CN111265615A - Traditional Chinese medicine treatment formula for radioactive lung injury - Google Patents

Traditional Chinese medicine treatment formula for radioactive lung injury Download PDF

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CN111265615A
CN111265615A CN202010257623.2A CN202010257623A CN111265615A CN 111265615 A CN111265615 A CN 111265615A CN 202010257623 A CN202010257623 A CN 202010257623A CN 111265615 A CN111265615 A CN 111265615A
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兰东强
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兰东强
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Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine treatment formula for radiation-induced lung injury, which is prepared from the following components in parts by weight: 13-17 parts of cortex moutan, 7-11 parts of ligusticum chuanxiong hort, 7-11 parts of radix paeoniae rubra, 8-12 parts of radix ophiopogonis, 8-12 parts of radix adenophorae, 10-14 parts of radix astragali, 13-17 parts of polyporus umbellatus, 13-17 parts of poria cocos, 13-17 parts of radix pseudostellariae, 7-11 parts of coltsfoot, 10-14 parts of loquat leaf, 6-10 parts of bulbus fritilariae, 2-6 parts of liquorice, 8-12 parts of rhodiola rosea, 22-26 parts of houttuynia cordata, 7-11 parts of scutellaria baicalensis, 8-12 parts of angelica sinensis and 13-17 parts of salvia miltiorrhiza. Because rays are fire evil and are easy to damage yin, the invention takes yin nourishing and heat clearing as a treatment rule, and after the breast tumor radiotherapy, the formula provided by the invention mainly treats stasis caused by heat toxin and has the effects of activating blood and dissolving stasis, and also has the effects of tonifying qi, nourishing yin and clearing heat, and has exciting treatment effect on the treatment of radioactive lung injury.

Description

Traditional Chinese medicine treatment formula for radioactive lung injury
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine treatment formula for radiation-induced lung injury.
Background
Radiation Induced Lung Injury (RILI) is an inflammatory response caused by damage of normal Lung tissues in a Radiation field area after radiotherapy of malignant breast tumors and chronic complication Radiation pulmonary fibrosis in a long term, and is mainly manifested by dyspnea, cough, shortness of breath, hemoptysis and the like. Statistically, the incidence rate of radiation pneumonitis is 29.6% -50.3%, and RILI has become a great challenge for breast tumor radiotherapy, which affects the quality of life of patients, and limits the increase of radiation dose and the irradiation range of lungs, and finally affects the overall efficacy of breast tumor radiotherapy, especially lung tumor radiotherapy.
Currently, the most common methods for treating radiation pneumonitis in western medicine include: adrenocortical hormone, antibiotics, oxygen uptake, phlegm elimination and the like. The corticoids are more effective in early use, and mainly exert an anti-inflammatory effect, thereby reducing the degree of damage to lung parenchymal cells and microvessels, and reducing exudation and edema of lung tissues, and further effectively relieving symptoms. A single daily cumulative dose of 20-40mg methylprednisolone equivalent (4 mg methylprednisolone equivalent to 0.75mg dexamethasone or 20mg hydrocortisone or 5mg prednisone) of short-range hormone therapy can be administered. In addition, aerosol inhalation may be used to relieve symptoms. The lung is easy to be infected after radioactive damage, and the antibiotic can be used as a preventive medicine; if the infection is complicated, the antibacterial agent should be selected according to drug sensitivity test. There are attempts to treat radiation-induced pulmonary fibrosis with pentoxifylline and/or vitamin E in combination with hyperbaric oxygen. However, once pulmonary fibrosis develops, these treatments have little effect.
The action mechanism of the traditional Chinese medicine for preventing and treating radiation pneumonitis mainly comprises the following 2 aspects: (1) resisting oxidation and scavenging free radicals. Radix astragali, radix Scutellariae, radix Ginseng, radix Trichosanthis, Coriolus versicolor, and Ganoderma have different degrees of oxidation resistance and free radical scavenging effects, and can reduce peroxidation injury caused by radioactive rays and apoptosis and necrosis of cells; (2) reducing the expression of cytokines.
Disclosure of Invention
The radioactive lung injury belongs to 'flaccidity of lung', 'lung impediment' and 'dyspnea syndrome' in the traditional Chinese medicine. The book "jin Kui Yao Yi Xin Dian Lung abscess with cough and qi-ascending disease" says that flaccidity people are withered and not honor, like withered and not honor grass and wood, and scorching of body fluid and burning of lung are also known. The consumptive lung disease means that the lung lobes are lost and moist for children, and the impotence is not used, and the pulmonary nodules means that the lung collaterals are blocked by the pathogenic factors of the phlegm nodules. The radiation belongs to the fire-heat toxin pathogen, while the lung is delicate, the invasion of the toxin in radiotherapy burns the lung fluid, the lung fluid is combated with turbid phlegm, the lung collaterals are blocked, the lung collaterals are damaged, the phlegm-heat is accumulated in the interior, the vital qi is damaged after long-term use, and the qi and yin are both deficient. Qi is the commander of blood, and qi deficiency makes blood flow unsmooth and blood stasis endogenous. Radiation is a fire pathogen, which tends to damage yin, so yin-nourishing and heat-clearing should be the therapeutic principle during radiotherapy. Most of radiation pneumonitis appear in one month after radiotherapy, and the stagnation caused by heat-toxin yin injury already occurs at this time, so the treatment principle mainly takes the functions of activating blood circulation to dissipate blood stasis and nourishing yin, clearing heat and tonifying qi. Based on the above, a brand-new traditional Chinese medicine treatment formula for treating the radioactive lung injury is provided.
The technical scheme adopted by the invention for solving the technical problems is as follows: a traditional Chinese medicine treatment formula for radiation-induced lung injury is prepared from the following components in parts by mass: 13-17 parts of cortex moutan, 7-11 parts of ligusticum chuanxiong hort, 7-11 parts of radix paeoniae rubra, 8-12 parts of radix ophiopogonis, 8-12 parts of radix adenophorae, 10-14 parts of radix astragali, 13-17 parts of polyporus umbellatus, 13-17 parts of poria cocos, 13-17 parts of radix pseudostellariae, 7-11 parts of coltsfoot, 10-14 parts of loquat leaf, 6-10 parts of bulbus fritilariae, 2-6 parts of liquorice, 8-12 parts of rhodiola rosea, 22-26 parts of houttuynia cordata, 7-11 parts of scutellaria baicalensis, 8-12 parts of angelica sinensis and 13-17 parts of salvia miltiorrhiza.
Preferably, the components are calculated according to the following parts by mass: 15 parts of cortex moutan, 9 parts of ligusticum chuanxiong hort, 9 parts of radix paeoniae rubra, 10 parts of radix ophiopogonis, 10 parts of adenophora stricta, 12 parts of radix astragali, 15 parts of polyporus umbellatus, 15 parts of poria cocos, 15 parts of radix pseudostellariae, 9 parts of coltsfoot, 12 parts of loquat leaf, 8 parts of bulbus fritilariae, 4 parts of liquorice, 10 parts of rhodiola rosea, 24 parts of houttuynia cordata, 9 parts of scutellaria baicalensis, 10 parts of angelica sinensis and 15 parts of salvia miltiorrhiza.
Because rays are fire evil and are easy to damage yin, the invention takes yin nourishing and heat clearing as a treatment rule, and after the breast tumor radiotherapy, the formula provided by the invention mainly treats stasis caused by heat toxin and has the effects of activating blood and dissolving stasis, and also has the effects of tonifying qi, nourishing yin and clearing heat, and has exciting treatment effect on the treatment of radioactive lung injury.
Drawings
FIG. 1 is a CT image of the lung 1 month after the end of radiotherapy in case 1 of the present invention.
Fig. 2 is another CT image of the lung 1 month after the end of the radiotherapy in case 1.
Fig. 3 is a CT image of the lung of case 1 after a single dose of the anti-inflammatory agent of the present invention for 3 months and 90 weeks.
FIG. 4 is a CT image of lungs after 1 month of hormone treatment of case 3 in the present invention.
Figure 5 is another pulmonary CT image after 1 month of hormone treatment of case 3 above.
FIG. 6 is a CT image of the lung 1 month after the hormone administration of the above-mentioned case 3 and the simultaneous administration of the anti-inflammatory agent of the present invention.
FIG. 7 is a CT image of the lungs of case 3, after hormone deprivation and continued 3 months of the anti-inflammatory formulation of the present invention.
Detailed Description
The present invention will be described in detail with reference to fig. 1 to 7, and the exemplary embodiments and descriptions of the present invention are provided to explain the present invention, but not to limit the present invention.
The invention provides a traditional Chinese medicine treatment formula for radiation-induced lung injury, which is prepared from the following components in parts by mass: 13-17 parts of cortex moutan, 7-11 parts of ligusticum chuanxiong hort, 7-11 parts of radix paeoniae rubra, 8-12 parts of radix ophiopogonis, 8-12 parts of radix adenophorae, 10-14 parts of radix astragali, 13-17 parts of polyporus umbellatus, 13-17 parts of poria cocos, 13-17 parts of radix pseudostellariae, 7-11 parts of coltsfoot, 10-14 parts of loquat leaf, 6-10 parts of bulbus fritilariae, 2-6 parts of liquorice, 8-12 parts of rhodiola rosea, 22-26 parts of houttuynia cordata, 7-11 parts of scutellaria baicalensis, 8-12 parts of angelica sinensis and 13-17 parts of salvia miltiorrhiza.
In the formula, the rhodiola rosea has the effects of dissipating blood stasis and reducing swelling, tonifying qi and clearing heat, the cortex moutan and the salvia miltiorrhiza have the effects of clearing heat and activating blood, the three medicines are monarch medicines together and are combined with ligusticum wallichii, radix paeoniae rubra, angelica and the like to strengthen the effects of activating blood and clearing heat, promoting qi circulation and dissipating blood stasis, the radix ophiopogonis, the adenophora stricta, the radix pseudostellariae and the astragalus mongholicus have the effects of tonifying qi, nourishing yin and clearing away lung heat, the polyporus umbellatus and the poria cocos have the effects. The whole formula has the effects of removing blood stasis, clearing heat, nourishing yin, clearing lung-heat, relieving cough and asthma and has good treatment effect on radioactive lung injury.
The use method comprises the following steps: the decoction is decocted into decoction for continuous administration for 1-6 months.
Preferably, the components are calculated according to the following parts by mass: 15 parts of cortex moutan, 9 parts of ligusticum chuanxiong hort, 9 parts of radix paeoniae rubra, 10 parts of radix ophiopogonis, 10 parts of adenophora stricta, 12 parts of radix astragali, 15 parts of polyporus umbellatus, 15 parts of poria cocos, 15 parts of radix pseudostellariae, 9 parts of coltsfoot, 12 parts of loquat leaf, 8 parts of bulbus fritilariae, 4 parts of liquorice, 10 parts of rhodiola rosea, 24 parts of houttuynia cordata, 9 parts of scutellaria baicalensis, 10 parts of angelica sinensis and 15 parts of salvia miltiorrhiza.
In the formula of the invention, rhodiola rosea, salvia miltiorrhiza, scutellaria baicalensis, houttuynia cordata, ligusticum wallichii, liquorice, angelica, scutellaria baicalensis and the like have the functions of resisting oxidation and removing free radicals; radix astragali, Saviae Miltiorrhizae radix, radix Rhodiolae, and radix Angelicae sinensis with radioprotective and cell stabilizing effects; polyporus, Poria, and radix astragali can reduce pulmonary exudation and interstitial edema; tussilago farfara, loquat leaves, tendril-leaved fritillary bulb, liquorice and the like can relieve cough; cortex moutan, rhizoma Ligustici Chuanxiong, radix Paeoniae Rubra, Saviae Miltiorrhizae radix, radix Angelicae sinensis, etc. can improve microcirculation, prevent and treat microthrombus, and reduce exudation; radix astragali and radix Angelicae sinensis can improve immunity and protect bone marrow; herba Houttuyniae, Scutellariae radix, Glycyrrhrizae radix, etc. have antiinflammatory effect; radix astragali, radix Rhodiolae, radix Angelicae sinensis, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, radix Adenophorae, cortex moutan, etc. have anti-fibrosis effect. The following are specific examples:
example 1: weighing 13g of cortex moutan, 7g of ligusticum chuanxiong hort, 7g of radix paeoniae rubra, 8g of radix ophiopogonis, 8g of adenophora stricta, 10g of radix astragali, 13g of polyporus umbellatus, 13g of poria cocos, 13g of radix pseudostellariae, 7g of coltsfoot, 10g of loquat leaf, 6g of bulbus fritilariae, 2g of liquorice, 8g of rhodiola rosea, 22g of houttuynia cordata, 7g of scutellaria baicalensis, 8g of angelica sinensis and 13g of salvia miltiorrhiza, and decocting the traditional Chinese medicines in water to obtain decoction for.
Example 2: weighing 15g of cortex moutan, 9g of ligusticum chuanxiong hort, 9g of radix paeoniae rubra, 10g of radix ophiopogonis, 10g of adenophora stricta, 12g of radix astragali, 15g of polyporus umbellatus, 15g of poria cocos, 15g of radix pseudostellariae, 9g of coltsfoot, 12g of loquat leaf, 8g of bulbus fritilariae, 4g of liquorice, 10g of rhodiola rosea, 24g of houttuynia cordata, 9g of scutellaria baicalensis, 10g of angelica sinensis and 15g of salvia miltiorrhiza, and decocting the traditional Chinese medicines in water to obtain decoction for.
Example 3: weighing 17g of cortex moutan, 11g of ligusticum chuanxiong hort, 11g of radix paeoniae rubra, 12g of radix ophiopogonis, 12g of adenophora stricta, 14g of radix astragali, 17g of polyporus umbellatus, 17g of poria cocos, 17g of radix pseudostellariae, 11g of coltsfoot, 14g of loquat leaf, 10g of bulbus fritilariae, 6g of liquorice, 12g of rhodiola rosea, 26g of houttuynia cordata, 1g of scutellaria baicalensis, 12g of angelica sinensis and 17g of salvia miltiorrhiza, and decocting the traditional Chinese medicines in water to obtain decoction for administration.
Clinical data: statistical table of 16 cases of radiation-induced lung injury after treatment with the above-described traditional Chinese medicine formulation (anti-inflammatory formulation) of examples 1-3 of the present invention:
case number Diagnosis of Grading of radiodermatitis Rotary return Method of treatment
1 Thymus gland cancer 3 Cure of disease Chinese medicine
2 Adenocarcinoma of lung 2 Show effect Chinese medicine
3 Lung (lung) 3 Show effect Chinese medicine for hormone and Chinese medicine combination
4 Squamous cell carcinoma of lung 3 Show effect Hormone combination of traditional Chinese medicine
5 Breast cancer 2 Recovery method Chinese medicine
6 Adenocarcinoma of lung 2 Recovery method Chinese medicine
7 Lung (lung) 2 Show effect Hormone 5 Chinese medicine
8 Lung (lung) 3 Show effect Hormone combined Chinese medicine
9 Lung (lung) 2 Show effect Chinese medicine
10 Small cell fibrosis 2 Improvement 2 Chinese medicine
11 Small cell lung cancer 2 Show effect Chinese medicine
12 Lung cancer 2 Recovery method Chinese medicine
13 Small cell lung cancer 4 Death was caused by death Hormone combination of traditional Chinese medicine
14 Adenocarcinoma of lung 2 Show effect Chinese medicine
15 Esophageal cancer 3 Show effect Hormone combination of traditional Chinese medicine
16 Lung cancer 3 Show effect Chinese medicine
Note: and (3) curing: the image and symptoms disappear completely; the effect is shown: the image improvement is more than 50%, and the symptoms are improved or disappeared; improvement: the symptoms are obviously relieved, and the improvement of the image is not more than 50%; and (4) invalidation: no change or progression of imaging symptoms occurred. The medicine is taken for 2 weeks in the shortest period and 5 months in the longest period, and the effective rate is 93.75 percent. The following are typical of the above cases:
case 1: acute cough, insomnia, chest distress and short breath appear 1 month after radiotherapy is finished, the grade is 3 RILI, and lung CT is shown in figure 1 and figure 2; the patient refuses to use hormone, after taking the inflammation relieving formula of the invention for 3 months and 90 weeks, the cough, the chest distress and the breathlessness are completely relieved, and the lung CT is rechecked as shown in figure 3.
Case 3: malignant tumor of lung, radiation pneumonia of grade 3 after radiotherapy, hormone treatment for 1 month, getting better and getting worse, CT of lung is as shown in figure 4, figure 5; continuing to use hormone, and taking the prescription of the invention 1 month later, wherein the lung CT is shown in figure 6; after the hormone is stopped and the anti-inflammatory formula of the invention is continuously taken for 3 months, the CT of the lung is as shown in figure 7.
Although the incidence of radioactive lung injury decreases with advances in radiotherapy equipment and technology, it is still a major adverse effect of breast tumors. The western medicine mainly takes hormone as the main treatment, but the hormone has the side effects of reducing immunity, central obesity, osteoporosis and the like, and particularly has great risk of infection under the condition that the resistance of a tumor patient is low. The above embodiment shows that the traditional Chinese medicine formula for treating inflammation provided by the invention is economic, mild and effective in medicine selection, has no obvious side effect, is high in effective rate, is mainly benefited by firstly proposing a treatment principle mainly based on blood stasis and is also in accordance with the diagnosis and treatment mechanism of western medicine, most of the medicine selection is modern pharmacological verification and acts on each pathological change link, the traditional Chinese medicine has macroscopic regulation and control as well as refinement of the western medicine theory, and finally the microenvironment is improved, so that the radioactive lung injury is reversed.

Claims (2)

1. The traditional Chinese medicine treatment formula for the radioactive lung injury is characterized by being prepared from the following components in parts by mass: 13-17 parts of cortex moutan, 7-11 parts of ligusticum chuanxiong hort, 7-11 parts of radix paeoniae rubra, 8-12 parts of radix ophiopogonis, 8-12 parts of radix adenophorae, 10-14 parts of radix astragali, 13-17 parts of polyporus umbellatus, 13-17 parts of poria cocos, 13-17 parts of radix pseudostellariae, 7-11 parts of coltsfoot, 10-14 parts of loquat leaf, 6-10 parts of bulbus fritilariae, 2-6 parts of liquorice, 8-12 parts of rhodiola rosea, 22-26 parts of houttuynia cordata, 7-11 parts of scutellaria baicalensis, 8-12 parts of angelica sinensis and 13-17 parts of salvia miltiorrhiza.
2. The traditional Chinese medicine treatment formula for radiation-induced lung injury according to claim 1, characterized in that the components are calculated in parts by mass as follows: 15 parts of cortex moutan, 9 parts of ligusticum chuanxiong hort, 9 parts of radix paeoniae rubra, 10 parts of radix ophiopogonis, 10 parts of adenophora stricta, 12 parts of radix astragali, 15 parts of polyporus umbellatus, 15 parts of poria cocos, 15 parts of radix pseudostellariae, 9 parts of coltsfoot, 12 parts of loquat leaf, 8 parts of bulbus fritilariae, 4 parts of liquorice, 10 parts of rhodiola rosea, 24 parts of houttuynia cordata, 9 parts of scutellaria baicalensis, 10 parts of angelica sinensis and 15 parts of salvia miltiorrhiza.
CN202010257623.2A 2020-04-03 2020-04-03 Traditional Chinese medicine treatment formula for radioactive lung injury Withdrawn CN111265615A (en)

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Application publication date: 20200612