CN111265649A - Chinese herbal medicine blood pressure lowering medicine and preparation method thereof - Google Patents

Chinese herbal medicine blood pressure lowering medicine and preparation method thereof Download PDF

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CN111265649A
CN111265649A CN201811372849.6A CN201811372849A CN111265649A CN 111265649 A CN111265649 A CN 111265649A CN 201811372849 A CN201811372849 A CN 201811372849A CN 111265649 A CN111265649 A CN 111265649A
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antihypertensive
medicine
chinese herbal
blood pressure
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不公告发明人
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Abstract

The invention provides a Chinese herbal medicine antihypertensive drug and a preparation method thereof, wherein the antihypertensive drug is prepared from 13-15 parts of radix scrophulariae, 1.4-1.6 parts of antihypertensive peptide extract, 9-11 parts of radix ophiopogonis, 19-21 parts of selfheal, 9-11 parts of poria cocos, 11-13 parts of folium mori, 29-31 parts of hawthorn, 9-11 parts of uncaria, 9-11 parts of chrysanthemum, 6-8 parts of periostracum cicada, 9-11 parts of radix achyranthis bidentatae, 14-16 parts of ruddle, 14-16 parts of keel, 14-16 parts of oyster, 5-7 parts of roasted polygala tenuifolia and 29-31 parts of cortex mori radicis. The invention is characterized by complete pulverization, 0.1 μm filtration and energy ray micromolecule cutting. High absorption and utilization rate, effective blood pressure reduction, and no side effect.

Description

Chinese herbal medicine blood pressure lowering medicine and preparation method thereof
Technical Field
The invention relates to a Chinese herbal medicine antihypertensive peptide medicine and a preparation method thereof, belonging to the technical field of health-care food or traditional Chinese medicine.
Background
The high-activity antihypertensive peptides all have similar small molecular structures and amino acid compositions, and the inhibition effect of the antihypertensive peptides on Angiotensin Converting Enzyme (ACE) can be divided into 3 inhibition models according to the relevance of the structures and the activities of the antihypertensive peptides.
C-terminal competitive inhibition of hypotensive peptides
In 1977 of the last century, a C-terminal-dominant model of the action of antihypertensive peptides was proposed in the laboratory: the penultimate amino acid, such as an aromatic amino acid, at the C-terminus of the substrate may provide a major affinity for binding to ACE, but both the penultimate amino acid PRO and the penultimate dihydroxy amino acid reduce the binding of the substrate to ACE. The structure of the C-terminus of the polypeptide is the strongest structure of the substrate for controlling the binding affinity of the active site with ACE.
Then, the N-terminal inhibition of hypotension
Although a systematic theory and model for the mechanism of inhibiting ACE activity at the N-terminus has not been proposed for some time, it was determined that the most active at the N-terminus are long chain or branched hydrophobic amino acids such as Val or Lie, Arg, and that the activity is reduced when the N-terminus is Pro.
Other types of inhibition
Many antihypertensive peptides were found to have ACE inhibitory activity that is not structurally related to the class 2 model described above. In addition, the activity of ACE inhibitors is related to the composition and structure of amino acids and also to the molecular weight of the ACE inhibitors.
The physiological function, namely the action mechanism of the antihypertensive peptide is to realize the function of lowering blood pressure by inhibiting the activity of Angiotensin Converting Enzyme (ACE). ACE has important physiological functions in the renal-vascular tone system for regulating blood pressure. Renin acts on angiotensin, giving off inactive angiotensin. Hypertension caused by the production of angiotensin having vascular smooth muscle activity by the action of ACE. The antihypertensive peptide inhibits the activity of angiotensin converting enzyme, so that angiotensin I type (inactive) cannot be converted into angiotensin II type (active), thereby inhibiting peripheral vasoconstriction and preventing and treating blood pressure increase.
Blood pressure in the normal human body is regulated by many factors, of which the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS) are one of the important regulatory systems. Angiotensin converting enzyme (abbreviated as ACE) is an enzyme that plays a key role in the above two regulatory systems. The antihypertensive peptide can be competitively combined with ACE so as to inhibit the effect of the antihypertensive peptide. In addition, researches show that the selenium-rich soybean oligopeptide has the effect of reducing SHR blood pressure, and the effect is the result of combined action of Se and the soybean oligopeptide, and is related to the inhibition of ACE activity and the reduction of Na + concentration and increase of Se content in rats.
The plant raw material is treated by acid and alkali to remove impurities such as crude fiber, and the animal raw material is degreased and desugared to obtain protein with high content, and then specific protease is added for hydrolysis and separation to obtain the required product.
At present, most of the medicines for treating hypertension are chemically synthesized, and patients take the medicines for a long time to cause side effects and hurt the liver and kidney. Through the extraction of Chinese herbal medicines and the physical micromolecule cutting technology of energy rays, the medicine and the nutrient components reach the micromolecule level, and through the combination with the antihypertensive peptide, the absorption and utilization rate of a human body reaches 99 percent, and the outstanding expression is as follows: quick effect, short treatment course, obvious blood pressure lowering effect, strong effect and no toxic or side effect. Therefore, it is necessary to research and improve the combination of the traditional Chinese medicine extract for reducing blood pressure and the antihypertensive peptide and the small molecule physical cutting technology, so as to improve the action rate of the antihypertensive traditional Chinese medicine.
Disclosure of Invention
The invention aims to provide a Chinese herbal medicine blood pressure lowering medicine and a preparation method thereof.
The purpose of the invention is realized by the following scheme:
a Chinese herbal medicine for reducing blood pressure and a preparation method thereof are characterized in that the Chinese herbal medicine is prepared by combining the following two traditional Chinese medicine blood pressure-reducing raw materials and antihypertensive peptides.
A method 1: 13-15 parts of radix scrophulariae, 9-11 parts of radix ophiopogonis, 9-11 parts of poria cocos, 9-11 parts of uncaria, 9-11 parts of chrysanthemum, 6-8 parts of periostracum cicadae, 14-16 parts of ruddle, 14-16 parts of dragon bone, 14-16 parts of oyster, 5-7 parts of roasted polygala tenuifolia, 29-31 parts of white mulberry root-bark, 9-11 parts of radix achyranthis bidentatae, 29-31 parts of hawthorn, 11-13 parts of folium mori, 19-21 parts of selfheal and 1.4-1.6 parts of antihypertensive peptide.
And 2, a method: 29-31 parts of root bark of white mulberry, 29-31 parts of root of rehmannia, 29-31 parts of bighead atractylodes rhizome, 14-16 parts of hawthorn, 11-13 parts of golden cypress, 11-13 parts of rhizoma anemarrhenae, 11-13 parts of raw gardenia, 11-13 parts of rhizoma alismatis, 11-13 parts of dried orange peel, 11-13 parts of fructus forsythiae, 11-13 parts of great burdock achene, 11-13 parts of radix ophiopogonis, 9-11 parts of raw liquorice, 29-31 parts of selfheal and 1.4-1.6 parts of antihypertensive peptide.
Further, according to the Chinese herbal medicine blood pressure lowering medicine and the preparation method thereof, the medicine comprises the following raw materials in parts by weight:
a method 1: 14-15 parts of radix scrophulariae, 10-11 parts of radix ophiopogonis, 10-11 parts of poria cocos, 10-11 parts of uncaria, 10-11 parts of chrysanthemum, 7-8 parts of periostracum cicadae, 15-16 parts of ruddle, 15-16 parts of dragon bone, 15-16 parts of oyster, 6-7 parts of roasted polygala tenuifolia, 30-31 parts of white mulberry root-bark, 10-11 parts of radix achyranthis bidentatae, 30-31 parts of hawthorn, 12-13 parts of folium mori, 20-21 parts of selfheal and 1.5-1.6 parts of antihypertensive peptide.
And 2, a method: 30-31 parts of cortex mori, 30-31 parts of radix rehmanniae, 30-31 parts of bighead atractylodes rhizome, 15-16 parts of hawthorn, 12-13 parts of golden cypress, 12-13 parts of rhizoma anemarrhenae, 12-13 parts of raw gardenia, 12-13 parts of rhizoma alismatis, 12-13 parts of dried orange peel, 12-13 parts of fructus forsythiae, 12-13 parts of burdock, 12-13 parts of radix ophiopogonis, 10-11 parts of raw liquorice, 30-31 parts of selfheal and 1.5-1.6 parts of antihypertensive peptide.
Furthermore, the Chinese herbal medicine antihypertensive drug and the preparation method thereof comprise the following raw materials in parts by weight:
a method 1: 15 parts of figwort, 10 parts of dwarf lilyturf tuber, 10 parts of poria cocos, 10 parts of uncaria, 10 parts of chrysanthemum, 8 parts of cicada slough, 15 parts of ruddle, 15 parts of dragon bone, 15 parts of oyster, 6 parts of roasted polygala tenuifolia, 30 parts of white mulberry root-bark, 10 parts of achyranthes root, 30 parts of hawthorn, 12 parts of mulberry leaf, 20 parts of selfheal and 1.5 parts of antihypertensive peptide.
And 2, a method: 30 parts of cortex mori radicis, 30 parts of radix rehmanniae, 30 parts of rhizoma atractylodis macrocephalae, 15 parts of hawthorn, 12 parts of cortex phellodendri, 12 parts of rhizoma anemarrhenae, 12 parts of raw gardenia, 12 parts of rhizoma alismatis, 12 parts of dried orange peel, 12 parts of fructus forsythiae, 12 parts of burdock, 12 parts of radix ophiopogonis, 10 parts of raw liquorice, 30 parts of selfheal and 1.5 parts of antihypertensive peptide.
The Chinese herbal medicine blood pressure lowering medicine and the preparation method thereof comprise the following steps:
step 1: respectively crushing the raw materials in the formula 1 and the raw materials in the formula 2 into 80 meshes, respectively adding micromolecular magnetized water, wherein the material-liquid ratio is 1: 10, respectively stirring uniformly, indirectly heating to 80 ℃, centrifugally filtering to 200 meshes, filtering to 800 meshes, then performing ultrafiltration of 0.1 mu m, concentrating the filtrate to 1/3 of the total liquid volume, passing through a 6000GS energy magnetic field ray tube, sequentially performing 5 cycles, repeatedly cutting micromolecules of various medicine components and nutrient substances, and enabling the fineness of each cut substance to reach 100 nanometers, 10 nanometers, 1 nanometer and part of element level.
Step 2: and taking out the two micromolecule cutting fluids, and putting the two micromolecule cutting fluids into a spray dryer for spray drying to obtain micromolecule extract dry powder.
And step 3: mixing the two small molecular extracts with antihypertensive peptide in proportion, and making into capsule, granule, tablet or other clinically acceptable dosage forms.
The dosage of the formula 1 and the formula 2 in the invention is the daily dosage of the Chinese herbal pieces decoction pieces of each person per day, the centrifugal filtration is carried out according to the fineness of 0.01 mu m, and the small molecule cutting is added, so the extraction ratio of the extract is 20: 1, namely, 1kg of extract dry powder is extracted from 20kg of Chinese herbal pieces decoction pieces, and the daily dosage is 20: 1, namely:
a method 1: 0.75 part of figwort root, 0.5 part of dwarf lilyturf tuber, 0.5 part of Indian buead, 0.5 part of uncaria, 0.5 part of chrysanthemum, 0.4 part of cicada slough, 0.75 part of ruddle, 0.75 part of dragon bone, 0.75 part of oyster, 0.3 part of roasted polygala tenuifolia, 1.5 parts of white mulberry root-bark, 0.5 part of twotooth achyranthes root, 1.5 parts of hawthorn, 0.6 part of mulberry leaf, 1.0 part of common selfheal fruit-spike and 1.5 parts of antihypertensive peptide.
And 2, a method: 1.5 parts of white mulberry root-bark, 1.5 parts of dried rehmannia root, 1.5 parts of largehead atractylodes rhizome, 1.5 parts of hawthorn, 0.6 part of amur corktree bark, 0.6 part of common anemarrhena rhizome, 0.6 part of raw gardenia, 0.6 part of oriental waterplantain rhizome, 0.6 part of tangerine peel, 0.6 part of weeping forsythia capsule, 0.6 part of great burdock achene, 0.6 part of dwarf lilyturf root, 0.5 part of raw liquorice, 1.5 parts of common selfheal fruit-spike and 1.5 parts of antihypertensive peptide.
When the medicinal composition is prepared into granules, the particle size is 5mm, and the content of each medicinal substance is as follows:
a method 1: 0.0075 parts of radix scrophulariae, 0.005 part of radix ophiopogonis, 0.005 part of poria cocos, 0.005 part of uncaria, 0.005 part of chrysanthemum, 0.004 part of periostracum cicadae, 0.0075 part of ruddle, 0.0075 part of keel, 0.0075 part of oyster, 0.003 part of roasted polygala tenuifolia, 0.015 part of white mulberry root-bark, 0.005 part of radix achyranthis bidentatae, 0.015 part of hawthorn, 0.006 part of folium mori, 0.01 part of selfheal and 0.015 part of antihypertensive peptide.
And 2, a method: 0.015 part of white mulberry root-bark, 0.015 part of dried rehmannia root, 0.015 part of largehead atractylodes rhizome, 0.015 part of hawthorn, 0.006 part of amur corktree bark, 0.006 part of common anemarrhena rhizome, 0.006 part of raw gardenia, 0.006 part of oriental waterplantain rhizome, 0.006 part of tangerine peel, 0.006 part of weeping forsythia capsule, 0.006 part of great burdock achene, 0.006 part of dwarf lilyturf tuber, 0.005 part of raw liquoric root, 0.015 part of common selfheal fruit-spike and 0.015 part of.
The daily dose is 2-3 times per day, 50-33 capsules each time.
Making into 5mm external diameter granules, and taking 50-33 granules for 2-3 times per day;
making into 6mm external diameter granule, and taking 40-22 granules each time for 2-3 times per day;
making into 4mm external particle size, and taking 60-44 granules for 2-3 times per day;
making into 3mm outer diameter granule, and taking for 2-3 times per day, 70-55 granules each time;
making into 0.3 parts of capsule, and taking 2-1 granule each time for 2-3 times a day;
making into 0.3 part tablet, and taking 2-1 tablet 2-3 times per day.
The function of the Chinese herbal medicines is analyzed:
the figwort in the invention is slightly bitter in taste and cool in nature, and enters spleen, lung and kidney meridians. Has sedative, antihypertensive, cardiotonic, vasodilating, and anticonvulsant effects;
the radix ophiopogonis in the invention is sweet in taste, slightly bitter and cool in nature. Enter heart, stomach and lung meridians. Has effects in nourishing yin, moistening lung, benefiting stomach, promoting salivation, clearing away heart-fire, and removing toxic materials.
The tuckahoe of the invention has sweet and light taste and mild property. Enter heart, spleen, lung and kidney meridians. Has effects in promoting diuresis, eliminating dampness, invigorating spleen, strengthening middle warmer, calming heart, and tranquilizing mind.
The uncaria in the invention is sweet in taste and slightly cold in nature. Enter liver and pericardium meridians. Has effects in calming endogenous wind, relieving spasm, clearing away heat, and calming liver. It can be used for treating headache, fullness of head, and dizziness due to hyperactivity of liver-yang and internal stirring of liver-wind, exciting respiratory center, inhibiting vasomotor center, dilating peripheral blood vessels, lowering blood pressure and heart rate, and tranquilizing mind.
The chrysanthemum in the invention is pungent, sweet and bitter in taste and slightly cold in nature. Enter lung and liver meridians. Has effects in dispelling pathogenic wind, clearing away toxic materials, improving eyesight, inhibiting headache and dizziness due to excessive liver-yang, and lowering blood pressure.
The cicada slough is sweet in taste and cold in nature. Entering lung and liver meridians, has effects of dispelling cold and clearing heat, promoting eruption, dispelling pathogenic wind and relieving spasm, removing nebula and improving eyesight, and has good inhibitory effect on diseases caused by liver wind hyperactivity.
The red ochre in the invention is bitter in taste and cold in nature. Enter liver and heart meridians. Has the functions of calming the liver, suppressing yang hyperactivity, lowering adverse qi and stopping bleeding, and has good functional inhibition effect on headache, dizziness, dim eyesight, blurred vision, nausea and other symptoms caused by liver-yang hyperactivity.
The dragon bone in the invention is sweet and astringent in taste and slightly cold in nature. Enter heart and liver meridians. Has effects in calming liver, suppressing yang hyperactivity, tranquilizing mind, and astringing.
The oyster in the invention is salty in taste and slightly cold in nature. Enter liver and kidney meridians. Has effects in suppressing hyperactive liver, subsiding yang, softening and resolving hard mass, astringing, and inducing astringency, and also has expectorant and blood pressure lowering effects.
The roasted polygala root in the invention is pungent and bitter in taste and slightly warm in nature. Enter lung, heart and kidney meridians. Has effects in calming heart, tranquilizing mind, eliminating phlegm, inducing resuscitation, and eliminating carbuncle and swelling. Has good yin and yang regulating effect for people with heart-kidney disharmony and phlegm obstruction in heart orifice.
The cortex mori radicis sweet in taste and cold in nature. Enter the lung meridian. Has effects in purging lung, relieving asthma, promoting urination, and relieving swelling. Also has the obvious effect of lowering blood pressure.
The achyranthes root in the invention is bitter and sour in taste and mild in nature. Enter liver and kidney meridians. Has effects in promoting blood circulation, dispelling blood stasis, promoting blood circulation, tonifying liver and kidney, and relieving stranguria. Also has analgesic, diuretic, and blood pressure lowering effects.
The hawthorn in the invention is sour and sweet in taste and slightly warm in nature. Enter spleen, stomach and liver meridians. Has effects in promoting digestion, promoting blood circulation, dispelling blood stasis, reducing blood fat, and lowering blood pressure.
The mulberry leaves in the invention are bitter, sweet and cold in nature. Enter lung and liver meridians. Has effects in dispelling pathogenic wind, clearing away heat, removing liver fire, and improving eyesight. Has effects in clearing liver-fire, moistening lung, and relieving cough.
The selfheal in the invention is bitter, pungent and cold in nature. Entering liver and gallbladder meridians. Has effects in clearing away liver heat, dispelling stagnated heat, lowering blood pressure, and inhibiting bacteria.
The antihypertensive peptide disclosed by the invention is sweet in taste and mild in nature. Has obvious blood pressure lowering effect.
The rehmannia root of the present invention is sweet, bitter and cold in nature. Enter heart, liver and kidney meridians. Has effects in clearing away heat and cooling blood. Nourishing yin and promoting fluid production.
The bighead atractylodes rhizome in the invention is bitter and sweet in taste and warm in nature. Enter spleen and stomach meridians. Has effects in invigorating qi, invigorating spleen, eliminating dampness, promoting diuresis, arresting sweating, preventing miscarriage, promoting gastrointestinal secretion, lowering blood sugar, protecting liver, and preventing hepatic glycogen decrease.
The phellodendron bark in the invention is bitter in taste and cold in nature. Enter kidney and bladder meridians. Has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic substances, relieving deficiency heat, lowering blood pressure, and lowering blood sugar.
The rhizoma anemarrhenae of the invention is bitter and sweet in taste and cold in nature. Enter lung, stomach and kidney meridians. Has effects in purging pathogenic fire, relieving restlessness, nourishing yin, and moistening dryness. It also has thirst quenching, diuretic, and antifungal effects.
The gardenia in the invention is bitter in taste and cold in nature. Enters lung, heart and triple energizer meridians. Has effects in purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, removing toxic substances, and inhibiting bacteria.
The alisma orientale in the invention is sweet and light in taste and cold in nature. Enter kidney and bladder meridians. Has effects in promoting diuresis, eliminating dampness, clearing away heat, promoting urination, increasing urine output, promoting discharge of urea and chloride, and slightly reducing blood cholesterol and blood sugar and preventing fatty liver.
The dried orange peel in the invention is pungent, bitter and sour in taste and warm in nature. Enter spleen and lung meridians. Has effects in regulating qi, regulating middle warmer, eliminating dampness, and eliminating phlegm.
The forsythia suspense is a forsythia suspense. Bitter in taste and slightly cold in nature. Enter lung, heart and small intestine meridians. Has effects of clearing away heat and toxic materials, resolving carbuncle and resolving hard mass, and inhibiting bacteria and fungi.
The burdock in the invention is pungent, bitter and cold in nature. Enter lung and stomach meridians. Has effects in dispelling pathogenic wind, removing heat, dispersing lung qi, promoting eruption, relieving sore throat, and removing toxic substance.
The raw licorice root in the invention is sweet in taste and mild in nature. Enter heart, spleen, lung and stomach meridians. Has effects in invigorating spleen, invigorating qi, moistening lung, relieving cough, relieving spasm and pain, and relieving drug property.
The invention aims at hypertension, which is a disease mainly manifested by arterial blood pressure rise and mainly caused by dysfunction of high-level nerve center to regulate blood pressure. In adults, the diastolic blood pressure is continuously above 13 kPa, which is generally regarded as high blood pressure.
The pure traditional Chinese medicine extract is matched with micromolecular protein peptide, namely the medicine for reducing blood pressure, which is prepared by combining blood pressure reducing additives, has very obvious blood pressure reducing effect and has no toxic or side effect.
The invention relates to a Chinese herbal medicine antihypertensive drug, a preparation method thereof and an antihypertensive peptide capsule which is taken alone, so as to compare the efficacy of each antihypertensive drug.
The experimental results are as follows:
name (R) Primary (effective rate) Secondary (effective rate)
The invention relates to a Chinese herbal medicine blood pressure reducing granule 98％ 94％
Antihypertensive peptide capsule 86％ 89％
Compound hypertension tablet 93.2％ 91％
From the above results, it is known that when 100 patients with primary hypertension for 5 years or longer take the antihypertensive peptide capsule and the compound antihypertensive tablet 2 times a day (taken before meals) 44 capsules/times of the present invention, the antihypertensive drug prepared by mixing the extract obtained by the magnetic energy ray small molecule cleavage treatment of the present invention with the antihypertensive peptide is sufficiently absorbed and utilized by the human body, and the obtained functional benefit is very high.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
Example 1
A method 1: 13-15 parts of radix scrophulariae, 9-11 parts of radix ophiopogonis, 9-11 parts of poria cocos, 9-11 parts of uncaria, 9-11 parts of chrysanthemum, 6-8 parts of periostracum cicadae, 14-16 parts of ruddle, 14-16 parts of dragon bone, 14-16 parts of oyster, 5-7 parts of roasted polygala tenuifolia, 29-31 parts of white mulberry root-bark, 9-11 parts of radix achyranthis bidentatae, 29-31 parts of hawthorn, 11-13 parts of folium mori, 19-21 parts of selfheal and 1.4-1.6 parts of antihypertensive peptide.
And 2, a method: 29-31 parts of cortex mori radicis, 29-31 parts of radix rehmanniae, 29-31 parts of bighead atractylodes rhizome, 14-16 parts of hawthorn, 11-13 parts of golden cypress, 11-13 parts of rhizoma anemarrhenae, 11-13 parts of raw gardenia and 11-13 parts of rhizoma alismatis. 11-13 parts of dried orange peel, 11-13 parts of fructus forsythiae, 11-13 parts of great burdock achene, 11-13 parts of dwarf lilyturf tuber, 9-11 parts of raw liquorice, 29-31 parts of selfheal and 1.4-1.6 parts of antihypertensive peptide.
Example 2
A method 1: 14-15 parts of radix scrophulariae, 10-11 parts of radix ophiopogonis, 10-11 parts of poria cocos, 10-11 parts of uncaria, 10-11 parts of chrysanthemum, 7-8 parts of periostracum cicadae, 15-16 parts of ruddle, 15-16 parts of dragon bone, 15-16 parts of oyster, 6-7 parts of roasted polygala tenuifolia, 30-31 parts of white mulberry root-bark, 10-11 parts of radix achyranthis bidentatae, 30-31 parts of hawthorn, 12-13 parts of folium mori, 20-21 parts of selfheal and 1.5-1.6 parts of antihypertensive peptide.
And 2, a method: 30-31 parts of cortex mori, 30-31 parts of radix rehmanniae, 30-31 parts of bighead atractylodes rhizome, 15-16 parts of hawthorn, 12-13 parts of golden cypress, 12-13 parts of rhizoma anemarrhenae, 12-13 parts of raw gardenia, 12-13 parts of rhizoma alismatis, 12-13 parts of dried orange peel, 12-13 parts of fructus forsythiae, 12-13 parts of burdock, 12-13 parts of radix ophiopogonis, 10-11 parts of raw liquorice, 30-31 parts of selfheal and 1.5-1.6 parts of antihypertensive peptide.
Example 3
A method 1: 15 parts of figwort, 10 parts of dwarf lilyturf tuber, 10 parts of poria cocos, 10 parts of uncaria, 10 parts of chrysanthemum, 8 parts of cicada slough, 15 parts of ruddle, 15 parts of dragon bone, 15 parts of oyster, 15 parts of roasted polygala tenuifolia, 30 parts of white mulberry root-bark, 10 parts of achyranthes root, 30 parts of hawthorn, 12 parts of mulberry leaf, 20 parts of selfheal and 1.5 parts of antihypertensive peptide.
And 2, a method: 30 parts of cortex mori radicis, 30 parts of radix rehmanniae, 30 parts of rhizoma atractylodis macrocephalae, 15 parts of hawthorn, 12 parts of cortex phellodendri, 12 parts of rhizoma anemarrhenae, 12 parts of raw gardenia, 12 parts of rhizoma alismatis, 12 parts of dried orange peel, 12 parts of fructus forsythiae, 12 parts of burdock, 12 parts of radix ophiopogonis, 10 parts of raw liquorice, 30 parts of selfheal and 1.5 parts of antihypertensive peptide.
The invention relates to a Chinese herbal medicine blood pressure lowering medicine and a preparation method thereof, wherein the preparation method comprises the following steps:
step 1: respectively pulverizing the above materials of formula 1 and formula 2 into 80 mesh powders, respectively adding small molecule magnetized water at a material-to-liquid ratio of 1: 10, respectively stirring, indirectly heating to 80 deg.C, centrifuging to filter with 200 mesh and 800 mesh powders, ultrafiltering to 0.1 μm, and concentrating the filtrate to 1/3 times of total liquid amount. Passing through a 6000 Gauss energy magnetic field ray tube, and performing 5 cycles in sequence to repeatedly cut small molecules of each medicine component and each nutrient substance, wherein the fineness of each cut substance reaches 100 nanometers, 10 nanometers, 1 nanometer and the fineness of partial element level.
Step 2: and taking out the two micromolecule cutting fluids, and putting the two micromolecule cutting fluids into a spray dryer for spray drying to obtain micromolecule extract dry powder.
And step 3: mixing the two small molecule extracts with antihypertensive peptide at a certain proportion, and making into capsule, granule, or tablet.
In conclusion, the Chinese medicinal herb extract disclosed by the invention is prepared from pure Chinese medicinal herb extracts, is small in toxic and side effects, is prepared from Chinese medicinal herb decoction pieces and antihypertensive peptide extracts, is high in absorption and utilization rate due to micromolecule cutting, is simple in preparation process step, and protects liver and kidney while lowering blood pressure.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.

Claims (7)

1. The invention relates to a Chinese herbal medicine antihypertensive drug and a preparation method thereof, which is characterized by being prepared by combining the following two traditional Chinese medicine antihypertensive raw materials and antihypertensive peptides:
a method 1: 13-15 parts of radix scrophulariae, 9-11 parts of radix ophiopogonis, 9-11 parts of poria cocos, 9-11 parts of uncaria, 9-11 parts of chrysanthemum, 6-8 parts of periostracum cicadae, 14-16 parts of ruddle, 14-16 parts of dragon bone, 14-16 parts of oyster, 5-7 parts of roasted polygala tenuifolia, 29-31 parts of white mulberry root-bark, 9-11 parts of radix achyranthis bidentatae, 29-31 parts of hawthorn, 11-13 parts of folium mori, 19-21 parts of selfheal and 1.4-1.6 parts of antihypertensive peptide.
2. The Chinese herbal medicine antihypertensive drug and the preparation method thereof according to claim 1, characterized by comprising the following raw materials in parts by weight:
and 2, a method: 29-31 parts of cortex mori radicis, 29-31 parts of radix rehmanniae, 29-31 parts of bighead atractylodes rhizome, 14-16 parts of hawthorn, 11-13 parts of golden cypress, 11-13 parts of rhizoma anemarrhenae, 11-13 parts of raw gardenia and 11-13 parts of rhizoma alismatis. 11-13 parts of dried orange peel, 11-13 parts of fructus forsythiae, 11-13 parts of great burdock achene, 11-13 parts of dwarf lilyturf tuber, 9-11 parts of raw liquorice, 29-31 parts of selfheal and 1.4-1.6 parts of antihypertensive peptide.
3. The Chinese herbal medicine blood pressure lowering medicine and the preparation method thereof according to the claims 1-2, characterized by further comprising the following raw materials by weight:
a method 1: 14-15 parts of radix scrophulariae, 10-11 parts of radix ophiopogonis, 10-11 parts of poria cocos, 10-11 parts of uncaria, 10-11 parts of chrysanthemum, 7-8 parts of periostracum cicadae, 15-16 parts of ruddle, 15-16 parts of dragon bone, 15-16 parts of oyster, 6-7 parts of roasted polygala tenuifolia, 30-31 parts of white mulberry root-bark, 10-11 parts of radix achyranthis bidentatae, 30-31 parts of hawthorn, 12-13 parts of folium mori, 20-21 parts of selfheal and 1.5-1.6 parts of antihypertensive peptide.
4. The Chinese herbal medicine blood pressure lowering medicine and the preparation method thereof according to the claims 1-2, characterized by comprising the following raw materials by weight:
and 2, a method: 30-31 parts of cortex mori, 30-31 parts of radix rehmanniae, 30-31 parts of bighead atractylodes rhizome, 15-16 parts of hawthorn, 12-13 parts of golden cypress, 12-13 parts of rhizoma anemarrhenae, 12-13 parts of raw gardenia, 12-13 parts of rhizoma alismatis, 12-13 parts of dried orange peel, 12-13 parts of fructus forsythiae, 12-13 parts of burdock, 12-13 parts of radix ophiopogonis, 10-11 parts of raw liquorice, 30-31 parts of selfheal and 1.5-1.6 parts of antihypertensive peptide.
5. The Chinese herbal medicine blood pressure lowering medicine and the preparation method thereof according to the claims 3-4, characterized in that the medicine further comprises the following raw materials by weight:
a method 1: 15 parts of figwort, 10 parts of dwarf lilyturf tuber, 10 parts of poria cocos, 10 parts of uncaria, 10 parts of chrysanthemum, 8 parts of cicada slough, 15 parts of ruddle, 15 parts of dragon bone, 15 parts of oyster, 15 parts of roasted polygala tenuifolia, 30 parts of white mulberry root-bark, 10 parts of achyranthes root, 30 parts of hawthorn, 12 parts of mulberry leaf, 20 parts of selfheal and 1.5 parts of antihypertensive peptide.
6. The Chinese herbal medicine blood pressure lowering medicine and the preparation method thereof according to the claims 3-4, characterized by comprising the following raw materials by weight:
and 2, a method: 30 parts of cortex mori radicis, 30 parts of radix rehmanniae, 30 parts of rhizoma atractylodis macrocephalae, 15 parts of hawthorn, 12 parts of cortex phellodendri, 12 parts of rhizoma anemarrhenae, 12 parts of raw gardenia, 12 parts of rhizoma alismatis, 12 parts of dried orange peel, 12 parts of fructus forsythiae, 12 parts of burdock, 12 parts of radix ophiopogonis, 10 parts of raw liquorice, 30 parts of selfheal and 1.5 parts of antihypertensive peptide.
7. The Chinese herbal medicine antihypertensive drug and the preparation method thereof according to claims 1, 2, 3, 4, 5 and 6, characterized by comprising the following steps:
step 1: respectively crushing the raw materials in the formula 1 and the formula 2 into 80 meshes, respectively adding micromolecular magnetized water, wherein the material-liquid ratio is 1: 10, respectively stirring uniformly, indirectly heating to 80 ℃, centrifugally filtering to 200 meshes and 800 meshes, then performing ultrafiltration for 0.1 mu m, concentrating the filtrate to 1/3 of the total liquid volume, passing through a 6000 gauss energy magnetic field ray tube, sequentially performing 5 cycles, repeatedly cutting micromolecules of each medicine component and nutrient substance, and enabling the fineness of each cut substance to reach 100 nanometers, 10 nanometers, 1 nanometer and the fineness of partial element level.
Step 2: and taking out the two micromolecule cutting fluids, and putting the two micromolecule cutting fluids into a spray dryer for spray drying to obtain micromolecule extract dry powder.
And step 3: mixing the two small molecule extracts with antihypertensive peptide at a certain proportion, and making into capsule, granule, or tablet.
CN201811372849.6A 2018-11-19 2018-11-19 Chinese herbal medicine blood pressure lowering medicine and preparation method thereof Pending CN111265649A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101240016A (en) * 2008-02-28 2008-08-13 山东大学 Shark protein antihypertensive peptide and preparation method and application thereof
CN103980347A (en) * 2014-05-22 2014-08-13 浙江海洋学院 Antihypertensive peptide of swim bladder of large yellow croaker and preparation method and use thereof
CN104232716A (en) * 2014-08-26 2014-12-24 陕西盛迈石油有限公司 Soybean antihypertensive peptide and preparation method thereof
CN106310069A (en) * 2016-11-10 2017-01-11 林树芳 Chinese herb preparation for treating advanced lung cancer, and preparation method and application thereof
CN107397776A (en) * 2017-09-05 2017-11-28 林树芳 A kind of Chinese medicine composition for treating disease in the liver and gallbladder and preparation method thereof
CN108273006A (en) * 2018-03-30 2018-07-13 林树芳 A kind of external used medicine and preparation method thereof for treating mammary gland disease

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101240016A (en) * 2008-02-28 2008-08-13 山东大学 Shark protein antihypertensive peptide and preparation method and application thereof
CN103980347A (en) * 2014-05-22 2014-08-13 浙江海洋学院 Antihypertensive peptide of swim bladder of large yellow croaker and preparation method and use thereof
CN104232716A (en) * 2014-08-26 2014-12-24 陕西盛迈石油有限公司 Soybean antihypertensive peptide and preparation method thereof
CN106310069A (en) * 2016-11-10 2017-01-11 林树芳 Chinese herb preparation for treating advanced lung cancer, and preparation method and application thereof
CN107397776A (en) * 2017-09-05 2017-11-28 林树芳 A kind of Chinese medicine composition for treating disease in the liver and gallbladder and preparation method thereof
CN108273006A (en) * 2018-03-30 2018-07-13 林树芳 A kind of external used medicine and preparation method thereof for treating mammary gland disease

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