CN111239426B - Sample analyzer and automatic calibration method thereof - Google Patents
Sample analyzer and automatic calibration method thereof Download PDFInfo
- Publication number
- CN111239426B CN111239426B CN201811446327.6A CN201811446327A CN111239426B CN 111239426 B CN111239426 B CN 111239426B CN 201811446327 A CN201811446327 A CN 201811446327A CN 111239426 B CN111239426 B CN 111239426B
- Authority
- CN
- China
- Prior art keywords
- calibration
- detection
- sample
- rack
- materials
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 238000001514 detection method Methods 0.000 claims abstract description 199
- 239000000463 material Substances 0.000 claims abstract description 104
- 238000005070 sampling Methods 0.000 claims abstract description 39
- 238000002347 injection Methods 0.000 claims abstract description 11
- 239000007924 injection Substances 0.000 claims abstract description 11
- 238000007599 discharging Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
Landscapes
- Engineering & Computer Science (AREA)
- Quality & Reliability (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The application discloses a method for automatically calibrating a sample analyzer, which comprises the steps of providing a plurality of calibration products with different concentrations, wherein the provided calibration products are placed on a placing rack, and the placing rack is placed at a sample injection position; controlling the placing frame to move to the detection position and pass through the detection position so that a plurality of calibration materials sequentially pass through the detection position, and controlling the sampling detection mechanism to sample and detect the calibration materials and obtain detection data of each calibration material when the calibration materials pass through the detection position; calibration is performed based on the detection data and a previously inputted known data sample analyzer of a plurality of calibration standards. The application also discloses a sample analyzer. Through the mode, the automatic calibration method and the automatic calibration device for the sample analyzer can achieve automatic calibration of the sample analyzer.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a sample analyzer and an automatic calibration method thereof.
Background
The sample analyzer is a common medical device, and is generally classified into an open type, a closed type, and an automatic sample injection type. Generally, a sample analyzer needs to be calibrated to ensure accuracy of a detection result.
The calibration of the existing sample analyzer requires a worker to manually complete the operation process, and particularly, when the multi-point calibration is performed, a great deal of manual operation is required in the calibration process, so that the calibration process is too complicated and is easy to make mistakes.
Disclosure of Invention
The application mainly solves the technical problem of providing a sample analyzer and an automatic calibration method thereof, which can realize the automatic calibration of the sample analyzer.
In order to solve the technical problems, one technical scheme adopted by the embodiment of the application is as follows: a method of providing automatic calibration of a sample analyzer, the method comprising: providing a plurality of calibration materials with different concentrations, wherein the provided calibration materials are placed on a placing rack, and the placing rack is placed at a sample feeding position; controlling the placing frame to move to the detection position and pass through the detection position so that a plurality of calibration materials sequentially pass through the detection position, and controlling the sampling detection mechanism to sample and detect the calibration materials and obtain detection data of each calibration material when the calibration materials pass through the detection position; the sample analyzer is calibrated based on the detection data and the known data of the plurality of calibration standards input in advance.
In order to solve the technical problems, another technical scheme adopted by the embodiment of the application is as follows: a sample analyzer, the sample analyzer comprising: the device comprises a sample injection base, at least one placing frame, a placing frame driving mechanism, a sampling detection mechanism and a processor; at least one rack is arranged at the sample injection base and can be driven to move by a rack driving mechanism, and the at least one rack is used for placing a plurality of calibration products; the processor is used for controlling the rack driving mechanism to drive the rack to move to the detection position and pass through the detection position so that a plurality of calibration materials sequentially pass through the detection position, when the calibration materials pass through the detection position, the sampling detection mechanism is controlled to sample and detect the calibration materials, detection data of each calibration material are obtained, and the sample analyzer is calibrated according to the detection data and the known data of the calibration materials which are input in advance.
The embodiment of the application discloses a method for automatically calibrating a sample analyzer, which comprises the following steps: providing a plurality of calibration materials with different concentrations, wherein the provided calibration materials are placed on a placing rack, and the placing rack is placed at a sample feeding position; controlling the placing frame to move to the detection position and pass through the detection position so that a plurality of calibration materials sequentially pass through the detection position, and controlling the sampling detection mechanism to sample and detect the calibration materials and obtain detection data of each calibration material when the calibration materials pass through the detection position; the sample analyzer is calibrated based on the detection data and the known data of the plurality of calibration standards input in advance. Because the rack is controlled to move to the detection position and pass through the detection position so that a plurality of calibration materials pass through the detection position in sequence, the automatic replacement of the calibration materials and the sampling and detection can be realized, and the automatic calibration of the sample analyzer can be realized.
Drawings
FIG. 1 is a schematic perspective view of a sample analyzer according to an embodiment of the present application;
FIG. 2 is a schematic diagram of the electrical connection principle of a sample analyzer according to an embodiment of the present application;
FIG. 3 is a flow chart of a method for automatically calibrating a sample analyzer according to an embodiment of the application;
FIG. 4 is a schematic diagram showing a specific flow of step S13 in FIG. 3;
FIG. 5 is a flow chart of a method for automatically calibrating a sample analyzer according to another embodiment of the application;
fig. 6 is a schematic diagram showing a specific flow of step S22 in fig. 5.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the application. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present application are shown in the drawings. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
The terms "first," "second," and the like in this disclosure are used for distinguishing between different objects and not for describing a particular sequential order. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those listed steps or elements but may include other steps or elements not listed or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
Referring to fig. 1 and fig. 2 in combination, fig. 1 is a schematic perspective view of a sample analyzer according to an embodiment of the application, and fig. 2 is a schematic view of an electrical connection principle of the sample analyzer according to an embodiment of the application.
In this embodiment, the sample analyzer includes a sample introduction base 11, at least one rack 12, a rack driving mechanism 22, a sampling detection mechanism 13, a mixing mechanism 23, a position sensor 24, and a processor 21.
The sample introduction base 11 comprises a frame feeding platform 111, a frame discharging platform 112, a detection platform 113 and a sensor bracket 114, wherein the sensor bracket 114 is arranged at a detection position of the detection platform 113.
The rack feeding platform 111 is used for conveying the racks 12 to the detection platform 113, the detection platform 113 is used for conveying the racks 12 from the rack feeding platform 111 to the rack discharging platform 112, and the rack discharging platform 112 is used for conveying the racks 12 from the detection platform 113 to a rack recovery place. As shown in particular by arrows S1-S2-S3-S4 in fig. 1, which refer to the direction of conveyance of the rack 12.
At least one rack 12 is disposed at the sample feeding position of the feeding platform 111, and can be driven to move by the rack driving mechanism 22, and the at least one rack 12 is used for placing a plurality of calibration standards.
It should be noted that, each of the racks 12 is provided with a plurality of receiving holes, and each receiving hole may correspondingly receive a sample container 14 containing a calibrator, and the sample container 14 may be a test tube.
In a specific embodiment, the number of at least one rack 12 may be two, wherein one rack 12 is used for placing a plurality of calibration standards, and the other rack 12 is used for placing samples to be tested.
It should be noted that, by providing two holders 12, the sample analyzer can directly perform the detection of the sample after calibration, so as to improve the accuracy and efficiency of the detection.
In another embodiment, the number of at least one rack 12 may also be an even number of at least four, at least four racks 12 may be used to place the calibrator and the sample at intervals in sequence, i.e., a first rack 12 is used to place the calibrator, a second rack 12 is used to place the sample to be tested, and so on.
It should be noted that, by setting the calibrator and the sample at intervals, calibration and sample inspection of the sample analyzer can be alternately performed, and calibration is performed before each sample inspection, so as to further improve the accuracy of the inspection.
The rack driving mechanism 22 is for driving the rack 12 to move on the rack feeding platform 111 in the above-described conveying direction.
The sampling detection mechanism 13 is used for sampling and detecting the calibration material, and the sampling detection mechanism 13 specifically comprises a sampling mechanism 131 arranged above the detection platform 113 and a detection mechanism 132 arranged inside the sample analyzer. The sampling mechanism 131 is used for collecting the calibration material and delivering the calibration material to the detection mechanism 132 for detection, and the detection mechanism 132 is used for detecting the calibration material collected by the sampling mechanism 131 and outputting detection data to the processor 21.
The mixing mechanism 23 is used for mixing a plurality of calibration materials to be detected. The processor 21 controls the mixing mechanism 23 to mix the plurality of calibration standards.
Before the plurality of calibration materials on the rack 12 are sampled and detected, the processor 21 may determine whether to control the mixing mechanism 23 to mix the plurality of calibration materials on the rack 12 according to the properties of the calibration materials, for example, when detecting a suspension such as a blood sample, the processor 21 may control the mixing mechanism 23 to mix the plurality of calibration materials. When detecting a solution such as potassium chloride, the processor 21 does not control the mixing mechanism 23 to mix the plurality of calibration materials on the rack 12.
The position sensor 24 is provided at a detection position on the detection platform 113 for detecting whether or not a calibrator is present on the rack 12 passing from the detection position.
Optionally, the position sensor 24 is disposed on the sensor mount 114.
Specifically, the position sensor 24 includes a first photosensor and a second photosensor that will block signal transmission between the first photosensor and the second photosensor when a calibrant passes the detection position.
The processor 21 is used for controlling the rack driving mechanism 22 to drive the rack 12 to move to the detection position and pass through the detection position so that a plurality of calibration standards sequentially pass through the detection position, and when the calibration standards pass through the detection position, the processor 21 controls the sampling detection mechanism 13 to sample and detect the calibration standards and acquire detection data of each calibration standard.
It should be noted that, the processor 21 controls the rack driving mechanism 22 to drive the rack 12 to move so that the first calibrator on the rack 12 moves to the detection position and stays for a preset time to be sampled and detected, and then the processor 21 controls the rack driving mechanism 22 to drive the rack 12 to move for a preset distance each time, so that a plurality of calibrators can be sequentially moved to the detection position and each calibrator stays at the detection position for a preset time to be sampled and detected until all calibrators are detected. When the processor 21 determines that all the calibrators are detected, the processor 21 calibrates the sample analyzer based on the detection data and the known data of the plurality of calibrators input in advance.
It should be noted that, the processor 21 may determine whether all the calibration materials are detected according to the change of the detection signal of the position sensor 24.
Referring to fig. 3, fig. 3 is a flowchart illustrating a method for automatically calibrating a sample analyzer according to an embodiment of the application.
In this embodiment, the method for automatically calibrating a sample analyzer includes:
step S11: providing a plurality of calibration materials with different concentrations, wherein the plurality of calibration materials are placed on a placing rack, and the placing rack is placed at a sample feeding position.
It should be noted that, the number of the placement frames 12 is at least one, and at least one placement frame 12 is sequentially arranged and all placed at the sample feeding position of the feeding platform 111. As described above, when the number of the racks 12 is two, one of the racks 12 is used to hold a plurality of calibration materials, and the other rack 12 holds samples to be tested. When the number of at least one rack 12 is an even number of at least four, at least four racks 12 may be used to sequentially place the calibrator and the sample to be tested at intervals.
In a specific embodiment, a plurality of calibrators are provided to be placed on the rack 12 in order of concentration.
In the detection, a plurality of calibration samples may pass through the detection positions in order of low concentration. Because when the cleaning of the sampling detection mechanism 13 is not clean and thorough, the detection error is larger when the high-concentration calibrator is detected first and then the low-concentration calibrator is detected, and the accuracy of detection can be improved, so that the effectiveness of calibration is ensured.
Step S12: and controlling the mixing mechanism to mix the plurality of calibration materials uniformly.
As described above, whether to control the mixing mechanism 23 to mix a plurality of calibration materials may be determined according to the properties of the calibration materials.
Step S13: the control rack moves to the detection position and passes through the detection position so that a plurality of calibration materials sequentially pass through the detection position, and when the calibration materials pass through the detection position, the control sampling detection mechanism samples and detects the calibration materials and acquires detection data of each calibration material.
Referring to fig. 4, fig. 4 is a schematic flowchart of step S13 in fig. 3.
In a specific embodiment, taking 3 calibration samples as an example, step S13 includes the following steps:
s131: and controlling the placing frame to move to the detection position, so that the first calibrator on the placing frame moves to the detection position and stays for a preset time to be sampled and detected.
Alternatively, the rack 12 may be driven to move on the rack-in platform 111 in the conveying direction described above by the rack driving mechanism 22.
S132: and controlling a sampling detection mechanism to sample and detect the calibrator at the detection position and acquiring detection data of the calibrator.
In a specific embodiment, the sampling detection mechanism 13 is controlled to sample and detect each calibration material multiple times, and an average value of the values detected multiple times by each calibration material is obtained as detection data.
It should be noted that, by sampling and detecting multiple times to obtain an average value of the detection values, accuracy of the detection data can be improved.
S133: after the first calibrator is detected, the placing frame is controlled to move for a preset distance, so that the next containing hole on the placing frame along the sample injection direction is moved to a detection position, and each containing hole stays at the detection position for a preset time.
S134: and detecting whether a calibrator exists on the rack passing through the detection position. I.e. detecting whether a calibrator is placed in the receiving hole on the placement frame.
Alternatively, whether or not a calibrator is present on the rack 12 passing from the detection position may be determined based on a change in the detection signal of the position sensor 24. Thereby judging whether all the calibration materials are detected.
When the presence of the calibration sample at the detection position is detected, the flow returns to S132, and the sampling detection mechanism 13 is continuously controlled to sample and detect the calibration material at the detection position and acquire the detection data of the calibration material.
When the presence of the calibration sample at the detection location is not detected, the next step is performed.
S135: when the presence of the calibration sample at the detection position is not detected, it is determined that all of the plurality of calibration samples are detected, and detection data of each of the plurality of calibration samples is stored after the detection is completed.
It should be noted that, after all the 3 calibration samples are detected, the rack 12 is continuously controlled to move by a preset distance, and at this time, because all the calibration samples on the rack 12 are detected, the existence of the calibration samples on the rack 12 cannot be detected, thereby judging that all the calibration samples are detected.
Meanwhile, the rack 12 can be controlled to move out of the detection position to the rack discharging platform 112, and the rack discharging platform 112 can convey the rack 12 to the rack recycling position and control the sampling detection mechanism 13 to stop sampling and detection.
The method for determining that the entire detection of the calibration material is completed is not limited to the above-described method for detecting the position sensor 24. For example, when the known data of a plurality of calibration standards are input in advance, the number of calibration standards may be acquired based on the number of known data, and the calibration time may be generated.
It should be further noted that, the time for the rack 12 to move from the sample feeding position to the detection position, the time for each movement of the rack 12 to sequentially pass the detection position, and the time for sampling and detecting each calibrator are all preset, and the calibration time can be calculated by the number of calibrators and the time spent in the above process.
After calibration is started, the calibration time is elapsed, all the calibration samples are judged to be detected, and detection data of each calibrator are stored after the detection is completed.
Step S14: the sample analyzer is calibrated based on the detection data and the known data of the plurality of calibration standards input in advance.
The type of the known data may be determined according to the detection requirement, for example, the concentration of the solution, the number of cells, the absorbance, etc., and the type of the known data is consistent with the type of the detection data, so as to perform data comparison.
Specifically, data fitting is performed according to the detection data and the known data of a plurality of calibration materials input in advance to form a calibration equation.
It should be noted that, the known data of the plurality of calibration materials are input in advance according to the detection sequence of the calibration materials with different concentrations, the detection data is plotted on the abscissa, the known data is plotted on the ordinate, a calibration curve is obtained, and according to the calibration curve, data fitting can be performed to form a calibration equation y=f (X), for example, the calibration equation can be y=ax 2 +bx+c, then a, b, c are calibration parameters, and again, for example, the calibration equation is y=dx+e, then d, e are calibration parameters.
Step S15: and correcting the detection result of the sample according to the calibration equation to obtain a calibrated detection result.
When the sample is detected, the real-time sample detection value x 'is substituted into the calibration equation to be corrected, and the corrected value is the value f (x'), i.e., the result after the calibration.
In another embodiment of the present application, after controlling the rack 12a to move to the detecting position and before controlling the sampling detecting mechanism 13a to sample and detect the calibration standards, the mixing mechanism 23a may be controlled to mix the plurality of calibration standards.
As described above, whether to control the mixing mechanism 23a to mix a plurality of calibration materials may be determined according to the properties of the calibration materials.
Through the mode, the calibrator at the detection position can be sequentially mixed, sampled and detected, so that the standing time of the calibrator after being mixed is reduced, a better mixing effect is achieved, and the calibration accuracy is improved.
Referring to fig. 5, fig. 5 is a flowchart illustrating a method for automatically calibrating a sample analyzer according to another embodiment of the application. In this embodiment, the method for automatically calibrating a sample analyzer includes:
step S21: providing a plurality of calibration materials with different concentrations, wherein the plurality of calibration materials are placed on a placing rack, and the placing rack is placed at a sample feeding position.
Step S22: the control rack moves to the detection position and passes through the detection position so that a plurality of calibration materials sequentially pass through the detection position, when the calibration materials pass through the detection position, the control mixing mechanism is used for mixing the calibration materials uniformly, the sampling detection mechanism is controlled for sampling and detecting the calibration materials, and the detection data of each calibration material are obtained.
Step S23: the sample analyzer is calibrated based on the detection data and the known data of the plurality of calibration standards input in advance.
Step S24: and correcting the detection result of the sample according to the calibration equation to obtain a calibrated detection result.
Referring to fig. 6, fig. 6 is a specific flowchart of step S22 in fig. 5.
Step S22 in this embodiment includes the steps of:
s221: and controlling the placing frame to move to the detection position, so that the first calibrator on the placing frame moves to the detection position and stays for a preset time to be sampled and detected.
S222: and controlling the mixing mechanism to mix the calibration material uniformly.
S223: and controlling a sampling detection mechanism to sample and detect the calibrator at the detection position and acquiring detection data of the calibrator.
S224: after the first calibrator is detected, the placing frame is controlled to move for a preset distance, so that the next containing hole on the placing frame along the sample injection direction is moved to a detection position, and each containing hole stays at the detection position for a preset time.
S225: and detecting whether a calibrator exists on the rack passing through the detection position. I.e. detecting whether a calibrator is placed in the receiving hole on the placement frame.
When the presence of the calibration sample at the detection position is detected, the flow returns to S222, and the sampling detection mechanism 13a is continuously controlled to sequentially mix, sample and detect the calibration material at the detection position, and acquire the detection data of the calibration material.
When the presence of the calibration sample at the detection location is not detected, the next step is performed.
S226: when the presence of the calibration sample at the detection position is not detected, it is determined that all of the plurality of calibration samples are detected, and detection data of each of the plurality of calibration samples is stored after the detection is completed.
In this embodiment, other contents are the same as those in the previous embodiment, and will not be described here again.
The embodiment of the application discloses a method for automatically calibrating a sample analyzer, which comprises the following steps: providing a plurality of calibration materials with different concentrations, placing the calibration materials on a placing rack, and placing the placing rack at a sample feeding position; controlling the placing frame to move to the detection position and pass through the detection position so that a plurality of calibration materials sequentially pass through the detection position, and controlling the sampling detection mechanism to sample and detect the calibration materials and obtain detection data of each calibration material when the calibration materials pass through the detection position; the sample analyzer is calibrated based on the detection data and the known data of the plurality of calibration standards input in advance. Because through control rack motion to detect the position and pass through the position of detection so that a plurality of calibrator pass through the position of detection in proper order, can realize automatic replacement calibrator to control sampling detection mechanism carries out sample and detection in proper order to the calibrator of position of detection, can improve the calibration efficiency of sample analyzer in order to practice thrift manpower and time cost.
The foregoing description is only of embodiments of the present application, and is not intended to limit the scope of the application, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present application or directly or indirectly applied to other related technical fields are included in the scope of the present application.
Claims (8)
1. A method for automatically calibrating a sample analyzer, the method comprising:
providing a plurality of calibration materials with different concentrations, wherein the provided plurality of calibration materials and a plurality of samples are placed on a placing rack, the placing rack is placed at a sample injection position, and the calibration materials and the samples are arranged at intervals;
controlling the placing frame to move to a detection position and pass through the detection position so that the plurality of calibration materials and the sample sequentially pass through the detection position, and controlling a sampling detection mechanism to sample and calibrate the calibration materials and obtain detection data of each calibration material when the calibration materials pass through the detection position; calibrating the sample analyzer according to the detection data and the known data of the calibration materials input in advance, and checking the sample;
before controlling the sampling detection mechanism to sample and detect the calibrator, the method further comprises:
determining whether a mixing mechanism is required to be controlled to mix the plurality of calibration standards according to the properties of the calibration standards;
the step of controlling the rack to move to the detection position and pass through the detection position so that the plurality of calibration materials sequentially pass through the detection position, when the calibration materials pass through the detection position, controlling the sampling detection mechanism to sample and detect the calibration materials and obtaining detection data of each calibration material comprises the following steps:
detecting whether the calibrator is present on the rack passing through the detection position;
when the presence of the calibration material at the detection position is detected, controlling the sampling detection mechanism to sample and detect the calibration material at the detection position;
acquiring calibration time according to the number of the calibration materials;
and judging that all the calibration materials are detected based on the calibration time, and storing detection data of each calibration material after the detection is completed.
2. The method of automatic calibration of a sample analyzer according to claim 1, wherein the plurality of calibrators are provided in order of concentration on the rack.
3. The method of automatic calibration of a sample analyzer according to claim 1, wherein the step of controlling the sampling detection mechanism to sample and detect the calibrator and to acquire detection data for each of the calibrators comprises:
and controlling the sampling detection mechanism to sample and detect the calibrator for a plurality of times, and acquiring the average value of the values detected by the calibrator for a plurality of times as detection data.
4. The method of automatic calibration of a sample analyzer according to claim 1, wherein the step of calibrating the sample analyzer based on the detection data and the previously inputted known data of the plurality of calibrators comprises:
and performing data fitting according to the detection data and the pre-input known data of the plurality of calibration materials to form a calibration equation.
5. The method of automatic calibration of a sample analyzer according to claim 4, further comprising, after the step of fitting data based on the detection data and the previously inputted known data of the plurality of calibrators to form a calibration equation:
and correcting the detection result of the sample according to the calibration equation to obtain a calibrated detection result.
6. A sample analyzer, the sample analyzer comprising: the device comprises a sample injection base, at least one placing frame, a placing frame driving mechanism, a sampling detection mechanism and a processor;
the at least one rack is arranged at the sample injection position of the sample injection base and can be driven to move by the rack driving mechanism, and the at least one rack is used for placing a plurality of calibration materials and a plurality of samples, and the calibration materials and the samples are arranged at intervals;
the processor is used for controlling the rack driving mechanism to drive the rack to move to the detection position and pass through the detection position so that the plurality of calibration materials and the sample sequentially pass through the detection position, when the calibration materials pass through the detection position, the sampling detection mechanism is controlled to sample and detect the calibration materials, detection data of each calibration material are obtained, and the sample analyzer is calibrated according to the detection data and the known data of the plurality of calibration materials which are input in advance;
the processor is also used for determining whether a mixing mechanism needs to be controlled to mix the plurality of calibration materials according to the properties of the calibration materials;
the processor is further configured to detect whether the calibrator is present on the rack passing from the detection location;
when the presence of the calibration material at the detection position is detected, controlling the sampling detection mechanism to sample and detect the calibration material at the detection position;
acquiring calibration time according to the number of the calibration materials;
and judging that all the calibration materials are detected based on the calibration time, and storing detection data of each calibration material after the detection is completed.
7. The sample analyzer of claim 6, further comprising: the mixing mechanism is used for mixing the plurality of calibration materials to be detected.
8. The sample analyzer of claim 7, further comprising: the position sensor is arranged at the detection position on the sample injection base and is used for detecting whether the calibrator exists on the rack passing through the detection position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811446327.6A CN111239426B (en) | 2018-11-29 | 2018-11-29 | Sample analyzer and automatic calibration method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811446327.6A CN111239426B (en) | 2018-11-29 | 2018-11-29 | Sample analyzer and automatic calibration method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111239426A CN111239426A (en) | 2020-06-05 |
| CN111239426B true CN111239426B (en) | 2023-12-01 |
Family
ID=70879314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811446327.6A Active CN111239426B (en) | 2018-11-29 | 2018-11-29 | Sample analyzer and automatic calibration method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111239426B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111812337A (en) * | 2020-08-24 | 2020-10-23 | 桂林优利特医疗电子有限公司 | System and method for realizing specific protein full-linear range calibration by using single-value calibrator |
| CN115932249A (en) * | 2022-12-30 | 2023-04-07 | 杭州纽太生物科技有限公司 | Real-time calibration immunochromatography detection method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960497A (en) * | 1975-08-19 | 1976-06-01 | Beckman Instruments, Inc. | Chemical analyzer with automatic calibration |
| JP2003083982A (en) * | 2001-09-12 | 2003-03-19 | Olympus Optical Co Ltd | Analysis apparatus |
| JP2004219218A (en) * | 2003-01-14 | 2004-08-05 | Fuji Photo Film Co Ltd | Automatic analyzer |
| CN104395730A (en) * | 2012-06-25 | 2015-03-04 | 株式会社日立高新技术 | Automatic analysis device and test sample measurement method |
| CN105572407A (en) * | 2016-01-27 | 2016-05-11 | 广州万孚生物技术股份有限公司 | Full-automatic fluorescent quantitative immunity analyzer and detection method |
| CN105637365A (en) * | 2013-06-07 | 2016-06-01 | 豪夫迈·罗氏有限公司 | Calibration for multi-component assays |
| CN105628948A (en) * | 2016-03-04 | 2016-06-01 | 深圳普门科技有限公司 | High-speed C reactive protein analyzer and analyzing method thereof |
-
2018
- 2018-11-29 CN CN201811446327.6A patent/CN111239426B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960497A (en) * | 1975-08-19 | 1976-06-01 | Beckman Instruments, Inc. | Chemical analyzer with automatic calibration |
| JP2003083982A (en) * | 2001-09-12 | 2003-03-19 | Olympus Optical Co Ltd | Analysis apparatus |
| JP2004219218A (en) * | 2003-01-14 | 2004-08-05 | Fuji Photo Film Co Ltd | Automatic analyzer |
| CN104395730A (en) * | 2012-06-25 | 2015-03-04 | 株式会社日立高新技术 | Automatic analysis device and test sample measurement method |
| CN105637365A (en) * | 2013-06-07 | 2016-06-01 | 豪夫迈·罗氏有限公司 | Calibration for multi-component assays |
| CN105572407A (en) * | 2016-01-27 | 2016-05-11 | 广州万孚生物技术股份有限公司 | Full-automatic fluorescent quantitative immunity analyzer and detection method |
| CN105628948A (en) * | 2016-03-04 | 2016-06-01 | 深圳普门科技有限公司 | High-speed C reactive protein analyzer and analyzing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111239426A (en) | 2020-06-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111239426B (en) | Sample analyzer and automatic calibration method thereof | |
| US3960497A (en) | Chemical analyzer with automatic calibration | |
| JP5355362B2 (en) | Specimen inspection system, specimen inspection method and computer program | |
| US9625482B2 (en) | Sample analyzer | |
| EP2182364B1 (en) | Sample analyzer and calibration method of sample analyzer | |
| JPH06130067A (en) | Automatic liquid specimen analyzer | |
| US8852505B2 (en) | Hematological analyzer on whole blood with stirring device | |
| US11187713B2 (en) | Laboratory module for storing and feeding to further processing of samples | |
| US20110294221A1 (en) | Control bracketing and results hold | |
| US11740254B2 (en) | Automatic analysis apparatus | |
| JP2018144900A (en) | Article distribution system | |
| JPH09243645A (en) | Transfer apparatus for sample rack | |
| GB2458778A (en) | Chromatography device with inclination sensor | |
| EP1889662B1 (en) | Method of normalizing surface tension of a sample fluid | |
| US20220390936A1 (en) | Systems, apparatus, and methods of analyzing specimens | |
| JP2008076342A (en) | Automatic analyzer | |
| CN114660310B (en) | Automatic calibration method of sample analysis system | |
| CN105510612B (en) | Instrument is selected in the handing-over quality supervision of fully automatic blood sample | |
| JP2012173251A (en) | Sample analysis device and sample analysis method | |
| JPH09318544A (en) | Method and equipment for analyzing specimen | |
| JPH0815265A (en) | Automatic chemical analysis apparatus | |
| WO2023176287A1 (en) | Analysis device, program, correction member, and protection member | |
| CN219320312U (en) | Sample injection device and sample analyzer | |
| CN220542773U (en) | Color calibration detection device | |
| KR102241251B1 (en) | Multiplexing blot assay automation system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |