CN110728704B - Brain magnetic multi-mode image registration system and method based on MRI and OPM - Google Patents
Brain magnetic multi-mode image registration system and method based on MRI and OPM Download PDFInfo
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Abstract
A brain magnetic multi-mode image registration system based on MRI and OPM comprises a double-mark combined registration module, wherein the registration module comprises an OPM brain magnetic imaging marking module and a nuclear magnetic resonance imaging marking module, the OPM brain magnetic imaging marking module comprises a flexible circuit board and a circular positioning coil arranged on the flexible circuit board, the nuclear magnetic resonance imaging marking module comprises a datum block which is made of non-magnetic materials and is internally provided with solid oil, the flexible circuit board is detachably arranged on the surface of the datum block, and a positioning component of the flexible circuit board is arranged on the upper surface of the datum block, so that datum point information of the position of the circular positioning coil in a brain magnetic map and space coordinate system information of a datum point of the position of the solid oil in the MRI map can be subjected to image registration by adopting a datum point positioning method which is simple and based on the basis, the registration precision is improved, the calculation time is greatly shortened, and the progress of a new generation brain magnetic map technology from an experimental design simulation stage to a medical clinical application stage is promoted.
Description
Technical Field
The invention relates to the technical field of magnetoencephalography, in particular to a magnetoencephalography multi-mode image registration system and method based on MRI and OPM.
Background
The existing magnetoencephalography Device based on Superconducting Quantum Interference Device (SQUID) principle is bulky, needs to replace liquid helium regularly, has extremely high cost, and requires the patient to keep still to collect signals when carrying out magnetoencephalography, so the magnetoencephalography detection for children and patients suffering from epilepsy is greatly limited. Compared with other types of magnetometers, the Optical Pump Magnetometer (OPM) has incomparable advantages in performance indexes, and exceeds SQUID at present, so that the sensitivity level of human magnetic field measurement is improved from fT level to sub fT level. Compared with SQUID, OPM does not need low temperature maintaining system, can be integrated on chip, and has been applied to the fields of biological magnetic signal detection, basic physical research and the like due to the advantages of small volume, low cost and the like.
The research trend of imaging of the magnetoencephalography is to carry out medical clinical application, so that a testee needing the magnetoencephalography carries out nuclear magnetic resonance scanning on the head, then carries out multi-mode analysis on the real human head, and the difficulty of carrying out the multi-mode analysis on the magnetoencephalography is that the positioning and the registration of markers under different devices are inaccurate.
Disclosure of Invention
In order to solve the above problems, the present invention provides a system and a method for registering a multi-modality magnetic brain image based on MRI and OPM, which are used for registering a multi-modality magnetic brain image in medical magnetic brain detection.
The invention is realized by the following technical scheme:
the utility model provides a brain magnetism multimode image registration system based on MRI and OPM, includes two mark combination formula registration module, registration module includes brain magnetism imaging mark module and nuclear magnetic resonance imaging mark module, brain magnetism imaging mark module include the flexible circuit board and set up in circular positioning coil on the flexible circuit board, nuclear magnetic resonance imaging mark module includes that the built-in benchmark piece that has solid-state oil that non-magnetic material made, the flexible circuit board detachably set up in surface on the benchmark piece, just the upper surface of benchmark piece is equipped with the locating component of flexible circuit board.
Preferably, the brain magnetic imaging marking module further comprises a high-precision current source for generating weak current with stable intensity to be supplied to the circular positioning coil for working.
Preferably, the reference block is a cuboid module made of polymethyl methacrylate, the flexible circuit board is detachably arranged on the upper surface of the cuboid module, and an annular cavity used for containing the solid oil is arranged inside the cuboid module.
Preferably, the axis of the annular cavity is perpendicular to the upper surface of the cuboid module, a positioning bulge is arranged at the intersection point of the axis of the annular cavity and the upper surface of the cuboid module, and a positioning groove is arranged at the position, corresponding to the axis of the circular positioning coil, on the flexible circuit board.
Preferably, the number of the registration modules is 3, and the registration modules are respectively arranged on the upper parts of the front edges of the auricles of the two ears and the eyebrows of the tested person which are relatively static.
Preferably, the MRI and OPM based brain magnetic multi-modal image registration system further comprises a brain magnetic detection device, the brain magnetic detection device comprises a special brain magnetic helmet and a magnetic shielding room, the special brain magnetic helmet comprises a telescopic rubber head sleeve made of flexible materials and an array type clamping groove which is arranged on the head sleeve and used for installing and fixing the OPM, the OPM based brain magnetic imaging process is completed in the magnetic shielding room, and the OPM collects calibration datum point information at the position of the circular positioning coil during brain magnetic imaging.
Preferably, the MRI and OPM based brain magnetic multi-modality image registration system further comprises an MRI detection device, before MRI imaging, the brain magnetic imaging marking module is detached from the MRI marking module, and calibration reference point information is collected at the position of the solid oil during MRI imaging.
Preferably, the fiducial point of the mri marker module in the mri map is registered with the fiducial point of the mri marker module in the mri map by a fiducial point locating method.
A brain magnetic multi-modality image registration method based on MRI and OPM uses the brain magnetic multi-modality image registration system based on MRI and OPM to carry out brain magnetic multi-modality image registration, and comprises the following steps:
step one, formulating or wearing the special magnetic helmet according to the outline of the head model of the testee, and installing and fixing a corresponding number of OPMs on corresponding clamping grooves of the special magnetic helmet;
step two, starting a magnetic shielding room, shielding the geomagnetic field to enable the ambient magnetic field to be lower than 50nT, providing a weak magnetic field working condition suitable for OPM detection, and arranging a clinical induced magnetic field related excitation device in the magnetic shielding room;
thirdly, the three registration modules are respectively attached to the glabella and the upper parts of the front edges of the auricles of the two ears of the testee, the testee enters a magnetic shielding room after wearing a special brain magnetic helmet, and a high-precision current source is started to generate weak direct current with stable strength for the circular positioning coil to work;
step four, starting the OPM to enable the OPM to normally work, acquiring a magnetoencephalogram, and collecting and storing corresponding information;
step five, after the acquisition of the magnetoencephalogram is finished, taking down the special magnetoencephalogram helmet and the magnetoencephalogram marking module in the registration module, and carrying out the nuclear magnetic resonance head model scanning in the MRI detection equipment by only wearing the lower nuclear magnetic resonance imaging marking module by a testee to obtain the nuclear magnetic resonance image, and acquiring and storing corresponding information;
and step six, processing the collected and stored information, and carrying out image registration on the spatial coordinate system information of the reference point information of the position of the circular positioning coil in the magnetoencephalogram and the reference point information of the position of the solid oil in the MRI picture by adopting a reference point positioning method.
Preferably, the reference point location method includes a singular value decomposition method, specifically:
known set of points x = [ x ] 1i ,x 2i ,...,x mi ] T And y = [ y = 1i ,y 2i ,...,y mi ] T Where i =1, 2.. Multidot.n, m × m rotation matrix R, scaling coefficient c, and m-dimensional translation vector t are found such that the following equation tends to be minimal:
the point set x is composed of reference points at positions where the circular positioning coils of the head of the testee are located, the reference points are obtained through OPM detection, and the point set y is composed of reference points at positions where the solid oil is located, the solid oil is obtained through image segmentation and three-dimensional reconstruction of magnetic resonance images of the head of the testee, the magnetic resonance images are obtained through MRI detection.
Order to
∑ xy Is decomposed into UDV T Then, there is,
R＝USV T
t＝μ y -cRμ x
in the formula (I), the compound has the following structure,
wherein I represents a unit array, diag () represents a diagonal array,
if sigma xy Is m-1, then
Compared with the prior art, the invention has the advantages that:
1. according to the magnetoencephalography multi-mode image registration system based on MRI and OPM, the OPM is combined with MRI equipment, and a registration module for acquiring images is arranged, so that the convenient acquisition of magnetoencephalography signals of different groups by using the OPM and more accurate medical clinical application are realized, and the development of a new generation magnetoencephalography technology is promoted;
2. according to the magnetoencephalography multimode image registration system based on MRI and OPM, the integrated detachable registration module is designed, namely the flexible circuit board is detachably arranged on the surface of the reference block and can be accurately positioned on the upper surface of the reference block, so that the datum point information of the position of the circular positioning coil in the magnetoencephalography and the space coordinate system information of the datum point of the position of the solid oil in the MRI diagram can be registered by adopting a basic and simple datum point positioning method, the registration precision is improved, the calculation time is greatly shortened, and the progress of a new generation magnetoencephalography technology from an experimental design simulation stage to a medical clinical application stage is promoted.
3. According to the method for registering the magnetoencephalography multi-mode images based on the MRI and the OPM, a testee wearing the registration module firstly carries out magnetoencephalography, then conveniently and quickly takes down the magnetoencephalography marking module in the registration module, and reserves the MRI imaging marking module and directly carries out head nuclear magnetic resonance scanning.
Drawings
FIG. 1 is a schematic structural diagram of a magnetic brain multi-modality image registration system based on MRI and OPM according to the present invention;
FIG. 2 is a schematic structural diagram of a registration module of the MRI and OPM based multi-modality brain magnetic image registration system according to the present invention;
FIG. 3 is a schematic structural diagram of a magnetoencephalography marking module of a magnetoencephalography multi-modality image registration system based on MRI and OPM of the present invention;
FIG. 4 is a schematic structural diagram of a magnetic resonance imaging marker module of a MRI and OPM based multi-modality brain magnetic image registration system according to the present invention;
fig. 5 is a flowchart of a method for registering a magnetoencephalography multi-modal image based on MRI and OPM according to the present invention.
The various reference numbers in the figures are listed below: 1-a registration module; 11-a brain magnetic imaging marking module, 12-a nuclear magnetic resonance imaging marking module, 111-a flexible circuit board, 112-a circular positioning coil, 121-solid oil, 122-a reference block, and 113-a high-precision current source; 2-magnetoencephalography equipment; 21-special brain magnetic helmet, 22-magnetic shielding room, 211-headgear, 212-optical pump magnetometer, 213-card slot.
Detailed Description
In order to facilitate an understanding of the invention, the invention is described in more detail below with reference to the accompanying drawings and specific examples.
Example 1
A brain magnetic multi-modality image registration system based on MRI and OPM is disclosed as shown in figures 1-4 and comprises 3 double-mark combined registration modules 1, wherein the number of the double-mark combined registration modules 1 is 3, the 3 registration modules 1 are respectively arranged on the upper parts of the front edges and the eyebrows of two auricles of a testee which are relatively motionless in consideration of weak interference action of the testee during detection, each registration module 1 comprises a brain magnetic imaging marking module 11 and a nuclear magnetic resonance imaging marking module 12, the brain magnetic imaging marking module 11 comprises a flexible circuit board 111 and a circular positioning coil 112 arranged on the flexible circuit board, the nuclear magnetic resonance imaging marking module 12 comprises a reference block 122 made of non-magnetic materials and internally provided with solid oil 121, and the non-magnetic materials comprise plastics, glass and the like. The solid oil 121 can form a highlight in an image during MRI (magnetic resonance imaging), so that the reference point can be quickly located and marked, the solid oil 121 is filled into the reference block 122, oil leakage can be well prevented, the location of the mark point is further influenced, and the service life of the nuclear magnetic resonance imaging mark module 12 is prolonged. The flexible circuit board 111 is detachably disposed on the surface of the reference block 122, and can be accurately positioned on the upper surface of the reference block 122. The OPM and the MRI equipment are combined, and a registration module for acquiring images is arranged, so that the convenient acquisition of different population magnetoencephalography signals by using the OPM and the more accurate medical clinical application are realized, and the development of a new generation magnetoencephalography technology is promoted. And through designing an integrated detachable registration module, namely the flexible circuit board is detachably arranged on the surface of the reference block and can be accurately positioned on the upper surface of the reference block, the reference point information of the position of the circular positioning coil in the magnetoencephalogram and the space coordinate system information of the reference point of the position of the solid oil in the MRI picture can be registered by adopting a basic and simple reference point positioning method, so that the registration precision is improved, the calculation time is greatly shortened, and the advance pace of the new generation magnetoencephalogram technology from the experimental design simulation stage to the medical clinical application stage is promoted.
Preferably, the magnetoencephalography marking module 11 further includes a high-precision current source 113 for generating a weak current with stable intensity to supply the circular positioning coil 112 to work, so as to facilitate the optical pump magnetometer 212 to calibrate the position of the circular positioning coil 112 appearing in magnetoencephalography.
Preferably, as shown in fig. 3, the flexible circuit board 111 has a thickness of 0.16mm, and the flexible circuit board 111 has a circular positioning coil 112 printed thereon, which may be equivalent to a magnetic dipole, made of copper, and having a diameter of 2.5mm and a thickness of 0.127 mm. The high-precision current source 113 can generate direct current with stable strength, and the direct current is led into the circular positioning coil 112 to generate a weak magnetic field of 1nT, so that the OPM can be identified and marked during detection.
Preferably, as shown in fig. 4, the reference block 122 is a rectangular parallelepiped block made of polymethyl methacrylate material, and has a length of 10mm, a width of 10mm, and a height of 4mm. Flexible circuit board 111 detachably set up in the upper surface of cuboid module, the inside being equipped with of cuboid module is used for holding solid-state oil 121's toroidal cavity, the center of toroidal cavity coincides mutually with the center of cuboid module, and its highly is 2 millimeters, and the diameter of inner ring is 2mm, and the diameter of outer loop is 8mm. When a subject performs head nuclear magnetic resonance scanning, because the nuclear magnetic signal of grease is higher than that of water, bright spots higher than other tissues appear in an MRI imaging image, the peripheries of the circle centers of grease markers are all highlighted, and therefore the marked points can be rapidly positioned and the reference points can be selected by performing image segmentation and three-dimensional reconstruction on a real head model.
Preferably, the MRI and OPM based magnetic brain multi-modality image registration system further includes a magnetic brain detection device 2, the magnetic brain detection device 2 includes a special magnetic brain helmet 21 and a magnetic shielding chamber 22, the special magnetic brain helmet 21 includes a flexible rubber headgear 211 made of a flexible material, a plurality of optical pump magnetometers 212, and an array type card slot 213 provided on the headgear and used for mounting and fixing the optical pump magnetometers 212, the OPM based magnetic brain imaging process is completed in the magnetic shielding chamber 22, and the OPM collects calibration reference point information at the position of the circular positioning coil 112 during magnetic brain imaging. The magnetic shielding room 22 can shield the earth magnetic field, so that the ambient magnetic field is lower than 50nT, and the working condition of weak magnetic field is provided for OPM imaging.
Preferably, the MRI and OPM based brain magnetic multi-modality image registration system further includes an MRI detection device, before MRI imaging, the brain magnetic imaging marker module 11 is detached from the MRI marker module 12, and calibration reference point information is collected at the position of the solid oil 121 during MRI imaging. The method simplifies the procedure steps of position calibration during detection, and ensures that the positioning is more accurate and the subsequent data processing is more convenient.
Preferably, the axis of the annular cavity is perpendicular to the upper surface of the cuboid module, a positioning protrusion is arranged at the intersection point of the axis of the annular cavity and the upper surface of the cuboid module, and a positioning groove is arranged at the position, corresponding to the axis of the circular positioning coil 112, of the flexible circuit board 111. Or a positioning groove is arranged at the crossed point of the axis of the annular cavity and the upper surface of the cuboid module, and a positioning bulge is arranged at the position, located at the axis of the circular positioning coil 112, on the corresponding flexible circuit board 111. Or other forms of positioning components, as long as the point where the axis of the annular cavity intersects with the upper surface of the rectangular parallelepiped module and the point on the flexible circuit board 111 located at the axis of the circular positioning coil 112 are overlapped with each other. The positional accuracy of the registration is further improved.
The reference point of the brain magnetic imaging marking module 11 in the brain magnetic map and the reference point of the nuclear magnetic resonance imaging marking module 12 in the nuclear magnetic resonance map are registered through a reference point positioning method.
Example 2
A brain magnetic multi-modality image registration method based on MRI and OPM uses the brain magnetic multi-modality image registration system based on MRI and OPM to carry out brain magnetic multi-modality image registration, and comprises the following steps:
step one, the purpose-made brain magnetic helmet 21 is made or worn according to the outline of a head model of a testee, and corresponding quantity of optical pump magnetometers 212 are installed and fixed on corresponding clamping grooves 213 of the purpose-made brain magnetic helmet 21;
step two, starting the magnetic shielding room 22, shielding the geomagnetic field to enable the environmental magnetic field to be lower than 50nT, providing the weak magnetic field working condition suitable for the detection of the optical pump magnetometer 212, and arranging the clinical induced magnetic field related excitation equipment in the magnetic shielding room 22;
thirdly, the three registration modules 1 are respectively attached to the glabella and the upper parts of the front edges of the two auricles of the testee, the testee wears the special brain magnetic helmet 21 and then enters the magnetic shielding room 22, and the high-precision current source 113 is started to generate weak direct current with stable strength to supply the circular positioning coil 112 to work;
step four, starting the optical pump magnetometer 212 to enable the optical pump magnetometer to work normally, acquiring a magnetoencephalogram, and collecting and storing corresponding information;
step five, after the acquisition of the magnetoencephalogram is finished, taking down the special magnetoencephalogram helmet 21 and the magnetoencephalogram marking module 11 in the registration module 1, and carrying out the nuclear magnetic resonance head model scanning in the MRI detection equipment by only wearing the lower nuclear magnetic resonance imaging marking module 12 by a testee to obtain the nuclear magnetic resonance image, and acquiring and storing corresponding information;
and sixthly, processing the collected and stored information, and performing image registration on the spatial coordinate system information of the reference point information of the position of the circular positioning coil 112 in the magnetoencephalogram and the reference point information of the position of the solid oil 121 in the MRI by adopting a reference point positioning method.
The MRI and OPM based brain magnetic multi-mode image registration method firstly carries out brain magnetic detection on a testee wearing the registration module, then conveniently and quickly takes down the brain magnetic imaging marking module in the registration module, reserves the MRI imaging marking module and directly carries out head nuclear magnetic resonance scanning, can shorten the detection time and greatly reduce the registration error of a head model and a brain magnetic image detected by MRI.
The fiducial point registration method is a positioning method which is firstly proposed in electroencephalogram electrodes, and the basic principle is to find a plurality of external fiducial points or anatomical fiducial points around the head of a subject, wherein the points can be accurately measured when the position of an EEG electrode is measured and can also be displayed in a nuclear magnetic resonance image. In the application of OPM to magnetoencephalography, the fiducial point registration method may also be applied to the fusion registration of a new generation magnetoencephalogram and a head model of an MRI image, and after the positions of these registration points in a nuclear magnetic resonance image are registered with the position of the circular positioning coil 112 obtained by magnetoencephalography detection in a helmet, the circular positioning coil 112 is transformed by using the same rotation matrix and translation vector, so that the position of the circular positioning coil 112 marked by the magnetoencephalography marking module 11 in the head model of the nuclear magnetic resonance can be obtained.
Preferably, the reference point positioning method includes a singular value decomposition method, specifically:
known set of points x = [ x ] 1i ,x 2i ,...,x mi ] T And y = [ y = 1i ,y 2i ,...,y mi ] T Where i =1, 2.. Times.n, m × m rotation matrix R, scaling coefficient c, and m-dimensional translation vector t are found so that the following equation tends to be minimal:
the point set x is composed of a reference point at the position of the circular positioning coil 112 of the head of the subject detected by the optical pump magnetometer 212, and the point set y is composed of a reference point at the position of the solid oil 121 obtained by performing image segmentation and three-dimensional reconstruction on a nuclear magnetic resonance image of the head of the subject detected by MRI.
Order to
∑ xy Is decomposed into UDV T Then, there is,
R＝USV T
t＝μ y -cRμ x
in the formula, the first and second organic solvents are,
wherein I represents a unit array, diag () represents a diagonal array,
if sigma xy Is m-1, then
The position of the circular positioning coil 112 in the head model obtained by the magnetoencephalography completely depends on the registration of the mark points, so the selection of the mark points and the measurement precision and method are particularly important. The subject is allowed to make a standard MRI scan and the data is saved and transmitted to the magnetoencephalogram workstation via the network. And finally, the magnetoencephalogram data measured by the image fusion is subjected to signal processing, so that the brain function medical anatomical image integrating the brain anatomical information and the brain function information can be obtained.
It should be noted that the above-described embodiments may enable those skilled in the art to more fully understand the present invention, but do not limit the present invention in any way. Therefore, although the present invention has been described in detail with reference to the drawings and examples, it will be understood by those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the invention.
Claims (6)
1. A brain magnetic multi-mode image registration system based on MRI and OPM is characterized by comprising brain magnetic detection equipment and a double-mark combined registration module, wherein the brain magnetic detection equipment comprises a specially-made brain magnetic helmet and a magnetic shielding room, the registration module comprises a brain magnetic imaging mark module and a magnetic resonance imaging mark module, the brain magnetic imaging mark module comprises a flexible circuit board and a circular positioning coil arranged on the flexible circuit board, the magnetic resonance imaging mark module comprises a reference block made of non-magnetic materials and internally provided with solid oil, the flexible circuit board is detachably arranged on the surface of the reference block, and the upper surface of the reference block is provided with a positioning part of the flexible circuit board;
the brain magnetic imaging marking module also comprises a high-precision current source which is used for generating weak current with stable intensity to supply the circular positioning coil to work;
the registration modules are 3 and are respectively arranged on the upper parts of the front edges of the auricles of the two ears and the eyebrows of the testee, wherein the ears are relatively static;
the special brain magnetic head helmet comprises a telescopic rubber head cover made of flexible materials and an array type clamping groove which is arranged on the head cover and used for installing and fixing an OPM (optical fiber memory), the brain magnetic imaging process based on the OPM is finished in a magnetic shielding room, and the OPM collects calibration datum point information at the position of a circular positioning coil during brain magnetic imaging;
the brain magnetic imaging marking module is detached from the nuclear magnetic resonance imaging marking module before MRI imaging, and calibration datum point information is collected at the position of the solid oil during MRI imaging.
2. The MRI and OPM based brain magnetic multi-modality image registration system according to claim 1, wherein the reference block is a cuboid module made of polymethyl methacrylate material, the flexible circuit board is detachably arranged on the upper surface of the cuboid module, and an annular cavity for containing the solid oil is arranged inside the cuboid module.
3. The MRI and OPM based brain magnetic multi-modal image registration system according to claim 2, wherein the axis of the annular cavity is perpendicular to the upper surface of the cuboid module, a positioning protrusion is arranged at the intersection point of the axis of the annular cavity and the upper surface of the cuboid module, and a positioning groove is arranged at the corresponding position of the flexible circuit board, which is located at the axis of the circular positioning coil.
4. The MRI and OPM-based brain magnetic multimodality image registration system according to claim 1, wherein the fiducial points of the brain magnetic imaging marker module in the brain magnetic map and the fiducial points of the nuclear magnetic resonance imaging marker module in the nuclear magnetic resonance map are registered by a fiducial point locating method.
5. A method for registering MRI and OPM-based magnetic brain multi-modality images, which is characterized in that the system for registering MRI and OPM-based magnetic brain multi-modality images according to any one of claims 1 to 4 is used for registering magnetic brain multi-modality images, and comprises the following steps:
step one, a special brain magnetic helmet is made and worn according to the outline of a head model of a testee, or the special brain magnetic helmet made according to the outline of the head model of the testee is directly worn; and corresponding quantity of OPM is fixed on the corresponding slot of the special brain magnetic helmet;
step two, starting a magnetic shielding room, shielding a geomagnetic field to enable an environmental magnetic field to be lower than 50nT, providing a weak magnetic field working condition suitable for OPM detection, and arranging a clinical induced magnetic field related excitation device in the magnetic shielding room;
step three, respectively attaching the three registration modules to the glabella and the upper parts of the front edges of the auricles of the two ears of the testee, enabling the testee to enter a magnetic shielding room after wearing a special brain magnetic helmet, and starting a high-precision current source to enable the high-precision current source to generate weak direct current with stable strength to supply a circular positioning coil to work;
step four, starting the OPM to enable the OPM to normally work, acquiring a magnetoencephalogram, and collecting and storing corresponding information;
step five, after the acquisition of the magnetoencephalogram is finished, taking down the special magnetoencephalogram helmet and the magnetoencephalogram marking module in the registration module, and carrying out the nuclear magnetic resonance head model scanning in the MRI detection equipment by only wearing the lower nuclear magnetic resonance imaging marking module by a testee to obtain the nuclear magnetic resonance image, and acquiring and storing corresponding information;
and step six, processing the collected and stored information, and carrying out image registration on the spatial coordinate system information of the reference point information of the position of the circular positioning coil in the magnetoencephalogram and the reference point information of the position of the solid oil in the MRI picture by adopting a reference point positioning method.
6. The MRI and OPM based brain magnetic multi-modality image registration method according to claim 5, wherein the fiducial point localization method comprises a singular value decomposition method, specifically:
known set of points x = [ x ] 1i ,x 2i ,...,x mi ] T And y = [ y = 1i ,y 2i ,...,y mi ] T Where i =1, 2.. Times.n, m × m rotation matrix R, scaling coefficient c, and m-dimensional translation vector t are found so that the following equation tends to be minimal:
the point set x is composed of reference points at positions where the circular positioning coils of the head of the testee are located, the reference points are obtained through OPM detection, and the point set y is composed of reference points at positions where the solid oil is located, the solid oil is obtained through image segmentation and three-dimensional reconstruction of magnetic resonance images of the head of the testee, the magnetic resonance images are obtained through MRI detection.
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