CN1112442A

CN1112442A - Baicaoshengshou oral liquor and its preparation

Info

Publication number: CN1112442A
Application number: CN95110208A
Authority: CN
Inventors: 陶振海
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-04-27
Filing date: 1995-04-27
Publication date: 1995-11-29
Anticipated expiration: 2015-04-27
Also published as: CN1053362C

Abstract

The nurishing oral liquid is prepared from rhizoma typhonii 125-500g, oldenlandia 90-340g., herb of scutellaria barbata 100-400g., root of astragalus membranaceus 30-120g., snakegourd peel 60-200g., honeysuckle flower 25-90g., root of sophora flavescens 15-30g., licorice root 15-20g., aristolochia debilis 15-30g., cortex phellodendri 100-200g., root of tinospora 70-150g., rhizoma sparganii 15-30g., zedoary 6-20g., leech 5-10g., dried body of centipede 1.5-3g., cordyceps 2-8g., frankincense 1.5-3g., myrrh 1.5-3g., honey 100ml. Chinese angelica 30g., stevioside 1.5g, and sodium benzoate 5g.

Description

Baicaoshengshou oral liquor and its preparation

The present invention relates to a kind of Chinese medicine oral liquid and production method thereof with the double auxotype function of treatment.

The oral liquid kind of Chu Shouing is a lot of in the market, but mainly is oral liquid and the nutritional tonics with functions such as cough-relieving, tonifying YANG, blood pressure lowerings.Have the functions such as pain that treatment cirrhotic ascites and cancer cause, and double auxotype oral liquid is not seen as yet.

Purpose of the present invention, provide a kind of function, be used for the treatment of the Bai cao sheng shou oral liquid of the pain that ascites that pyretic toxicity wet accumulates, qi depression to blood stasis causes tympanites, cirrhotic ascites, belly cavity tumor cause and cancer cause with heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, promoting the circulation of QI to induce diuresis.

The compatibility of drugs of Bai cao sheng shou oral liquid is: monarch drug Rhizoma Typhonii 125～500g, Herba Hedyotidis Diffusae 90～340g, Herba Scutellariae Barbatae 100～400g, the Radix Astragali 30～120g, Pericarpium Trichosanthis 60～200g; Ministerial drug Flos Lonicerae 25～90g, Radix Sophorae Flavescentis 15～30g, Radix Glycyrrhizae 15～20g, Radix Aristolochiae 15～30g, Cortex Phellodendri 100～200g, Radix Tinosporae 70～150g, rhizoma sparganic 15～30g; Adjuvant drug Rhizoma Curcumae 6～20g, Hirudo 5～10g, Scolopendra 1.5～3g, Cordyceps 2～8g, Olibanum 1.5～3g, Myrrha 1.5～3g; Make oxymel 100ml, Radix Angelicae Sinensis 30g, stevioside 1.5g, sodium benzoate 5g.Be mixed with 500～2000ml Bai cao sheng shou oral liquid.

The manufacture method of Bai cao sheng shou oral liquid is as follows:

Get Rhizoma Curcumae 6～20g, Radix Angelicae Sinensis 30g, rhizoma sparganic 15～30g, Flos Lonicerae 25～90g, add 8 times of amounts of water, reflux, extract, 6 hours is collected volatile oil, and the aqueous solution after backflow device is in addition collected; Medicinal residues and Rhizoma Typhonii 125～500g, Herba Hedyotidis Diffusae 90～340g, Herba Scutellariae Barbatae 100～400g, the Radix Astragali 30～120g, Pericarpium Trichosanthis 60～200g, Radix Sophorae Flavescentis 15～30g, Radix Glycyrrhizae 15～20g, Radix Aristolochiae 15～30g, Cortex Phellodendri 100～200g, Radix Tinosporae 70～150g, Hirudo 5～10g, Scolopendra 1.5～3g, Cordyceps 2～8g, Olibanum 1.5～3g, Myrrha 1.5～3g, add 6～8 times of amounts of water, decoct secondary, each 1 hour, filter, the filtrate of gained and the aqueous solution after the backflow are merged, be concentrated to relative density and be 1.10～1.12(60～70 ℃), put cold, add ethanol, making ethanol content is 70%, leaves standstill 16 hours after-filtration, reclaims ethanol, the volatile oil that filters filtrate and collection merges, add Mel 100ml then successively, stevioside 1.5g, stupid sodium formate 5g adds water to 500～2000ml, mixing.Through packing, embedding, sterilization, be the Bai cao sheng shou oral liquid finished product.

Embodiment:

A, get Rhizoma Curcumae 11g, Radix Angelicae Sinensis 30g, rhizoma sparganic 22g, Flos Lonicerae 54g, add 6～8 times of water gagings, reflux, extract, 6 hours is collected volatile oil (1) and is packed in the container, and the aqueous solution (2) after refluxing is packed in another container;

B, back gained medicinal residues and Rhizoma Typhonii 250g will reflux, Herba Hedyotidis Diffusae 170g, Herba Scutellariae Barbatae 200g, Radix Astragali 63g, Pericarpium Trichosanthis 112g, Radix Sophorae Flavescentis 27g, Radix Glycyrrhizae 18g, Radix Aristolochiae 22g, Cortex Phellodendri 150g, Radix Tinosporae 90g, Hirudo 6g, Scolopendra 2g, Cordyceps 4g, Olibanum 2g, Myrrha 2g mix, add 7 times of water gagings, decoct secondary, each 1 hour, decoct after-filtration, get filtrate (3);

C, with filtrate (3) with reflux after aqueous solution (2) merge, being concentrated into relative density under 60～70 ℃ of temperature is 1.10～1.12, puts coldly, adds ethanol, makes that to contain the alcohol amount be 70%, quiet 16 hours after-filtration reclaim ethanol, filtrate (4);

D, filtrate (4) and volatile oil (1) are merged, add Mel 100ml, stevioside 1.5g, sodium benzoate 5g successively, add water to 1000ml, mixing, packing, embedding, sterilization is Bai cao sheng shou oral liquid finished product of the present invention.

Bai cao sheng shou oral liquid has heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, strengthening the body resistance, benefiting qi and nourishing blood, hard masses softening and resolving, promoting the circulation of QI to induce diuresis, functions such as enhancing immunity.Be used for pyretic toxicity wet accumulates, tympanites, cirrhotic ascites, kidney and the spleen of qi depression to blood stasis cause because of a variety of causes edema and tympanites disease.In addition, this medicine is also to delaying patients with advanced cancer life, improves feed and alleviate the pain that pain that terminal cancer causes causes to have obvious curative effects.

Bai cao sheng shou oral liquid has no side effect ［ maximum tolerated dose to 1 gastric infusion of white mice is that 542.25g/kg(amounts to the crude drug amount) more than, be about 1125 times with dosage of clinical plan, do not see the overt toxicity reaction ］, and taking convenience is evident in efficacy.

In order further to understand the anticancer sick effect of Bai cao sheng shou oral liquid, delivering to this medicine inside and outside the province, the higher hospital of some popularity carries out clinical observation on the therapeutic effect.With this medicine mice transplanted tumor S/80 is carried out the antitumor test as China Academy of TCM, capital Gate of Pervasive Peace hospital, its as a result tumour inhibiting rate compare anti-tumor effect with matched group and be significantly increased up to more than 30 ‰.The colorectal carcinoma cell line 42129 of the used medicine butt joint person of modern times cells in vivo biological characteristics of the present invention of Chinese Medical Sciences University's tumor research has been done collective and has been implemented culture experiment, its result does not see has the cancerous cell colony to form, only see cancerous cell profile in heaven (clone's number is 0), its medicine contrast is implanted with colony and forms, growth of cancer cells is active, can see big colony (clone's number is 2451), and that blank is planted cancer cell multiplication is rapid, colony big (cloning several 3582), this has proved absolutely that Bai cao sheng shou oral liquid has significant effect to suppressing and killing 41219 colorectal cancer cells.By some hospitals such as Shenyang, Tianjin, Nanjing, Wuhan, Lanzhou, Dalian, Beijing, Anshan, Fushun patient clinical taken treatment for another example, show that Bai cao sheng shou oral liquid is applicable to various cancers, can alleviate patient's pain effectively, appetite stimulator, improve sleep, alleviate and improve overall health of patients, gross tumor volume is obviously dwindled.

Claims

1, Bai cao sheng shou oral liquid is mixed with by monarch drug, ministerial drug, adjuvant drug and messenger drug, it is characterized in that described monarch drug is Rhizoma Typhonii, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, the Radix Astragali, Pericarpium Trichosanthis; Ministerial drug is Flos Lonicerae, Radix Sophorae Flavescentis, Radix Glycyrrhizae, Radix Aristolochiae, Cortex Phellodendri, Radix Tinosporae, rhizoma sparganic; Adjuvant drug is Rhizoma Curcumae, Hirudo, Scolopendra, Cordyceps, Olibanum, Myrrha; Messenger drug is Mel, Radix Angelicae Sinensis, stevioside, sodium benzoate; Monarch drug, ministerial drug, adjuvant drug, the compatibility of messenger drug is Rhizoma Typhonii 125～500g, Herba Hedyotidis Diffusae 90～340g, Herba Scutellariae Barbatae 100～400g, the Radix Astragali 30～120g, Pericarpium Trichosanthis 60～200g, Flos Lonicerae 25～90g, Radix Sophorae Flavescentis 15～30g, Radix Glycyrrhizae 15～20g, Radix Aristolochiae 15～30g, Cortex Phellodendri 100～200g, Radix Tinosporae 70～150g, rhizoma sparganic 15～30g, Rhizoma Curcumae 6～20g, Hirudo 5～10g, Scolopendra 1.5～3g, Cordyceps 2～8g, Olibanum 1.5～3g, Myrrha 1.5～3g, Mel 100ml, Radix Angelicae Sinensis 30g, stevioside 1.5g, sodium benzoate 5g.

2, Bai cao sheng shou oral liquid according to claim 1, the best compatibility that it is characterized in that described monarch drug, ministerial drug, adjuvant drug, messenger drug are Rhizoma Typhonii 250g, Herba Hedyotidis Diffusae 170g, Herba Scutellariae Barbatae 200g, Radix Astragali 63g, Pericarpium Trichosanthis 112g, Flos Lonicerae 54g, Radix Sophorae Flavescentis 27g, Radix Glycyrrhizae 18g, Radix Aristolochiae 22g, Cortex Phellodendri 150g, Radix Tinosporae 90g, rhizoma sparganic 22g, Rhizoma Curcumae 11g, Hirudo 6g, Scolopendra 2g, Cordyceps 4g, Olibanum 2g, Myrrha 2g, Mel 100ml, Radix Angelicae Sinensis 30g, stevioside 1.5g, sodium benzoate 5g.

3, the production method of Bai cao sheng shou oral liquid is characterized in that:

A, get Rhizoma Curcumae 6～20g, Radix Angelicae Sinensis 30g, rhizoma sparganic 15～30g, Flos Lonicerae 25～90g, add the water of 8 times of amounts, reflux, extract, 6 hours is collected volatile oil (1) and is packed in the container, and it is standby in another container that the aqueous solution (2) that refluxes is packed into;

The medicinal residues of B, the back gained that will reflux mix with Rhizoma Typhonii 125～500g, Herba Hedyotidis Diffusae 90～340g, Herba Scutellariae Barbatae 100～400g, the Radix Astragali 30～120g, Pericarpium Trichosanthis 60～200g, Radix Sophorae Flavescentis 15～30g, Radix Glycyrrhizae 15～20g, Radix Aristolochiae 15～30g, Cortex Phellodendri 100～200g, Radix Tinosporae 70～150g, Hirudo 5～10g, Scolopendra 1.5～3g, Cordyceps 2～8g, Olibanum 1.5～3g, Myrrha 1.5～3g, add 8 times of amounts of water, decoct secondary, each one hour, filter, get filtrate (3);

C, with filtrate (3) with reflux after aqueous solution (2) merge, being concentrated to relative density under 60～70 ℃ of temperature is 1.10～1.12, puts coldly, adds ethanol, ethanol content is 70%, leaves standstill 16 hours after-filtration, reclaims ethanol, and filtrate (4);

D, filtrate (4) and volatile oil (1) are merged, add Mel 100ml, stevioside 1.5, sodium benzoate 5g then successively, add water to 500～2000ml again, mixing, through packing, embedding, sterilization is the Bai cao sheng shou oral liquid finished product.