CN111317590A - Adjustable rat restraint device for noninvasive blood pressure monitoring - Google Patents
Adjustable rat restraint device for noninvasive blood pressure monitoring Download PDFInfo
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- CN111317590A CN111317590A CN202010122972.3A CN202010122972A CN111317590A CN 111317590 A CN111317590 A CN 111317590A CN 202010122972 A CN202010122972 A CN 202010122972A CN 111317590 A CN111317590 A CN 111317590A
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- 230000036772 blood pressure Effects 0.000 title claims abstract description 26
- 238000012544 monitoring process Methods 0.000 title claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 9
- 230000036541 health Effects 0.000 claims description 6
- 241000700159 Rattus Species 0.000 abstract description 34
- 241001465754 Metazoa Species 0.000 abstract description 10
- 230000017525 heat dissipation Effects 0.000 abstract description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 238000001125 extrusion Methods 0.000 abstract description 3
- 238000013461 design Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 7
- 238000009530 blood pressure measurement Methods 0.000 description 4
- 230000007547 defect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241000581650 Ivesia Species 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 208000015606 cardiovascular system disease Diseases 0.000 description 1
- 231100000132 chronic toxicity testing Toxicity 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009532 heart rate measurement Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02141—Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
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- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Animal Husbandry (AREA)
- Wood Science & Technology (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
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Abstract
The invention discloses an adjustable rat restraint device for noninvasive blood pressure monitoring, which comprises a body restraint device and a head and tail restraint device, wherein the head and tail restraint device consists of a horizontal rod, a head adjusting device and a tail adjusting device, and the head adjusting device and the tail adjusting device are respectively movably arranged at two ends of the horizontal rod; the body binding device is assembled on the horizontal rod and is matched with the head and tail binding device. The invention adopts the flexible material to weave the reticular device for flexible constraint, which not only limits the movement of the rat, but also can adjust the shape to adapt to rats with different body types by extrusion and overlapping, and simultaneously, the design of the reticular structure is beneficial to the heat dissipation of animals, and can ensure the normal breathing of the rat and avoid the damage to the mouth and nose of the rat.
Description
Technical Field
The invention belongs to the field of experimental devices, and particularly relates to an adjustable rat restraint device for noninvasive blood pressure monitoring.
Background
In the field of drug/toxicology experimental research of cardiovascular system diseases, a noninvasive blood pressure measurement technology is widely adopted, and the noninvasive blood pressure measurement method has the unique advantages that invasive operation on experimental animals is not needed, and the experimental reliability is improved. In a non-invasive blood pressure measurement experiment, a tail sleeve method is generally adopted to carry out non-invasive blood pressure and pulse measurement on rodents, and compared with the traditional invasive blood pressure monitoring method, the tail sleeve method avoids the influence of wound operations such as anesthesia and carotid intubation on blood pressure and the physiological function of animals, is simple and convenient to operate and good in repeatability, and is particularly suitable for intermittent or continuous measurement of blood pressure in a chronic toxicity test.
But at present, the binding sleeve matched with the noninvasive blood pressure detector uses canvas to flexibly bind an experimental rat, the binding process is complex, the effect is poor, and the specific expression is as follows:
(1) the interference of animal body movement/tail movement on the sensor causes failure of blood pressure monitoring and inaccurate experimental result;
(2) because the animal is in a waking state, hind limbs of the animal are easy to kick out of the mouse sleeve, the mouse tail is easy to slip from the sensor, or the animal body moves to severely interfere the sensor;
(3) the canvas is adopted for binding, a totally-enclosed binding mode is close to the mode that the rat does not facilitate the breathing and the heat dissipation, and meanwhile, the pollution of the rat defecation and urination to the animal experiment environment in the blood pressure detection process is not considered, so that the accuracy and the scientificity of the experiment result are influenced.
In view of the above defects of the prior art, the invention provides a novel adjustable rat restraint device in order to make the noninvasive blood pressure monitoring result more accurate.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides an adjustable rat restraint device for noninvasive blood pressure monitoring, which has a good restraint effect on rats and accurate experimental results.
In order to achieve the above object, the present invention provides an adjustable rat restraint device for noninvasive blood pressure monitoring, which is characterized in that: including health constraint device and head and tail constraint device, the head and tail constraint device comprises horizon bar, head adjusting device and afterbody adjusting device movable mounting respectively in the both ends of horizon bar, the assembly of health constraint device is in on the horizon bar, and with head and tail constraint device cooperation.
By adopting the structure, the head adjusting device and the tail adjusting device can be adjusted according to the size of an experimental rat, so that the movement of the rat is limited, and the adjustment can be carried out by extrusion and overlapping, so that the device is suitable for rats with different body types, and the accuracy of experimental data acquisition of the rat is ensured.
Furthermore, the body binding device is a cylinder net with openings at two ends, the cylinder body of the cylinder net is provided with an adjusting port, and the body binding device is fixedly arranged on the horizontal rod.
Furthermore, the head adjusting device consists of a head fixing net and a head adjusting rod, and the position of the head adjusting device is adjusted by a knob on the head adjusting rod.
Adopt above-mentioned structure, head adjusting device, afterbody adjusting device and health constraint device all adopt netted material to carry out the flexible constraint, are favorable to the health heat dissipation of rat and guarantee its normal breathing, avoid producing the damage to its mouth nose.
Furthermore, the head adjusting rod is composed of a vertical rod and a horizontal rod, the horizontal rod and the head fixing net are integrally formed, and the vertical rod is movably connected with the horizontal rod and the horizontal rod through knobs respectively.
By adopting the structure, the spatial position of the head fixing net can be adjusted by the combined action of the cross rod and the vertical rod, so that the binding device can adapt to rats with different body types.
Furthermore, the tail adjusting device is composed of a tail fixing net and a tail adjusting rod, the tail adjusting device is movably mounted on the horizontal rod through the tail adjusting rod, and a through hole is formed in the tail end of the tail fixing net.
Adopt above-mentioned structure, the through-hole size of afterbody fixed network tail end and the blood pressure monitoring sensing external member phase-match of noninvasive sphygmomanometer can be with probe embedding wherein, have avoided the sensor slippage that the activity of monitoring in-process rat tail leads to. In addition, the axis of the tail tube of the rat coincides with the axis of the blood pressure monitoring sensor suite, so that the phenomenon that the blood pressure monitoring is inaccurate or fails due to the fact that the tail blood vessel is pressed due to tail folding is avoided.
Furthermore, head fixed network and afterbody fixed network all are the loudspeaker form, just the head fixed network with the afterbody fixed network sets up relatively.
By adopting the structure, the head fixing net and the tail fixing net are matched, can be well adapted to the head and the tail of a rat, and can also reduce the damage to the rat.
Furthermore, the body binding device, the head fixing net and the tail fixing net are all net-shaped structures woven by plastic materials.
The net structure woven by the plastic material has certain flexibility, and can avoid the damage to the animal while limiting the movement of the animal.
The invention has the beneficial effects that: the flexible constraint of the mesh device woven by plastic materials not only limits the movement of the rat, but also can adjust the shape of the rat to adapt to rats with different body types by extrusion and overlapping, and meanwhile, the design of the mesh structure is beneficial to the heat dissipation of animals, and can ensure the normal breathing of the rat and avoid the damage to the mouth and nose of the rat; the vertical height of the tail adjusting device can be adjusted through a knob, so that the tail adjusting device is suitable for extending the tail of the rat at different positions; and the size of the through hole is matched with a blood pressure monitoring sensing suite of the noninvasive sphygmomanometer, so that the probe can be embedded into the through hole, and the defect of sensor slippage caused by the movement of a rat in the monitoring process is overcome.
Drawings
FIG. 1 is a schematic view of the present invention;
FIG. 2 is a schematic representation of the present invention after being adjusted according to the body shape of a rat;
FIG. 3 is a left side view of the present invention;
FIG. 4 is a schematic view of the assembly of the head adjustment device with the horizontal bar;
FIG. 5 is a schematic view of the assembly of the tail adjusting device with the horizontal rod;
figure 6 is a schematic view of the structure of the body restraint device.
Detailed Description
The invention is further described with reference to the following figures and examples:
example (b):
as shown in fig. 1, 2, 3 and 5, an adjustable rat restraint device for noninvasive blood pressure monitoring is characterized in that: the head and tail restraint device comprises a body restraint device 1 and a head and tail restraint device, wherein the head and tail restraint device consists of a horizontal rod 2, a head adjusting device 3 and a tail adjusting device 4, and the head adjusting device 3 and the tail adjusting device 4 are respectively movably arranged at two ends of the horizontal rod 2; the body binding device 1 is a cylinder net with openings at two ends, the cylinder body of the cylinder net is provided with an adjusting port, and the body binding device 1 is fixedly arranged on the horizontal rod 2 and is matched with the head binding device and the tail binding device.
As shown in fig. 3 and 4, the head adjusting device 3 is composed of a head fixing net 31 and a head adjusting rod 32, and the position of the head adjusting device 3 is adjusted by a knob on the head adjusting rod 32. The head adjusting rod 32 is composed of a vertical rod and a horizontal rod, the horizontal rod and the head fixing net 31 are integrally formed, and the vertical rod is movably connected with the horizontal rod and the horizontal rod 2 through knobs respectively. The tail adjusting device 4 consists of a tail fixing net 41 and a tail adjusting rod, and the tail adjusting device 4 is movably arranged on the horizontal rod 2 through the tail adjusting rod; the tail end of the tail fixing net 41 is provided with a through hole 42. The through hole 42 is used for mounting a sensor, and the mouse tail penetrates out of a hole in the middle of the sensor during monitoring.
As shown in fig. 4, 5 and 6, the head fixing net 31 and the tail fixing net 41 are both trumpet-shaped, and the head fixing net 31 and the tail fixing net 41 are oppositely arranged to form a space for fixing the head and the tail of the rat. And the body binding device 1, the head fixing net 31 and the tail fixing net 41 are all net-shaped structures woven by plastic materials. The body of the body-restraining device 1 is larger than the opening size of the head fixing net 31 and the tail fixing net 41. The plastic material in the embodiment is a copper wire; iron wires, steel wires and other materials can also be adopted.
Finally, it should be noted that the above-mentioned description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and scope of the present invention.
Claims (7)
1. An adjustable rat restraint device for noninvasive blood pressure monitoring, which is characterized in that: including health constraint device (1) and head and tail constraint device, the head and tail constraint device comprises horizon bar (2), head adjusting device (3) and afterbody adjusting device (4) movable mounting respectively the both ends of horizon bar (2), health constraint device (1) assembly is in on horizon bar (2), and with the head and tail constraint device cooperation.
2. The adjustable rat restraint device for non-invasive blood pressure monitoring of claim 1, wherein: the body binding device (1) is a cylinder net with openings at two ends, the cylinder body of the cylinder net is provided with an adjusting port, and the body binding device (1) is fixedly arranged on the horizontal rod (2).
3. An adjustable rat restraint device for non-invasive blood pressure monitoring according to claim 2, characterized in that: the head adjusting device (3) is composed of a head fixing net (31) and a head adjusting rod (32), and the position of the head adjusting device (3) is adjusted through a knob on the head adjusting rod (32).
4. An adjustable rat restraint device for non-invasive blood pressure monitoring according to claim 3, characterized in that: the head adjusting rod (32) is composed of a vertical rod and a horizontal rod, the horizontal rod is integrally formed with the head fixing net (31), and the vertical rod is movably connected with the horizontal rod and the horizontal rod (2) through knobs respectively.
5. An adjustable rat restraint device for non-invasive blood pressure monitoring according to claim 3, characterized in that: the tail adjusting device (4) is composed of a tail fixing net (41) and a tail adjusting rod, the tail adjusting device (4) is movably mounted on the horizontal rod (2) through the tail adjusting rod, and a through hole (42) is formed in the tail end of the tail fixing net (41).
6. The adjustable rat restraint device for non-invasive blood pressure monitoring of claim 5, wherein: the head fixing net (31) and the tail fixing net (41) are both trumpet-shaped, and the head fixing net (31) and the tail fixing net (41) are arranged oppositely.
7. The adjustable rat restraint device for non-invasive blood pressure monitoring of claim 5, wherein: the body binding device (1), the head fixing net (31) and the tail fixing net (41) are all of net structures woven by plastic materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010122972.3A CN111317590A (en) | 2020-02-27 | 2020-02-27 | Adjustable rat restraint device for noninvasive blood pressure monitoring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010122972.3A CN111317590A (en) | 2020-02-27 | 2020-02-27 | Adjustable rat restraint device for noninvasive blood pressure monitoring |
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| Publication Number | Publication Date |
|---|---|
| CN111317590A true CN111317590A (en) | 2020-06-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010122972.3A Pending CN111317590A (en) | 2020-02-27 | 2020-02-27 | Adjustable rat restraint device for noninvasive blood pressure monitoring |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224554A (en) * | 2021-12-21 | 2022-03-25 | 中国人民解放军陆军军医大学 | Adjustable experimental animal fixes device of getting blood |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201710494U (en) * | 2010-06-23 | 2011-01-19 | 南京中医药大学 | Device for fixing experimental animal |
| CN202235758U (en) * | 2011-08-29 | 2012-05-30 | 中国科学院昆明动物研究所 | Tree shrew fixing device for test |
| CN103222900A (en) * | 2013-05-22 | 2013-07-31 | 闫洪涛 | Rat fixator |
| CN103622761A (en) * | 2013-12-16 | 2014-03-12 | 中国人民解放军第三军医大学第一附属医院 | Binding device for small animal |
| CN205094668U (en) * | 2015-10-22 | 2016-03-23 | 南京信息工程大学 | A fixing device for big rattail blood sampling |
| CN206403880U (en) * | 2016-09-08 | 2017-08-15 | 东阿阿胶股份有限公司 | donkey tail restrainer |
| CN209916283U (en) * | 2019-04-11 | 2020-01-10 | 黄薇园 | Rat fixing device |
-
2020
- 2020-02-27 CN CN202010122972.3A patent/CN111317590A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201710494U (en) * | 2010-06-23 | 2011-01-19 | 南京中医药大学 | Device for fixing experimental animal |
| CN202235758U (en) * | 2011-08-29 | 2012-05-30 | 中国科学院昆明动物研究所 | Tree shrew fixing device for test |
| CN103222900A (en) * | 2013-05-22 | 2013-07-31 | 闫洪涛 | Rat fixator |
| CN103622761A (en) * | 2013-12-16 | 2014-03-12 | 中国人民解放军第三军医大学第一附属医院 | Binding device for small animal |
| CN205094668U (en) * | 2015-10-22 | 2016-03-23 | 南京信息工程大学 | A fixing device for big rattail blood sampling |
| CN206403880U (en) * | 2016-09-08 | 2017-08-15 | 东阿阿胶股份有限公司 | donkey tail restrainer |
| CN209916283U (en) * | 2019-04-11 | 2020-01-10 | 黄薇园 | Rat fixing device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224554A (en) * | 2021-12-21 | 2022-03-25 | 中国人民解放军陆军军医大学 | Adjustable experimental animal fixes device of getting blood |
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Application publication date: 20200623 |