CN111298206A

CN111298206A - Multifunctional condom containing pine tree extract

Info

Publication number: CN111298206A
Application number: CN201811515596.3A
Authority: CN
Inventors: 瞿洪强; 吴江平; 肖建伟
Original assignee: Hunan Meizai Meitian Health Technology Co ltd
Current assignee: Hunan Meizai Meitian Health Technology Co ltd
Priority date: 2018-12-12
Filing date: 2018-12-12
Publication date: 2020-06-19

Abstract

The multifunctional condom containing pine extract comprises 1-3 parts by weight of pine extract and traditional Chinese medicine extract; the weight part of the traditional Chinese medicine composition is 4-8 parts; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-45 parts of pine extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis, 8-16 parts of caulis spatholobi, 8-12 parts of herba epimedii, 5-10 parts of semen cuscutae, 3-6 parts of motherwort, 1-5 parts of ligusticum chuanxiong hort and 5-8 parts of cherokee rose root. The traditional Chinese medicine has the conditioning effects of promoting blood circulation to remove blood stasis, activating qi to alleviate pain, clearing away heat and toxic materials, clearing and activating the channels and collaterals, warming uterus and dispelling cold, is used for treating internal diseases, enables the internal environment of a female body to be in a stable and mild state, prevents and treats vaginitis, and has obvious curative effects on male yang-strengthening, sexual function improvement and sexual dysfunction such as impotence and premature ejaculation.

Description

Multifunctional condom containing pine tree extract

Technical Field

The invention belongs to the field of family planning, and particularly relates to a multifunctional condom containing pine tree extract.

Background

Gynecological inflammation is a common disease of women, and mainly refers to inflammation of female reproductive organs (vulvitis, vaginitis, cervicitis, metritis, pelvic inflammation, adnexitis, sexually transmitted diseases and the like), wherein the female reproductive organs usually have different acute and chronic inflammations and the inflammations after being infected by various pathogenic bacteria. The untimely prevention and treatment of inflammation can cause a plurality of complications besides the mutual spread and cross infection of inflammation at various physiological positions, and can generate adverse effects on immune function, metabolism and endocrine system, and even cause malignant lesion at certain positions. If pregnant women, intrauterine infection, birth canal infection and the like can be caused to affect newborns, and serious consequences such as abortion, premature birth, congenital developmental deformity, mental retardation and the like can be caused.

When sexual hygiene is poor, if sexual intercourse is carried out and hygiene is not noticed, bacteria can be brought into the vagina, so that genital organ inflammation such as endometritis and adnexitis can be caused, even some people can block the vagina due to oviduct inflammation, and menstrual disorder such as increased menstrual amount and prolonged menstrual period can be caused.

The general condom has all the functions of passive disease prevention, active disease treatment, female gynecological inflammation treatment, male sexual intercourse time enhancement and the like. The application number is CN201310441441.0 discloses a multifunctional condom containing pine extract and a preparation method thereof, which can effectively treat gynecological inflammations such as vaginitis, cervicitis, pelvic inflammation, endometritis and adnexitis by utilizing the functionality of a traditional Chinese medicine composition, can also effectively improve the erection hardness and prolong the sexual intercourse endurance, and is worthy of clinical popularization and application due to small dosage, good local transdermal absorption effect and small toxic and side effect on human body.

The retrieved pine extract is not reported to be used in condoms, and belongs to the blank in the field.

Disclosure of Invention

The invention aims at the problems and provides a multifunctional condom containing pine tree extract. The multifunctional condom containing the pine extract comprises the pine extract and the traditional Chinese medicine extract, the composition of the pine extract has higher content of effective components, better curative effect can be achieved through the mutual combination effect of various traditional Chinese medicines, the medicine efficacy is concentrated, no toxic or side effect exists, the multifunctional condom has better prevention and treatment effects on gynecological inflammations such as vulvar diseases, vaginal diseases, uterine diseases and the like, the male sexual function can be improved, the sexual life is harmonious, and the functionality is strong.

The multifunctional condom containing pine extract has the conditioning effects of promoting blood circulation to disperse blood clots, benefiting qi for relieving pain, clearing away heat and toxic material, dredging meridian passage and warming uterus to dispel cold.

The invention is realized by the following technical scheme:

the disclosed multifunctional condom containing pine extract comprises a condom substrate and a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition accounts for 4-8 parts by weight of the total weight of the condom; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-45 parts of pine extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis, 8-16 parts of caulis spatholobi, 8-12 parts of herba epimedii, 5-10 parts of semen cuscutae, 3-6 parts of motherwort, 1-5 parts of ligusticum chuanxiong hort, 5-8 parts of cherokee rose root and 20-30 parts of frankincense.

Further, the preparation of the traditional Chinese medicine composition comprises the following steps:

s1, pine extract treatment: pulverizing pine tree branches, degreasing with petroleum ether, adding into water, soaking, microwave extracting and ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain filtrate I;

s2, evaporating and concentrating the filtrate I to obtain a concentrated solution I;

s3, extracting the traditional Chinese medicines by a distillation method, respectively adding distilled water into common cnidium fruit, folium artemisiae argyi, almond, radix sophorae flavescentis, caulis spatholobi, herba epimedii, semen cuscutae, motherwort, ligusticum chuanxiong hort and cherokee rose root, hydrolyzing at 40-60 ℃, performing ultrasonic treatment, and performing distillation treatment to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II;

s4, extracting the traditional Chinese medicine filtrate for multiple times by using diethyl ether, collecting diethyl ether extract, adding anhydrous sodium sulfate, drying, and recovering diethyl ether in a water bath at 50-75 ℃ to obtain a concentrated solution II;

s5, uniformly mixing the concentrated solution I and the concentrated solution II through ultrasonic vibration, and placing the mixture in a sterilization box for sterilization treatment for 20-25 minutes.

Further, the ratio of the gram number of the pine tree to the milliliter number of the water is 1: 9-12.

Further, the conditions of the microwave extraction in step S1 are as follows: microwave extraction is carried out for 5min to 10min at the power of 450W to 600W; the ultrasonic oscillation extraction conditions are as follows: the frequency is 10-30 KHz, and the ultrasonic oscillation extraction is performed for 20-30 min.

Further, the mass ratio of the total mass of the cnidium fruit, the artemisia leaf, the almond, the sophora flavescens, the suberect spatholobus stem, the epimedium herb, the dodder, the motherwort herb, the ligusticum chuanxiong hort and the cherokee rose root in the step S3 to the distilled water is 1: 12-15.

Further, the ultrasonic power of step S3 is 70-90W, the frequency is 20-90 KHz, and the processing time is 10-20 min.

Further, the extraction pressure of the carbon dioxide supercritical extraction is 60-80 MPa, the temperature is 60-80 ℃, and CO is extracted at 60-80 DEG C₂The flow rate is 2-5L/h, and the extraction time is 100-120 min.

Further, in the step S5, the ultrasonic oscillation is processed for 5-10 min at a frequency of 60-80 MHz.

Further, the matrix is latex.

The pine tree extract of the invention can prolong the efficacy of vitamin C in human body, activate the action of vitamin C and vitamin E, inhibit nucleic acid damage caused by lipoprotein oxidation and hydroxyl free radical, activate the secretion of growth hormone of human body, improve immune response and protect nerve cells from being damaged by glutamate salt, fat or anion form thereof, can delay the decline of immunity and the decline of metabolism function of blood cells in the aging process, and can restore the normal level of the immunity and the fat and the metabolism function of the blood cells. The pine extract can increase hormone secretion, delay cell aging, and promote cell regeneration.

Fructus Cnidii has effects of eliminating dampness, dispelling pathogenic wind, killing parasites, warming kidney and tonifying yang. Can be used for treating sexual impotence, cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; it can be used for treating vulval eczema, pudendal pruritus, and trichomonal vaginitis. Folium Artemisiae Argyi is used for external treatment of skin pruritus. The almond contains a bioactive substance, namely amygdalin, and can enter blood to kill cancer cells without affecting healthy cells; meanwhile, the carotene is rich, so that the protein can resist oxidation, prevent free radicals from invading cells and has the effect of preventing tumors. Radix Sophorae Flavescentis can be used for treating dysentery, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis by external application. Caulis Spatholobi has effects of promoting blood circulation, relaxing muscles and tendons, nourishing blood, and regulating menstruation; it can be used for treating rheumatic arthralgia, menoxenia, dysmenorrhea, amenorrhea, and leukopenia. The essential herbs of epimedium herb for replenishing essence and qi, strengthening tendons and bones, tonifying kidney and strengthening yang are usually used for treating impotence, spermatorrhea, premature ejaculation, urinary incontinence and infertility of women. Herba Epimedii contains icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E, etc. Can excite sexual function, and promote semen secretion for animals. Pharmacological experimental research shows that epimedium can increase blood flow of heart and cerebral vessels, promote hemopoiesis, immunity and bone metabolism, and has the functions of resisting senility, resisting tumor, etc. Semen Cuscutae has effects of nourishing liver and kidney, stopping nocturnal emission, reducing urination, preventing miscarriage, improving eyesight, and relieving diarrhea. Sweet flavor has the nourishing effect, is sweet, pungent and slightly warm, can neutralize intrinsic qi, can tonify yang and yin, and has the characteristics of warmness without dryness and tonification without stagnation. Secure essence and prevent miscarriage and has the same effect as sex hormone. Motherwort has the functions of inducing diuresis to reduce edema and contracting uterus, and is the essential medicine for treating gynecopathy in doctors of all generations. Herba Leonuri contains various alkaloids such as leonurine, stachydrine, leonuridine, leonurine, etc., benzoic acid, potassium chloride, etc. The herba Leonuri preparation has effects of exciting animal uterus, and herba Leonuri has strong and lasting exciting effect on uterus, not only can enhance its contractility, but also can improve its tensity and shrinkage. The ligusticum chuanxiong hort can inhibit various bacilli; has antihistaminic and choleretic effects. Rosa laevigata root can secure essence and astringe intestines. It is indicated for seminal emission, enuresis, dysentery, diarrhea, metrorrhagia, leukorrhagia, and metroptosis.

Compared with the prior art, the multifunctional condom containing the pine tree extract has the following advantages:

the traditional Chinese medicine composition disclosed by the invention takes pine extract as a main raw material, retains effective essence of pine to the maximum extent through special extraction, and has the conditioning effects of promoting blood circulation to remove blood stasis, benefiting qi to relieve pain, clearing heat and detoxicating, clearing and activating the channels and collaterals and warming uterus to dispel cold by assisting with fructus cnidii, folium artemisiae argyi, almond, radix sophorae flavescentis, caulis spatholobi, herba epimedii, semen cuscutae, herba leonuri, ligusticum chuanxiong hort and cherokee rose root.

The traditional Chinese medicine composition contained in the multifunctional condom containing the pine extract disclosed by the invention is extracted according to the characteristics of all raw materials, and effective components of all components can be effectively separated, so that after the effective components of all components are combined, a better drug effect is exerted, and the prevention and treatment effects are optimal.

The traditional Chinese medicine composition of the multifunctional condom containing the pine extract disclosed by the invention is simple in process and preparation process, free of any harmful substance to the environment in the reaction process, convenient to operate, low in energy consumption and less in pollution.

Detailed Description

The invention is further illustrated by the following specific examples. The starting materials and the methods employed in the examples of the present invention are those conventionally available in the art and those conventionally used, and the equipment used is equipment conventional in the art, unless otherwise specified.

The multifunctional condom containing the pine extract comprises a condom substrate (the substrate is latex) and a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition accounts for 4-8 parts by weight of the total weight of the condom; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-45 parts of pine extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis, 8-16 parts of caulis spatholobi, 8-12 parts of herba epimedii, 5-10 parts of semen cuscutae, 3-6 parts of motherwort, 1-5 parts of ligusticum chuanxiong hort and 5-8 parts of cherokee rose root.

The preparation method of the multifunctional condom containing the pine extract comprises the steps of centrifuging latex, mixing materials, adding the traditional Chinese medicine composition, uniformly mixing, and feeding into a head tank. Washing a mold, drying, dipping in glue, drying for 50min at 100-110 ℃, dipping in glue again, drying for 50min at 60-100 ℃, curling, drying for 50min at 100-130 ℃, demolding, soaking and washing for 30min at 50-60 ℃, drying for 1h at 120 ℃, oiling and packaging.

Example 1

The multifunctional condom containing pine tree extract provided by the embodiment comprises the following components, wherein the weight of the medicinal composition accounts for 4% of the total weight of the condom; the traditional Chinese medicine composition is prepared from the raw materials in the following weight parts in the table 1. The preparation method comprises the following steps:

s1, pine extract treatment: pulverizing branches of pine trees, degreasing with petroleum ether, adding into water at a ratio of the gram number of the pine trees to the milliliter number of the water of 1:9, soaking, performing microwave extraction and ultrasonic oscillation extraction, and filtering to obtain fiber residues; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain filtrate I; the microwave extraction conditions are as follows: microwave extracting at power of 450W for 10 min; the ultrasonic oscillation extraction conditions are as follows: the frequency is 30KHz, and the ultrasonic oscillation extraction is carried out for 20 min.

S2, evaporating and concentrating the filtrate I at 100-105 ℃ for 40min to obtain a concentrated solution I;

s3, extracting the traditional Chinese medicines by a distillation method, adding distilled water into common cnidium fruit, folium artemisiae argyi, almond, radix sophorae flavescentis, caulis spatholobi, herba epimedii, semen cuscutae, motherwort, ligusticum chuanxiong hort and cherokee rose root respectively, wherein the mass ratio of the total mass of the traditional Chinese medicines to the distilled water is 1:12, carrying out steam distillation to collect volatile oil and distilled primary extract, and carrying out ultrasonic extraction; distilling to recover primary extract; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II; wherein the ultrasonic power is 70W, the frequency is 90KHz, and the processing time is 10 min; the extraction pressure of the supercritical carbon dioxide extraction is 60MPa, the temperature is 80 ℃, and CO is added₂Flow rate5L/h, and the extraction time is 100 min.

Example 2

The multifunctional condom containing pine tree extract provided by the embodiment comprises 8% of the medicinal composition by weight; the traditional Chinese medicine composition is prepared from the raw materials in the following weight parts in the table 1. The preparation method comprises the following steps:

s1, pine extract treatment: pulverizing branches of pine trees, degreasing with petroleum ether, adding into water at a ratio of the gram number of the pine trees to the milliliter number of the water of 1:12, soaking, performing microwave extraction and ultrasonic oscillation extraction, and filtering to obtain fiber residues; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain filtrate I; the microwave extraction conditions are as follows: microwave extracting at power of 600W for 5 min; the ultrasonic oscillation extraction conditions are as follows: the frequency is 10KHz, and ultrasonic oscillation extraction is performed for 30 min.

s3, extracting the traditional Chinese medicines by a distillation method, adding distilled water into common cnidium fruit, folium artemisiae argyi, almond, radix sophorae flavescentis, caulis spatholobi, herba epimedii, semen cuscutae, motherwort, ligusticum chuanxiong hort and cherokee rose root respectively, wherein the mass ratio of the total mass of the medicines to the distilled water is 1:15, carrying out steam distillation to collect volatile oil and a distilled primary extracting solution, and carrying out ultrasonic extraction; after ultrasonic treatment, carrying out distillation treatment to recover a primary extracting solution; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II; wherein the ultrasonic power is 90W, the frequency is 20KHz, and the processing time is 20 min; the extraction pressure of the supercritical carbon dioxide extraction is 80MPa, the temperature is 60 ℃, and CO is added₂The flow rate is 2L/h, and the extraction time is 120 min.

Example 3

The multifunctional condom containing pine tree extract provided by the embodiment comprises 5% of the medicinal composition by weight; the traditional Chinese medicine composition is prepared from the raw materials in the following weight parts in the table 1. The specific preparation method is basically the same as in example 1, except that in s1. treatment of pine extract: pulverizing pine tree branches, degreasing with petroleum ether, and adding into water, wherein the ratio of the gram of pine tree to the milliliter of water is 1: 12; soaking, microwave extracting, ultrasonic oscillating extracting, and filtering to obtain fiber residue; decolorizing the filtrate, concentrating to obtain pine tree extract, standing for layering, and collecting the intermediate clear solution to obtain filtrate I; wherein, the microwave extraction conditions are as follows: microwave extracting at power of 650W for 5 min; the ultrasonic oscillation extraction conditions are as follows: the frequency is 20KHz, and the ultrasonic oscillation extraction is carried out for 325 min. The rest of the procedure was the same as in example 1.

Comparative example 1

The multifunctional condom containing pine extract provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following weight parts in the table 1. The specific procedure was the same as in example 1.

Comparative example 2

Comparative example 3

The multifunctional condom containing pine extract provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following weight parts in the table 1. The pine extract was not added to the raw materials, the specific procedure was substantially the same as in example 1, and the steps for pine extract preparation were eliminated.

Comparative example 4

The multifunctional condom containing pine extract provided by the comparative example is a traditional Chinese medicine composition prepared from the raw materials in the following weight parts in the table 1. The preparation method is different from the embodiment 1 in that the original steps S1 and S2 are not needed, namely, distillation, carbon dioxide supercritical extraction and fractional microwave extraction are carried out on the pine tree branches by adopting a distillation method, and the other preparation methods are the same as the embodiment 1.

TABLE 1

The results of the bacteriostatic experiments of the traditional Chinese medicine compositions of examples 1 to 3 and comparative examples 1 to 4 on the bacteriostatic diameter (mm) are shown in table 2:

TABLE 2

	Staphylococcus aureus	Escherichia coli	Mould fungus	Diplococcus gonorrhoeae	Candida species
						Example 1	12.4	8.1	14.1	10.4	11.0
Example 2	11.5	6.9	13.6	9.6	10.7
						Example 3	13.3	7.5	13.4	10.7	9.8
Comparative example 1	9.5	5.2	9.4	7.3	8.4
						Comparative example 2	11.1	6.1	10.2	7.8	9.6
Comparative example 3	6.6	5.4	7.5	6.4	6.5
						Comparative example 4	7.4	6.8	8.0	7.0	7.2

While the invention has been described in terms of specific process equipment and process steps, it will be understood by those skilled in the art that the invention is not limited to the embodiments described above, which are included to illustrate the principles of the invention, and that various changes and modifications, which will be apparent to those skilled in the art, may be made without departing from the spirit and scope of the invention and, therefore, the invention is to be limited only by the appended claims.

Claims

1. A multifunctional condom containing pine extract comprises a condom substrate and a traditional Chinese medicine composition, and is characterized in that the traditional Chinese medicine composition accounts for 4-8 parts by weight of the total weight of the condom; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30-45 parts of pine extract, 6-12 parts of fructus cnidii, 9-15 parts of folium artemisiae argyi, 1-3 parts of almond, 10-18 parts of radix sophorae flavescentis, 8-16 parts of caulis spatholobi, 8-12 parts of herba epimedii, 5-10 parts of semen cuscutae, 3-6 parts of motherwort, 1-5 parts of ligusticum chuanxiong hort and 5-8 parts of cherokee rose root.

2. The multifunctional condom containing pine tree extract as claimed in claim 1, wherein the preparation of the Chinese medicinal composition comprises the following steps:

s3, extracting the traditional Chinese medicines by a distillation method, adding distilled water into common cnidium fruit, folium artemisiae argyi, almond, radix sophorae flavescentis, caulis spatholobi, herba epimedii, semen cuscutae, motherwort, ligusticum chuanxiong hort and cherokee rose root respectively, carrying out steam distillation to collect volatile oil and distilled primary extract, and carrying out ultrasonic extraction; distilling to recover primary extract; performing carbon dioxide supercritical extraction on the primary extracting solution, and filtering to obtain a traditional Chinese medicine filtrate II;

3. The multifunctional condom containing pine tree extract as claimed in claim 2, wherein the ratio of gram of pine tree to ml of water is 1: 9-12.

4. The multifunctional condom containing pine tree extract as claimed in claim 2, wherein the microwave extraction conditions of step S1 are: microwave extraction is carried out for 5min to 10min at the power of 450W to 600W; the ultrasonic oscillation extraction conditions are as follows: the frequency is 10-30 KHz, and the ultrasonic oscillation extraction is performed for 20-30 min.

5. The multifunctional condom containing pine extract as claimed in claim 2, wherein the mass ratio of the total mass of the cnidium fruit, the artemisia leaf, the almond, the sophora flavescens, the suberect spatholobus stem, the epimedium herb, the dodder, the motherwort, the ligusticum chuanxiong hort and the cherokee rose root in the step S3 to the distilled water is 1: 12-15.

6. The multifunctional condom containing pine tree extract as claimed in claim 2, wherein the ultrasonic power of step S3 is 70-90W, the frequency is 20-90 KHz, and the treatment time is 10-20 min.

7. The multifunctional condom containing pine tree extract as claimed in claim 2, wherein the supercritical carbon dioxide extraction is performed at 60-80 MPa and 60-80 deg.C under CO₂The flow rate is 2-5L/h, and the extraction time is 100-120 min.

8. The multifunctional condom containing pine tree extract as claimed in claim 2, wherein the ultrasonic oscillation in step S5 is processed for 5-10 min at a frequency of 60-80 MHz.

9. The multifunctional condom containing pine tree extract as claimed in claim 1, wherein the matrix is latex.