production cost and the grinding effect are considered, and the experiment 6 is selected, namely 2 times of the raw material amount of water is added, and the grinding is carried out for 40 min.

3.3.2 inspecting the ginger grinding time and water addition amount:

And (4) conclusion: taking gingerol and volatile oil yield as indexes, experiments 5 and 6 have small difference, and considering production cost and grinding effect, experiment 5 is selected, namely 2 times of water of raw material amount is added, and grinding is carried out for 30 min.

3.4 inspecting the extraction time of the volatile oil extracted by directly passing through the folium artemisiae argyi, the angelica, the ligusticum and the cinnamon:

and (4) conclusion: the yield of the volatile oil is taken as an index, the yield of the volatile oil is gradually improved along with the increase of time, the content of the volatile oil is slowly increased from 8 hours to 10 hours, and 12 hours, and the time for extracting the volatile oil by direct steam is selected to be 8 hours from the production cost.

3.5 investigation of 11-flavor water extraction conditions of folium artemisiae argyi, angelica sinensis and the like:

and (4) conclusion: taking production cost and yield into consideration, extracting for 2 times, adding 10 times of water for the first time

2 hours, adding 10 times of water for the second time, and taking 2 hours as the best extraction process

4. Nano dispersion process research:

the Chinese medicinal extract or serous fluid and volatile oil obtained by extraction or squeezing need to be homogenized to obtain Chinese medicinal nanometer dispersion bath lotion with stable property and high bioavailability.

4.1 parameters are preferably: the pressure and the number of homogenization are considered, the pressure of the ultrahigh-pressure micro-jet homogenizer is 40 MPa, the pressure of the ultrahigh-pressure micro-jet homogenizer is 80MPa, the number of homogenization is 2, 4, 6 and 8, and the particle size of the homogenized emulsion is observed by a microscope.

4.2 conclusion:

(1) effect of number of homogenizers on particle size: the particle size of the liquid drops is reduced along with the increase of the homogenization times from the whole trend, the particle size of the liquid drops is basically minimized after 6 times of homogenization, and the particle size is not obviously changed after more than 6 times of homogenization, and shows fluctuation change in a small range. From this, it is not necessarily the case that the emulsion prepared with a larger number of homogenization times has a better quality and a smaller particle size. Excessive times waste resources and exacerbate wear on the homogenizing valve spool and the homogenizing ring. The number of homogenisations was chosen to be 6.

(2) Effect of homogenization pressure on droplet size: when the pressure is less than 80MPa, the particle size decreases with the increase of the pressure, and when the pressure is more than 80MPa, the larger the homogenizing pressure is, the larger the particle size liquid is. Therefore, the homogenization pressure was 80 MPa.

5. Product evaluation

The intuitive property and the use comfort level of the product are adopted as indexes, and the nanoemulsion bath lotion is compared with the bath lotion prepared by the traditional method.

6. Applications of

On trial in a health-preserving house, inviting 20 subjects with blood stasis pain parts, cleaning the blood stasis pain parts, smearing 0.4g of nano dispersion gel, beating to enable the gel to be quickly absorbed, pouring 15g of nano dispersion medicine bath liquid into a fumigation instrument, then putting the blood stasis pain parts into the fumigation instrument for fumigation for 15-30min, fumigating once a day, after 2 weeks, scoring the nano dispersion gel and the nano dispersion bath liquid, respectively scoring pain relieving conditions, comfort conditions and body cold resistance conditions after fumigation, wherein 100 points are full points, one highest point is removed from each score, one lowest point is removed, and the average value is calculated as the final score of each item. The results are shown in the following table.

And (4) conclusion:

as can be seen from the above table, the nanodispersion and the gel have excellent effects of relieving pain, comfort and cold resistance.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. The composition with the effects of warming channel for dispelling cold, promoting blood circulation and relieving pain is characterized by comprising the following raw materials: radix Ginseng Rubra, rhizoma Zingiberis recens, folium Artemisiae Argyi, radix Angelicae sinensis, radix Paeoniae Rubra, rhizoma Ligustici, radix Saposhnikoviae, cortex Cinnamomi, rhizoma Cibotii, rhizoma Drynariae, Pyritum, rhizoma Dioscoreae Septemlobae, and radix Cynanchi Paniculati; preferably, the composition is prepared from the following raw materials in parts by weight: 7-11 parts of red ginseng, 8-12 parts of ginger, 8-12 parts of folium artemisiae argyi, 2-4 parts of angelica sinensis, 2-4 parts of radix paeoniae rubra, 2-4 parts of ligusticum, 2-4 parts of radix saposhnikoviae, 2-4 parts of cinnamon, 2-4 parts of rhizoma cibotii, 2-4 parts of rhizoma drynariae, 2-4 parts of native copper, 2-4 parts of rhizoma dioscoreae hypoglaucae and 2-4 parts of paniculate swallowwort root.

2. The composition of claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 8-10 parts of red ginseng, 9-11 parts of ginger, 8-10 parts of folium artemisiae argyi, 2-4 parts of angelica sinensis, 2-4 parts of radix paeoniae rubra, 2-4 parts of ligusticum, 2-4 parts of radix saposhnikoviae, 2-4 parts of cinnamon, 2-4 parts of rhizoma cibotii, 2-4 parts of rhizoma drynariae, 2-4 parts of native copper, 2-4 parts of rhizoma dioscoreae hypoglaucae and 2-4 parts of paniculate swallowwort root.

3. A nanodispersion with channel warming, cold expelling, blood circulation promoting and pain relieving effects, wherein the nanodispersion is prepared from the composition of any one of claims 1-2 and one or more adjuvants.

4. A method for preparing a nanodispersion as claimed in claim 3, comprising the steps of:

5. The method according to claim 4, wherein the step (1) is specifically performed by: adding water into Ginseng radix Rubri, distilling, collecting Ginseng radix Rubri volatile oil and steamed Ginseng radix water, respectively, crushing Ginseng radix Rubri, adding steamed Ginseng radix water, grinding, filtering to obtain Ginseng radix Rubri slurry, mixing Ginseng radix Rubri volatile oil, Ginseng radix seed oil and Ginseng radix Rubri slurry, and homogenizing with dynamic ultrahigh pressure micro-jet homogenizer to obtain Ginseng radix Rubri homogeneous nanometer dispersion; preferably, the red ginseng is ground and crushed for 30-50 min by a colloid mill.

6. The method according to claim 4, wherein the step (2) is specifically performed by: weighing ginger with a compatible dose, adding 1-3 parts of water, grinding, squeezing, filtering and centrifuging to obtain ginger slurry, and homogenizing by using a dynamic ultrahigh-pressure micro-jet homogenizer to obtain a ginger nano dispersion liquid; preferably, the ginger is ground for 20-40 min by a colloid mill.

7. The preparation method according to claim 4, wherein in the step (3), the folium artemisiae argyi, the angelica sinensis, the ligusticum sinensis and the cinnamon are taken to be directly steamed for 6-10 hours to extract volatile oil, and the volatile oil is filtered to obtain an extracting solution A for later use; preferably, the steam temperature is 100-.

8. The preparation method according to claim 4, wherein in the step (4), the residue of the artemisia leaves, the angelica, the ligusticum sinense and the cinnamon which are extracted in the step (3) is added with red paeony root, the divaricate saposhnikovia root, the cibotium rhizome, the drynaria rhizome, the pyrite, the yam rhizome and the paniculate swallowwort root, and is decocted for two times by adding water, wherein 9-11 times of water is added for the first time and is decocted for 2-3 hours, and 9-11 times of water is added for the second time and is decocted for 1-3 hours; preferably, the extracting solution B is combined with the extracting solution A, the extracting solution B is concentrated into thick paste, the volatile oil A is added, and then a dynamic ultrahigh pressure micro-jet homogenizer is used for homogenizing treatment to obtain the mixed nano-dispersion.

9. A gel preparation for warming channel for dispelling cold, promoting blood circulation and relieving pain, which is prepared from the nano dispersion liquid of claim 3 and one or more pharmaceutically acceptable auxiliary materials; preferably, the gel preparation is prepared from the nano dispersion liquid, carbomer 940, tween-80, glycerol, triethanolamine aqueous solution and water; or the gel formulation of claim 9, prepared by the following process: grinding 2-5g of carbomer 940, 50-160ml of water, 1-5g of tween 80 and 10-30g of glycerol in a mortar for swelling for 2-3h, and mixing uniformly to obtain a transparent product; dropwise adding triethanolamine water solution, neutralizing to obtain transparent gel matrix with pH of 6-7, adding 5-15g nanometer dispersion, and stirring.

10. A combination drug package with effects of warming channel for dispelling cold, promoting blood circulation and relieving pain, which is characterized in that the combination drug package comprises the gel preparation of claim 9 and the nano dispersion liquid of claim 3, and the gel preparation is coated on an affected part before the nano dispersion liquid is used for fumigating the affected part.