CN111344394A - 分离对p53癌症-特异性突变具有抗原特异性的t细胞的方法 - Google Patents

分离对p53癌症-特异性突变具有抗原特异性的t细胞的方法 Download PDF

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CN111344394A
CN111344394A CN201880063656.4A CN201880063656A CN111344394A CN 111344394 A CN111344394 A CN 111344394A CN 201880063656 A CN201880063656 A CN 201880063656A CN 111344394 A CN111344394 A CN 111344394A
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德鲁·C·丹尼格尔
史蒂文·A·罗森伯格
帕里萨·马勒克扎德
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4238—Regulators of development
    • A61K40/424—Apoptosis related proteins, e.g. survivin or livin
    • A61K40/4241—Apoptosis related proteins, e.g. survivin or livin p53
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CN201880063656.4A 2017-09-29 2018-09-17 分离对p53癌症-特异性突变具有抗原特异性的t细胞的方法 Pending CN111344394A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762565464P 2017-09-29 2017-09-29
US62/565,464 2017-09-29
PCT/US2018/051280 WO2019067242A1 (en) 2017-09-29 2018-09-17 METHODS FOR ISOLATING T CELLS HAVING ANTIGENIC SPECIFICITY FOR SPECIFIC MUTATION OF CANCER P53

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CN111344394A true CN111344394A (zh) 2020-06-26

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US (1) US20200316121A1 (https=)
EP (2) EP3688142B1 (https=)
JP (1) JP7391015B2 (https=)
KR (1) KR102809909B1 (https=)
CN (1) CN111344394A (https=)
AU (1) AU2018342245B2 (https=)
CA (1) CA3080274A1 (https=)
IL (1) IL273516B2 (https=)
SG (1) SG11202002635RA (https=)
WO (1) WO2019067242A1 (https=)

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CN112301088A (zh) * 2020-10-21 2021-02-02 杭州纽安津生物科技有限公司 一种筛选新生抗原或新生抗原编码序列的方法
CN117736301A (zh) * 2022-12-23 2024-03-22 上海市第一人民医院 靶向巨细胞病毒pp65的TCR和表达其的T细胞及应用

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DE102016123847B3 (de) 2016-12-08 2018-04-05 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
HUE058957T2 (hu) * 2016-12-08 2022-10-28 Immatics Biotechnologies Gmbh Új T-sejt receptorok és velük végzett immunterápia
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US11807662B2 (en) 2017-05-16 2023-11-07 The Johns Hopkins University MANAbodies and methods of using
CA3144070A1 (en) * 2019-06-27 2020-12-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing r175h or y220c mutation in p53
CN112390875B (zh) * 2019-08-16 2023-01-24 香雪生命科学技术（广东）有限公司 一种识别afp的高亲和力t细胞受体
EP4077370A4 (en) * 2019-12-17 2024-02-28 The Johns Hopkins University MANABODIES TARGETING TUMOR ANTIGENS AND METHODS OF USE
WO2021123832A1 (en) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof
CN113621070A (zh) 2020-05-06 2021-11-09 华夏英泰（北京）生物技术有限公司 一种t细胞抗原受体、其多聚体复合物及其制备方法和应用
EP4208473A2 (en) * 2020-09-04 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services T cell receptors recognizing r273c or y220c mutations in p53
IL305393A (en) 2021-02-25 2023-10-01 Alaunos Therapeutics Inc Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof
US20240165120A1 (en) * 2021-03-08 2024-05-23 Taiho Pharmaceutical Co., Ltd. Treating cancer in patient having co-occurring genetic alteration in fgfr2 and a cancer driver gene
CA3215580A1 (en) * 2021-03-31 2022-10-06 The Johns Hopkins University Methods and materials for targeting tumor antigens
WO2022236050A1 (en) * 2021-05-07 2022-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors recognizing c135y, r175h, or m237i mutation in p53
CA3225252A1 (en) 2021-07-14 2023-01-19 Jordan JARJOUR Engineered t cell receptors fused to binding domains from antibodies
EP4423143A4 (en) * 2021-10-29 2025-10-01 Yafei Hou T CELL RECEPTOR RECOGNIZING R175H MUTATION IN P53 AND ITS APPLICATION
CN119546328A (zh) 2022-04-08 2025-02-28 再生元制药公司 多部分受体和信号传导复合物
KR20260028688A (ko) * 2023-05-25 2026-03-04 엘리시오 테라퓨틱스, 인크. P53 펩티드 양친매체를 함유하는 조성물 및 이의 이용 방법
CN116970058B (zh) * 2023-09-22 2023-12-15 成都朗谷生物科技股份有限公司 针对tp53基因r249s突变的肿瘤新抗原多肽及其应用
WO2025060149A1 (zh) * 2023-09-22 2025-03-27 上海市第一人民医院 一种分离的tcr及其用途

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Publication number Priority date Publication date Assignee Title
CN112301088A (zh) * 2020-10-21 2021-02-02 杭州纽安津生物科技有限公司 一种筛选新生抗原或新生抗原编码序列的方法
CN112301088B (zh) * 2020-10-21 2022-12-13 杭州纽安津生物科技有限公司 一种筛选新生抗原或新生抗原编码序列的方法
CN117736301A (zh) * 2022-12-23 2024-03-22 上海市第一人民医院 靶向巨细胞病毒pp65的TCR和表达其的T细胞及应用

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EP3688142A1 (en) 2020-08-05
AU2018342245A1 (en) 2020-04-16
KR102809909B1 (ko) 2025-05-22
EP4495133A2 (en) 2025-01-22
KR20200065026A (ko) 2020-06-08
IL273516A (en) 2020-05-31
US20200316121A1 (en) 2020-10-08
JP7391015B2 (ja) 2023-12-04
AU2018342245B2 (en) 2024-06-13
IL273516B2 (en) 2025-06-01
WO2019067242A1 (en) 2019-04-04
EP3688142B1 (en) 2025-04-09
EP4495133A3 (en) 2025-04-09
IL273516B1 (en) 2025-02-01
SG11202002635RA (en) 2020-04-29
JP2020534839A (ja) 2020-12-03
CA3080274A1 (en) 2019-04-04

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