CN111344281B - 取代苯并咪唑类的钾通道抑制剂 - Google Patents

取代苯并咪唑类的钾通道抑制剂 Download PDF

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Publication number
CN111344281B
CN111344281B CN201880065901.5A CN201880065901A CN111344281B CN 111344281 B CN111344281 B CN 111344281B CN 201880065901 A CN201880065901 A CN 201880065901A CN 111344281 B CN111344281 B CN 111344281B
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alkyl
amino
phenyl
trifluoromethyl
methyl
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Chinese (zh)
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CN111344281A (zh
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U·S·瑟伦森
A·梅特
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Acesion Pharma ApS
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Acesion Pharma ApS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201880065901.5A 2017-08-14 2018-08-13 取代苯并咪唑类的钾通道抑制剂 Active CN111344281B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17020353.3 2017-08-14
EP17020353 2017-08-14
PCT/EP2018/071911 WO2019034603A1 (en) 2017-08-14 2018-08-13 SUBSTITUTED BENZIMIDAZOLES USEFUL AS INHIBITORS OF THE POTASSIUM CHANNEL

Publications (2)

Publication Number Publication Date
CN111344281A CN111344281A (zh) 2020-06-26
CN111344281B true CN111344281B (zh) 2023-11-14

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ID=59699444

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CN201880065901.5A Active CN111344281B (zh) 2017-08-14 2018-08-13 取代苯并咪唑类的钾通道抑制剂

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Country Link
US (1) US11098018B2 (enExample)
EP (1) EP3668841B1 (enExample)
JP (1) JP7158464B2 (enExample)
CN (1) CN111344281B (enExample)
CA (1) CA3072648A1 (enExample)
WO (1) WO2019034603A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109153667B (zh) * 2016-02-24 2021-04-02 阿塞西翁制药公司 新型钾通道抑制剂
EP3672953B1 (en) * 2017-08-23 2021-07-28 Acesion Pharma ApS Benzimidazole derivatives useful as potassium channel inhibitors
EP4313973A1 (en) * 2021-03-22 2024-02-07 Acesion Pharma ApS Novel potassium channel inhibitors
EP4245753A1 (en) * 2022-03-17 2023-09-20 Acesion Pharma ApS Imidazole derivatives as potassium channel inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1856472A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉酮钾通道抑制剂
CN1856475A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉钾通道抑制剂
CN104011054A (zh) * 2011-11-15 2014-08-27 森申有限公司 用作钾通道抑制剂的噻吩并和呋喃并嘧啶类和吡啶类

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7737167B2 (en) * 2004-08-05 2010-06-15 Neurosearch A/S 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels
EP2319512A1 (en) * 2005-01-11 2011-05-11 NeuroSearch AS Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels.
EP2139855A1 (en) 2007-03-22 2010-01-06 NeuroSearch A/S Medicaments useful as potassium channel modulators
WO2013104577A1 (en) * 2012-01-11 2013-07-18 Acesion Pharma Aps Benzimidazolyl-acetamide derivatives useful as potassium channel modulators
CN109153667B (zh) 2016-02-24 2021-04-02 阿塞西翁制药公司 新型钾通道抑制剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1856472A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉酮钾通道抑制剂
CN1856475A (zh) * 2003-09-23 2006-11-01 默克公司 异喹啉钾通道抑制剂
CN104011054A (zh) * 2011-11-15 2014-08-27 森申有限公司 用作钾通道抑制剂的噻吩并和呋喃并嘧啶类和吡啶类

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
2-Amino-substituted derivatives of benzimidazoles from 2-isothiocyanato carboxylates;Ľubomír Floch et al.;《Collection of Czechoslovak Chemical Communications》;19891231;第54卷;第206-214页 *
Direct Amination of α-Hydroxy Amides;Ajay L. Chandgude. et al.;《Asian Journal Of Organic Chemistry》;20170517;第6卷;第981-983页 *
Iodoacetic Acid is an Efficient Reagent for the Synthesis of Amino Acid Derived 2-Aminobenzimidazoles;Andrejs Krasikovs et al.;《SYNTHESIS》;20131231;第45卷;第683-693页 *
Microwave Assisted Synthesis of Trifluoro Substituted 2-Aminobenzimidazole Derivatives via Iodoacetic Acid Mediated One-pot Condensation;R. Sriram et al.;《Journal of Heterocyclic Chemistry》;20170701;第55卷;第2440-2446页 *

Also Published As

Publication number Publication date
EP3668841A1 (en) 2020-06-24
US11098018B2 (en) 2021-08-24
CA3072648A1 (en) 2019-02-21
EP3668841B1 (en) 2026-07-08
JP7158464B2 (ja) 2022-10-21
WO2019034603A1 (en) 2019-02-21
US20200216398A1 (en) 2020-07-09
JP2020530479A (ja) 2020-10-22
CN111344281A (zh) 2020-06-26

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