CN111297962A - Condom for preventing and treating gynecological inflammation - Google Patents
Condom for preventing and treating gynecological inflammation Download PDFInfo
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- CN111297962A CN111297962A CN201811515460.2A CN201811515460A CN111297962A CN 111297962 A CN111297962 A CN 111297962A CN 201811515460 A CN201811515460 A CN 201811515460A CN 111297962 A CN111297962 A CN 111297962A
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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Abstract
The condom for preventing and treating gynecological inflammation comprises a birch extract and a traditional Chinese medicine extract, wherein the traditional Chinese medicine composition comprises 1-3 parts by weight; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-40 parts of birch extract, 6-12 parts of fructus cnidii, 1-3 parts of combined spicebush root, 9-15 parts of folium artemisiae argyi, 5-8 parts of dahurian rhododendron leaf, 2-10 parts of motherwort, 3-8 parts of dandelion and 1-3 parts of almond. The birch extract composition has high content of effective components, has good prevention and treatment effects on gynecological inflammation such as vulva diseases, vaginal diseases, uterine diseases and the like, has the conditioning effects of promoting blood circulation to remove blood stasis, activating qi to relieve pain, clearing heat and removing toxicity, clearing and activating the channels and collaterals and warming uterus and dispelling cold by combining various traditional Chinese medicine components, is treated by the traditional Chinese medicine from inside, ensures that the internal environment of a female body is in a steady state and is mild, treats both symptoms and root causes, and can effectively prevent and treat the gynecological inflammation caused by sexual life.
Description
Technical Field
The invention belongs to the field of family planning, and particularly relates to a condom for preventing and treating gynecological inflammation.
Background
Gynecological inflammation is a common disease of women, and mainly refers to inflammation of female reproductive organs (vulvitis, vaginitis, cervicitis, metritis, pelvic inflammation, adnexitis, sexually transmitted diseases and the like), wherein the female reproductive organs usually have different acute and chronic inflammations and the inflammations after being infected by various pathogenic bacteria. The untimely prevention and treatment of inflammation can cause a plurality of complications besides the mutual spread and cross infection of inflammation at various physiological positions, and can generate adverse effects on immune function, metabolism and endocrine system, and even cause malignant lesion at certain positions. If pregnant women, intrauterine infection, birth canal infection and the like can be caused to affect newborns, and serious consequences such as abortion, premature birth, congenital developmental deformity, mental retardation and the like can be caused.
When sexual hygiene is poor, if sexual intercourse is carried out and hygiene is not noticed, bacteria can be brought into the vagina, so that genital organ inflammation such as endometritis and adnexitis can be caused, even some people can block the vagina due to oviduct inflammation, and menstrual disorder such as increased menstrual amount and prolonged menstrual period can be caused.
The prior art discloses a condom for treating gynecological inflammation, which mainly utilizes the functionality of a traditional Chinese medicine composition to treat gynecological inflammation, easily causes damage to beneficial flora of uterine mucosa, and causes frequent relapse and even aggravation of inflammation; treating the symptoms and not the root cause.
Disclosure of Invention
The invention aims at the problems and provides a condom for preventing and treating gynecological inflammation. The condom for preventing and treating gynecological inflammation comprises a birch extract and traditional Chinese medicine extracts, wherein the composition of the birch extract has high content of effective components, can achieve better curative effect through the mutual combination effect of various traditional Chinese medicines, has concentrated drug efficacy and no toxic or side effect, and has very good prevention and treatment effects on gynecological inflammation such as vulva diseases, vaginal diseases, uterine diseases and the like.
The invention is realized by the following technical scheme:
the disclosed condom for preventing and treating gynecological inflammation comprises a condom substrate and a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition accounts for 1-3 parts by weight of the total weight of the condom; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35-45 parts of birch extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis and 8-16 parts of caulis spatholobi
Further, the preparation of the traditional Chinese medicine composition comprises the following steps:
s1, treatment of the birch extract: pulverizing birch branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain birch extract, standing for layering, and collecting intermediate clear liquid to obtain filtrate I;
s2, evaporating and concentrating the filtrate I to obtain a concentrated solution I;
s3, extracting the traditional Chinese medicines by a distillation method, adding common cnidium fruit, folium artemisiae argyi, almond, radix sophorae flavescentis and caulis spatholobi into distilled water, hydrolyzing at 45-50 ℃, performing ultrasonic treatment, and performing distillation treatment to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II;
s4, extracting the traditional Chinese medicine filtrate for multiple times by using diethyl ether, collecting diethyl ether extract, adding anhydrous sodium sulfate, drying, and recovering diethyl ether in a water bath at 45-60 ℃ to obtain a concentrated solution II;
s5, uniformly mixing the concentrated solution I and the concentrated solution II through ultrasonic vibration, and placing the mixture in a sterilization box for sterilization treatment for 20-25 minutes.
Further, the ratio of the grams of the birch to the milliliters of water is 1: 10-15.
Further, the conditions of the microwave extraction in step S1 are as follows: microwave extraction is carried out for 5min to 10min at the power of 650W to 780W; the ultrasonic oscillation extraction conditions are as follows: ultrasonic oscillation extraction is carried out for 20-30 min at the power of 80-110W.
Further, the mass ratio of the fructus cnidii, the radix linderae, the folium artemisiae argyi, the almonds, the radix sophorae flavescentis and the frankincense in the step S3 to the distilled water is 1: 12-15.
Furthermore, the ultrasonic power of step S3 is 70-90W, and the processing time is 10-20 min.
Further, the extraction pressure of the carbon dioxide supercritical extraction is 30-50 MPa, the temperature is 50-70 ℃, and CO is used2The flow rate is 2-5L/h, and the extraction time is 100-120 min.
Further, in the step S5, the ultrasonic oscillation is processed for 5-10 min at a frequency of 60-80 MHz.
Further, the matrix is latex.
The birch extract contains active substances such as betulin, polysaccharide, saponin, protein, mineral substances and the like, has unique anti-inflammatory capability, can isolate external bacterial infection, sterilize and promote cell growth, and has good effect of resisting gynecological inflammation. The birch extract contains cytokinin, and has effects of promoting cell regeneration, removing necrotic tissue, promoting granulation, repairing wound, and protecting cervix.
Fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, warming kidney and tonifying yang. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; it can be used for treating vulval eczema, pudendal pruritus, and trichomonal vaginitis. Folium Artemisiae Argyi is used for external treatment of skin pruritus. The almond contains a bioactive substance, namely amygdalin, and can enter blood to kill cancer cells without affecting healthy cells; meanwhile, the carotene is rich, so that the protein can resist oxidation, prevent free radicals from invading cells and has the effect of preventing tumors. Radix Sophorae Flavescentis can be used for treating dysentery, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis by external application. Caulis Spatholobi has effects of promoting blood circulation, relaxing muscles and tendons, nourishing blood, and regulating menstruation; it can be used for treating rheumatic arthralgia, menoxenia, dysmenorrhea, amenorrhea, and leukopenia.
Compared with the prior art, the condom for preventing and treating gynecological inflammation has the following advantages:
the traditional Chinese medicine composition disclosed by the invention takes the birch extract as a main raw material, the effective essence of the birch is retained to the maximum extent through special extraction, and the common cnidium fruit, the folium artemisiae argyi, the almond, the lightyellow sophora root and the suberect spatholobus stem are used as auxiliary materials, so that the effect of the composition is enhanced, the effects of promoting blood circulation to remove blood stasis, benefiting qi and relieving pain, clearing heat and removing toxicity, removing pruritus and warming uterus and dispelling cold can be achieved, the effect of preventing cancer can be achieved, the effect of preventing and treating gynecological inflammation can be achieved by adding the composition into a condom, the effect is fast, the symptoms and root causes are treated, the recurrence is not.
The traditional Chinese medicine composition contained in the condom for preventing and treating gynecological inflammation disclosed by the invention is extracted according to the characteristics of all raw materials, and the effective components of all components can be effectively separated, so that after the effective components of all components are combined, a better drug effect is exerted, and the prevention and treatment effects are optimal.
The traditional Chinese medicine composition of the condom for preventing and treating gynecological inflammation disclosed by the invention has the advantages of simple process and preparation process, no harmful substance to the environment in the reaction process, convenience in operation, low energy consumption and less pollution.
Detailed Description
The invention is further illustrated by the following specific examples. The starting materials and the methods employed in the examples of the present invention are those conventionally available in the art and those conventionally used, and the equipment used is equipment conventional in the art, unless otherwise specified.
The condom for preventing and treating gynecological inflammation comprises a condom substrate (the substrate is latex) and a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition accounts for 1-3 parts by weight of the total weight of the condom; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35-45 parts of birch extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis and 8-16 parts of caulis spatholobi.
The preparation method of the condom for preventing and treating gynecological inflammation comprises the steps of centrifuging latex, mixing materials, adding the traditional Chinese medicine composition, uniformly mixing, and feeding into an elevated tank. Washing a mold, drying, dipping in glue, drying for 50min at 100-110 ℃, dipping in glue again, drying for 50min at 60-100 ℃, curling, drying for 50min at 100-130 ℃, demolding, soaking and washing for 30min at 50-60 ℃, drying for 1h at 120 ℃, oiling and packaging.
Example 1
The condom for preventing and treating gynecological inflammation provided by the embodiment, wherein the weight of the medicinal composition accounts for 4% of the total weight of the condom; the traditional Chinese medicine composition is prepared from the raw materials in the following weight parts in the table 1. The preparation method comprises the following steps:
s1, treatment of the birch extract: pulverizing branches of birch, defatting with petroleum ether, and adding into water at a ratio of 1: 10; soaking, microwave extracting, ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain birch extract, standing for layering, and collecting intermediate clear liquid to obtain filtrate I; wherein, the microwave extraction conditions are as follows: microwave extracting at power of 650W for 5 min; the ultrasonic oscillation extraction conditions are as follows: extracting with 110W ultrasonic oscillation for 30 min.
S2, evaporating and concentrating the filtrate I to obtain a concentrated solution I;
s3, extracting the traditional Chinese medicines by a distillation method, and adding distilled water into the common cnidium fruit, the folium artemisiae argyi, the almond, the radix sophorae flavescentis and the caulis spatholobi respectively, wherein the mass ratio of the total mass of the medicines to the distilled water is 1: 12. Hydrolyzing at 45-50 ℃, specifically, adding enough water into the Chinese medicinal materials in the step for soaking, adding maltose and glucoside synthetase during soaking, and decocting the soaked Chinese medicinal materials to obtain an aqueous solution; cooling the aqueous solution, adding glycoside hydrolase (cellulase and pectinase) for hydrolysis reaction at 45-50 ℃ to obtain a hydrolysis solution; after ultrasonic treatment, the ultrasonic power is 90W, and the treatment time is 10 min; carrying out distillation treatment on the ultrasonic wave with the frequency of 50-100 KHz to recover a primary extracting solution; subjecting the primary extractive solution to supercritical carbon dioxide extractionFiltering to obtain a second traditional Chinese medicine filtrate; the extraction pressure of the supercritical carbon dioxide extraction is 30MPa, the temperature is 60 ℃, and CO is2The flow rate is 2L/h, and the extraction time is 120 min.
S4, extracting the traditional Chinese medicine filtrate for 3 times by using diethyl ether, collecting diethyl ether extract, adding anhydrous sodium sulfate, drying, and recovering diethyl ether in a water bath at 45-60 ℃ to obtain a concentrated solution II;
s5, uniformly mixing the concentrated solution I and the concentrated solution II through ultrasonic oscillation, placing the mixture in a sterilization box for sterilization treatment for 20-25 minutes, and treating the mixture for 10 minutes through ultrasonic oscillation with the frequency of 60 MHz.
Example 2
The condom for preventing and treating gynecological inflammation provided by the embodiment, wherein the weight of the medicinal composition accounts for 8% of the total weight of the condom; the traditional Chinese medicine composition is prepared from the raw materials in the following weight parts in the table 1. The preparation method comprises the following steps:
s1, treatment of the birch extract: pulverizing branches of birch, defatting with petroleum ether, and adding into water at a ratio of gram of birch to milliliter of water of 1: 15; soaking, microwave extracting, ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain birch extract, standing for layering, and collecting intermediate clear liquid to obtain filtrate I; wherein, the microwave extraction conditions are as follows: microwave extracting at power of 750W for 10 min; the ultrasonic oscillation extraction conditions are as follows: extracting with 80W ultrasonic oscillation for 20 min.
S2, evaporating and concentrating the filtrate I to obtain a concentrated solution I;
s3, extracting the traditional Chinese medicines by a distillation method, and adding distilled water into the common cnidium fruit, the folium artemisiae argyi, the almond, the radix sophorae flavescentis and the caulis spatholobi respectively, wherein the mass ratio of the total mass of the medicines to the distilled water is 1: 15. Hydrolyzing at 45-50 ℃, specifically, adding enough water into the Chinese medicinal materials in the step for soaking, adding maltose and glucoside synthetase during soaking, and decocting the soaked Chinese medicinal materials to obtain an aqueous solution; cooling the aqueous solution, adding glycoside hydrolase (cellulase and pectinase) for hydrolysis reaction at 45-50 ℃ to obtain a hydrolysis solution; after ultrasonic treatment, the ultrasonic power is 70W, and the treatment time is 10 min; the ultrasonic frequency is 50-100 KHz, and the distillation is carried outRecovering the primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II; the extraction pressure of carbon dioxide supercritical extraction is 50MPa, the temperature is 70 ℃, and CO is added2The flow rate is 5L/h, and the extraction time is 100 min.
S4, extracting the traditional Chinese medicine filtrate for 3 times by using diethyl ether, collecting diethyl ether extract, adding anhydrous sodium sulfate, drying, and recovering diethyl ether in a water bath at 45-60 ℃ to obtain a concentrated solution II;
s5, uniformly mixing the concentrated solution I and the concentrated solution II through ultrasonic oscillation, placing the mixture in a sterilization box for sterilization treatment for 20-25 minutes, and treating the mixture for 5 minutes through the ultrasonic oscillation with the frequency of 80 MHz.
Example 3
The condom for preventing and treating gynecological inflammation provided by the embodiment, wherein the weight of the medicinal composition accounts for 5% of the total weight of the condom; the traditional Chinese medicine composition is prepared from the raw materials in the following weight parts in the table 1. The specific preparation method is essentially the same as in example 1, except that s1. treatment of birch extract: pulverizing branches of birch, defatting with petroleum ether, and adding into water at a ratio of gram of birch to milliliter of water of 1: 12; soaking, microwave extracting, ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain birch extract, standing for layering, and collecting intermediate clear liquid to obtain filtrate I; wherein, the microwave extraction conditions are as follows: microwave extracting at power of 700W for 8 min; the ultrasonic oscillation extraction conditions are as follows: extracting with 100W ultrasonic oscillation for 25 min. The rest of the procedure was the same as in example 1.
Comparative example 1
The condom for preventing and treating gynecological inflammation provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following table 1 in parts by weight. The specific procedure was the same as in example 1.
Comparative example 2
The condom for preventing and treating gynecological inflammation provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following table 1 in parts by weight. The specific procedure was the same as in example 1.
Comparative example 3
The condom for preventing and treating gynecological inflammation provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following table 1 in parts by weight. The raw materials are not added with birch extract, the specific operation steps are basically the same as the example 1, and the steps related to the preparation of the birch extract are removed.
Comparative example 4
The condom for preventing and treating gynecological inflammation provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following table 1 in parts by weight. The preparation method is different from the example 1 in that the original steps S1 and S2 are not needed, namely, distillation, carbon dioxide supercritical extraction and fractional microwave extraction are carried out on birch branches by adopting a distillation method, and the other preparation methods are the same as the example 1.
TABLE 1
| Serial number | Birch extract | Fructus cnidii | Folium Artemisiae Argyi | Almond | Sophora flavescens ait | Caulis Spatholobi |
| Example 1 | 35 | 10 | 12 | 3 | 18 | 15 |
| Example 2 | 45 | 12 | 15 | 2 | 16 | 10 |
| Example 3 | 40 | 6 | 10 | 1 | 12 | 9 |
| Comparative example 1 | 20 | 10 | 12 | 3 | 18 | 15 |
| Comparative example 2 | 48 | 5 | 8 | 10 | 9 | 5 |
| Comparative example 3 | -- | 10 | 12 | 3 | 18 | 15 |
| Comparative example 4 | 35 | 10 | 12 | 3 | 18 | 15 |
The results of the bacteriostatic experiments of the traditional Chinese medicine compositions of examples 1 to 3 and comparative examples 1 to 4 on the bacteriostatic diameter (mm) are shown in table 2:
TABLE 2
The traditional Chinese medicine composition disclosed by the invention takes the birch extract as a main raw material, the effective essence of the birch is retained to the maximum extent through special extraction, and the common cnidium fruit, the folium artemisiae argyi, the almond, the lightyellow sophora root and the suberect spatholobus stem are used as auxiliary materials, so that the effect of the composition is enhanced, the effects of promoting blood circulation to remove blood stasis, benefiting qi and relieving pain, clearing heat and removing toxicity, removing pruritus and warming uterus and dispelling cold can be achieved, the effect of preventing cancer can be achieved, the effect of preventing and treating gynecological inflammation can be achieved by adding the composition into a condom, the effect is fast, the symptoms and root causes are treated, the recurrence is not.
While the invention has been described in terms of specific process equipment and process steps, it will be understood by those skilled in the art that the invention is not limited to the embodiments described above, which are included to illustrate the principles of the invention, and that various changes and modifications, which will be apparent to those skilled in the art, may be made without departing from the spirit and scope of the invention and, therefore, the invention is to be limited only by the appended claims.
Claims (9)
1. A condom for preventing and treating gynecological inflammation comprises a condom substrate and a traditional Chinese medicine composition, and is characterized in that the traditional Chinese medicine composition accounts for 4-8 parts by weight of the total weight of the condom; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35-45 parts of birch extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis and 8-16 parts of caulis spatholobi.
2. The condom for preventing and treating gynecological inflammation according to claim 1, wherein the preparation of the traditional Chinese medicine composition comprises the following steps:
s1, treatment of the birch extract: pulverizing birch branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain birch extract, standing for layering, and collecting intermediate clear liquid to obtain filtrate I;
s2, evaporating and concentrating the filtrate I to obtain a concentrated solution I;
s3, extracting the traditional Chinese medicines by a distillation method, adding distilled water into common cnidium fruit, folium artemisiae argyi, almond, radix sophorae flavescentis and caulis spatholobi, hydrolyzing at 45-50 ℃, performing ultrasonic treatment, and performing distillation treatment to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II;
s4, extracting the traditional Chinese medicine filtrate for multiple times by using diethyl ether, collecting diethyl ether extract, adding anhydrous sodium sulfate, drying, and recovering diethyl ether in a water bath at 45-60 ℃ to obtain a concentrated solution II;
s5, uniformly mixing the concentrated solution I and the concentrated solution II through ultrasonic vibration, and placing the mixture in a sterilization box for sterilization treatment for 20-25 minutes.
3. The condom for preventing and treating gynecological inflammation according to claim 2, wherein the ratio of the grams of birch to the milliliters of water is 1: 10-15.
4. The condom for preventing and treating gynecological inflammation according to claim 2, wherein the conditions of microwave extraction in step S1 are as follows: microwave extraction is carried out for 5min to 10min at the power of 650W to 780W; the ultrasonic oscillation extraction conditions are as follows: ultrasonic oscillation extraction is carried out for 20-30 min at the power of 80-110W.
5. The condom for preventing and treating gynecological inflammation according to claim 2, wherein the mass ratio of the total mass of the fructus cnidii, the radix linderae, the folium artemisiae argyi, the almond, the radix sophorae flavescentis and the frankincense in the step S3 to the distilled water is 1: 12-15.
6. The condom for preventing and treating gynecological inflammation according to claim 2, wherein the ultrasonic power of step S3 is 70-90W, and the treatment time is 10-20 min.
7. The condom for preventing and treating gynecological inflammation according to claim 2, wherein the extraction pressure of the supercritical carbon dioxide extraction is 30-50 MPa, the temperature is 50-70 ℃, and CO is used2The flow rate is 2-5L/h, and the extraction time is 100-120 min.
8. The condom for preventing and treating gynecological inflammation according to claim 2, wherein the ultrasonic oscillation of step S5 is processed for 5-10 min at a frequency of 60-80 MHz.
9. The condom for preventing and treating gynecological inflammations according to claim 1, wherein said matrix is latex.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811515460.2A CN111297962A (en) | 2018-12-12 | 2018-12-12 | Condom for preventing and treating gynecological inflammation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811515460.2A CN111297962A (en) | 2018-12-12 | 2018-12-12 | Condom for preventing and treating gynecological inflammation |
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| CN111297962A true CN111297962A (en) | 2020-06-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112812385A (en) * | 2021-01-15 | 2021-05-18 | 威乐士医疗卫生用品（湖北）有限公司 | Preparation method of latex condom |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112812385A (en) * | 2021-01-15 | 2021-05-18 | 威乐士医疗卫生用品（湖北）有限公司 | Preparation method of latex condom |
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