CN111278469A - 用于治疗三阴性乳腺癌的方法 - Google Patents
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- CN111278469A CN111278469A CN201880060608.XA CN201880060608A CN111278469A CN 111278469 A CN111278469 A CN 111278469A CN 201880060608 A CN201880060608 A CN 201880060608A CN 111278469 A CN111278469 A CN 111278469A
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- cdk19
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560140P | 2017-09-18 | 2017-09-18 | |
| US62/560,140 | 2017-09-18 | ||
| PCT/US2018/051489 WO2019055977A1 (en) | 2017-09-18 | 2018-09-18 | METHODS OF TREATING NEGATIVE TRIPLE BREAST CANCER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111278469A true CN111278469A (zh) | 2020-06-12 |
Family
ID=65723126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880060608.XA Pending CN111278469A (zh) | 2017-09-18 | 2018-09-18 | 用于治疗三阴性乳腺癌的方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11471477B2 (https=) |
| EP (1) | EP3684420A4 (https=) |
| JP (1) | JP7392954B2 (https=) |
| CN (1) | CN111278469A (https=) |
| AU (1) | AU2018333072B2 (https=) |
| WO (1) | WO2019055977A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117144008A (zh) * | 2023-08-31 | 2023-12-01 | 武汉科技大学 | 三阴性乳腺癌生物标志物及其应用 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023044041A1 (en) * | 2021-09-16 | 2023-03-23 | University Of South Carolina | Cdk8/19 inhibitors for preventing drug resistance |
| CN114908168A (zh) * | 2022-05-04 | 2022-08-16 | 重庆大学附属肿瘤医院 | 一种mon1a表达水平检测试剂在制备卵巢癌干性诊断试剂中的应用 |
| CN114854755B (zh) * | 2022-05-30 | 2023-05-23 | 陕西师范大学 | 一种抑制vstm2l表达的慢病毒载体及其应用 |
| CN114832110B (zh) * | 2022-06-21 | 2023-04-28 | 中山大学孙逸仙纪念医院 | 长链非编码rna crcal-3抑制剂在制备治疗放疗抵抗乳腺癌的产品中的用途 |
| KR20250149634A (ko) * | 2022-11-07 | 2025-10-16 | 씨비에스바이오사이언스 주식회사 | 삼중 음성 유방암을 예측하고 치료하는 방법 및 조성물 |
| EP4620979A1 (en) * | 2022-11-14 | 2025-09-24 | Cognano, Inc. | Antibody and method for producing antibody |
| WO2025020931A1 (en) * | 2023-07-21 | 2025-01-30 | The Chinese University Of Hong Kong | Cdk20 in cancer diagnosis and therapy |
| CN116773815B (zh) * | 2023-08-14 | 2023-11-10 | 四川省医学科学院·四川省人民医院 | Slc2a6作为治疗靶点和筛查靶点的用途及乳腺癌筛查试剂盒 |
| CN118001402B (zh) * | 2024-01-10 | 2025-09-05 | 中山大学 | Pacsin2在促进sting信号通路激活中的应用 |
| CN119264251B (zh) * | 2024-12-09 | 2025-03-14 | 上海交通大学医学院附属仁济医院 | 一种cbln1单克隆抗体和应用 |
| CN120309727B (zh) * | 2025-06-13 | 2025-08-15 | 昆明医科大学 | 一种靶向人igfl1的单域抗体及其应用 |
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| CN104363913A (zh) * | 2012-02-02 | 2015-02-18 | 申内克斯生物科技公司 | Cdk8/cdk19选择性抑制剂及其在癌症的抗转移和化学预防方法中的用途 |
| TW201629071A (zh) * | 2015-01-19 | 2016-08-16 | 武田藥品工業股份有限公司 | 稠合雜環化合物 |
| TW201714883A (zh) * | 2015-10-16 | 2017-05-01 | 武田藥品工業股份有限公司 | 雜環化合物 |
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| EP3569254B1 (en) | 2009-04-17 | 2022-07-20 | Oxford University Innovation Limited | Composition for delivery of genetic material |
| HUE048622T2 (hu) | 2011-11-18 | 2020-08-28 | Alnylam Pharmaceuticals Inc | RNSi szerek, készítmények és alkalmazási eljárások transztiretin (TTR) asszociált betegségek kezelésére |
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2018
- 2018-09-18 JP JP2020536930A patent/JP7392954B2/ja active Active
- 2018-09-18 US US16/648,088 patent/US11471477B2/en active Active
- 2018-09-18 CN CN201880060608.XA patent/CN111278469A/zh active Pending
- 2018-09-18 AU AU2018333072A patent/AU2018333072B2/en active Active
- 2018-09-18 EP EP18856034.6A patent/EP3684420A4/en active Pending
- 2018-09-18 WO PCT/US2018/051489 patent/WO2019055977A1/en not_active Ceased
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2022
- 2022-08-29 US US17/823,028 patent/US20230285439A1/en active Pending
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| US20140309224A1 (en) * | 2011-09-13 | 2014-10-16 | Roninson Igor B | TREATMENT OF DISEASES OR DISORDERS CAUSED BY INDUCED NFkB TRANSCRIPTIONAL ACTIVITY |
| CN104363913A (zh) * | 2012-02-02 | 2015-02-18 | 申内克斯生物科技公司 | Cdk8/cdk19选择性抑制剂及其在癌症的抗转移和化学预防方法中的用途 |
| TW201629071A (zh) * | 2015-01-19 | 2016-08-16 | 武田藥品工業股份有限公司 | 稠合雜環化合物 |
| TW201714883A (zh) * | 2015-10-16 | 2017-05-01 | 武田藥品工業股份有限公司 | 雜環化合物 |
Non-Patent Citations (2)
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|---|
| AURÉLIE MALLINGER等: "Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19", 《JOURNAL OF MEDICINAL CHEMISTRY》, vol. 59, 21 January 2016 (2016-01-21), pages 1078 - 1101, XP055336343, DOI: 10.1021/acs.jmedchem.5b01685 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117144008A (zh) * | 2023-08-31 | 2023-12-01 | 武汉科技大学 | 三阴性乳腺癌生物标志物及其应用 |
| CN117144008B (zh) * | 2023-08-31 | 2024-03-08 | 武汉科技大学 | 三阴性乳腺癌生物标志物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018333072A1 (en) | 2020-03-26 |
| JP7392954B2 (ja) | 2023-12-06 |
| EP3684420A1 (en) | 2020-07-29 |
| US11471477B2 (en) | 2022-10-18 |
| WO2019055977A1 (en) | 2019-03-21 |
| WO2019055977A9 (en) | 2019-04-25 |
| US20210121495A1 (en) | 2021-04-29 |
| US20230285439A1 (en) | 2023-09-14 |
| CA3075784A1 (en) | 2019-03-21 |
| AU2018333072B2 (en) | 2022-09-29 |
| EP3684420A4 (en) | 2021-06-16 |
| JP2020534354A (ja) | 2020-11-26 |
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