CN111248323B - 一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药 - Google Patents
一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药 Download PDFInfo
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Abstract
本发明公开了一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药，涉及一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药。它由下列原料组成：藿香9～12g、佩兰9～12g、荷叶9～12g、千里香6～9g、玳玳花6～9g、长春花6～9g。本发明的有益效果是：药物组成简单，服用便捷，口感芳香，安全可靠，无毒副作用，促进胃黏膜的修复，提高患者自愈能力，效果显著。
Description
技术领域
本发明涉及一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药，具体的说是以中草药为原料制备的中成药。
背景技术
慢性萎缩性胃炎是以胃黏膜上皮和腺体萎缩，数目减少，胃黏膜变薄，黏膜基层增厚，或伴幽门腺化生和肠腺化生，或伴不典型增生为特征的慢性消化系统疾病。常表现为上腹部隐痛、胀满、嗳气，食欲不振，或消瘦、贫血等，无特异性。是一种多致病因素性疾病及癌前病变。该病是消化系统常见疾病之一，在我国一般人群中，慢性萎缩性胃炎的发病率甚高，萎缩性胃炎可演变为胃癌。
目前，对萎缩性胃炎的治疗通常会选择服用西药来治疗，但是大部分用药只能暂时缓解患者病痛，很难根治病患，复发率高，而且西药价格昂贵，长期服用也会对身体产生一定的毒副作用。
慢性萎缩性胃炎属中医学“痞满”、“胃脘痛”等的范畴，可由外感之邪内陷，或饮食不节，或过食膏粱厚味，或嗜食烟酒，损伤脾胃助湿生热，湿久化生浊邪，酿生毒邪，浊毒为患；又可因情志不畅，或忧思郁怒，导致肝气不舒，肝郁气滞，木郁土壅，脾失健运，聚水生湿，日久变浊；同时，脾不升清，浊气不降，壅滞中焦，湿浊蕴久，酿生毒邪，浊毒并见，合而为患，损伤胃络。或因先天禀赋不足，脾胃素虚，生化乏源，胃失荣养，致运化失司，浊毒内蕴，损伤胃膜，渐而黏膜萎缩。其演变规律为：多由肝郁气滞，木旺克土，脾虚湿盛，继而积湿成浊，浊郁化热，热蕴成毒，浊毒之邪深伏胃脉血分，最终形成慢性萎缩性胃炎繁杂的病理改变。中医主要从整体出发，根据辨证论治的原则进行治疗。李佃贵国医大师的浊毒证理论认为浊毒内蕴是慢性萎缩性胃炎的基本病理机制，浊毒内蕴证是慢性萎缩性胃炎的主要证型，因此采用化浊解毒方法治疗慢性萎缩性胃炎，取得良好的临床疗效，且无毒副作用。
发明内容
本发明所要解决的技术问题，是针对上述存在的技术不足，提供一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药。药物组成简单，服用便捷，口感芳香，安全可靠，无毒副作用，促进胃黏膜的修复，提高患者自愈能力，效果显著。
本发明采用的技术方案是：提供一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药，由下列原料组成：藿香9～12g、佩兰9～12g、荷叶9～12g、千里香6～9g、玳玳花6～9g、长春花6～9g。
优选的，所述药材原料的重量配比为：藿香9g、佩兰9g、荷叶9g、千里香6g、玳玳花6g、长春花6g。
优选的，本发明的中药制备和服用方法为：取原料的各组分，第一煎加水400mL，浸泡1h，煎30min，取汁200mL；第二煎加水400mL，煎20min，取汁200mL。将2次药液混合后，每日1剂，代茶饮。服用疗程为2～3个疗程(1个疗程为3个月)。
现代药理学研究表明，藿香可抑制肠管痉挛性收缩及内脏绞痛，增加胃酸分泌，提高胃蛋白酶活性；佩兰生物总碱具有抗肿瘤活性，可刺激胃粘膜、促进胃液分泌、帮助消化；千里香有麻醉镇痛的作用。荷叶气味清香，有降血脂作用；玳玳花所含之挥发油对胃肠有温和的刺激作用，能促进消化性分泌，排除肠内积气；长春花有抗肿瘤作用。
根据浊毒内蕴为慢性萎缩性胃炎的核心病机，该药以芳香化浊、清热解毒为大法，对消化脏器全面调理，全方位调理人体机能综合疗法。
本发明有益效果在于：药物组成简单，服用便捷，口感芳香，安全可靠，无毒副作用，促进胃黏膜的修复，提高患者自愈能力，效果显著。
具体实施方式
下面结合具体实施方式对本发明作进一步详细的说明，但不是对本发明的限定。
一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药，由下列原料组成：藿香9～12g、佩兰9～12g、荷叶9～12g、千里香6～9g、玳玳花6～9g、长春花6～9g。
实施例1
藿香9g、佩兰9g、荷叶9g、千里香6g、玳玳花6g、长春花6g。
实施例2
藿香12g、佩兰9g、荷叶9g、千里香6g、玳玳花6g、长春花6g。
实施例3
藿香9g、佩兰9g、荷叶12g、千里香6g、玳玳花6g、长春花6g。
本发明的服用方法为煎熬，代茶饮，具体操作方式可根据实际情况调整。
慢性萎缩性胃炎病程长，迁延难愈，李佃贵国医大师认为浊毒内蕴是胃癌前病变的主要病机之一，化浊解毒法是治疗本病的有效方法。认为浊毒既是致病因素，又为病理产物，慢性萎缩性胃炎与湿浊关系甚为密切。湿浊之邪致病，有内外之分，外感湿浊由外受湿邪所引起，内生湿浊由脾胃功能减退或失调，不能正常运化以致湿浊从中生。内外湿浊之邪相互关联，外感湿浊困脾，必致脾失健运，胃失和降；内生湿浊停滞，又常易招致外感湿浊侵袭。因慢性萎缩性胃炎病变病位在胃，胃属阳土，胃病易于化热化火，即阳道实。热毒之成因有二：热甚为火，火入血分为毒；或初为湿盛，湿盛则浊聚，久郁化热，湿浊化热蕴毒，故毒由温热转化而来,亦可由湿浊演变而生，即热为毒之渐，毒为热之极，毒寓于热，热由毒生，变由毒起。首次从理论上阐明了慢性萎缩性胃炎及其癌前期病变的病因病机，并以此为理论依据，制定了以“化浊”、“解毒”、“和胃”三法合一为主治疗胃癌前病变，取得良好疗效。
藿香、佩兰芳香化浊，芳香之品悦脾醒脾，内消湿浊；荷叶健脾升阳，散瘀止血；千里香行气活血，散瘀止痛，解毒消肿；玳玳花疏肝理气、和胃止痛；长春花解毒抗癌，清热平肝。诸药合用，共凑芳香化浊，清热解毒之功，能有效地改善胃黏膜血流情况，预防腺体萎缩。
典型病例1
张××，男，68岁。主症：胃脘隐痛，嗳气，脘腹胀满，口干口粘，纳呆，排便黏腻不爽，舌暗红苔黄厚腻，脉弦细滑。电子胃镜示：慢性萎缩性胃炎。病理示：胃窦黏膜慢性炎症，腺体轻度肠上皮化生。中医诊断：胃脘痛，浊毒内蕴证。西医诊断：慢性萎缩性胃炎。
处方如下：藿香12g、佩兰9g、荷叶9g、千里香6g、玳玳花6g、长春花6g，上述六味中药，凉水浸泡40分钟左右，煎熬30分钟，取汁300ml，每日一剂，代茶饮。服药7付后，患者胃脘隐痛及嗳气均减轻，脘腹胀满及口干口粘较前好转，食欲增。后仍遵前治法随证加减，6个月后复查胃镜示：慢性非萎缩性胃炎，病理示：胃黏膜慢性炎症。
典型病例2
任××，女，42岁。主症：胃脘痞满、偶有隐痛、食后加重，口干、纳呆，大便干，2～3日一行，舌暗红，苔黄腻，脉弦滑。电子胃镜示：慢性浅表-萎缩性胃炎，Hp(+)。病理诊断示：(胃窦)黏膜慢性炎症，腺体肠上皮化生。中医诊断：胃痞痛，浊毒内蕴。西医诊断：慢性浅表-萎缩性胃炎。
处方如下：藿香9g、佩兰9g、荷叶12g、千里香6g、玳玳花6g、长春花6g，上述六味中药，凉水浸泡40分钟左右，煎熬30分钟，取汁300ml，每日一剂，代茶饮。服药14付后，患者胃脘痞满症状好转，食欲增，二便调。
Claims (2)
1.一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药，其特征在于：由下列原料组成：藿香9～12g、佩兰9～12g、荷叶9～12g、千里香6～9g、玳玳花6～9g、长春花6～9g；
制备方法为：取原料的各组分，凉水浸泡40分钟，煎熬30分钟，取汁300ml，代茶饮。
2.根据权利要求1所述的一种基于浊毒理论指导下防治慢性萎缩性胃炎的中成药，其特征在于：各原料的重量配比为：藿香9g、佩兰9g、荷叶9g、千里香6g、玳玳花6g、长春花6g。
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| 杜艳茹.李佃贵教授应用浊毒理论治疗慢性萎缩性胃炎临床经验.《河北中医》.2017,645-648页. * |
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