CN111249347A - Composition for dispelling effects of alcohol and protecting liver and product - Google Patents

Composition for dispelling effects of alcohol and protecting liver and product Download PDF

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Publication number
CN111249347A
CN111249347A CN201911205090.7A CN201911205090A CN111249347A CN 111249347 A CN111249347 A CN 111249347A CN 201911205090 A CN201911205090 A CN 201911205090A CN 111249347 A CN111249347 A CN 111249347A
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product
composition
bifidobacterium lactis
hangover
cfu
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陈醇
何剑
华彦俊
赵子夫
冯昊天
朱佳
陈奕旻
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Inner Mongolia Yili Industrial Group Co Ltd
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Inner Mongolia Yili Industrial Group Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/127—Fermented milk preparations; Treatment using microorganisms or enzymes using microorganisms of the genus lactobacteriaceae and other microorganisms or enzymes, e.g. kefir, koumiss
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
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    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
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    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
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    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
    • A23L2/84—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter using microorganisms or biological material, e.g. enzymes
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract

The invention relates to the field of food and medicine, in particular to a composition for dispelling effects of alcohol and protecting liver and a product thereof. In particular, the invention relates to an anti-hangover and hepatoprotective composition comprising a plant extract and probiotics, and products (such as food and pharmaceutical products) comprising the anti-hangover and hepatoprotective composition.

Description

Composition for dispelling effects of alcohol and protecting liver and product
Technical Field
The invention relates to the field of food and medicines, in particular to a composition for relieving alcoholism and protecting liver and a product containing the composition.
Background
China is one of the origins of wine brewing technology. According to the evidence, the method and the process of manual wine brewing are mastered by the Chinese civilization at the latest in the summer. Since then, wine culture and wine shop culture have become important components of Chinese civilization. The customers need to pay for drinking, companies need to drink in a party, classmates need to drink in a party, and the liquor is less in the coming years. Besides the pleasure feeling brought by drinking and the cultural function carried by the drinking, the moderate drinking also has the functions of activating blood, dispelling cold, relieving tension and promoting metabolism. However, the related diseases may be caused and induced by long-term drinking or by taking large amounts of alcoholic beverages at a time. Alcohol poisoning not only harms the health of individuals, but also affects the harmonious safety of the society. Investigation studies have shown that about 57.5% of people who drink alcohol for a long time are fatty liver patients and 15% of people who drink alcohol for a long time are cirrhosis patients. The incidence of some digestive system tumors such as gastric cancer, esophageal cancer and liver cancer is increased and the tumors are closely related to alcoholism. In addition, acute alcoholism is easily caused by excessive drinking once, and the central nervous system, the cardiovascular system and the like are damaged, so that a drinker is unconscious, slow in action, easy to dry and irritable.
Therefore, there is a need to develop anti-hangover and hepatoprotective products to reduce the harm of alcohol drinking to human body.
Disclosure of Invention
The invention provides a composition for relieving alcoholism and protecting liver and a product containing the composition, wherein the composition accelerates alcohol metabolism in vivo through the combination of plant extracts, probiotics and other nutrient substances, improves intestinal flora disorder caused by alcohol, has auxiliary protection effect on alcoholic liver injury, and achieves the effects of relieving alcoholism and protecting liver.
In one aspect, the application provides an anti-alcoholism and liver-protecting composition comprising hovenia dulcis thunb extract, taurine, yeast powder, pueraria extract and probiotics, wherein the probiotics comprise lactobacillus acidophilus NCFM, lactobacillus paracasei Lpc-37, bifidobacterium lactis Bi-07, bifidobacterium lactis Bl-04 and bifidobacterium lactis HN 019.
In some embodiments, the weight ratio of hovenia dulcis thunb extract, taurine, yeast powder and pueraria extract is 10-30: 2-8: 25-100: 5-15, such as 20:4:50: 10.
In certain embodiments, the ratio of viable bacteria addition amounts of lactobacillus acidophilus NCFM, lactobacillus paracasei Lpc-37, bifidobacterium lactis Bi-07, bifidobacterium lactis Bl-04, bifidobacterium lactis HN019 is 1-4: 1-4: 1-4: 1-4: 4 to 10, for example 1:1:1:1: 6.
In some embodiments, each part of the hangover alleviating and liver protecting composition comprises 420-1530 mg of hovenia dulcis thunb extract, taurine, yeast powder and radix puerariae extract, and 8 × 10 probiotics9～2.6×1010colony forming unit(CFU)。
In certain embodiments, the anti-hangover and hepatoprotective composition comprises 100-300 mg, such as 200mg, of Hovenia dulcis Thunb extract per serving.
In certain embodiments, taurine is included in an amount of 20-80 mg, such as 40mg, per serving of the anti-hangover and hepatoprotective composition.
In some embodiments, the anti-hangover and hepatoprotective composition comprises 250 to 1000mg, such as 500mg, of yeast powder per serving.
In some embodiments, the anti-hangover and hepatoprotective composition comprises 50-150 mg, such as 100mg, of the kudzu root extract per serving.
In certain embodiments, each anti-hangover and hepatoprotective composition comprises lactobacillus acidophilus NCFM1 × 109～4×109CFU, e.g. 1X 109CFU。
In certain embodiments, each anti-hangover and hepatoprotective composition comprises lactobacillus paracasei Lpc-371 × 109～4×109CFU, e.g. 1X 109CFU。
In certain embodiments, each part of the hangover-alleviating and liver-protecting composition comprises bifidobacterium lactis Bi-071 x 109～4×109CFU, e.g. 1X 109CFU。
In certain embodiments, Bifidobacterium lactis Bl-041X 10 is included in each anti-hangover and hepatoprotective composition9～4×109CFU, e.g. 1X 109CFU。
In certain embodiments, bifidobacterium lactis is included per anti-hangover and hepatoprotective compositionHN0194×109～1×1010CFU, e.g. 6X 109CFU。
In the composition of the present invention, hovenia dulcis thunb extract and pueraria lobata extract are generally considered to have bacteriostatic action, and those skilled in the art will not generally use these plant extracts in combination with probiotics in order to avoid the activity of the probiotics from being affected. However, the present invention uses the plant extract in combination with probiotics, which unexpectedly has good anti-hangover and liver-protecting effects.
In addition, the components in the composition can generate synergistic action, and the combination of the components can realize synergistic effect compared with the single use.
The application also relates to a product, wherein the product or the raw material of the product comprises any one of the hangover-alleviating and liver-protecting compositions.
In certain embodiments, the product is a food product, such as a general or health food, for example, a yogurt, a lactic acid bacteria beverage, a milk tablet, a solid beverage, or a tabletted candy.
In certain embodiments, the solid beverage further comprises a carrier (e.g., a sugar alcohol).
For solid beverages, plant extracts such as hovenia dulcis thunb extract, pueraria lobata extract and the like and probiotics are preferably present in different packages to avoid the influence of a small amount of moisture that may be present in the plant extracts on the probiotics.
The product of the invention can be used for shortening the drunk time and/or sobering time of a drinker, reducing the blood ethanol content level of the drinker and/or reducing the ethanol accumulation level in the blood of the drinker, or can be used for auxiliary protection of chemical liver injury (such as alcoholic liver injury).
In certain embodiments, the product is a pharmaceutical product (e.g., a Chinese patent drug) that can be used to prevent and/or treat chemical liver injury (e.g., alcoholic liver injury).
In the product of the present invention, the pharmaceutical or health food may be prepared into any dosage form suitable for oral administration, such as tablet, granule, capsule, pill or oral liquid.
In certain embodiments, each minimum sales unit of the product comprises a minimum effective dose of 1-50 times (e.g., 1-fold, 5-fold, 10-fold, 15-fold, 20-fold, 30-fold, 40-fold, or 50-fold) of the anti-hangover and liver-protecting composition. For food products, the minimum sales unit can be the minimum amount a consumer purchases at one time. For pharmaceutical products, the minimum sales unit may be a prescription bolus, a minimum amount purchased by a consumer at a time, a seven day minimum bolus, or a one course bolus.
In certain embodiments, the least effective dose is the least effective dose for an adult human weighing about 70 kg. In certain embodiments, the minimum effective dose is one serving of the anti-hangover and hepatoprotective composition.
In certain embodiments, each of the smallest packaged products comprises:
100-300 mg, such as 200mg, of Hovenia dulcis Thunb extract;
20-80 mg, for example 40mg, of taurine;
250-1000 mg of yeast powder, such as 500 mg;
50-150 mg, for example 100mg, of kudzu root extract;
lactobacillus acidophilus NCFM1 x 109～4×109CFU, e.g. 1X 109CFU；
Lactobacillus paracasei Lpc-371X 109～4×109CFU, e.g. 1X 109CFU；
Bifidobacterium lactis Bi-071 multiplied by 109～4×109CFU, e.g. 1X 109CFU；
Bifidobacterium lactis Bl-041X 109～4×109CFU, e.g. 1X 109CFU；
Bifidobacterium lactis HN 0194X 109-1×1010CFU, e.g. 6X 109CFU。
In certain embodiments, each of the smallest packaged products comprises:
500-1500 mg, such as 1g, of semen Hoveniae extract;
100-400 mg, for example 200mg, of taurine;
750-5000 mg of yeast powder, for example 2.5 g;
250-750 mg, for example 500mg, of kudzu root extract;
lactobacillus acidophilus NCFM 5 x 109～2×1010CFU, e.g. 5X 109CFU；
Lactobacillus paracasei Lpc-375 x 109～2×1010CFU, e.g. 5X 109CFU；
Bifidobacterium lactis Bi-075X 109～2×1010CFU, e.g. 5X 109CFU；
Bifidobacterium lactis Bl-045X 109～2×1010CFU, e.g. 5X 109CFU；
Bifidobacterium lactis HN 0195X 109～5×1010CFU, e.g. 3X 1010CFU。
In certain embodiments, each of the smallest packaged products comprises:
1-3 g, such as 2g, of semen Hoveniae extract;
200-800 mg, for example 400mg, of taurine;
2.5-10 g of yeast powder, for example 5 g;
500-1500 mg, such as 1g, of kudzu root extract;
lactobacillus acidophilus NCFM1 x 1010～4×1010CFU, e.g. 1X 1010CFU；
Lactobacillus paracasei Lpc-371X 1010～4×1010CFU, e.g. 1X 1010CFU；
Bifidobacterium lactis Bi-071 multiplied by 1010～4×1010CFU, e.g. 1X 1010CFU；
Bifidobacterium lactis Bl-041X 1010～4×1010CFU, e.g. 1X 1010CFU；
Bifidobacterium lactis HN 0194X 1010～1×1011CFU, e.g. 6X 1010CFU。
In the composition of the present invention, hovenia dulcis thunb extract, pueraria extract, taurine, yeast powder or probiotic bacteria may be used in the form of powder, i.e., hovenia dulcis thunb powder, pueraria powder, taurine powder, yeast powder or probiotic bacteria powder, respectively, independently.
In some embodiments, the hovenia dulcis thunb powder, pueraria lobata powder, taurine powder, yeast powder or probiotic powder has a mesh number of 80-180 mesh (e.g., 80-100 mesh, 100-120 mesh, 120-140 mesh, 140-160 mesh or 160-180 mesh) independently.
The application also relates to a preparation method of the hangover-alleviating and liver-protecting composition, which comprises the steps of mixing, granulating or tabletting the components contained in the composition.
The application also relates to an application of any one of the hangover-alleviating and liver-protecting compositions in preparation of products.
In certain embodiments, the product is a food product, such as a general or health food, for example, a yogurt, a solid beverage, a lactic acid bacteria beverage, a milk tablet, or a tabletted candy.
In certain embodiments, the product is a solid beverage with a sugar alcohol as a carrier.
In certain embodiments, the product may be used to reduce the time to intoxication and/or the time to sober-up for a drinker, to reduce the level of alcohol content in the drinker's blood and/or to reduce the level of alcohol accumulation in the drinker's blood, or may be used for the auxiliary protection of chemical liver injury (e.g. alcoholic liver injury).
In certain embodiments, the product is a pharmaceutical product (e.g., a Chinese patent drug) that can be used to prevent and/or treat chemical liver injury (e.g., alcoholic liver injury).
The application also relates to the following technical scheme:
scheme 1: a composition for relieving alcoholism and protecting liver comprises semen Hoveniae powder, taurine, yeast powder, radix Puerariae powder and probiotics, wherein the probiotics comprise Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium lactis Bi-07, Bifidobacterium lactis Bl-04 and Bifidobacterium lactis HN 019;
preferably, the addition ratio of the hovenia dulcis thunb powder, taurine, yeast powder and radix puerariae powder is 10-30: 2-8: 25-100: 5-15;
preferably, the ratio of the viable bacteria addition amount of lactobacillus acidophilus NCFM, lactobacillus paracasei Lpc-37, bifidobacterium lactis Bi-07, bifidobacterium lactis Bl-04 and bifidobacterium lactis HN019 is 1-4: 1-4: 1-4: 1-4: 4-10.
Scheme 2: a product, e.g. a food, e.g. a general food or a health food, such as a yoghurt, a lactic acid bacteria beverage, a milk tablet, a solid beverage or a tabletted candy, comprising the anti-hangover and hepatoprotective composition of scheme 1.
Scheme 3: the preparation method of the hangover-alleviating and liver-protecting composition according to the scheme 1 comprises the steps of mixing, granulating or tabletting the components contained in the composition.
Scheme 4: use of the anti-hangover and hepatoprotective composition of scheme 1 for the preparation of a product, preferably a food, such as a general food or a health food, such as yogurt, lactic acid bacteria beverage, milk tablet, solid beverage or tabletted candy.
Definition of terms
In the present application, unless otherwise specified, scientific and technical terms used herein have the meanings commonly understood by those skilled in the art, however, in order to better understand the present invention, definitions of some terms are provided below. Where the definitions and explanations of terms provided herein do not conform to the meanings commonly understood by those skilled in the art, the definitions and explanations of terms provided herein shall control.
As used herein, the term "hovenia dulcis thunb extract" refers to an extract derived from dried mature seeds of hovenia dulcis thunb, a plant belonging to the genus hovenia of the family rhamnaceae, by an extraction method which may be water, and the main active ingredient may comprise alkaloid, flavone and/or saponin, etc.
As used herein, the term "pueraria extract" refers to an extract derived from the dried root of pueraria lobata, pueraria lobata or pueraria lobata of leguminosae, which may be extracted with water, and the main active ingredient may include isoflavones, triterpenes and/or coumarins, etc.
As used herein, the term "anti-hangover" refers to the effect of reducing the time a drinker is intoxicated and/or the time of sobering up, reducing the alcohol content in the drinker's blood and/or reducing the accumulation of alcohol in the drinker's blood.
As used herein, the term "liver protection" refers to the action of protecting the liver, reducing liver damage (e.g., reducing alcoholic liver damage).
Advantageous effects
The composition or product of the invention can improve the discomfort after drinking, shorten the drunk time and/or sober-up time of drinkers, reduce the blood ethanol content of drinkers and/or reduce the ethanol accumulation in the blood of drinkers. The composition or product of the present invention can be taken before drinking to prevent drunkenness. In addition, the composition or the product of the invention has auxiliary protection effect on alcoholic liver injury.
Embodiments of the present invention will be described in detail below with reference to the drawings and examples, but those skilled in the art will understand that the following drawings and examples are only for illustrating the present invention and are not to be construed as limiting the scope of the present invention. Various objects and advantageous aspects of the present invention will become apparent to those skilled in the art from the accompanying drawings and the following detailed description of the preferred embodiments.
Drawings
FIG. 1 shows the blood ethanol content curve of rat in Experimental example 2.
FIG. 2 shows the effect of the composition of the present invention on MDA (FIG. 2A), GSH (FIG. 2B), TG (FIG. 2C) in liver tissue of mice with alcoholic liver injury in Experimental example 3.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
Preparation of the anti-hangover and hepatoprotective composition
Raw materials:
a kudzu root extract; (Jianshixing Biotechnology research & development (Shanghai) Co., Ltd., batch No. 180622, actual measurement of puerarin content 8.3%);
hovenia dulcis thunb extract (Jianshi xing biotechnology research and development (Shanghai) Co., Ltd., batch No. 180515, actually measured content of dihydromyricetin is 6.5%);
taurine (shineway Yongan pharmaceuticals, Inc.);
yeast powder (Lesfu management (Shanghai) Co., Ltd., product type: Lynside Forte BUS vitamin-enriched yeast);
mixed probiotic powder (danisc (china) investment limited) containing per gram: lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium lactis Bi-07, Bifidobacterium lactis Bl-04 each 5 × 108CFU and Bifidobacterium lactis HN 0193X 109CFU。
Preparation: the haplotype formulation was determined based on the daily dose of 70kg human, as shown in Table 1. The raw materials were mixed according to the formulation of table 1.
TABLE 1
Composition (I) Adding the additive in each part
Semen Hoveniae extract 200mg
Taurine 40mg
Yeast powder 500mg
Kudzu root extract 100mg
Lactobacillus acidophilus NCFM 1×109CFU
Lactobacillus paracasei Lpc-37 1×109CFU
Bifidobacterium lactis Bi-07 1×109CFU
Bifidobacterium lactis Bl-04 1×109CFU
Bifidobacterium lactis HN019 6×109CFU
Experimental example the composition of the present invention is used for the research of the hangover alleviating effect of an alcoholic intoxication model and the evaluation of the protective effect of alcoholic liver injury
1. Experimental Material
Materials and reagents: the anti-hangover and hepatoprotective composition of example 1; 56% (V/V) Hongxing Erguotou white spirit (Beijing Hongxing GmbH); reduced Glutathione (GSH) assay kit, Malondialdehyde (MDA) assay kit, and Triglyceride (TG) assay kit (sigma aldrich trade ltd).
Instruments and equipment: spectrophotometer, ultra-high speed refrigerated centrifuge, Agilent 7890A gas chromatograph, electronic balance.
Experimental animals:
SD male rats (8 weeks old, 220-240 g), male Kunming mice (8 weeks old, 18-20 g), provided by Beijing Wittingli experiment technology Limited; license number: SCXK (Jing) 2014-. Animals are raised in animal laboratories of the institute of occupational health and poisoning control of the Chinese disease prevention and control center, room temperature (25 +/-2 ℃), relative humidity (55 +/-2)%, 12h/12h illumination, and free food intake and drinking.
2. Sample preparation
Preparing a mouse experimental sample:
in the mouse experiment, 1 time, 5 times and 10 times of the human body dose are respectively used as the low dose, the medium dose and the high dose of the mouse experiment, the required amount of a 20g mouse sample is calculated according to the conversion coefficient of 70kg human body dose and 20g mouse dose of 0.0026, the stomach filling dose of the mouse is 2mL/100g bw (bw: body weight) during preparation, and the specific dose is shown in table 2.
TABLE 2 mouse body dose table (unit: mg)
Figure BDA0002296760010000091
According to the daily mouse sample requirement, 10mL of each sample is prepared for intragastric administration, and the table shows the amount of the sample required for preparing 10mL of intragastric administration solution for each dosage group.
Preparation of experimental samples of rats:
in rat experiments, 1 time, 5 times and 10 times of human body dose are taken as rat dose, a conversion coefficient of 70kg human body dose and 200g rat dose is referred to be 0.018, 2.0mL/100g bw is taken as rat gavage dose during preparation, and specific dose is shown in table 3.
TABLE 3 rat body dosage table (unit: mg)
Figure BDA0002296760010000092
According to the gavage dosage and the volume of the rats, 100mL of each dose of the gavage liquid is prepared by each gavage.
3. Data processing
The behavioral index data are expressed as mean ± standard deviation, median and quartile, and the other data are expressed as mean ± standard deviation. SAS 9.4 software is adopted for data analysis, and single-factor method analysis or rank-sum inspection is adopted for significance comparison among groups. The difference is statistically significant with p < 0.05.
Experimental example 1 behavioral Observation experiment
The experimental method comprises the following steps:
80 mice, after 3 days of acclimation, were randomly divided into 4 groups of 20 mice each, based on body weight. And before the experiment, the patient is fasted and water is not forbidden for 12 hours. The experimental group was administered with different doses of anti-hangover composition (1, 5 and 10 times of the human dose as low, medium and high dose of experiment), respectively, at a gavage dose of 2mL/100g bw, and the control group was administered with distilled water, and the gavage time was recorded. After 30min of administration, each group was drenched with 56% (V/V) Hongxing Erguotou 0.19mL/10g body weight, and the behavioral indexes of the mice were observed.
After the mice were drenched with white spirit, they were immediately placed on a vertical metal net, and the climbing time of the mice on the metal net was recorded.
And continuously observing the activity condition of the mouse, and recording the drunkenness time and the sobering time of the mouse. The drunk time is the righting reflex recovery time-righting reflex disappearance time. Sobering-up time is the righting reflex recovery time-drinking time. The drunk time is the comprehensive embodiment of drunk latency and sleeping time.
The experimental results are as follows:
the results of the experiment are shown in table 4.
Table 4 effect of the composition of the invention on behavioural indicators of drunk mice
Figure BDA0002296760010000101
Note: indicates that the difference is significant compared with the model control group, and p is less than 0.05. The data in the table are: mean. + -. standard deviation (median, P25-P75 quantile) for the distribution of climax, intoxication and sober-up times.
As shown in Table 4, the alcohol intoxication rate of the model control group was 80%, that of the low and medium dose test groups was 60%, and that of the high dose test group was 75%, which were lower than those of the model control group. Each group of test mice exhibited greater intra-group individual variability in climbing time, intoxication time and sobering time. Compared with the average climbing time (5.85 +/-4.42 min) of the mice in the model control group, the climbing time distribution of the mice in each dose experiment group is basically consistent. Compared with the average drunkenness time (482.79 +/-227.39 min) and the median and quartile (577min, P25-P75: 511-634 min) of mice in a model control group, the average drunkenness time of the mice in each dose experiment group is shortened to a certain degree, and is respectively shortened by 46.10%, 30.89% and 28.83%, wherein the difference between a low dose group and a high dose group is obvious, and the difference has statistical significance (P is less than 0.05). Compared with the average value of the sobering-up time of the mice in the model control group (626.05 +/-68.04 min), the median and the quartile (630min, P25-P75: 571-683 min), the average value of the sobering-up time of the mice in each dose experiment group is shortened to a certain extent (28.02%, 13.26% and 19.57% respectively), wherein the shortening of the low dose group and the shortening of the high dose group are obvious, and the difference has statistical significance (P is less than 0.05).
Experimental example 2 ethanol content measurement
The experimental method comprises the following steps:
after 3 days of acclimation, 40 rats were randomly divided into 4 groups of 10 rats each according to body weight. Fasting for 12h before the experiment, and water is forbidden. The experimental group is respectively given different doses of the anti-alcoholism composition with the intragastric administration dose of 2mL/100g bw (respectively according to the conversion method of the animal pharmacology experiment medication, the conversion coefficient of 70kg human body dose and 200g rat dose is 0.018, and 1 time, 5 times and 10 times of the human body dose are taken as the low dose, the medium dose and the high dose of the experiment), the control group is given distilled water, and the intragastric administration time is recorded. After 30min, each group was gavaged with 56% white wine at 1.33mL/100g bw and the gavage time was recorded. Blood is taken from inner canthus at four time points of 0.5h, 1.0h, 2.0h and 3.0h after wine filling respectively, and the content of blood ethanol is detected by adopting a gas chromatograph.
The experimental results are as follows:
FIG. 1 shows the curve of ethanol content in rat blood, wherein ▲ shows that the difference is significant compared with the model control group, and p is less than 0.05. As shown in the figure, after 0.5h of wine filling, the ethanol content in the model control group is 3.08 +/-0.85 mg/mL, the ethanol level continuously rises but tends to be stable within 1h to 3 h.
Table 5 shows the area under the blood ethanol curve of the rat (indicating the accumulation degree of ethanol in the blood of the rat), the area under the blood ethanol curve of the rat in the experimental group with different doses at each time point is obviously lower than that of the model control group, and the difference between the low dose group and the high dose group with 0.5h and 1.0h and the model control group has statistical significance (p is less than 0.05). The above results show that the composition of the present invention can rapidly reduce the blood ethanol content level of rats and reduce the accumulation level of ethanol in blood.
TABLE 5 area under the curve of the ethanol content in rat blood (unit: mg/mL. h)
Figure BDA0002296760010000121
Note: indicates that the difference is significant compared with the model control group, and p is less than 0.05.
Experimental example 3 evaluation of protective action against alcoholic liver injury
Refer to "health food function evaluation program and technical Specification", evaluation method of auxiliary protection function for chemical liver injury, alcoholic liver injury model ", issued by Ministry of health. After adaptive feeding of 70 mice for 3 days, they were randomly divided into 5 groups of 14 mice each based on body weight. Experimental settings were blank control, model control, low dose, medium dose and high dose (methods above). The experimental group is given with different dosages of the anti-inebriation composition to be tested at the dosage of 0.4mL/20g bw every day, and the blank control group and the model control group are given with distilled water, and the intervention period is 45 days. And (3) feeding 12mL/kg bw of 50% ethanol to the model control group and each dose experiment group by intragastric administration at one time at the end of the intervention period to establish an acute alcoholic liver injury model, feeding distilled water to the blank control group, and killing the animals after fasting for 16 h. A part of liver of a mouse is taken and placed in physiological saline to prepare 10% liver homogenate for MDA, GSH and TG detection.
The experimental results are as follows:
FIG. 2 shows the effect of the composition of the present invention on MDA, GSH, TG in liver tissue of mice with alcoholic liver injury, wherein a indicates the significance of the difference compared with the blank control (p < 0.05) and a # indicates the significance of the difference compared with the model control (p < 0.05).
As shown in FIGS. 2A, 2B and 2C, compared with the MDA (5.22 + -0.71 nmol/mgprot), GSH (5.52 + -0.37 mg/gpprot) and TG (0.80 + -0.14 mmol/gpprot) of the mice in the blank control group, the MDA and TG contents of liver tissues of the mice in the model control group are significantly higher than those in the blank control group, the GSH content is significantly lower than that in the blank control group, and the difference has statistical significance (p is less than 0.05), which indicates that the alcohol-induced hepatocytes generate certain damage and the modeling is successful.
Compared with a model control group, the liver tissue homogenate MDA content of mice in each dose group is reduced, wherein the MDA content of low, medium and high dose groups is reduced by 16.10%, 10.98% and 16.98%, and the difference between the low dose group and the high dose group has statistical significance (p is less than 0.05). The content of TG in mice in each dose group is obviously lower than that in a model control group, wherein the content is 42.11%, 40.13% and 38.82%, and the difference has statistical significance (p is less than 0.05). Compared with the model control group, the GSH content of the mice in each dose group is obviously increased and is respectively 18.33%, 35.73% and 38.98%, and the difference has statistical significance (p is less than 0.05). In conclusion, the composition provided by the invention can be used for intervention for a long time, so that the MDA and TG contents of liver tissues of an alcoholic liver injury mouse model can be effectively reduced, and the GSH content can be increased.
The experiments prove that the composition can shorten the drunk time and the sobering-up time of a subject, reduce the blood ethanol content level of the subject, reduce the ethanol accumulation level in blood and have auxiliary protection effect on alcoholic liver injury. In conclusion, the composition has the effects of relieving alcoholism and protecting liver.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (9)

1. A composition for relieving alcoholism and protecting liver comprises hovenia dulcis thunb extract, taurine, yeast powder, radix puerariae extract and probiotics, wherein the probiotics comprise lactobacillus acidophilus NCFM, lactobacillus paracasei Lpc-37, bifidobacterium lactis Bi-07, bifidobacterium lactis Bl-04 and bifidobacterium lactis HN 019.
2. The anti-hangover and hepatoprotective composition of claim 1, having one or more of the following characteristics:
(1) the weight ratio of the hovenia dulcis thunb extract to the taurine to the yeast powder to the kudzu root extract is 10-30: 2-8: 25-100: 5-15;
(2) the ratio of the viable bacteria addition amount of lactobacillus acidophilus NCFM, lactobacillus paracasei Lpc-37, bifidobacterium lactis Bi-07, bifidobacterium lactis Bl-04 and bifidobacterium lactis HN019 is 1-4: 1-4: 1-4: 1-4: 4-10;
(3) each part of the anti-alcoholism and liver-protecting composition comprises 420-1530 mg of hovenia dulcis thunb extract, taurine, yeast powder and kudzu root extract and 8 x 10 probiotics9～2.6×1010CFU。
3. A product, or starting material for said product, comprising the anti-hangover and hepatoprotective composition of claim 1 or 2.
4. The product according to claim 3, which is a food product, such as a general food or a health food, such as a yoghurt, a lactic acid bacteria drink, a milk tablet, a solid drink or a tabletted candy.
5. The product of claim 3, which is a pharmaceutical product (e.g., a Chinese patent drug);
preferably, the medicament is for the prevention and/or treatment of chemical liver injury (e.g. alcoholic liver injury).
6. A process for preparing a hangover-alleviating and hepatoprotective composition according to claim 1 or 2, comprising mixing, granulating or tableting the ingredients comprising the composition.
7. Use of the anti-hangover and hepatoprotective composition of claim 1 or 2 for the preparation of a product.
8. Use according to claim 7, said product being a food product, such as a general food product or a health food product, such as a yoghurt, a solid drink, a lactic acid bacteria drink, a milk tablet or a tabletted candy.
9. The use of claim 7, said product being a pharmaceutical (e.g. a Chinese patent medicine);
preferably, the medicament is for the prevention and/or treatment of chemical liver injury (e.g. alcoholic liver injury).
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