CN111265413B - Preparation method of toothpaste containing water and bioactive glass components - Google Patents
Preparation method of toothpaste containing water and bioactive glass components Download PDFInfo
- Publication number
- CN111265413B CN111265413B CN202010089791.5A CN202010089791A CN111265413B CN 111265413 B CN111265413 B CN 111265413B CN 202010089791 A CN202010089791 A CN 202010089791A CN 111265413 B CN111265413 B CN 111265413B
- Authority
- CN
- China
- Prior art keywords
- oil
- water
- toothpaste
- mixture
- bioactive glass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8111—Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
A method for preparing toothpaste containing water and bioactive glass components comprises adding water-in-oil emulsion with stable solid particles to obtain toothpaste containing water and bioactive glass components. Since the water and bioactive glass in the toothpaste are separated by the oil prior to use, both are present at the same time. When the toothpaste is used, the water-in-oil emulsion in the toothpaste matrix with stable solid particles is broken under the actions of friction, extrusion and the like, so that the water wrapped in the water-in-oil emulsion is released, the water quantity in the oral cavity is increased, the mouthfeel of the toothpaste during use can be improved, and the reaction rate of bioactive glass in the toothpaste can be increased.
Description
Technical Field
The invention belongs to the field of daily chemical products and hard oral tissue medical care, nursing and cleaning products, and particularly relates to a preparation method of toothpaste which contains water and bioactive glass components and is used for medical care and oral cleaning and nursing.
Background
The bioactive glass is made of SiO 2 、Na 2 O, caO and P 2 O 5 And the like. After the bioactive glass is implanted into human body, its surface composition and structure can be changed with time to form a bioactive hydroxyapatite carbonate layer, and can provide bonding interface for bone and soft tissue restoration and growth, and can be used for bone replacement, repair and regeneration, and has no cell damage, no degradation product and no infectionAnd (4) risks.
The bioactive glass is added into toothpaste, and has effects of promoting healing of oral ulcer wound, sealing dentinal tubule, and eliminating dentin anaphylaxis. The bioactive glass is added directly into the water-containing toothpaste, and the bioactive glass component in the toothpaste is reduced continuously during the storage period due to the easy reaction of the bioactive glass and water.
The water plays an important role in the toothpaste, and has a great influence on the foaming property, the strip property, the cleaning value, the pH value, the rheological property, the mouthfeel and the like of the toothpaste besides the stability of the toothpaste is increased by combining with the hydrophilic colloid.
In order to reduce the effect of water on the degradation of bioactive glass, toothpaste containing bioactive glass can be prepared in an anhydrous formulation, i.e., using materials such as glycerin, polyethylene glycol, etc. as a base. The toothpaste can reduce the attenuation of bioactive glass components during storage, but because the toothpaste contains no moisture, the stability is poor, the mouthfeel is poor, the pH value fluctuates when the toothpaste is used, and the water is provided only by saliva, the reaction rate of the bioactive glass is low in limited tooth brushing time, so that the utilization rate of the bioactive glass and the quality of the toothpaste are directly reduced.
Disclosure of Invention
The invention aims to provide a preparation method of toothpaste containing water and bioactive glass components, which can increase the water amount in the oral cavity, improve the mouthfeel of the toothpaste when in use and improve the reaction rate of bioactive glass in the toothpaste.
In order to achieve the purpose, the invention adopts the technical scheme that:
1) The preparation method of the water-in-oil emulsion with stable solid particles comprises the following steps:
mixing organic and inorganic micro-nano particles or solid particles of a mixture thereof for preparing the solid stable emulsion according to the weight ratio of 0.1-25: 100, adding the mixture into natural oil of all plant sources, animal sources or mineral sources for oral treatment or preparation of toothpaste, or synthetic oil processed by petrochemical products and natural extraction raw materials, heating to 30-80 ℃, and uniformly stirring to form an oil phase;
mixing water and oil phase at 30-80 deg.c in the ratio of 0.5: 9.5-1.5: mixing the materials according to the volume ratio of 0.5, and stirring the mixture for 0.5 to 120 minutes by a high-speed dispersion machine at 10 to 24000 revolutions per minute to prepare water-in-oil emulsion;
2) The preparation method of the toothpaste containing the bioactive glass and the water simultaneously comprises the following steps:
according to the proportion of 0.1:100 to 25: adding solid particles of organic and inorganic micro-nano particles or a mixture thereof for preparing solid stable emulsion into a non-aqueous bioactive glass toothpaste matrix according to a mass ratio of 100, uniformly mixing to obtain a mixture, and mixing the mixture with a mixture according to a weight ratio of water-in-oil emulsion to 0.5: 9.5-1.5: 0.5, adding the water-in-oil emulsion into the mixture, heating to 30-80 ℃, and dispersing for 0.5-120 minutes on a high-speed dispersion machine at 10-24000 r/m to obtain the toothpaste containing water and bioactive glass components.
The solid particles of the organic and inorganic micro-nano particles or the mixture thereof used for preparing the solid stable emulsion in the step 1 and 2) are one or a mixture of at least two of silicon dioxide, aluminum oxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, hydrotalcite, mica, attapulgite, zeolite, polyethylene, polystyrene, polyacrylic resin, natural plant powder and surface-modified natural plant powder, cellulose and functional group amphiphilic derivatives thereof;
the solid particles are one or a mixture of at least two of silicon dioxide, aluminum oxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, hydrotalcite, mica, attapulgite and zeolite which are modified by a silane coupling agent, a titanate coupling agent and a surfactant;
the surfactant used for modifying the solid particles refers to amphipathy substances which can be used for oral cleaning and nursing products and a composition of the amphipathy substances in any proportion, and comprises one or a mixture of at least two of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate, glucan glycoside type nonionic surfactant and betaine.
The natural oil from all plant sources, animal sources or mineral sources for oral treatment or preparation of the toothpaste or the synthetic oil processed by petrochemical products and natural extraction raw materials is one or a mixture of at least two of rapeseed oil, peanut oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil, grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard oil, beef tallow, mutton fat, fish oil, frog oil, snake oil, silicone oil, straight-chain alkanes, lipids and water-immiscible alcohols.
Compared with the prior art, the invention has the following advantages:
the invention prepares toothpaste containing water and bioactive glass simultaneously by adding water-in-oil emulsion with stable solid particles. Since the water and bioactive glass in the toothpaste are separated by the oil prior to use, both are present at the same time. When the toothpaste is used, the water-in-oil emulsion in the toothpaste matrix with stable solid particles is broken under the actions of friction, extrusion and the like, so that the water wrapped in the water-in-oil emulsion is released, the water quantity in the oral cavity is increased, the mouthfeel of the toothpaste during use can be improved, and the reaction rate of bioactive glass in the toothpaste can be increased.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
1) Preparation of solid particle-stabilized Water-in-oil emulsion
Adding 0.1 g of silicon dioxide into 100 g of rapeseed oil, heating to 30 ℃, and uniformly stirring to obtain an oil phase. Then 0.5 ml of water and 9.5 ml of rapeseed oil containing silica were heated to 80 ℃ and mixed, and stirred for 120 minutes at 10 rpm with a high speed disperser to obtain a water-in-oil emulsion.
2) Preparation of toothpaste containing bioactive glass and water
1 gram of silica was added to 10 grams of bioactive glass toothpaste base and mixed well. 0.5 g of water-in-oil emulsion and 9.5 g of bioactive glass toothpaste base containing solid particles were mixed by heating to 30 ℃ and dispersed with a high speed disperser at 24000 rpm for 0.5 minute to obtain a finished toothpaste.
When the toothpaste containing the bioactive glass is used, the mouthfeel is better than that of the toothpaste containing the bioactive glass with the same quality without water, the viscosity is reduced by 30 percent compared with that of anhydrous toothpaste, the fragrance sensing time and the foaming performance of the toothpaste are improved by 2 seconds, and the reaction rate of the bioactive glass is improved by 4.5 times.
Example 2
This example is the same as example 1, except that: the solid particles are all organic and inorganic particles which can be used in oral cleaning and nursing products except silica particles, and include but are not limited to aluminum oxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, hydrotalcite, mica, attapulgite, zeolite, polyethylene, polystyrene, polyacrylic resin, natural plant powder and surface modified natural plant powder, cellulose and one of functional group amphiphilic derivatives, or mixed particles of at least two of silica, aluminum trioxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, hydrotalcite, mica, zeolite, polyethylene, polystyrene, polyacrylic resin, natural plant powder and surface modified natural plant powder, cellulose and functional group amphiphilic derivatives, or mixed particles of at least two of silica, aluminum trioxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, mica and montmorillonite, or mixed particles of at least two of attapulgite, titanate coupling agent, zeolite, montmorillonite, zeolite, montmorillonite, attapulgite coupling agent modified by using a silane coupling agent, surface active agent; the surfactant used for modifying the solid particles is one of or a mixture of at least two of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate, dextran glycoside nonionic surfactant, betaine and the like; the oil is any less polar substance which can be used for oral care, and includes, but is not limited to peanut oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (linseed oil), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, butter, mutton fat, all fish oils, frog oil, snake oil, silicone oil, straight-chain alkanes, lipids, alcohols immiscible with water, or a mixed oil of at least two of rapeseed oil, peanut oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (linseed oil), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, tallow, mutton fat, all fish oils, frog oil, snake oil, silicone oil, straight-chain alkanes, lipids, alcohols immiscible with water.
When the toothpaste is used, the taste is better than that of the toothpaste which contains no water and contains the bioactive glass with the same quality, the viscosity is reduced by 20-200 percent compared with that of the anhydrous toothpaste, the fragrance sensing time and the foaming performance of the toothpaste are improved by 1-3 seconds, and the reaction rate of the bioactive glass is improved by more than 2.7 times.
Example 3
1) Preparation of solid particle-stabilized Water-in-oil emulsion
Adding 0.5 g of calcium carbonate into 2 g of sunflower seed oil, heating to 80 ℃, and uniformly stirring to obtain an oil phase. Then, 1.5 ml of water and 1 ml of sunflower seed oil containing calcium carbonate were heated to 30 ℃ and mixed, and stirred with a high speed disperser at 24000 rpm for 0.5 minute to obtain a water-in-oil emulsion.
2) Toothpaste is prepared containing bioactive glass and water.
0.5 g of calcium carbonate is added to 20 g of bioactive glass toothpaste base and mixed evenly to obtain the bioactive glass toothpaste base containing solid particles. 2 g of water-in-oil emulsion and 10 g of bioactive glass toothpaste base containing solid particles were mixed by heating to 80 ℃ and stirred with a high speed disperser at 24000 rpm for 0.5 minute to obtain a toothpaste containing both bioactive glass and water.
When the toothpaste containing the bioactive glass is used, the mouthfeel is better than that of the toothpaste containing the bioactive glass with the same quality without water, and the reaction rate of the bioactive glass is improved by 3.1 times.
Example 4
This example is the same as example 3, except that: the solid particles used are all solid particles useful for oral care except the particles used in example 3, including but not limited to silica, alumina, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomaceous earth, montmorillonite, hydrotalcite, mica, attapulgite, zeolite, polyethylene, polystyrene, polyacrylic resin, natural plant powder and surface-modified natural plant powder thereof, one of cellulose and functional group-amphiphilic derivatives thereof, and mixed particles thereof, or mixed particles of at least two of silica, alumina, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomaceous earth, montmorillonite, hydrotalcite, mica, attapulgite, zeolite, polyethylene, polystyrene, polyacrylic resin, natural plant powder and surface-modified natural plant powder thereof, cellulose and functional group-amphiphilic derivatives thereof, or mixed particles of at least two of silica, alumina, calcium carbonate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, hydrotalcite, magnesium hydroxide, hydrotalcite, and montmorillonite, and mixed particles of at least two of silica, alumina, calcium carbonate, calcium phosphate, calcium titanate, calcium hydroxide, magnesium hydroxide, zeolite, and montmorillonite, and mixed particles of at least two of montmorillonite; the surfactant used for modifying the solid particles is one of or a mixture of at least two of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate, dextran glycoside nonionic surfactant and betaine; the oil is a mixture of at least two of rapeseed oil, peanut oil, corn oil, olive oil, camellia oil, palm oil, soybean oil, sesame oil, linseed oil (linseed oil), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard, beef tallow, mutton fat, all fish oils, frog oil, snake oil, silicone oil, straight chain alkanes, lipids, alcohols immiscible with water, or rapeseed oil, peanut oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil (linseed oil), grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine, lard, beef tallow, mutton fat, all fish oils, frog oil, snake oil, silicone oil, straight chain alkanes, lipids, alcohols immiscible with water.
When the toothpaste containing the bioactive glass is used, the mouthfeel is better than that of the toothpaste containing the bioactive glass with the same quality without water, and the reaction rate of the bioactive glass is improved by more than 4.8 times.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and all simple modifications, changes and equivalent structural changes made to the above embodiment according to the technical spirit of the present invention still fall within the protection scope of the technical solution of the present invention.
Claims (3)
1. A method for preparing toothpaste containing water and bioactive glass components simultaneously is characterized by comprising the following steps:
1) The preparation method of the water-in-oil emulsion with stable solid particles comprises the following steps:
mixing organic or inorganic micro-nano particles or solid particles of a mixture thereof for preparing a solid stable emulsion according to the weight ratio of 0.1-25: 100, adding the mixture into natural oil of plant origin, animal origin or mineral origin for oral treatment or preparation of toothpaste, or synthetic oil processed by petrochemical products and natural extraction raw materials, heating to 30-80 ℃, and uniformly stirring to form an oil phase;
mixing water and oil phase at 30-80 deg.c in the weight ratio of 0.5: 9.5-1.5: mixing the materials according to the volume ratio of 0.5, and stirring the mixture for 0.5 to 120 minutes by a high-speed dispersion machine at 10 to 24000 revolutions per minute to prepare water-in-oil emulsion;
the natural oil from plant sources or animal sources or mineral sources for oral treatment or toothpaste preparation or the synthetic oil processed by petrochemical products and natural extraction raw materials is one or a mixture of at least two of rapeseed oil, peanut oil, corn oil, olive oil, camellia oil, palm oil, sunflower oil, soybean oil, sesame oil, linseed oil, grape seed oil, walnut oil, peony seed oil, coconut oil, edible paraffin, turpentine oil, lard oil, beef tallow, mutton fat, fish oil, frog oil, snake oil and silicone oil;
2) The preparation method of the toothpaste containing the bioactive glass and the water simultaneously comprises the following steps:
according to the weight ratio of 0.1:100 to 25: adding solid particles of organic or inorganic micro-nano particles or a mixture thereof for preparing solid stable emulsion into a non-aqueous bioactive glass toothpaste matrix according to a mass ratio of 100, uniformly mixing to obtain a mixture, and mixing the mixture with a water-in-oil emulsion according to a ratio of 0.5: 9.5-1.5: 0.5, adding the water-in-oil emulsion into the mixture, heating to 30-80 ℃, and dispersing for 0.5-120 minutes on a high-speed dispersion machine at 10-24000 r/m to obtain the toothpaste containing water and bioactive glass components;
the solid particles of the organic or inorganic micro-nano particles or the mixture thereof used for preparing the solid stable emulsion in the step 1 and the step 2) are one or a mixture of at least two of silicon dioxide, aluminum oxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, hydrotalcite, mica, attapulgite, zeolite, polyethylene, polystyrene, polyacrylic resin, natural plant powder and surface-modified natural plant powder, cellulose and functional group amphiphilic derivatives thereof.
2. The method of claim 1, wherein the toothpaste comprises water and bioactive glass, and further comprises: the solid particles are one or a mixture of at least two of silicon dioxide or aluminum oxide, calcium carbonate, calcium silicate, calcium phosphate, hydroxyapatite, zinc oxide, titanium dioxide, magnesium carbonate, magnesium hydroxide, diatomite, montmorillonite, hydrotalcite, mica, attapulgite and zeolite which are modified by a silane coupling agent or a titanate coupling agent or a surfactant.
3. The method of claim 2 wherein the toothpaste contains water and bioactive glass components together, wherein the method comprises the steps of: the surfactant for modifying solid particles refers to an amphiphilic substance which can be used in oral cleaning and nursing products and a composition thereof in any proportion, and comprises one or a mixture of at least two of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, glucan glycoside type nonionic surfactant and betaine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010089791.5A CN111265413B (en) | 2020-02-13 | 2020-02-13 | Preparation method of toothpaste containing water and bioactive glass components |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010089791.5A CN111265413B (en) | 2020-02-13 | 2020-02-13 | Preparation method of toothpaste containing water and bioactive glass components |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111265413A CN111265413A (en) | 2020-06-12 |
| CN111265413B true CN111265413B (en) | 2022-11-29 |
Family
ID=70991052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010089791.5A Active CN111265413B (en) | 2020-02-13 | 2020-02-13 | Preparation method of toothpaste containing water and bioactive glass components |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111265413B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114917169B (en) * | 2022-05-24 | 2023-09-29 | 佛山嘿黑科技有限公司 | Toothpaste containing zinc-rich brown rice fermentation liquor and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1488859A (en) * | 1973-11-13 | 1977-10-12 | Procter & Gamble | Compositions for remineralizing tooth enamel |
| CN1192673A (en) * | 1995-08-08 | 1998-09-09 | 埃纳梅隆公司 | Composition and method for remineralization of teeth |
| US5817296A (en) * | 1996-09-27 | 1998-10-06 | Enamelon, Inc. | Processes and compositions for the remineralization of teeth |
| CN101811014A (en) * | 2010-04-01 | 2010-08-25 | 西安科技大学 | Method for preparing microcapsule |
| CN103120623A (en) * | 2012-12-01 | 2013-05-29 | 云南白药集团股份有限公司 | Dentin sensitivity preventing oral hygiene nursing preparation |
| CN106511105A (en) * | 2017-01-10 | 2017-03-22 | 杭州皎洁口腔保健用品有限公司 | Anhydrous toothpaste repairing demineralized enamel and dentin and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9724542B2 (en) * | 2012-10-12 | 2017-08-08 | Premier Dental Products Company | Remineralizing and desensitizing compositions, treatments and methods of manufacture |
-
2020
- 2020-02-13 CN CN202010089791.5A patent/CN111265413B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1488859A (en) * | 1973-11-13 | 1977-10-12 | Procter & Gamble | Compositions for remineralizing tooth enamel |
| CN1192673A (en) * | 1995-08-08 | 1998-09-09 | 埃纳梅隆公司 | Composition and method for remineralization of teeth |
| US5817296A (en) * | 1996-09-27 | 1998-10-06 | Enamelon, Inc. | Processes and compositions for the remineralization of teeth |
| CN101811014A (en) * | 2010-04-01 | 2010-08-25 | 西安科技大学 | Method for preparing microcapsule |
| CN103120623A (en) * | 2012-12-01 | 2013-05-29 | 云南白药集团股份有限公司 | Dentin sensitivity preventing oral hygiene nursing preparation |
| CN106511105A (en) * | 2017-01-10 | 2017-03-22 | 杭州皎洁口腔保健用品有限公司 | Anhydrous toothpaste repairing demineralized enamel and dentin and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111265413A (en) | 2020-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111110576B (en) | Preparation method of dental enamel regeneration composition | |
| CA2388342C (en) | Composition for restoring defects in calcified tissues | |
| EP2648692B1 (en) | Cleansing composition | |
| US20100303737A1 (en) | Tooth-Cleaning Formulation | |
| JPH0272112A (en) | Toothpaste composition having stripes | |
| CN102885698B (en) | A kind of ultra micro hydrocolloid powder possessing core, shell structure and its production and use | |
| CN111265413B (en) | Preparation method of toothpaste containing water and bioactive glass components | |
| CN107049798A (en) | It is a kind of to be used to treat desensitizer of dental hypersensitiveness and preparation method thereof | |
| JP5689674B2 (en) | Process for producing dentifrice granules | |
| CN106074311A (en) | A kind of toothpaste that can use as collutory and preparation method thereof | |
| CN1558749A (en) | Oral composition for treating sensitive teeth | |
| CN111281817B (en) | Preparation method of water-containing bioactive glass toothpaste | |
| CN106265105A (en) | A kind of toothpaste adding kieselguhr and extract from pine needles and preparation method thereof | |
| KR20140130830A (en) | Cleansing agent composition including natural compounds and method for manufacturing the same | |
| KR100359154B1 (en) | Method of producing a soap for antibiosis and beauty utilizing liquefied bio-ceramics | |
| CN111249165B (en) | Lipophilic colloid stable water-in-oil emulsion and preparation method of product for repairing tooth enamel by using same | |
| JPWO2005000251A1 (en) | Remineralization accelerator, oral composition | |
| CN110613635A (en) | Hand cream containing passion fruit essential oil and preparation method | |
| KR20170033991A (en) | Cosmetic capsulized with high content oil and method for manufacturing the same | |
| JPH09291015A (en) | Cosmetic composition | |
| CN114681341B (en) | Stable toothpaste capable of removing stains, whitening skin and reducing gingivitis and preparation method thereof | |
| RU2785167C1 (en) | Medical-preventive toothpaste based on glauconite powder | |
| WO2022132690A1 (en) | Composition and method for treatment of insect bites | |
| CN102488637A (en) | Environment-friendly and carrier-free food-grade cosmetic membrane | |
| CN1803190A (en) | Immune and antiallergic oral product containing IgY and potassium salt, strontium salt added composition, and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |