CN111281817B - Preparation method of water-containing bioactive glass toothpaste - Google Patents
Preparation method of water-containing bioactive glass toothpaste Download PDFInfo
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- CN111281817B CN111281817B CN202010089789.8A CN202010089789A CN111281817B CN 111281817 B CN111281817 B CN 111281817B CN 202010089789 A CN202010089789 A CN 202010089789A CN 111281817 B CN111281817 B CN 111281817B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a preparation method of water-containing bioactive glass toothpaste, which prepares a toothpaste with a water-in-oil-in-toothpaste matrix water-in-oil structure and stable by adding a water-in-oil emulsion stabilized by a surfactant. The toothpaste contains bioactive glass and water, and the water and bioactive glass in the toothpaste are separated by oil before use, so that the water and bioactive glass can exist stably at the same time. When the toothpaste is used, the water-in-oil emulsion of the toothpaste matrix with stable surfactant is broken under the action of friction, extrusion and the like to release the water wrapped in the water-in-oil emulsion, so that the mouthfeel of the toothpaste during use can be improved, and the reaction rate of bioactive glass in the toothpaste can be increased.
Description
Technical Field
The invention belongs to the field of daily chemical products and oral hard tissue medical care, nursing and cleaning products, and particularly relates to a preparation method of water-containing bioactive glass toothpaste for medical care and oral cleaning and nursing.
Background
The bioactive glass is made of SiO 2 、Na 2 O, CaO and P 2 O 5 And the like. After the bioactive glass is implanted into a human body, the surface composition and the structure of the bioactive glass change along with time to form a hydroxyapatite carbonate layer with bioactivity, and a bonding interface is provided for the recovery and growth of bones and soft tissues.
Toothpaste containing bioactive glass can be used for treating dental hypersensitivity and periodontal disease. The bioactive glass is added directly into the water-containing toothpaste, and the bioactive glass component in the toothpaste is reduced continuously during the storage period due to the easy reaction of the bioactive glass and water.
The water plays an important role in the toothpaste, and has a great influence on the foaming property, the stringiness, the cleaning value, the pH value, the rheological property, the mouthfeel and the like of the toothpaste besides the stability of the toothpaste is increased by combining with the hydrophilic colloid.
To reduce the effect of water on the degradation of the active glass, toothpaste containing bioactive glass can be prepared in an anhydrous formulation, i.e., using materials such as glycerin, oligoethylene glycol, etc. as the base. The toothpaste can reduce the attenuation of bioactive glass components during storage, but has poor stability, and can generate heat due to the fact that a water-free system absorbs saliva of the oral cavity when the toothpaste is used, so that the mouth feel is strange, water is provided only by the saliva, the reaction rate of the bioactive glass is low in limited tooth brushing time, so that the utilization rate is reduced, the quality of the toothpaste is reduced, the problem of coexistence of the two is effectively solved, the use amount of the bioactive glass can be reduced, the cost of the toothpaste is reduced, and the mouth feel of the toothpaste and the quality of the toothpaste in the aspects of ulcer healing, enamel remineralization, tubule blocking and gingival bleeding are improved.
Disclosure of Invention
The invention aims to provide a preparation method of water-containing bioactive glass toothpaste, which can enable water and bioactive glass to coexist and effectively reduce the using amount of the bioactive glass, thereby reducing the cost of the toothpaste, improving the mouthfeel of the toothpaste and reducing gingival bleeding during ulcer healing, enamel remineralization, tubule blockage and gingival bleeding.
In order to achieve the purpose, the invention adopts the technical scheme that:
1) the surfactant-stabilized water-in-oil emulsion is prepared as follows:
at 30-80 ℃ and according to the weight ratio of 0.1: 100-5: 100, adding a surfactant for medical treatment and oral care into all natural oil and fat from plant sources, animal sources or mineral sources for oral treatment or toothpaste preparation or synthetic oil and fat processed by petrochemical products and natural extraction raw materials, and uniformly stirring to obtain an oil phase;
mixing water and oil phase according to the weight ratio of 0.5: 9.5-1.5: mixing and heating to 30-80 ℃ in a volume ratio of 0.5, and stirring for 0.5-120 minutes by a high-speed dispersion machine at 10-24000 r/m to prepare water-in-oil emulsion;
2) the preparation method of the toothpaste containing the bioactive glass and the water simultaneously comprises the following steps:
adding a surfactant for medical treatment and oral care into a bioactive glass toothpaste matrix, uniformly mixing to obtain a mixture, then adding a water-in-oil emulsion into the mixture at the temperature of 30-80 ℃, and stirring for 0.5-120 minutes at 10-24000 r/min by a high-speed dispersion machine to prepare the toothpaste simultaneously containing water and bioactive glass, wherein the mass ratio of the surfactant for medical treatment and oral care to the bioactive glass toothpaste matrix is 0.1: 100-5: 100, water-in-oil emulsion and toothpaste base containing surfactant for medical and oral care in a volume ratio of 0.5: 9.5-1.5: 0.5.
the surfactant used in the medical treatment and oral care in the step 1) is one of or a mixture of at least two of sucrose fatty acid ester, Span60, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate, calcium stearoyl lactylate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene sorbitan monostearate, hydrogenated rosin glyceride, diacetyl tartaric acid mono-di-glyceride, propylene glycol fatty acid ester, diglycerol monostearate, monoglyceride, triglycerol, propylene glycol fatty acid ester, soybean lecithin, a glucose nonionic surfactant, a polyoxyethylene hydrogenated oil castor nonionic surfactant, sodium lauryl sarcosinate, sodium lauryl glutamate and monoglycerol laurate monoglyceride.
The oil is one or a mixture of at least two of rapeseed oil, peanut oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, sunflower seed oil, soybean oil, sesame oil, linseed oil, grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine, lard, beef tallow, mutton fat, fish oil, frog oil, snake oil, silicone oil, straight-chain alkanes, lipids and alcohol which is not mutually soluble with water.
The surfactant used in the medical treatment and oral care in the step 2) is one or a mixture of at least two of sodium dodecyl sulfate, sodium caseinate, sesbania gum, Tween60, Tween80, sodium lauryl sulfate, sodium lauryl sarcosinate and sodium lauryl glutamate.
Compared with the prior art, the invention has the following advantages:
the invention prepares the toothpaste with a water-in-oil-in-toothpaste matrix structure and stable surface active agent by adding the water-in-oil emulsion with stable surface active agent. The toothpaste contains bioactive glass and water, and the water and bioactive glass in the toothpaste are separated by oil before use, so that the water and bioactive glass can exist stably at the same time. When the toothpaste is used, the water-in-oil emulsion in the toothpaste matrix with the stable surfactant is broken under the action of friction, extrusion and the like, and the water wrapped in the water-in-oil emulsion is released, so that the mouthfeel of the toothpaste during use can be improved, and the reaction rate of bioactive glass in the toothpaste can be increased.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
1) Preparation of Water-in-oil emulsions
0.1 g of sucrose fatty acid ester is added into 100 g of rapeseed oil, heated to 30 ℃ and stirred uniformly to obtain an oil phase. Then, 0.5 ml of water and 9.5 ml of rapeseed oil containing sucrose fatty acid ester were heated to 80 ℃ and mixed, and stirred for 120 minutes at 10 rpm with a high-speed disperser to obtain a water-in-oil emulsion.
2) Preparation of toothpaste containing bioactive glass and water
0.5 grams of water-in-oil emulsion and 9.5 grams of a bioactive glass toothpaste base containing sodium lauryl sulfate were mixed by heating to 30 c and dispersed with a high speed disperser at 24000 rpm for 0.5 minutes to give a finished toothpaste.
The mouthfeel of the toothpaste is better than that of anhydrous toothpaste containing the same amount of bioactive glass when the toothpaste is used, the extrusion pressure of the toothpaste is reduced by 30%, the viscosity value of the toothpaste is reduced by 10 times, the stability is better when the toothpaste is examined at 48 ℃ in 3 months, and the remineralization rate of enamel is increased by 6.1 times.
Example 2
This example is the same as example 1, except that: the surfactant used for preparing the water-in-oil emulsion in the step (1) is all surfactants which can be used for oral cleaning and nursing products except sucrose fatty acid ester, and comprises, but is not limited to, Span60, Span65, glycerol stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate, calcium stearoyl lactylate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene sorbitan monostearate, hydrogenated rosin glyceride, diacetyl tartaric acid ester, diglyceride, propylene glycol fatty acid ester, diglycerol monostearate, monoglyceride, triglycerin, propylene glycol fatty acid ester, soybean lecithin, sodium lauryl sulfate, glucoside nonionic surfactant, polyoxyethylene hydrogenated castor oil nonionic surfactant, amino acid surfactant (sodium lauryl sarcosinate), and the like, Sodium lauryl glutamate), lauric acid monoglyceride, or sucrose fatty acid ester, Span60, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearyl lactate, calcium stearyl lactate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene sorbitan monostearate, hydrogenated rosin glycerin ester, diacetyl tartaric acid ester, diglyceride, propylene glycol fatty acid ester, diglyceride monostearate, monoglyceride, triglycerol ester, propylene glycol fatty acid ester, soybean phospholipid, sodium lauryl sulfate, glucoside type nonionic surfactant, polyoxyethylene hydrogenated castor oil type nonionic surfactant, amino acid type surfactant (sodium lauryl sarcosinate and sodium lauryl glutamate) and lauric acid monoglyceride; the surfactant used for preparing the toothpaste in the step (2) is a surfactant which can be used for medical treatment and oral care, and comprises or a mixture of at least two of sodium dodecyl sulfate, sodium caseinate, sesbania gum, Tween60, Tween80, sodium lauryl sulfate, sodium lauryl sarcosinate and sodium lauryl glutamate; the oil is less polar substance for oral care, and includes but is not limited to peanut oil, oleum Sesami, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (oleum Sesami), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, butter, mutton fat, all fish oil, frog oil, snake oil, silicone oil, straight chain alkanes, lipids, and water-immiscible alcohols, or rapeseed oil, peanut oil, sesame oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (oleum Sesami), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, beef tallow, mutton fat, all fish oil, frog oil, snake oil, silicone oil, etc, A mixed oil of at least two of straight-chain hydrocarbons, lipids, and water-immiscible alcohols.
When the toothpaste is used, the mouthfeel is better than that of anhydrous toothpaste containing the same amount of bioactive glass, the extrusion pressure of the toothpaste is reduced by 20-40%, but the strip property is better; the viscosity value of the toothpaste is reduced by 10-30 times, the dispersion performance of the toothpaste in the oral cavity is increased by more than 5 times, and the remineralization rate of enamel is increased by more than 4 times.
Example 3
1) A water-in-oil emulsion is prepared.
0.5 g of Span60 is added to 10 g of peanut oil, heated to 80 ℃ and stirred uniformly to obtain an oil phase. Then 1.5 ml of water and 1 ml of peanut oil containing Span60 were heated to 30 ℃ and mixed, and stirred with a high speed disperser at 24000 rpm for 0.5 minute to obtain a water-in-oil emulsion.
2) Toothpaste is prepared containing bioactive glass and water.
Adding 0.5 g sodium caseinate to 15 g of a non-aqueous bioactive glass toothpaste base to obtain a bioactive glass toothpaste base containing sodium caseinate. 4 g of water-in-oil emulsion and 20 g of a bioactive glass toothpaste base containing sodium caseinate were mixed by heating to 80 ℃ and stirred for 120 minutes at 10 rpm with a high speed disperser to obtain a finished toothpaste.
This example gives a better mouthfeel in use than an anhydrous toothpaste containing the same amount of bioactive glass, and the rate of enamel remineralization is increased by 3.2 times.
Example 4
This example is the same as example 3, with the following differences: the surfactant used in step (1) is any surfactant which can be used for oral care, except the surfactant used in example 3, including but not limited to sucrose fatty acid ester, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate, calcium stearoyl lactylate, glyceryl rosinate, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene xylitol monostearate, hydrogenated glyceryl rosinate, diacetyl tartaric acid ester, diglyceride, propylene glycol fatty acid ester, diglycerin monostearate, monoglyceride, triglyceride, propylene glycol fatty acid ester, soybean lecithin, sodium lauryl sulfate, glucoside nonionic surfactant, polyoxyethylene hydrogenated castor oil nonionic surfactant, amino acid surfactants (sodium lauryl sarcosinate, sodium lauryl sulfate, sorbitan monopalmitate, sodium stearyl lactylate, glyceryl monostearate, and the like, Sodium lauryl glutamate), lauric acid monoglyceride, or sucrose fatty acid ester, Span60, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearyl lactate, calcium stearyl lactate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene sorbitan monostearate, hydrogenated rosin glycerin ester, diacetyl tartaric acid ester of mono-and diglycerides, propylene glycol fatty acid ester, diglycerin monostearate, monoglyceride, triglycerol ester, propylene glycol fatty acid ester, soybean lecithin, sodium lauryl sulfate, glucoside type nonionic surfactant, polyoxyethylene hydrogenated castor oil type nonionic surfactant, amino acid type surfactant (sodium lauryl sarcosinate and sodium lauryl glutamate) and lauric acid monoglyceride; the oil is any nonpolar substance used for oral care including, but not limited to, rapeseed oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (linseed oil), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, beef tallow, mutton fat, all fish oils, frog oil, snake oil, silicone oil, straight chain alkanes, lipids, alcohols immiscible with water, or rapeseed oil, peanut oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (linseed oil), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, beef tallow, mutton fat, all fish oils, frog oil, snake oil, silicone oil, A mixed oil of at least two of straight-chain hydrocarbons, lipids and water-immiscible alcohols.
The mouth feel of the use of this example is better than that of anhydrous toothpaste containing the same amount of bioactive glass, and the rate of enamel remineralization is increased by more than 3.3 times.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and all simple modifications, changes and equivalent structural changes made to the above embodiment according to the technical spirit of the present invention still fall within the protection scope of the technical solution of the present invention.
Claims (4)
1. A method for preparing an aqueous bioactive glass toothpaste, characterized by comprising the steps of:
1) the surfactant-stabilized water-in-oil emulsion is prepared as follows:
at 30-80 ℃ and according to the weight ratio of 0.1: 100-5: 100, adding a surfactant for medical treatment and oral care into all natural oil and fat of plant sources, animal sources or mineral sources for oral treatment or toothpaste preparation or synthetic oil and fat processed by petrochemical products and natural extraction raw materials, and uniformly stirring to obtain an oil phase;
mixing water and oil phase according to the weight ratio of 0.5: 9.5-1.5: 0.5, heating to 30-80 ℃, and stirring for 0.5-120 minutes at 10-24000 r/min by a high-speed dispersion machine to prepare water-in-oil emulsion;
2) the preparation method of the toothpaste containing the bioactive glass and the water simultaneously comprises the following steps:
adding a surfactant for medical treatment and oral care into a bioactive glass toothpaste matrix, uniformly mixing to obtain a mixture, then adding a water-in-oil emulsion into the mixture at the temperature of 30-80 ℃, and stirring for 0.5-120 minutes at 10-24000 r/min by a high-speed dispersion machine to prepare the toothpaste simultaneously containing water and bioactive glass, wherein the mass ratio of the surfactant for medical treatment and oral care to the bioactive glass toothpaste matrix is 0.1: 100-5: 100, water-in-oil emulsion and toothpaste base containing surfactant for medical and oral care in a volume ratio of 0.5: 9.5-1.5: 0.5.
2. the method of preparing an aqueous bioactive glass toothpaste according to claim 1, wherein: the surfactant used in the medical treatment and oral care in the step 1) is one of sucrose fatty acid ester, Span60, Span65, glyceryl stearate, sorbitan monostearate, sorbitan monopalmitate, sodium stearoyl lactylate, calcium stearoyl lactylate, rosin glyceride, sucrose acetate, sucrose isobutyrate, Span80, polyoxyethylene sorbitan monostearate, hydrogenated rosin glyceride, diacetyl tartaric acid monoglyceride, diglycerol monostearate, triglycerol, propylene glycol fatty acid ester, soybean lecithin, glucoside nonionic surfactant, polyoxyethylene hydrogenated castor oil nonionic surfactant, sodium lauryl sarcosinate, sodium lauryl glutamate and monolaurin or a mixed surfactant of at least two of the surfactants.
3. The method of making an aqueous bioactive glass toothpaste according to claim 1, wherein: the oil is one or a mixture of at least two of rapeseed oil, peanut oil, hemp oil, corn oil, olive oil, camellia oil, palm oil, sunflower seed oil, soybean oil, sesame oil, linseed oil, grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine, lard, beef tallow, mutton fat, fish oil, frog oil, snake oil and organic silicone oil.
4. The method of preparing an aqueous bioactive glass toothpaste according to claim 1, wherein: the surfactant used in the medical treatment and oral care in the step 2) is one or a mixture of at least two of sodium dodecyl sulfate, sodium caseinate, sesbania gum, Tween60, Tween80, sodium lauryl sarcosinate and sodium lauryl glutamate.
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| CN112043622A (en) * | 2020-09-22 | 2020-12-08 | 上海绿瑞生物科技有限公司 | Repairing and whitening toothpaste containing enzyme preparation and bioglass and preparation method thereof |
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| US9724542B2 (en) * | 2012-10-12 | 2017-08-08 | Premier Dental Products Company | Remineralizing and desensitizing compositions, treatments and methods of manufacture |
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| GB1488859A (en) * | 1973-11-13 | 1977-10-12 | Procter & Gamble | Compositions for remineralizing tooth enamel |
| GB9005384D0 (en) * | 1990-03-09 | 1990-05-02 | Boots Co Plc | Cosmetic formulation |
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| CN103209671A (en) * | 2010-08-12 | 2013-07-17 | 荷兰联合利华有限公司 | Oral care compositions |
| CN104411290A (en) * | 2012-06-21 | 2015-03-11 | 宝洁公司 | Mouth rinse emulsions |
| CN107428880A (en) * | 2014-12-17 | 2017-12-01 | 路博润先进材料公司 | Surfactant response emulsion polymerization microgel |
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