CN111281370B - Gradiometer configuration type magnetoencephalography system based on SERF atomic magnetometer - Google Patents
Gradiometer configuration type magnetoencephalography system based on SERF atomic magnetometer Download PDFInfo
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- CN111281370B CN111281370B CN202010103353.XA CN202010103353A CN111281370B CN 111281370 B CN111281370 B CN 111281370B CN 202010103353 A CN202010103353 A CN 202010103353A CN 111281370 B CN111281370 B CN 111281370B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
- A61B5/245—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
- A61B5/246—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals using evoked responses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
- G01R33/032—Measuring direction or magnitude of magnetic fields or magnetic flux using magneto-optic devices, e.g. Faraday or Cotton-Mouton effect
Abstract
The invention relates to a gradiometer configuration type magnetoencephalography system based on a SERF atomic magnetometer, which comprises: the magnetic shielding room, the brain magnetic measurement cap suitable for the configuration mode of the gradiometer, the SERF atomic magnetometer sensor array, the SERF atomic magnetometer reference sensor array, the brain magnetic induction stimulation system and the data acquisition and processing system. Compared with the traditional SQUID (superconducting quantum interferometer) magnetoencephalography system with high price, high operation cost, large volume and heavy structure, the magnetoencephalography system based on the SERF atomic magnetometer has flexible structure and negligible operation cost, and can realize magnetoencephalography which is the same as the SQUID. And secondly, compared with other magnetoencephalography systems which only use the SERF atomic magnetometer to measure the magnetic field in a single direction, the gradiometer configuration type magnetoencephalography measurement system based on the SERF atomic magnetometer can more effectively counteract the environmental magnetic field noise and improve the signal-to-noise ratio.
Description
Technical Field
The invention relates to the field of biomedical instruments, in particular to a device system for gradient type magnetoencephalography by adopting an atomic magnetometer, such as a Spin-Exchange Relaxation-Free (SERF) atomic magnetometer.
Background
The magnetoencephalogram has higher time resolution and spatial resolution, so that the magnetoencephalogram has important application value in clinical and brain science research. The magnetoencephalogram technology based on the superconducting quantum interference device (SQUID) is developed well, but the magnetoencephalogram is limited in wide application due to the defects of high price, high maintenance and operation cost, heavy structure and the like.
Nowadays, SERF magnetometers have achieved sensitivity comparable to SQUID devices, and therefore magnetoencephalography systems based on SERF magnetometers are evolving. The brain magnetic map system based on the SERF magnetometer can arrange the SERF magnetometer at each position of the brain at will according to the requirements, can customize brain magnetic caps and the like with different sizes according to the 3D printing technology, is more flexible in application, has lower cost compared with the SQUID brain magnetic map system, and is expected to replace the SQUID brain magnetic map instrument.
At present, the magnetoencephalography system based on the SERF magnetometer uses the magnetometer to be directly inserted into a probe slot on a magnetoencephalography helmet for magnetoencephalography measurement. Because the magnetoencephalography signal is weak, the influence of the environmental magnetic field on magnetoencephalography is large, the single use of the SERF atomic magnetometer for magnetoencephalography can not effectively reduce noise interference, and the signal-to-noise ratio is low. The gradiometer configuration type magnetoencephalography measurement system based on the SERF magnetometer can effectively reduce the interference of an environmental magnetic field, and is the development direction of a magnetoencephalography device system of the SERF magnetometer.
Disclosure of Invention
The invention solves the problems: aiming at the defects of the existing brain magnetic measurement system based on the SERF magnetometer, the gradiometer configuration type brain magnetic measurement system based on the SERF atomic magnetometer is provided, compared with a SQUID brain magnetic measurement system, the brain magnetic measurement equivalent to the SQUID can be realized, and the operation and maintenance cost is low; compared with other magnetoencephalography systems which only use a SERF atomic magnetometer to measure a magnetic field in a single direction, the magnetoencephalography system can more effectively offset the environmental magnetic field noise and improve the signal-to-noise ratio.
The technical scheme of the invention is as follows:
a gradiometer configuration type magnetoencephalometry system structure based on a SERF atomic magnetometer comprises: the magnetic shielding room, the brain magnetic measurement cap suitable for the configuration mode of the gradiometer, the SERF atomic magnetometer sensor array, the SERF atomic magnetometer reference sensor array, the brain magnetic induction stimulation module and the data acquisition and processing module.
The SERF atomic magnetometer-based gradiometer configured magnetoencephalography measurements were performed in a magnetic shielded room. The head of a subject wears a gradiometer configuration helmet and receives auditory, visual or tactile related stimulation of a brain magnetic induction stimulation module, a SERF atomic magnetometer sensor array is inserted into a slot on the helmet, and a SERF atomic magnetometer reference sensor array is arranged above the SERF atomic magnetometer sensor array. Signals of the SERF atomic magnetometer reference sensor and the SERF atomic magnetometer sensor array are output to a data acquisition and processing module outside the shielding room for brain magnetic data processing.
1) Magnetic shielding room
The magnetic shielding room is used for shielding the magnetic field of the earth environment, so that the SERF atomic magnetometer can work in the zero magnetic environment. The magnetic shielding room is built on a vibration isolation foundation and is made of three layers of permalloy with ultrahigh magnetic conductivity, the permalloy is separated by an aluminum layer, and the high-frequency shielding of the earth environment magnetic field is formed according to the eddy current shielding principle. And collecting the magnetic field of the human brain in a shielding room.
2) Magnetoencephalography cap and SERF atomic magnetometer sensor array suitable for gradiometer configuration
The brain magnetic measuring cap extracts the outer contour of the head of a human according to an MRI image obtained by nuclear Magnetic Resonance (MRI) scanning of a subject, and expands 1cm outwards according to the actual outer contour of the head to form the surface of the helmet. The number of channels is distributed on the surface of the brain magnetic cap according to the size of a single SERF atomic magnetometer, the channels are in a slot shape, each channel comprises two slots, the single SERF atomic magnetometer is inserted into the slots during measurement, and each channel forms an SERF atomic magnetometer.
The SERF atomic magnetometer can simultaneously measure magnetic fields Bz and By in two directions, namely, the SERF atomic magnetometer has two sensitive axes, namely a Z 'axis and a Y' axis, wherein the Z 'axis is the axial direction of the SERF atomic magnetometer, and the Y' axis is the tangential direction of the bottom surface of the SERF atomic magnetometer. Each channel of the brain magnetic measuring cap comprises two SERF atomic magnetometers, the Z 'axes of the two SERF atomic magnetometers are overlapped and opposite in direction, the X' axes are parallel and opposite in direction, a gradiometer mode is formed, and a radial gradiometer and a tangential measuring radial gradiometer are formed. The distance between the centers of the two SERF atomic magnetometers is the base line b, and the base line is 2cm to 8 cm. And the two SERF atomic magnetometers of each channel form an SERF atomic magnetometer gradiometer, and the SERF atomic magnetometer gradiometers of all the channels form an SERF atomic magnetometer sensor array.
3) SERF atomic magnetometer reference sensor array
4 groups of reference sensor arrays are arranged on a panel above a seat in the magnetic shielding room, each group comprises 6 SERF atomic magnetometers, and a first-order gradiometer reference sensor array is formed. Each set of reference sensor array configurations is described as follows: in rectangular coordinate system O-XYZ, 6 SERF atomic magnetometers of each group are placed on plane XOY, wherein two SERF atomic magnetometers sensor1 and sensor2 are located on the X axis, the position coordinates are (a,0,0) and (-a,0,0), respectively, sensor1 measures the-X and Z axis magnetic fields, and sensor2 measures the X and Z axis magnetic fields. Two SERF atomic magnetometers sensor3 and sensor4 are located next to each other (0, b,0), sensor3 measures the-Y axis and the-X axis, and sensor4 measures the Z axis. Two other SERF atomic magnetometers sensor5 and sensor6 are located next to (0, -b,0), sensor5 measures the Y and X axes, and sensor6 measures the-Z axis. The 4 groups of reference sensor arrays are arranged at different positions on the reference array fixing panel in the same way, and the distance between the centers of the groups is 15-25 cm.
4) Brain magnetic induction stimulation module
The brain magnetic induction stimulation module is arranged in the magnetic shielding room and used for generating visual, auditory and somatosensory stimulation and outputting a path of synchronous trigger signal, and the synchronous trigger signal is output to the data acquisition and processing module outside the magnetic shielding room and used for synchronizing with the acquired brain magnetic.
5) Data acquisition and processing module
Output signals of the SERF atomic magnetometer and the SERF atomic magnetometer sensor array and synchronous trigger signals of the stimulation module are output to a data acquisition and processing module outside the magnetic shielding room for data processing related to magnetoencephalography.
Compared with other magnetoencephalography systems, the gradiometer configuration type magnetoencephalography system based on the SERF atomic magnetometer has the advantages that:
(1) the traditional SQUID measuring system has high price, high operation cost, large volume and heavy structure; the magnetoencephalography system based on the SERF atomic magnetometer has a flexible structure, the operation cost can be ignored, and the same magnetoencephalography can be realized.
(2) Compared with other magnetoencephalography systems which only use the SERF magnetometer to measure the magnetic field in a single direction, the gradiometer configuration type magnetoencephalography measurement system based on the SERF atomic magnetometer can more effectively counteract the environmental magnetic field noise and improve the signal-to-noise ratio.
Drawings
FIG. 1 is a system diagram of a SERF atomic magnetometer-based configured magnetocardiogram system according to the present invention;
in the figure: the system comprises a magnetic shielding room 1, a magnetoencephalography measuring cap 2 in a gradiometer configuration mode, an SERF atomic magnetometer sensor array 3, an SERF atomic magnetometer reference sensor array 4, a reference sensor fixing panel 5, a magnetoencephalography evoked stimulation module 6 and a data acquisition and processing module 7;
FIG. 2 is a magnetoencephalography cap and SERF atomic magnetometer sensor array with gradiometer configuration of the present invention; (a) the method is indicated by a sensitive axis of a single gradiometer SERF atomic magnetometer, and (b) is a front view and (c) is a left view;
fig. 3 is a SERF atomic magnetometer reference sensor array in accordance with the present invention: (a) a group of reference arrays, and (b) forming a SERF atomic magnetometer reference sensor array layout for four groups of reference arrays.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and examples.
As shown in fig. 1, the gradient meter configuration type magnetoencephalometry system based on the SERF atomic magnetometer of the present invention includes: the magnetic shielding room 1, a brain magnetic measurement cap 2 in a gradiometer configuration mode, an SERF atomic magnetometer sensor array 3, an SERF atomic magnetometer reference sensor array 4, a reference sensor fixing panel 5, a brain magnetic induction stimulation module 6 and a data acquisition and processing module 7.
The implementation process is concretely as follows: the SERF atomic magnetometer-based gradiometer configured magnetoencephalography measurements were performed in a magnetic shielded room. The head of a testee wears a brain magnetic measuring cap 2 suitable for a gradiometer configuration mode, and receives related stimulation such as auditory sensation, visual sensation or tactile sensation of a brain magnetic induction stimulation module 6, a SERF atomic magnetometer sensor array 3 is inserted into a clamping groove on a helmet, and a SERF atomic magnetometer reference sensor array 4 is arranged above the SERF atomic magnetometer sensor array 3. Signals of the SERF atomic magnetometer reference sensor array 4 and the SERF atomic magnetometer sensor array 3 are output to an electronic acquisition and data processing module outside the shielding room for data acquisition and brain magnetic data processing.
1) Magnetic shielding room 1
The magnetic shielding room 1 is used for shielding the earth environment magnetic field, so that the SERF atomic magnetometer can work in a zero magnetic environment. The magnetic shielding room is built on a vibration isolation foundation and is made of three layers of permalloy with ultrahigh magnetic conductivity, the permalloy is separated by an aluminum layer, and the high-frequency shielding of the earth environment magnetic field is formed according to the eddy current shielding principle. And collecting the magnetic field of the human brain in a shielding room.
2) Magnetoencephalography cap 2 and SERF atomic magnetometer sensor array 3 suitable for gradiometer configuration
As shown in fig. 2, the magnetoencephalometry cap 2 extracts the outer contour of the head of a human according to an Magnetic Resonance Imaging (MRI) image obtained by MRI scanning of the brain, and expands outward by 1cm according to the actual outer contour of the head to form the surface of the helmet. The number of channels is arranged on the basis of the surface of the helmet according to the size of the SERF atomic magnetometer, the channels are in a slot shape, and the channels are inserted into the slots during measurement of the SERF magnetometer.
The SERF atomic magnetometer can measure magnetic fields Bz and By in two directions simultaneously, that is, there are two sensitive axes, a Z 'axis and a Y' axis, where the Z 'axis is an axial direction of the SERF atomic magnetometer, and the Y' axis is a tangential direction of a bottom surface of the SERF atomic magnetometer, as shown in (a) of fig. 2. Each channel of the brain magnetic measuring cap comprises two SERF atomic magnetometers, the Z 'axes of the two SERF atomic magnetometers are overlapped and opposite in direction, the X' axes are parallel and opposite in direction, a gradiometer mode is formed, and a radial gradiometer and a tangential measuring radial gradiometer are formed. The distance between the centers of the two SERF atomic magnetometers is the base line b, and the base line is 2cm to 8 cm. The magnetometers of each channel are arranged in the manner described, forming a gradiometer sensor array 3.
3) SERF atomic magnetometer reference sensor array 4
On the above-seat panel in the magnetic shield room 1, 4 sets of reference sensor arrays each including 6 SERF atomic magnetometers were arranged, forming a first-order gradiometer reference sensor array, as shown in fig. 3 (a). Each set of reference sensor array configurations is described as follows: in rectangular coordinate system O-XYZ, 6 sensors of each group are placed on a plane XOY, where two SERF atomic magnetometers sensor1 and sensor2 are located on the X axis with position coordinates (a,0,0) and (-a,0,0), respectively, sensor1 measures the-X and Z axis magnetic fields and sensor2 measures the X and-Z axis magnetic fields. Two SERF atomic magnetometers sensor3 and sensor4 are located next to each other (0, b,0), sensor3 measures the-Y axis and the-X axis, and sensor4 measures the Z axis. Two other SERF atomic magnetometers sensor5 and sensor6 are located next to (0, -b,0), sensor5 measures the Y and X axes, and sensor6 measures the-Z axis.
The 4 groups of reference sensor arrays are arranged at different positions on the reference array fixing panel in the same way, and the distance between the centers of the groups is 15-25 cm, as shown in (b) of figure 3.
4) Brain magnetic induction stimulation module 5
The brain magnetic induction stimulation module is arranged in the magnetic shielding room and used for generating visual, auditory and somatosensory stimulation and outputting a path of synchronous trigger signal, and the synchronous trigger signal is output to the data acquisition and processing module outside the magnetic shielding room and used for synchronizing with the acquired brain magnetic.
5) Data acquisition and processing module 6
The output signals of the SERF atomic magnetometer gradiometer sensor array and the reference sensor array and the synchronous trigger signal of the stimulation module are output to a data acquisition and processing module 6 outside the magnetic shielding room for data processing related to magnetoencephalography.
Claims (5)
1. A gradiometer-deployed magnetoencephalometry system based on a SERF atomic magnetometer, comprising: the system comprises a magnetic shielding room, a magnetoencephalography measuring cap used for a gradiometer configuration mode, an SERF atomic magnetometer sensor array, an SERF atomic magnetometer reference sensor array, a magnetoencephalography evoked stimulation system module and a data acquisition and processing module;
the magnetic shielding room is made of three layers of permalloy, the permalloy is separated by an aluminum layer and used for shielding the earth magnetic field, and the configured magnetoencephalography measurement of a gradiometer based on an SERF atomic magnetometer is carried out in the magnetic shielding room;
the magnetoencephalography cap is used for placing a gradiometer-type SERF atomic magnetometer;
the SERF atomic magnetometer gradiometer sensor array is inserted into a configured magnetoencephalography cap for a gradiometer and is used for measuring magnetoencephalography signals, the SERF atomic magnetometer gradiometer sensor array is composed of a plurality of independent SERF atomic magnetometer gradiometers, and each SERF atomic magnetometer is composed of two same SERF atomic magnetometers;
the SERF atomic magnetometer reference sensor array is arranged on the panel, consists of a single SERF atomic magnetometer and is used for measuring an environmental magnetic field near the SERF atomic magnetometer sensor array, the magnetoencephalography cap matched with the gradiometer is fixed with the reference sensor array panel, and the SERF atomic magnetometer reference sensor array and the SERF atomic magnetometer sensor array jointly offset environmental noise;
the brain magnetic induction stimulation module is arranged in the magnetic shielding room and used for generating visual, auditory and somatosensory stimulation and outputting a path of synchronous trigger signal to the data acquisition and processing module outside the magnetic shielding room, and the synchronous trigger signal is used for synchronizing with the acquired brain magnetic;
the data acquisition and processing module is arranged outside the magnetic shielding room, receives an output signal of the SERF atomic magnetometer including the SERF atomic magnetometer sensor array and the SERF atomic magnetometer reference sensor array and a synchronous trigger signal of the brain magnetic evoked stimulation module, and carries out brain magnetic signal processing aiming at the obtained signal.
2. The SERF atomic magnetometer-based configured magnetoencephalography system of claim 1, wherein: the structure of the magnetoencephalography measuring cap for the arrangement of the gradiometer is as follows: based on an MRI image obtained by nuclear magnetic resonance MRI scanning, extracting the outer contour of a human head, expanding the outer contour of the human head by 1cm outwards according to the actual outer contour of the head to form a magnetoencephalography cap surface, arranging the number of channels on the magnetoencephalography cap surface according to the size of a single SERF atomic magnetometer in a gradiometer and a reference sensor array, wherein each channel is in a slot shape and comprises two slots, the single SERF atomic magnetometer is inserted into the slots when in measurement, and each channel forms an SERF atomic magnetometer.
3. The SERF atomic magnetometer-based configured magnetoencephalography system of claim 1, wherein: the SERF atomic magnetometer gradiometer sensor array and the SERF atomic magnetometer ladder reference sensor array are both composed of a single SERF atomic magnetometer, the single SERF atomic magnetometer can simultaneously measure magnetic fields Bz and By in two directions, namely two sensitive axes, namely a Z 'axis and a Y' axis, the Z 'axis is the axial direction of the SERF atomic magnetometer, and the Y' axis is the tangential direction of the bottom surface of the SERF atomic magnetometer.
4. The SERF atomic magnetometer-based configured magnetoencephalography system of claim 1, wherein: the SERF atomic magnetometer gradiometer sensor array is composed of a plurality of independent SERF atomic magnetometer gradiometers, a single SERF atomic magnetometer is inserted into a slot on a brain magnetic measurement cap, each SERF atomic magnetometer gradiometer comprises two SERF atomic magnetometers, the Z 'axes of the two SERF atomic magnetometers are overlapped, the directions are opposite, the X' axes are parallel, the directions are opposite, the SERF atomic magnetometer gradiometers are in a gradiometer mode, a radial gradiometer and a tangential measurement radial gradiometer are formed, the distance between the centers of the two SERF atomic magnetometers on each SERF atomic magnetometer gradiometer is a base line b, the base line is 2cm-8cm, the two SERF atomic magnetometers of each channel form the SERF atomic magnetometer gradiometer, and the SERF atomic magnetometer gradiometers of all the channels form the SERF atomic magnetometer sensor array.
5. The SERF atomic magnetometer-based configured magnetoencephalography system of claim 1, wherein: the SERF atomic magnetometer reference sensor array is composed of single SERF atomic magnetometers, each 6 single SERF atomic magnetometers form a group, and the groups are 4 groups in total, so that a first-order gradiometer reference sensor array is formed, and each group of reference sensor array is formed and described as follows: in rectangular coordinate system O-XYZ, each set of 6 SERF atomic magnetometers is placed on plane XOY, where two SERF atomic magnetometer sensors 1 and sensor2 are located on the X axis, the position coordinates are (a,0,0) and (-a,0,0), respectively, sensor1 measures the-X and Z axis magnetic fields, sensor2 measures the X and Z axis magnetic fields, further, two SERF atomic magnetometer sensors 3 and sensor4 are located next to (0, b,0), sensor3 measures the-Y axis and the-X axis, sensor4 measures the Z axis; two more SERF atomic magnetometers sensor5 and sensor6 are located next to (0, -b,0), sensor5 measures the Y and X axes, sensor6 measures the-Z axis; the 4 groups of reference sensor arrays are arranged at different positions on the reference sensor fixing panel in the same mode, and the distance between the centers of the groups is 15-25 cm.
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| CN113768505A (en) * | 2021-08-11 | 2021-12-10 | 季华实验室 | Wearable magnetoencephalography environmental noise suppression system and method |
| CN113876327B (en) * | 2021-11-22 | 2023-05-26 | 北京航空航天大学 | High-spatial-resolution magnetocardiogram imaging method based on SERF atomic magnetometer |
| CN113827246A (en) * | 2021-11-25 | 2021-12-24 | 北京航空航天大学杭州创新研究院 | Magnetoencephalography data acquisition and analysis method and system |
| CN114287944B (en) * | 2021-12-02 | 2023-03-28 | 北京航空航天大学杭州创新研究院 | Electrical stimulation induced nerve magnetic signal acquisition and analysis device and method |
| CN115047386B (en) * | 2022-08-15 | 2022-12-16 | 之江实验室 | Lunar soil magnetic detection and transmission device for SERF atomic magnetometer |
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